LOCUS       NM_001284522            6550 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus La ribonucleoprotein 4 (Larp4), transcript variant 4,
            mRNA.
ACCESSION   NM_001284522
VERSION     NM_001284522.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6550)
  AUTHORS   Tian,Y., Zeng,Z., Li,X., Wang,Y., Chen,R., Mattijssen,S.,
            Gaidamakov,S., Wu,Y., Maraia,R.J., Peng,W. and Zhu,J.
  TITLE     Transcriptome-wide stability analysis uncovers LARP4-mediated
            NFkappaB1 mRNA stabilization during T cell activation
  JOURNAL   Nucleic Acids Res 48 (15), 8724-8739 (2020)
   PUBMED   32735645
  REMARK    GeneRIF: Transcriptome-wide stability analysis uncovers
            LARP4-mediated NFkappaB1 mRNA stabilization during T cell
            activation.
REFERENCE   2  (bases 1 to 6550)
  AUTHORS   Mattijssen,S., Arimbasseri,A.G., Iben,J.R., Gaidamakov,S., Lee,J.,
            Hafner,M. and Maraia,R.J.
  TITLE     LARP4 mRNA codon-tRNA match contributes to LARP4 activity for
            ribosomal protein mRNA poly(A) tail length protection
  JOURNAL   Elife 6, e28889 (2017)
   PUBMED   28895529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6550)
  AUTHORS   Mattijssen,S. and Maraia,R.J.
  TITLE     LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a
            Tristetraprolin-Dependent Manner
  JOURNAL   Mol Cell Biol 36 (4), 574-584 (2015)
   PUBMED   26644407
  REMARK    GeneRIF: Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6550)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 6550)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 6550)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ083603.1, AK139636.1, AK139909.1, AK141743.1, AK052358.1,
            BE951991.1 and AI853685.1.
            
            Transcript Variant: This variant (4) contains an alternate
            5'-terminal exon and initiates translation at an alternate start
            codon, compared to variant 1. The encoded isoform (4) has a shorter
            and distinct N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CJ083603.1         1-9
            10-214              AK139636.1         3-207
            215-736             AK139636.1         211-732
            737-2530            AK139909.1         578-2371
            2531-3761           AK141743.1         313-1543
            3762-5633           AK052358.1         13-1884
            5634-6186           BE951991.1         156-708
            6187-6550           AI853685.1         1-364               c
FEATURES             Location/Qualifiers
     source          1..6550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..6550
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
     exon            1..214
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2356
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="isoform 4 is encoded by transcript variant 4;
                     la-related protein 4; La ribonucleoprotein domain family,
                     member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform 4"
                     /protein_id="NP_001271451.1"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
                     /translation="MALEVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAATS
                     GSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDVSG
                     ESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKL
                     TTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNENC
                     PKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNG
                     YRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPLAP
                     FPNGSFVNGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGDGP
                     LSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDD
                     DRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCREK
                     DSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPKD
                     TLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKEPS
                     PVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRGAA
                     GKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK"
     exon            215..350
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            351..506
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            507..582
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            583..719
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            720..823
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            824..934
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            935..988
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1198
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1302
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1515
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1564
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1726
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1848
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2017
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..6540
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: AATAAA"
     polyA_site      4530
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="major polyA site"
     regulatory      6430..6435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: CATAAA"
     polyA_site      6447
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
ORIGIN      
        1 tgttgaagag ctgctgcagt taccgtaagc cacgaagacc atacaatggg gtttttatga
       61 acaaactaaa aatgggggaa aaattaagat aaactataag ttgctaacta aagacatgaa
      121 gagatctgtg aagtagagtc ttggggagaa ccttatatag agagatattg attgacaaat
      181 acggaagata ccttgatgca tcatggcttt ggaggtgaca tctaaaggca ctggtttaaa
      241 tcctaatgcc aaagtatggc aagaaattcc ttctggaaat ccggatggca ctcctgtaac
      301 tgaaccctct tggcatgaaa ctgcagccac atctggatct caccctgagg gccatacaga
      361 actttcagaa gatatgtgta aggaatatga agtaatgtat tctccatctt gtgaaaccac
      421 aaggaatact gcagatgttg aagagtcagc tgatggaatg atcttaggac cggaagacct
      481 gagttaccaa ctctatgatg tttctggaga aagcagttca gcaatttcta cagaagattt
      541 aaaagaatgt ctgaaaaaac aattggaatt ctgtttctca cgagaaaatt tatcaaagga
      601 cctttacttg atatctcaaa tggatagtga tcagttcgtc ccaatatgga cggttgccaa
      661 catggaagaa attaaaaaat tgactacaaa tacagattta attcttgaag tattgagatc
      721 ttcccctatg gtacaagttg atgagaaggg agaaaaggtg agaccaagtc ataagcgatg
      781 tattgtgatt ctcagagaga ttcctgagac aacgcctgta gaggaagtga aagctttgtt
      841 taaaaatgaa aactgcccca aagtgataag ctgtgagttt gcgcacaaca gcaactggta
      901 catcactttc cagtcagaca cagatgcaca gcaggctttt aaatacttaa gagaagaagt
      961 taaaacattt cagggcaagc caatcatggc aaggataaaa gccatcaata cattttttgc
     1021 taagaatggt tatcgattaa tggattctag tatgtatact caacctattc agactcctac
     1081 ccaatatccc tcaccagtct tcatgcaacc agtgtataat cctcagcagt actcagtgta
     1141 tagtcttgtg cctcagtctt ggtctccaag tcctgcacct tactttgaaa caccactggc
     1201 tccctttccc aatggtagtt ttgtgaatgg ctttagttca ccaggatctt acaaaacaaa
     1261 tgctgctgct atgaatatgg gccgaccatt cccaaaaaat cgtgtgaagc ctcattttag
     1321 gtcatccagt ggttcagaac actcaacaga gggctccgtg tcattggggg atggaccact
     1381 gagcagatct agttcaagga tctttctttc tgaacggcat aacccaacag taacagggca
     1441 gcaggaacaa acttatcttc caaaggaggc tcccatttta cagatggaac agaatgggga
     1501 ctttggaaga ggcaggcgaa ctctcttcag aggccgaagg cgaagggatg atgacaggat
     1561 cccaagaccc caacctgcag caactgaagc caaggctcca actccgaagt ttgatttgct
     1621 tgctacaaat ttccctcctt tacctggaag ctcatcgaga gtgccagatg aacttggttt
     1681 ggagaacaga atgtctgatg tcgttaaagg tgtctgcaga gaaaaggaca gcgaggacgt
     1741 gcgagttagt tgcccagtgc ctgcagagga cggacagaca gactgcactt ctgcgccgct
     1801 cagcataagt cctagtcctc cgtgtacagc tgagcctcct gtgttaagca cgactcagca
     1861 agagcaggat cagatggagg actctgctgt tccaaaggac actctcaacc cagtagctgt
     1921 gccagtgtct tctccaactg ccacaaagcc atccccggca aacacggctt caccttgcac
     1981 tagtaacata aacccaccga gagctgtggc cctgcaggaa cctcgaaagt taagctatgc
     2041 tgaagtgtgc cagaagcctc ctaaagagcc atctccagtt ctcgtacagc cgctgcggga
     2101 actccggtct aatgcagtat cccccaccag aaatgaagag aacggagctc ccgagaagcc
     2161 tgttgagaag ccgcatgaga aaccagaaac aagggctagt aaggatcatt ctggcttccg
     2221 aggcaacact attcccaggg gagcggctgg aaaaatcagg gaacagagac gccagttcag
     2281 ccatagggct acacctcagg gagtgactcg acgtaatggg aaagagcaat acgtgccacc
     2341 cagatcacca aagtaaaaac aaagcctaca aaaactactc agaagcttct cttcccacta
     2401 aacttgagcc tctgttgaac tgttttggag gggaggaagt agccaggaaa gaatgggaag
     2461 taagccctaa atatgacgga tttttgaaat tgcgagtagg aagagcccaa aattcatctc
     2521 taaatgattt tcaaatgctg gaggattcca atcagtataa atatatataa atatatatat
     2581 atacacacat atatatataa atataatttt tctatttttg tttttgattt taatttgcag
     2641 gaattttctg cctggaatca attttgaggg ttcagattta gcttgggaga gaaaacaaaa
     2701 aacattatac atccttcagt ataggagatg agggagtgag agaaaatatt ttttgaagaa
     2761 acatttctgt aaaaattaga aattactttt tttaatctat ttaaagtttg gcttgaagaa
     2821 tgctatctct gactaaatgg ccttgtgttg cagagtagat gagtggctag ggagtctgtt
     2881 ctgggtccga gtgtgtgcaa aagtgattta agccaaatct gttgtcatgg tagtaaatga
     2941 tttcaaagct gaatgtaata cttgagtaga ttttctttgt agtttggaat ttagttgttt
     3001 ttgttttttg acattactaa tactgtattg tatgaacaag ctataaagct ctgattgtgt
     3061 gtgaagctgt gactaccaat cagtttgata ttcaaggaaa gaatggagat tattcaaaaa
     3121 aaatattgaa aattctgttt tagacctgaa tactggatag gtcaaataga ttgcagaggt
     3181 ttaaactgcc ctgtgacctt tttttttcct ttttaatttt ttttctgatt gtttgttagt
     3241 ctctgttctt agactgtctt ccccccaaaa gcaatatgac taactgttta ctggacagta
     3301 tgtttcttac tactttgacc agtttaatca aattatataa ctattctaag ctacataatg
     3361 gaatattgaa agatttttat tcaattagaa ttttaggtcc caggatggta ctgacctgcc
     3421 agtaatttat ttgtattggt gttaaaaaaa tgaaatagtg cttctggctg tgcgggcata
     3481 aatctccaac cctggcctcc agaggtgtgg caggtggatc tcagtcccag tccatccagg
     3541 gctctacctc tcactagttt ctgtctaaag aaagaaaagg aaaaggaaag aaagatgaaa
     3601 ccgtgtaact gactttttaa atggtctaac ggaaaaattc aaacattaat ttggggaatt
     3661 ttgttgttta caatgtttat catctttctt tggcttgccc ccaaaagtac agtttagcat
     3721 ttgcagacta aaaatagcaa gtcaaggatt tttttttttt tgagataaag cgaaaaagtg
     3781 gttgaagaaa ataaatgcat aatttctcag tgaataaagt tgtagctgtc agacattaaa
     3841 taggcaaagt tacatgctga tatttagaaa acagctcaaa tatgaaaaac catgtttcat
     3901 taatctgttt aagtcaggcc atttttatag ttttatgtag ggtggtttat ttttcttagg
     3961 gacagtttac aatagtaaga gctgtctctc atattaagtg agttacttat gtacaaattg
     4021 aaactgtaaa ttgtaaacac tggaacgcac cattgtgaca taaacatcgt agtaatatat
     4081 taaaatgaat gtaaatggaa gttaaaatta cattactgtg aaacttacct tccagctgtt
     4141 aagtgtcaga gatttgtgtt agtgggtaat tcttaaagag ctttgaaaac actgcataat
     4201 ccgtgtaacc cagaattatt atttctttgt aacttattat tcagcttggc gagcgctttt
     4261 gatttggcag attgataaca tggtatattt acttagttgg aaacaattat ttctacatac
     4321 ttttaaaaaa atatctgcta gatgaaacat acaataaaac tacctgtact aaaatttggg
     4381 agaactttag gtcctttaaa aagtattaat cattattagc aacatctatg ataaaagtgt
     4441 ttattctggt ttacttagaa atgataaaca tttaaagtgt taacatctta tgaatgcagt
     4501 gaattaatag aataaacatt ttgcaaaaaa tcacttgata aggattagaa actttatttt
     4561 tgcacttaaa atgaaaaata actttgtttt ctctaaatgt gtcacagatg tagtttccga
     4621 tttcttgcta ctttgtgtga ctttctgata atccattact acaggttggt ttttttgaac
     4681 agttcttccc ttgaaaccag ggccgtagac agaccccatg agtgttacaa cactgagcta
     4741 tacctccaac ttctaaaggt ctgactgaaa tccaagaaaa atttcctctt aaagcaagta
     4801 tattcttggt tttttttttc tccaaatact gagtgtagag tttttttaaa gcataggatt
     4861 tttatttcaa ttttcctcag tatttctaaa cagctcccat ttgatggggg tgtatgtggg
     4921 gaggggtaat gaatgtgaat gtgtaatata tatttgcagt gtgtatttgg ccgttatttt
     4981 attgcagcgt gtgtaaatga tgcctgtgag ttatgtgaaa ccggcttttc cccatcatca
     5041 ttactcaagt caattgggtg ggtgttcatt gtacttcaac tatttattgg ttctgtagat
     5101 gggggaattt taaacgtcag agtgtgttct tcaccttatg gcttgcttca ttgaaggcca
     5161 agagtagata acgtgatgct tattgtgtcc tacagtagtg catcgtggtt cccactgcat
     5221 gaagagagca gaactcacac aagttcatca tgttgtgctt catagagaag gtgcttagag
     5281 gggctggcat ggcaaaacct tctcatctct gtcttgatga tatctagtct ttaatctgaa
     5341 tactcactct cagttttgcc aaagactcag tggcgtttaa aagcgttcta tctacgttct
     5401 tacccaccta tgttttggag acagatgaaa ccttccaggg ataggggttt gttgtcttac
     5461 ctgcatatct ttacatataa tcaaatgata tgcagaattt taatttattt ttagttccta
     5521 aagttaaggt agcttcaata ttatttcaca ttcctttttc tctttaaatt gccagatttg
     5581 cttttcaaag acttaggggc agaattaagt tagtatcttt cacttagagt aaagagaaca
     5641 agacaatatt atttaagagt taggagcact ttgtctagtt ctgttagtta tgtatggcct
     5701 taataatcag tctcttggct taagtgttca ctggtttcac tttgacacag ttgaacagca
     5761 ctggggttca gttcctgatg cttgtgttgg caatatatat taaccatatt ttaagagtat
     5821 cattctggct ttttatggaa aagatgaaaa tcaaacagta tattcctttt gagggttttt
     5881 ttaatacgta aatatatata aatataatat atgatggatt ttttctaatt ttttatattt
     5941 ccttacaatt tggtgactat tactctaact ttagactctt tggcatatac taagtagcta
     6001 gtctgggctt taaaaatatg catggacatt tcagtttgtt ttagctgaat gaggacattt
     6061 tgaattctct taaaagtcac ctgattatta aataacaatg tttattttta aaactaacaa
     6121 tgtgttgtgt cttattacac attacacagt cctaaaggtg cggctctgat gtctgtgagc
     6181 tgtgggccaa gtattctgtt ttcagttcta tagcacagaa cagtgattag aaatgtaaag
     6241 agatacccac atcaactttc tgtttttgtt tttccaactg attcaggtgt ccattgaatg
     6301 acgtatctct taaatgttgg gggagtggtg tgtcagaacc agttacctgg cttctgtttt
     6361 gtccatagct tagatttgtt ccgttgtcaa aactgtcccc ccccccaaat tgtgtgacac
     6421 atattcatgc ataaactgtt aaaacgagca tctttgtatt tgtattgttt tcaacattgc
     6481 caaggtgcta tgggaaatta aaattacaaa attagaaaaa aataaaatta ttgaaaaaca
     6541 aaaaaaaaaa
//
