LOCUS       NM_001284521            6527 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus La ribonucleoprotein 4 (Larp4), transcript variant 3,
            mRNA.
ACCESSION   NM_001284521
VERSION     NM_001284521.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6527)
  AUTHORS   Tian,Y., Zeng,Z., Li,X., Wang,Y., Chen,R., Mattijssen,S.,
            Gaidamakov,S., Wu,Y., Maraia,R.J., Peng,W. and Zhu,J.
  TITLE     Transcriptome-wide stability analysis uncovers LARP4-mediated
            NFkappaB1 mRNA stabilization during T cell activation
  JOURNAL   Nucleic Acids Res 48 (15), 8724-8739 (2020)
   PUBMED   32735645
  REMARK    GeneRIF: Transcriptome-wide stability analysis uncovers
            LARP4-mediated NFkappaB1 mRNA stabilization during T cell
            activation.
REFERENCE   2  (bases 1 to 6527)
  AUTHORS   Mattijssen,S., Arimbasseri,A.G., Iben,J.R., Gaidamakov,S., Lee,J.,
            Hafner,M. and Maraia,R.J.
  TITLE     LARP4 mRNA codon-tRNA match contributes to LARP4 activity for
            ribosomal protein mRNA poly(A) tail length protection
  JOURNAL   Elife 6, e28889 (2017)
   PUBMED   28895529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6527)
  AUTHORS   Mattijssen,S. and Maraia,R.J.
  TITLE     LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a
            Tristetraprolin-Dependent Manner
  JOURNAL   Mol Cell Biol 36 (4), 574-584 (2015)
   PUBMED   26644407
  REMARK    GeneRIF: Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6527)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 6527)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 6527)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ080411.1, AK139636.1, AK139909.1, AK141743.1, AK052358.1,
            BE951991.1 and AI853685.1.
            
            Transcript Variant: This variant (3) differs in its 5' UTR and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (3) has a shorter N-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139909.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               CJ080411.1         2-205
            205-713             AK139636.1         224-732
            714-2507            AK139909.1         578-2371
            2508-3738           AK141743.1         313-1543
            3739-5610           AK052358.1         13-1884
            5611-6163           BE951991.1         156-708
            6164-6527           AI853685.1         1-364               c
FEATURES             Location/Qualifiers
     source          1..6527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..6527
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
     exon            1..204
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            205..327
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            328..483
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2333
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="isoform 3 is encoded by transcript variant 3;
                     la-related protein 4; La ribonucleoprotein domain family,
                     member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform 3"
                     /protein_id="NP_001271450.1"
                     /db_xref="CCDS:CCDS88842.1"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
                     /translation="MCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDVS
                     GESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKK
                     LTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNEN
                     CPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKN
                     GYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPLA
                     PFPNGSFVNGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGDG
                     PLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRD
                     DDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCRE
                     KDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPK
                     DTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKEP
                     SPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRGA
                     AGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK"
     exon            484..559
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            560..696
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            697..800
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            801..911
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            912..965
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1175
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1279
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1492
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1541
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1703
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1825
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1994
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..6517
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: AATAAA"
     polyA_site      4507
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="major polyA site"
     regulatory      6407..6412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: CATAAA"
     polyA_site      6424
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
ORIGIN      
        1 agttgttgct tcccgggagg agggactggg cgggtcaggg cgcagcggct gacggcgggg
       61 gaggagccgg gtccactgcc gggtggaggg gcaaggcgag tgtccttatc ctaccgaccg
      121 gggcccgggc ctgggagcca gttggagtcg cggcagcgtg aacgatcggg ccgagcggaa
      181 gcagacatgt tgctcttcgt tgaggcactg gtttaaatcc taatgccaaa gtatggcaag
      241 aaattccttc tggaaatccg gatggcactc ctgtaactga accctcttgg catgaaactg
      301 cagccacatc tggatctcac cctgagggcc atacagaact ttcagaagat atgtgtaagg
      361 aatatgaagt aatgtattct ccatcttgtg aaaccacaag gaatactgca gatgttgaag
      421 agtcagctga tggaatgatc ttaggaccgg aagacctgag ttaccaactc tatgatgttt
      481 ctggagaaag cagttcagca atttctacag aagatttaaa agaatgtctg aaaaaacaat
      541 tggaattctg tttctcacga gaaaatttat caaaggacct ttacttgata tctcaaatgg
      601 atagtgatca gttcgtccca atatggacgg ttgccaacat ggaagaaatt aaaaaattga
      661 ctacaaatac agatttaatt cttgaagtat tgagatcttc ccctatggta caagttgatg
      721 agaagggaga aaaggtgaga ccaagtcata agcgatgtat tgtgattctc agagagattc
      781 ctgagacaac gcctgtagag gaagtgaaag ctttgtttaa aaatgaaaac tgccccaaag
      841 tgataagctg tgagtttgcg cacaacagca actggtacat cactttccag tcagacacag
      901 atgcacagca ggcttttaaa tacttaagag aagaagttaa aacatttcag ggcaagccaa
      961 tcatggcaag gataaaagcc atcaatacat tttttgctaa gaatggttat cgattaatgg
     1021 attctagtat gtatactcaa cctattcaga ctcctaccca atatccctca ccagtcttca
     1081 tgcaaccagt gtataatcct cagcagtact cagtgtatag tcttgtgcct cagtcttggt
     1141 ctccaagtcc tgcaccttac tttgaaacac cactggctcc ctttcccaat ggtagttttg
     1201 tgaatggctt tagttcacca ggatcttaca aaacaaatgc tgctgctatg aatatgggcc
     1261 gaccattccc aaaaaatcgt gtgaagcctc attttaggtc atccagtggt tcagaacact
     1321 caacagaggg ctccgtgtca ttgggggatg gaccactgag cagatctagt tcaaggatct
     1381 ttctttctga acggcataac ccaacagtaa cagggcagca ggaacaaact tatcttccaa
     1441 aggaggctcc cattttacag atggaacaga atggggactt tggaagaggc aggcgaactc
     1501 tcttcagagg ccgaaggcga agggatgatg acaggatccc aagaccccaa cctgcagcaa
     1561 ctgaagccaa ggctccaact ccgaagtttg atttgcttgc tacaaatttc cctcctttac
     1621 ctggaagctc atcgagagtg ccagatgaac ttggtttgga gaacagaatg tctgatgtcg
     1681 ttaaaggtgt ctgcagagaa aaggacagcg aggacgtgcg agttagttgc ccagtgcctg
     1741 cagaggacgg acagacagac tgcacttctg cgccgctcag cataagtcct agtcctccgt
     1801 gtacagctga gcctcctgtg ttaagcacga ctcagcaaga gcaggatcag atggaggact
     1861 ctgctgttcc aaaggacact ctcaacccag tagctgtgcc agtgtcttct ccaactgcca
     1921 caaagccatc cccggcaaac acggcttcac cttgcactag taacataaac ccaccgagag
     1981 ctgtggccct gcaggaacct cgaaagttaa gctatgctga agtgtgccag aagcctccta
     2041 aagagccatc tccagttctc gtacagccgc tgcgggaact ccggtctaat gcagtatccc
     2101 ccaccagaaa tgaagagaac ggagctcccg agaagcctgt tgagaagccg catgagaaac
     2161 cagaaacaag ggctagtaag gatcattctg gcttccgagg caacactatt cccaggggag
     2221 cggctggaaa aatcagggaa cagagacgcc agttcagcca tagggctaca cctcagggag
     2281 tgactcgacg taatgggaaa gagcaatacg tgccacccag atcaccaaag taaaaacaaa
     2341 gcctacaaaa actactcaga agcttctctt cccactaaac ttgagcctct gttgaactgt
     2401 tttggagggg aggaagtagc caggaaagaa tgggaagtaa gccctaaata tgacggattt
     2461 ttgaaattgc gagtaggaag agcccaaaat tcatctctaa atgattttca aatgctggag
     2521 gattccaatc agtataaata tatataaata tatatatata cacacatata tatataaata
     2581 taatttttct atttttgttt ttgattttaa tttgcaggaa ttttctgcct ggaatcaatt
     2641 ttgagggttc agatttagct tgggagagaa aacaaaaaac attatacatc cttcagtata
     2701 ggagatgagg gagtgagaga aaatattttt tgaagaaaca tttctgtaaa aattagaaat
     2761 tacttttttt aatctattta aagtttggct tgaagaatgc tatctctgac taaatggcct
     2821 tgtgttgcag agtagatgag tggctaggga gtctgttctg ggtccgagtg tgtgcaaaag
     2881 tgatttaagc caaatctgtt gtcatggtag taaatgattt caaagctgaa tgtaatactt
     2941 gagtagattt tctttgtagt ttggaattta gttgtttttg ttttttgaca ttactaatac
     3001 tgtattgtat gaacaagcta taaagctctg attgtgtgtg aagctgtgac taccaatcag
     3061 tttgatattc aaggaaagaa tggagattat tcaaaaaaaa tattgaaaat tctgttttag
     3121 acctgaatac tggataggtc aaatagattg cagaggttta aactgccctg tgaccttttt
     3181 ttttcctttt taattttttt tctgattgtt tgttagtctc tgttcttaga ctgtcttccc
     3241 cccaaaagca atatgactaa ctgtttactg gacagtatgt ttcttactac tttgaccagt
     3301 ttaatcaaat tatataacta ttctaagcta cataatggaa tattgaaaga tttttattca
     3361 attagaattt taggtcccag gatggtactg acctgccagt aatttatttg tattggtgtt
     3421 aaaaaaatga aatagtgctt ctggctgtgc gggcataaat ctccaaccct ggcctccaga
     3481 ggtgtggcag gtggatctca gtcccagtcc atccagggct ctacctctca ctagtttctg
     3541 tctaaagaaa gaaaaggaaa aggaaagaaa gatgaaaccg tgtaactgac tttttaaatg
     3601 gtctaacgga aaaattcaaa cattaatttg gggaattttg ttgtttacaa tgtttatcat
     3661 ctttctttgg cttgccccca aaagtacagt ttagcatttg cagactaaaa atagcaagtc
     3721 aaggattttt ttttttttga gataaagcga aaaagtggtt gaagaaaata aatgcataat
     3781 ttctcagtga ataaagttgt agctgtcaga cattaaatag gcaaagttac atgctgatat
     3841 ttagaaaaca gctcaaatat gaaaaaccat gtttcattaa tctgtttaag tcaggccatt
     3901 tttatagttt tatgtagggt ggtttatttt tcttagggac agtttacaat agtaagagct
     3961 gtctctcata ttaagtgagt tacttatgta caaattgaaa ctgtaaattg taaacactgg
     4021 aacgcaccat tgtgacataa acatcgtagt aatatattaa aatgaatgta aatggaagtt
     4081 aaaattacat tactgtgaaa cttaccttcc agctgttaag tgtcagagat ttgtgttagt
     4141 gggtaattct taaagagctt tgaaaacact gcataatccg tgtaacccag aattattatt
     4201 tctttgtaac ttattattca gcttggcgag cgcttttgat ttggcagatt gataacatgg
     4261 tatatttact tagttggaaa caattatttc tacatacttt taaaaaaata tctgctagat
     4321 gaaacataca ataaaactac ctgtactaaa atttgggaga actttaggtc ctttaaaaag
     4381 tattaatcat tattagcaac atctatgata aaagtgttta ttctggttta cttagaaatg
     4441 ataaacattt aaagtgttaa catcttatga atgcagtgaa ttaatagaat aaacattttg
     4501 caaaaaatca cttgataagg attagaaact ttatttttgc acttaaaatg aaaaataact
     4561 ttgttttctc taaatgtgtc acagatgtag tttccgattt cttgctactt tgtgtgactt
     4621 tctgataatc cattactaca ggttggtttt tttgaacagt tcttcccttg aaaccagggc
     4681 cgtagacaga ccccatgagt gttacaacac tgagctatac ctccaacttc taaaggtctg
     4741 actgaaatcc aagaaaaatt tcctcttaaa gcaagtatat tcttggtttt ttttttctcc
     4801 aaatactgag tgtagagttt ttttaaagca taggattttt atttcaattt tcctcagtat
     4861 ttctaaacag ctcccatttg atgggggtgt atgtggggag gggtaatgaa tgtgaatgtg
     4921 taatatatat ttgcagtgtg tatttggccg ttattttatt gcagcgtgtg taaatgatgc
     4981 ctgtgagtta tgtgaaaccg gcttttcccc atcatcatta ctcaagtcaa ttgggtgggt
     5041 gttcattgta cttcaactat ttattggttc tgtagatggg ggaattttaa acgtcagagt
     5101 gtgttcttca ccttatggct tgcttcattg aaggccaaga gtagataacg tgatgcttat
     5161 tgtgtcctac agtagtgcat cgtggttccc actgcatgaa gagagcagaa ctcacacaag
     5221 ttcatcatgt tgtgcttcat agagaaggtg cttagagggg ctggcatggc aaaaccttct
     5281 catctctgtc ttgatgatat ctagtcttta atctgaatac tcactctcag ttttgccaaa
     5341 gactcagtgg cgtttaaaag cgttctatct acgttcttac ccacctatgt tttggagaca
     5401 gatgaaacct tccagggata ggggtttgtt gtcttacctg catatcttta catataatca
     5461 aatgatatgc agaattttaa tttattttta gttcctaaag ttaaggtagc ttcaatatta
     5521 tttcacattc ctttttctct ttaaattgcc agatttgctt ttcaaagact taggggcaga
     5581 attaagttag tatctttcac ttagagtaaa gagaacaaga caatattatt taagagttag
     5641 gagcactttg tctagttctg ttagttatgt atggccttaa taatcagtct cttggcttaa
     5701 gtgttcactg gtttcacttt gacacagttg aacagcactg gggttcagtt cctgatgctt
     5761 gtgttggcaa tatatattaa ccatatttta agagtatcat tctggctttt tatggaaaag
     5821 atgaaaatca aacagtatat tccttttgag ggttttttta atacgtaaat atatataaat
     5881 ataatatatg atggattttt tctaattttt tatatttcct tacaatttgg tgactattac
     5941 tctaacttta gactctttgg catatactaa gtagctagtc tgggctttaa aaatatgcat
     6001 ggacatttca gtttgtttta gctgaatgag gacattttga attctcttaa aagtcacctg
     6061 attattaaat aacaatgttt atttttaaaa ctaacaatgt gttgtgtctt attacacatt
     6121 acacagtcct aaaggtgcgg ctctgatgtc tgtgagctgt gggccaagta ttctgttttc
     6181 agttctatag cacagaacag tgattagaaa tgtaaagaga tacccacatc aactttctgt
     6241 ttttgttttt ccaactgatt caggtgtcca ttgaatgacg tatctcttaa atgttggggg
     6301 agtggtgtgt cagaaccagt tacctggctt ctgttttgtc catagcttag atttgttccg
     6361 ttgtcaaaac tgtccccccc cccaaattgt gtgacacata ttcatgcata aactgttaaa
     6421 acgagcatct ttgtatttgt attgttttca acattgccaa ggtgctatgg gaaattaaaa
     6481 ttacaaaatt agaaaaaaat aaaattattg aaaaacaaaa aaaaaaa
//
