LOCUS       NM_001024526            6548 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus La ribonucleoprotein 4 (Larp4), transcript variant 1,
            mRNA.
ACCESSION   NM_001024526 XM_128090 XM_902516 XM_902517 XM_902518 XM_916154
            XM_924121 XM_924125
VERSION     NM_001024526.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6548)
  AUTHORS   Tian,Y., Zeng,Z., Li,X., Wang,Y., Chen,R., Mattijssen,S.,
            Gaidamakov,S., Wu,Y., Maraia,R.J., Peng,W. and Zhu,J.
  TITLE     Transcriptome-wide stability analysis uncovers LARP4-mediated
            NFkappaB1 mRNA stabilization during T cell activation
  JOURNAL   Nucleic Acids Res 48 (15), 8724-8739 (2020)
   PUBMED   32735645
  REMARK    GeneRIF: Transcriptome-wide stability analysis uncovers
            LARP4-mediated NFkappaB1 mRNA stabilization during T cell
            activation.
REFERENCE   2  (bases 1 to 6548)
  AUTHORS   Mattijssen,S., Arimbasseri,A.G., Iben,J.R., Gaidamakov,S., Lee,J.,
            Hafner,M. and Maraia,R.J.
  TITLE     LARP4 mRNA codon-tRNA match contributes to LARP4 activity for
            ribosomal protein mRNA poly(A) tail length protection
  JOURNAL   Elife 6, e28889 (2017)
   PUBMED   28895529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6548)
  AUTHORS   Mattijssen,S. and Maraia,R.J.
  TITLE     LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a
            Tristetraprolin-Dependent Manner
  JOURNAL   Mol Cell Biol 36 (4), 574-584 (2015)
   PUBMED   26644407
  REMARK    GeneRIF: Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6548)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 6548)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 6548)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ080411.1, AK049756.1, AK139909.1, AC133868.10 and BP757308.1.
            
            On Feb 1, 2007 this sequence version replaced NM_001024526.1.
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.115084.1,
                                           SRR1660821.74811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                CJ080411.1         2-75
            75-1215             AK049756.1         2-1142
            1216-2520           AK139909.1         1067-2371
            2521-6332           AC133868.10        101389-105200       c
            6333-6548           BP757308.1         1-216               c
FEATURES             Location/Qualifiers
     source          1..6548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..6548
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
     exon            1..204
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2346
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     la-related protein 4; La ribonucleoprotein domain family,
                     member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform 1"
                     /protein_id="NP_001019697.2"
                     /db_xref="CCDS:CCDS37208.1"
                     /db_xref="GeneID:207214"
                     /db_xref="MGI:MGI:2443114"
                     /translation="MLLFVEVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAA
                     TSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDV
                     SGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIK
                     KLTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNE
                     NCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAK
                     NGYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPL
                     APFPNGSFVNGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGD
                     GPLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRR
                     DDDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCR
                     EKDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVP
                     KDTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKE
                     PSPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRG
                     AAGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK"
     exon            205..340
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            341..496
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            497..572
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            573..709
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            710..813
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            814..924
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            925..978
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1188
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1292
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1505
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1554
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1716
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1838
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2007
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..6530
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4501..4506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: AATAAA"
     polyA_site      4520
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="major polyA site"
     regulatory      6420..6425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
                     /note="hexamer: CATAAA"
     polyA_site      6437
                     /gene="Larp4"
                     /gene_synonym="DXErtd793; DXErtd793e"
ORIGIN      
        1 agttgttgct tcccgggagg agggactggg cgggtcaggg cgcagcggct gacggcgggg
       61 gaggagccgg gtccactgcc gggtggaggg gcaaggcgag tgtccttatc ctaccgaccg
      121 gggcccgggc ctgggagcca gttggagtcg cggcagcgtg aacgatcggg ccgagcggaa
      181 gcagacatgt tgctcttcgt tgaggtgaca tctaaaggca ctggtttaaa tcctaatgcc
      241 aaagtatggc aagaaattcc ttctggaaat ccggatggca ctcctgtaac tgaaccctct
      301 tggcatgaaa ctgcagccac atctggatct caccctgagg gccatacaga actttcagaa
      361 gatatgtgta aggaatatga agtaatgtat tctccatctt gtgaaaccac aaggaatact
      421 gcagatgttg aagagtcagc tgatggaatg atcttaggac cggaagacct gagttaccaa
      481 ctctatgatg tttctggaga aagcagttca gcaatttcta cagaagattt aaaagaatgt
      541 ctgaaaaaac aattggaatt ctgtttctca cgagaaaatt tatcaaagga cctttacttg
      601 atatctcaaa tggatagtga tcagttcgtc ccaatatgga cggttgccaa catggaagaa
      661 attaaaaaat tgactacaaa tacagattta attcttgaag tattgagatc ttcccctatg
      721 gtacaagttg atgagaaggg agaaaaggtg agaccaagtc ataagcgatg tattgtgatt
      781 ctcagagaga ttcctgagac aacgcctgta gaggaagtga aagctttgtt taaaaatgaa
      841 aactgcccca aagtgataag ctgtgagttt gcgcacaaca gcaactggta catcactttc
      901 cagtcagaca cagatgcaca gcaggctttt aaatacttaa gagaagaagt taaaacattt
      961 cagggcaagc caatcatggc aaggataaaa gccatcaata cattttttgc taagaatggt
     1021 tatcgattaa tggattctag tatgtatact caacctattc agactcctac ccaatatccc
     1081 tcaccagtct tcatgcaacc agtgtataat cctcagcagt actcagtgta tagtcttgtg
     1141 cctcagtctt ggtctccaag tcctgcacct tactttgaaa caccactggc tccctttccc
     1201 aatggtagtt ttgtgaatgg ctttagttca ccaggatctt acaaaacaaa tgctgctgct
     1261 atgaatatgg gccgaccatt cccaaaaaat cgtgtgaagc ctcattttag gtcatccagt
     1321 ggttcagaac actcaacaga gggctccgtg tcattggggg atggaccact gagcagatct
     1381 agttcaagga tctttctttc tgaacggcat aacccaacag taacagggca gcaggaacaa
     1441 acttatcttc caaaggaggc tcccatttta cagatggaac agaatgggga ctttggaaga
     1501 ggcaggcgaa ctctcttcag aggccgaagg cgaagggatg atgacaggat cccaagaccc
     1561 caacctgcag caactgaagc caaggctcca actccgaagt ttgatttgct tgctacaaat
     1621 ttccctcctt tacctggaag ctcatcgaga gtgccagatg aacttggttt ggagaacaga
     1681 atgtctgatg tcgttaaagg tgtctgcaga gaaaaggaca gcgaggacgt gcgagttagt
     1741 tgcccagtgc ctgcagagga cggacagaca gactgcactt ctgcgccgct cagcataagt
     1801 cctagtcctc cgtgtacagc tgagcctcct gtgttaagca cgactcagca agagcaggat
     1861 cagatggagg actctgctgt tccaaaggac actctcaacc cagtagctgt gccagtgtct
     1921 tctccaactg ccacaaagcc atccccggca aacacggctt caccttgcac tagtaacata
     1981 aacccaccga gagctgtggc cctgcaggaa cctcgaaagt taagctatgc tgaagtgtgc
     2041 cagaagcctc ctaaagagcc atctccagtt ctcgtacagc cgctgcggga actccggtct
     2101 aatgcagtat cccccaccag aaatgaagag aacggagctc ccgagaagcc tgttgagaag
     2161 ccgcatgaga aaccagaaac aagggctagt aaggatcatt ctggcttccg aggcaacact
     2221 attcccaggg gagcggctgg aaaaatcagg gaacagagac gccagttcag ccatagggct
     2281 acacctcagg gagtgactcg acgtaatggg aaagagcaat acgtgccacc cagatcacca
     2341 aagtaaaaac aaagcctaca aaaactactc agaagcttct cttcccacta aacttgagcc
     2401 tctgttgaac tgttttggag gggaggaagt agccaggaaa gaatgggaag taagccctaa
     2461 atatgacgga tttttgaaat tgcgagtagg aagagcccaa aattcatctc taaatgattt
     2521 tcaaatgctg gaggattcca atcagtataa atatatataa atatatatat atacacacat
     2581 atatatataa atataatttt tctatttttg tttttgattt taatttgcag gaattttctg
     2641 cctggaatca attttgaggg ttcagattta gcttgggaga gaaaacaaaa aacattatac
     2701 atccttcagt ataggagatg agggagtgag agaaaatatt ttttgaagaa acatttctgt
     2761 aaaaattaga aattactttt tttaatctat ttaaagtttg gcttgaagaa tgctatctct
     2821 gactaaatgg ccttgtgttg cagagtagat gagtggctag ggagtctgtt ctgggtccga
     2881 gtgtgtgcaa aagtgattta agccaaatct gttgtcatgg tagtaaatga tttcaaagct
     2941 gaatgtaata cttgagtaga ttttctttgt agtttggaat ttagttgttt ttgttttttg
     3001 acattactaa tactgtattg tatgaacaag ctataaagct ctgattgtgt gtgaagctgt
     3061 gactaccaat cagtttgata ttcaaggaaa gaatggagat tattcaaaaa aaatattgaa
     3121 aattctgttt tagacctgaa tactggatag gtcaaataga ttgcagaggt ttaaactgcc
     3181 ctgtgacctt tttttttcct ttttaatttt ttttctgatt gtttgttagt ctctgttctt
     3241 agactgtctt ccccccaaaa gcaatatgac taactgttta ctggacagta tgtttcttac
     3301 tactttgacc agtttaatca aattatataa ctattctaag ctacataatg gaatattgaa
     3361 agatttttat tcaattagaa ttttaggtcc caggatggta ctgacctgcc agtaatttat
     3421 ttgtattggt gttaaaaaaa tgaaatagtg cttctggctg tgcgggcata aatctccaac
     3481 cctggcctcc agaggtgtgg caggtggatc tcagtcccag tccatccagg gctctacctc
     3541 tcactagttt ctgtctaaag aaagaaaagg aaaaggaaag aaagatgaaa ccgtgtaact
     3601 gactttttaa atggtctaac ggaaaaattc aaacattaat ttggggaatt ttgttgttta
     3661 caatgtttat catctttctt tggcttgccc ccaaaagtac agtttagcat ttgcagacta
     3721 aaaatagcaa gtcaaggatt tttttttttt tgagataaag cgaaaaagtg gttgaagaaa
     3781 ataaatgcat aatttctcag tgaataaagt tgtagctgtc agacattaaa taggcaaagt
     3841 tacatgctga tatttagaaa acagctcaaa tatgaaaaac catgtttcat taatctgttt
     3901 aagtcaggcc atttttatag ttttatgtag ggtggtttat ttttcttagg gacagtttac
     3961 aatagtaaga gctgtctctc atattaagtg agttacttat gtacaaattg aaactgtaaa
     4021 ttgtaaacac tggaacgcac cattgtgaca taaacatcgt agtaatatat taaaatgaat
     4081 gtaaatggaa gttaaaatta cattactgtg aaacttacct tccagctgtt aagtgtcaga
     4141 gatttgtgtt agtgggtaat tcttaaagag ctttgaaaac actgcataat ccgtgtaacc
     4201 cagaattatt atttctttgt aacttattat tcagcttggc gagcgctttt gatttggcag
     4261 attgataaca tggtatattt acttagttgg aaacaattat ttctacatac ttttaaaaaa
     4321 atatctgcta gatgaaacat acaataaaac tacctgtact aaaatttggg agaactttag
     4381 gtcctttaaa aagtattaat cattattagc aacatctatg ataaaagtgt ttattctggt
     4441 ttacttagaa atgataaaca tttaaagtgt taacatctta tgaatgcagt gaattaatag
     4501 aataaacatt ttgcaaaaaa tcacttgata aggattagaa actttatttt tgcacttaaa
     4561 atgaaaaata actttgtttt ctctaaatgt gtcacagatg tagtttccga tttcttgcta
     4621 ctttgtgtga ctttctgata atccattact acaggttggt ttttttgaac agttcttccc
     4681 ttgaaaccag ggccgtagac agaccccatg agtgttacaa cactgagcta tacctccaac
     4741 ttctaaaggt ctgactgaaa tccaagaaaa atttcctctt aaagcaagta tattcttggt
     4801 tttttttttc tccaaatact gagtgtagag tttttttaaa gcataggatt tttatttcaa
     4861 ttttcctcag tatttctaaa cagctcccat ttgatggggg tgtatgtggg gaggggtaat
     4921 gaatgtgaat gtgtaatata tatttgcagt gtgtatttgg ccgttatttt attgcagcgt
     4981 gtgtaaatga tgcctgtgag ttatgtgaaa ccggcttttc cccatcatca ttactcaagt
     5041 caattgggtg ggtgttcatt gtacttcaac tatttattgg ttctgtagat gggggaattt
     5101 taaacgtcag agtgtgttct tcaccttatg gcttgcttca ttgaaggcca agagtagata
     5161 acgtgatgct tattgtgtcc tacagtagtg catcgtggtt cccactgcat gaagagagca
     5221 gaactcacac aagttcatca tgttgtgctt catagagaag gtgcttagag gggctggcat
     5281 ggcaaaacct tctcatctct gtcttgatga tatctagtct ttaatctgaa tactcactct
     5341 cagttttgcc aaagactcag tggcgtttaa aagcgttcta tctacgttct tacccaccta
     5401 tgttttggag acagatgaaa ccttccaggg ataggggttt gttgtcttac ctgcatatct
     5461 ttacatataa tcaaatgata tgcagaattt taatttattt ttagttccta aagttaaggt
     5521 agcttcaata ttatttcaca ttcctttttc tctttaaatt gccagatttg cttttcaaag
     5581 acttaggggc agaattaagt tagtatcttt cacttagagt aaagagaaca agacaatatt
     5641 atttaagagt taggagcact ttgtctagtt ctgttagtta tgtatggcct taataatcag
     5701 tctcttggct taagtgttca ctggtttcac tttgacacag ttgaacagca ctggggttca
     5761 gttcctgatg cttgtgttgg caatatatat taaccatatt ttaagagtat cattctggct
     5821 ttttatggaa aagatgaaaa tcaaacagta tattcctttt gagggttttt ttaatacgta
     5881 aatatatata aatataatat atgatggatt ttttctaatt ttttatattt ccttacaatt
     5941 tggtgactat tactctaact ttagactctt tggcatatac taagtagcta gtctgggctt
     6001 taaaaatatg catggacatt tcagtttgtt ttagctgaat gaggacattt tgaattctct
     6061 taaaagtcac ctgattatta aataacaatg tttattttta aaactaacaa tgtgttgtgt
     6121 cttattacac attacacagt cctaaaggtg cggctctgat gtctgtgagc tgtgggccaa
     6181 gtattctgtt ttcagttcta tagcacagaa cagtgattag aaatgtaaag agatacccac
     6241 atcaactttc tgtttttgtt tttccaactg attcaggtgt ccattgaatg acgtatctct
     6301 taaatgttgg gggagtggtg tgtcagaacc agttacctgg cttctgtttt gtccatagct
     6361 tagatttgtt ccgttgtcaa aactgtcccc ccccccaaat tgtgtgacac atattcatgc
     6421 ataaactgtt aaaacgagca tctttgtatt tgtattgttt tcaacattgc caaggtgcta
     6481 tgggaaatta aaattacaaa attagaaaaa aataaaatta ttgaaaaaca aaaaaaaaaa
     6541 aaaaaaaa
//
