LOCUS       NM_001040399            4443 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus La ribonucleoprotein 1B (Larp1b), transcript variant
            1, mRNA.
ACCESSION   NM_001040399 XR_001602 XR_002335 XR_004547
VERSION     NM_001040399.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102794.8.
            
            On May 21, 2021 this sequence version replaced NM_001040399.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160155.1, AK076732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-857               AC102794.8         100938-101794
            858-916             AC102794.8         112718-112776
            917-976             AC102794.8         113279-113338
            977-1151            AC102794.8         115078-115252
            1152-1292           AC102794.8         118475-118615
            1293-1436           AC102794.8         121001-121144
            1437-1602           AC102794.8         121561-121726
            1603-1747           AC102794.8         123471-123615
            1748-1922           AC102794.8         127611-127785
            1923-4443           AC102794.8         128318-130838
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 19.61 cM"
     gene            1..4443
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="La ribonucleoprotein 1B"
                     /db_xref="GeneID:214048"
                     /db_xref="MGI:MGI:1914604"
     exon            1..857
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1942
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="isoform 3 is encoded by transcript variant 1; La
                     ribonucleoprotein domain family, member 2; La
                     ribonucleoprotein domain family, member 1B"
                     /codon_start=1
                     /product="la-related protein 1B isoform 3"
                     /protein_id="NP_001035489.2"
                     /db_xref="GeneID:214048"
                     /db_xref="MGI:MGI:1914604"
                     /translation="MSARAPVPAAATREDPPAVAGDRDALLAATSRRAEQPAPGEREG
                     KEAREERAAAATSAGARGEPSPALVLGHSVPQAAVPVRPLALHLAHKARAPGGPFGGE
                     APPLPPPPPPPPPPPPPLPPPAPRDPPEDAREDPAAAGPEDKPPPPPPKGNPWTKKLP
                     QHLSTVGTGVPSPAQDSPEAELSSPKIIKAGKLKTKKSNKASDFSDMANWPTPGELVN
                     TGSQSVINQGNKKPQIRKEKEEKIEKRSNSESKENREAKLDGPTENISEDEAQSSSQR
                     KRANKHKWVPLHLDDVRPDSQERPGSRNSSRCQPEANKPTHSNRKSDTRSWRREREKR
                     DDQDEVSSVRSEGGTIRGSTRGRGRGRGRGRGRGRGNPRLNFDYSYGYREPGERTEQP
                     FSTELNTSMMYYYDDGTGVRVYPVEETLLKEYIKRQIEYYFSTENLERDFFLRRKMDE
                     QGFLPISLIAGFHRVQALTTNLNLILEALKDSTEVEIVDEKMRKKIEPEKWPIPGPPP
                     RNVPQTDFSQLIDCPEFIPGQAFGSHTVRVMIY"
     exon            858..916
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..976
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1151
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1292
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1436
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1602
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1747
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1922
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..4443
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="hexamer: AATAAG"
     polyA_site      2512
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="major polyA site"
     regulatory      4060..4065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="hexamer: ATTAAA"
     polyA_site      4084
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
                     /note="hexamer: AATAAA"
     polyA_site      4443
                     /gene="Larp1b"
                     /gene_synonym="1700108L22Rik; 4933421B21Rik; Larp2"
ORIGIN      
        1 agctcgccag agatccttca gactggctgg agcgccgcgt tgtcgcccgc gcccgctgag
       61 ggctcgcggc tcgggcgcgc ccggcgcgag tggcgagctc cggccgtgcg ctgcgacgag
      121 gccaggcggc gggcggttag cgctccgctc ggcgggcggg gaggacgggc acgccgggcg
      181 ctgcacgcct cggcgggcgg gttccgcgtc ccaggaccga agcgggtcgg tgcccccgtg
      241 tggagagagg ggcggccggg ctccctggac ccggacggcc cccggctggg caggaggctg
      301 gggccagggg ccggccatgt ccgctcgcgc cccggtgccc gccgctgcca cccgggagga
      361 cccgcccgcc gtggccggag accgggacgc gctgttggca gcgacgagcc ggcgggcgga
      421 gcagccggcg cccggcgagc gggagggcaa ggaggcgagg gaggagcggg ccgcggccgc
      481 caccagcgcg ggtgcgcggg gagagccgtc gccggcgctc gtgctgggac acagcgtgcc
      541 gcaagcggcc gtgcccgtga ggccgctggc gctgcacctg gcgcacaagg cgcgtgcgcc
      601 cgggggtccc ttcggcgggg aggctccgcc gctgccgccg ccgcctccgc cgccgccacc
      661 accaccgccg ccgctgccgc cgccagcacc gcgggaccca ccggaggacg cccgcgagga
      721 cccagcggca gccggcccgg aggacaagcc gccgccgccg ccgccaaagg ggaacccgtg
      781 gaccaagaag ctgccgcagc acctgtccac cgtgggcacc ggcgtgccgt cgcccgctca
      841 ggactccccg gaggccgagc tcagttcccc caaaattata aaagcgggaa aactcaagac
      901 aaagaaatcc aacaaggcta gtgacttcag tgatatggca aactggccaa caccaggtga
      961 attggttaac acggggtctc agagtgttat caaccaagga aataaaaagc cacaaattag
     1021 aaaagaaaaa gaagagaaga ttgaaaaaag aagcaacagt gagagcaaag agaaccggga
     1081 agcaaaacta gatggtccta ctgagaacat cagcgaggat gaggctcagt caagcagcca
     1141 gaggaagaga gctaataagc acaaatgggt accactccac ttagatgatg tgagaccaga
     1201 cagccaggaa agacctgggt cccggaacag ctctagatgt caacctgaag caaataaacc
     1261 aacgcacagt aataggaaaa gtgatacacg aagttggaga cgggagagag aaaagagaga
     1321 tgatcaagat gaagtgtcca gtgtgagaag tgagggtggt accatccgag gttccactag
     1381 aggtcgggga cgaggccggg gccgaggaag aggccgaggc cgagggaacc ctcgattgaa
     1441 ctttgattat tcatatggtt atcgagagcc tggggaaagg actgagcagc cattttctac
     1501 agagcttaat accagcatga tgtattacta tgatgatggc acaggtgtgc gtgtgtatcc
     1561 tgttgaagaa acactgctta aagagtacat taagcgccaa attgagtatt acttcagcac
     1621 agagaacttg gaacgggact tctttcttcg aagaaagatg gacgagcagg ggttcctgcc
     1681 catttccctg attgctggtt ttcaccgtgt gcaggctctc accacaaacc ttaatctcat
     1741 cttggaggca cttaaggata gcacagaagt agaaattgtg gatgagaaaa tgaggaaaaa
     1801 gatagaacca gaaaaatggc caattccagg ccctcctcca cgaaatgtgc cacaaacaga
     1861 cttctctcag ttgattgatt gtccggagtt catacctggc caggcctttg gctcccatac
     1921 agtcagggtg atgatctact gatgctcttg gatgtcatat gatcggaata tacagtggag
     1981 taggtgactc cctgaaatac catgtaaata tgagagcaaa tcgtgctgca gaagtgagag
     2041 tgaccatact gtcttctgtg caagaatgtc tacgcccacc cccttgtgga gaaggttggg
     2101 ccagcctgca gtggagaaaa ccacctttac gataatgatg tgagacagac cagaggactg
     2161 cggttactgt aggagcctct cctttctatg tcattagctt aggctgcacg ggctacttca
     2221 ttcatggtgg gaaagttaat tgttatcatt ggggaaatac tgcaaatttt atcttttgtt
     2281 tccaggcatt tatactttgc ccagatcaat aaagcagaaa aagagaggat tgagtagcat
     2341 ttccaaaatt gttaggtcct ttgctatctg acttgctctt taatatagta tactttgcat
     2401 aactcacatt tgtcattttt cacatgtact ataagatgta ttaatgtgaa tacttaaggg
     2461 gtaagaaatt taagttaaat aaataagggc atttttcctt tatgcttcaa aattgttttt
     2521 aagggctttt ctttttttat tgtttattta ttattgtgta catatgatat gtatgttttc
     2581 tgagtgtggg catatgtgtg ccatggtgtg tatgtgtgga gataagagga caactttaca
     2641 gagttggttc tttatttcca ctgtgggact caggtattaa actcaggtgg ttagatatgc
     2701 ccagcaagtg cccttacctt ctgagccatt ttgctggctt caaaattgta tttcatatac
     2761 tggcatgaaa gcactgcctg cctatctatg ttcctcaaac tgtaaaccag aataaatccc
     2821 tcttgttagg aatttgggga cagcaatgga aaaaaaaaat aaagttagta tgaagaataa
     2881 cctgctgtgc taacctgacc atgtggtatg taggcttttg gaactggtct tcagaaggaa
     2941 tgtgaaagac ttggaggcag atctctgtgg gtcattctga gtggcttatg ggaggccagc
     3001 atgccaatga acagctagaa agtgaacatt atgctcagga gttttcagag aggggcaagt
     3061 atactgtgga gaggtgagct aaaggctatt tgcattttct tctgaaggag aatatgggtg
     3121 taatctgccc attcctgaga aagtaagtca tagagtgatt tgcagtttgt ttggcattgg
     3181 caggttcaag actgaggcat gtttactact cacggtgctt attcagatct gtagcaggag
     3241 aaagcaggag gactgggaaa tgtgcagttt ggggaataaa ggagtgcacc aagcagagtg
     3301 cacagagctt tttataatta aggaaattag caccattgtt tactgaggca ggacaggtgc
     3361 cctgagagta aaacctatgg aagtctccaa ctagtgaaaa taggaattga tttgaaagaa
     3421 gagaaactaa actgagactg tggctatgta aacagacttt tatgagaact atttcccggt
     3481 tttggaagac cacgtgtgtt ggaatgctgg ttagaggcta gttaagctgc ttacaggtaa
     3541 taggagccag cacagcaccc cagtctggca gtagaacttg gatgcttcat cagcatgtaa
     3601 aatgctagtt acagagtcat ggaggcttac accattgtta gaagctctat aaggtcaagt
     3661 tgcaaagtag tcttccaggc tgttgggagt tccagaattg tggaacacct accaaggaaa
     3721 tctggaatag agtcatccca tgagagaggc tgtatatata tactacacgt gacaaagttg
     3781 gaggggcgga gctgttcatg gtcactggat cccagatgat agtcccacaa gccccagatg
     3841 ctgatcatgg tatagtgctt tccctcctag gtttagctgt tgctttgatc cagtcttccc
     3901 ttgctatacc ccattcctct ccgttggaat ggaaatgttt actctatatg cctttgtaca
     3961 ttggaagtat gtaacttgtt ttctgaaatt atagaaactc acggttaaga ccttgcctgg
     4021 catctcagag cctttgggct tttgagcaat gttgggacaa ttaaagactg tggtgacttt
     4081 tgaagtcaga ctgaatttat tttgctttat gagcctatgg gagtcagaga tgaaatgtaa
     4141 tggtttaaaa gtgatttgtt tgacagtcag gttgacaagg agtgtacttg tgataattaa
     4201 tcttcattgt caacttgact ggttatgtct gtgggggcat ttccagagag ggttaactga
     4261 agagggaaga cccatcctaa gcatgggctg ggtgcttggc ctgagtacca gcattcatct
     4321 ctgtgcttcc tgactgcaga cacagtgtga ccagccacct catgctccta tcaccatgcc
     4381 ttccctgcca tcatggattc tgcccttcaa actgtgagcc aaaataaatc cttcttccct
     4441 taa
//
