LOCUS       NM_010686               2416 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus lysosomal-associated protein transmembrane 5 (Laptm5),
            mRNA.
ACCESSION   NM_010686 XM_911032
VERSION     NM_010686.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Zhang,Y., Zhang,X., Zhang,Y., Xu,H., Wei,Z., Wang,X., Li,Y.,
            Guo,J., Wu,F., Fang,X., Pang,L., Deng,B. and Yu,D.
  TITLE     c-Myc inhibits LAPTM5 expression in B-cell lymphomas
  JOURNAL   Ann Hematol 102 (12), 3499-3513 (2023)
   PUBMED   37713124
  REMARK    GeneRIF: c-Myc inhibits LAPTM5 expression in B-cell lymphomas.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Hua,W., Ma,S., Pang,Y., Liu,Q., Wang,Y., Liu,Z., Zhao,N., Ren,N.,
            Jin,S., Wang,B., Song,Y. and Qi,J.
  TITLE     Intracerebral Hemorrhage-Induced Brain Injury: the Role of
            Lysosomal-Associated Transmembrane Protein 5
  JOURNAL   Mol Neurobiol 60 (12), 7060-7079 (2023)
   PUBMED   37525083
  REMARK    GeneRIF: Intracerebral Hemorrhage-Induced Brain Injury: the Role of
            Lysosomal-Associated Transmembrane Protein 5.
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Jiang,L., Zhao,J., Yang,Q., Li,M., Liu,H., Xiao,X., Tian,S., Hu,S.,
            Liu,Z., Yang,P., Chen,M., Ye,P. and Xia,J.
  TITLE     Lysosomal-associated protein transmembrane 5 ameliorates
            non-alcoholic steatohepatitis by promoting the degradation of CDC42
            in mice
  JOURNAL   Nat Commun 14 (1), 2654 (2023)
   PUBMED   37156795
  REMARK    GeneRIF: Lysosomal-associated protein transmembrane 5 ameliorates
            non-alcoholic steatohepatitis by promoting the degradation of CDC42
            in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Zhang,Z., Wang,L., Wang,Z., Zhang,T., Shi,M., Xin,C., Zou,Y.,
            Wei,W., Li,X., Chen,J. and Zhao,W.
  TITLE     Lysosomal-associated transmembrane protein 5 deficiency exacerbates
            cerebral ischemia/reperfusion injury
  JOURNAL   Front Mol Neurosci 15, 971361 (2022)
   PUBMED   36046710
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Fouladkou,F., Landry,T., Kawabe,H., Neeb,A., Lu,C., Brose,N.,
            Stambolic,V. and Rotin,D.
  TITLE     The ubiquitin ligase Nedd4-1 is dispensable for the regulation of
            PTEN stability and localization
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8585-8590 (2008)
   PUBMED   18562292
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Scott,L.M., Mueller,L. and Collins,S.J.
  TITLE     E3, a hematopoietic-specific transcript directly regulated by the
            retinoic acid receptor alpha
  JOURNAL   Blood 88 (7), 2517-2530 (1996)
   PUBMED   8839844
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Adra,C.N., Zhu,S., Ko,J.L., Guillemot,J.C., Cuervo,A.M.,
            Kobayashi,H., Horiuchi,T., Lelias,J.M., Rowley,J.D. and Lim,B.
  TITLE     LAPTM5: a novel lysosomal-associated multispanning membrane protein
            preferentially expressed in hematopoietic cells
  JOURNAL   Genomics 35 (2), 328-337 (1996)
   PUBMED   8661146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627104.16.
            
            On Aug 17, 2018 this sequence version replaced NM_010686.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153877.1, AK163146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL627104.16        162598-162716
            120-213             AL627104.16        175387-175480
            214-290             AL627104.16        176053-176129
            291-416             AL627104.16        177919-178044
            417-539             AL627104.16        178702-178824
            540-635             AL627104.16        180053-180148
            636-728             AL627104.16        181299-181391
            729-2416            AL627104.16        183743-185430
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.0 cM"
     gene            1..2416
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /note="lysosomal-associated protein transmembrane 5"
                     /db_xref="GeneID:16792"
                     /db_xref="MGI:MGI:108046"
     exon            1..119
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            120..213
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            214..290
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            291..416
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            417..539
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            540..635
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            636..728
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     exon            729..2416
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="Laptm5"
                     /gene_synonym="E3; Stra13"
                     /note="major polyA site"
ORIGIN      
        1 actcagagcc tccgaagagg ggactgcgca ccatggcctc ccgtgcagcg ccggtcagac
       61 agacatgctg ttgtttcaac atccgagtcg ccaccatagc cctggccatt taccacatag
      121 tcatgagtgt cctgctgttc attgagcatg tggtggaggt ggcccgcggt aaagtgtcct
      181 gtaggttctt caagatgccg tacctcagga tggctgacct gctctccagc ttcctgctca
      241 ttggcgtgct cttcatcatc agcatcagcc tgctgttcgg cgtggtcaag aaccgggaga
      301 agtacctgat acccttcctg tcccttcaaa tcatggactt cctgctctgc ctgctcacac
      361 tgctgggctc ctacatcgaa ttgccagcgt acttgaagct tgcccggccc cggcctggtc
      421 cttctaaggt ccccttgatg acactgcagc tgctagactt ctgtttgagt atcctgaccc
      481 tgtgcagctc ctacatggaa gtgcccacct acctcaactt caagtccatg aaccacatga
      541 attacctccc aagccaggag ggtgtgccgc acagccagtt catcaacatg atgctcatct
      601 tctcagtggc ctttatcacc gtgctcatcc tgaaggtcta catgttcaag tgtgtgtaca
      661 catgctacaa attcttgaag cacatgaatt cggccatgga ggacagcagc tccaagatgt
      721 tcctcaaggt ggctctgccg tcctacgagg aagccttgtc tctgccccct aagactccag
      781 agggggaccc tgcaccaccc ccatactcag aagtgtgatc cccaccaggc ctttagccct
      841 tgggctggga gaggcagaac ttcctcctcc tgcttcttca ctttggtggt tgctgtggcc
      901 tgcctgctac aggacaatct gcttgtgccc cccctcactg tcctctcctc tcggggaccc
      961 ctcactcaca actgagtcac cctgggctca gtgacccttt gcggctcagg atactcagcc
     1021 tagcagcccg tctcgtctcc atcagcagtg acacttgttc agagcgcagc cataggaagt
     1081 tagggtgcgt ttggttaaca gctaccggct tgatctgttt ggccaggcag cagcaggaag
     1141 agaatctggc caagcaatag ttcctggtgt cagtttatac tcagctgtca gacgacagga
     1201 tgggtcatga ttgtggtgcc cgtttgccac ctccagtacc ccaaaagtgt acaaacaaaa
     1261 caattccttc aaatagcttg cttaaatagc gattcagcca actgctgtca ttaggaatta
     1321 tgataaaatc tagtaagaaa ctgaggagaa aaagaaatag aaacggagcc cctcccacca
     1381 ctcactgcag tgctcaccat ggagcccctc ccaccactca ttgcagtgct caccatggag
     1441 cccctcccac cactcactgc agtgctcacc atggagcccc tcccaccact cactgcagtg
     1501 ctcaccatgg agcccctccc accactcact gcagtgctca ccatggagcc cctcccacca
     1561 ctcactgcag tgctcaccat ggagcccctc ccaccactca ctgcagtgct caccatggag
     1621 cccctcccac cactcactgc agtgctcacc atggagcccc tcccaccact cactgcagtg
     1681 ctcaccatgg agcccctccc accactcact gcagtgctca tcatggagcc cctcccacca
     1741 ctcactgcag tgctcaccat ggagcccctc ccaccactca ctgcagtgct caccacggag
     1801 cccagcctct gcttgagttt ctccagcacc tggaggctgg gaagtccaac agtctcgccg
     1861 ctggcctgaa catcctgttc agcgtgggaa aaaaaatgtt gcttctgttt taaataatcc
     1921 cttcccatga gccactgctc tgatggcaag ctgtccttat cttcagtcaa gtgttcccta
     1981 gggccacaca gtggtgaggt ccctgcaaga gtccctttag cctggcagat ttagggtctg
     2041 gtgatcacac atcccagcgg ccaggttgct tcagcttgct tgccctgggc tacgctcagg
     2101 ggatggcagg tttggagttg gccgccctgg gggtggctgt ctgtcactat ggctgcccag
     2161 ttggggcagg ctagcctatg gggtgtgaag agttggccag agtcatgtgt tctatggtgg
     2221 cagcaaggag ggtcagttca tatgcctctg ctggcttttc tatcgctagg ggttgctagg
     2281 ggttgctagg gatctacacc ctgcctgtgg tgtagatggg gctgcagggc tgaaaagttc
     2341 ccactgtacc tgtgtcattg cttgtgtatg acttggaaga agggccaata aagcaactgc
     2401 aagctttgct ctgtct
//
