LOCUS       NM_033521               1797 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus lysosomal-associated protein transmembrane 4B
            (Laptm4b), mRNA.
ACCESSION   NM_033521
VERSION     NM_033521.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Zhou,Y.Y., Wang,Z.K., Huang,Y.X., Fu,X.M., Zhang,X.L., Hou,Y.,
            Ju,Z.Y. and Liu,B.
  TITLE     [Effect of Laptm4b Deletion on Hematopoietic Stem and Progenitor
            Cells Homeostasis in Mice]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 29 (5), 1623-1630 (2021)
   PUBMED   34627451
  REMARK    GeneRIF: [Effect of Laptm4b Deletion on Hematopoietic Stem and
            Progenitor Cells Homeostasis in Mice].
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1797)
  AUTHORS   Gu,S., Tan,J., Li,Q., Liu,S., Ma,J., Zheng,Y., Liu,J., Bi,W.,
            Sha,P., Li,X., Wei,M., Cao,N. and Yang,H.T.
  TITLE     Downregulation of LAPTM4B Contributes to the Impairment of the
            Autophagic Flux via Unopposed Activation of mTORC1 Signaling During
            Myocardial Ischemia/Reperfusion Injury
  JOURNAL   Circ Res 127 (7), e148-e165 (2020)
   PUBMED   32693673
  REMARK    GeneRIF: Downregulation of LAPTM4B Contributes to the Impairment of
            the Autophagic Flux via Unopposed Activation of mTORC1 Signaling
            During Myocardial Ischemia/Reperfusion Injury.
            Erratum:[Circ Res. 2023 Mar 3;132(5):e94. doi:
            10.1161/RES.0000000000000597. PMID: 36862816]
REFERENCE   5  (bases 1 to 1797)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1797)
  AUTHORS   Milkereit,R. and Rotin,D.
  TITLE     A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4
            proteins
  JOURNAL   PLoS One 6 (11), e27478 (2011)
   PUBMED   22096579
  REMARK    GeneRIF: The results suggest that while some requisites of LAPTM5
            lysosomal sorting are conserved among LAPTM4 proteins, LAPTM4a and
            LAPTM4b have also developed distinct sorting requirements.
REFERENCE   7  (bases 1 to 1797)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   8  (bases 1 to 1797)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1797)
  AUTHORS   Shao,G.Z., Zhou,R.L., Zhang,Q.Y., Zhang,Y., Liu,J.J., Rui,J.A.,
            Wei,X. and Ye,D.X.
  TITLE     Molecular cloning and characterization of LAPTM4B, a novel gene
            upregulated in hepatocellular carcinoma
  JOURNAL   Oncogene 22 (32), 5060-5069 (2003)
   PUBMED   12902989
  REMARK    GeneRIF: A potential protooncogene whose overexpression is involved
            in carcinogenesis and progression of hepatocellular carcinoma
REFERENCE   10 (bases 1 to 1797)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133101.4.
            
            On Jan 23, 2023 this sequence version replaced NM_033521.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU561010.1, AK082807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC133101.4         73255-73544         c
            291-402             AC133101.4         52885-52996         c
            403-476             AC133101.4         39260-39333         c
            477-599             AC133101.4         38327-38449         c
            600-698             AC133101.4         35443-35541         c
            699-794             AC133101.4         34150-34245         c
            795-1797            AC133101.4         27375-28377         c
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.98 cM"
     gene            1..1797
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /note="lysosomal-associated protein transmembrane 4B"
                     /db_xref="GeneID:114128"
                     /db_xref="MGI:MGI:1890494"
     exon            1..290
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            291..402
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            403..476
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            477..599
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            600..698
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            699..794
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1797
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /note="hexamer: ATTAAA"
     polyA_site      1797
                     /gene="Laptm4b"
                     /gene_synonym="C330023P13Rik; LAPTM4beta"
                     /note="major polyA site"
ORIGIN      
        1 gcctcctagc gtcgccgcgg tcttcgagcc cagtgtcccg tcgcagcggc cactcggagc
       61 tctcggtaca gtgcagagcc aagggtcggg cgagcggtcc gagggtcggg gcggccaagg
      121 agaggggcag gagcagcgga cccaagacga agcgagcgac gctctcacaa acttccacga
      181 gcgccggagc tatgaagatg gtcgctccct ggactcggtt ctactcccac agctgctgtt
      241 tgtgctgcca tgtccgcacc ggcaccatcc tgctgggcgt ctggtacctg atcatcaatg
      301 ctgtggtcct gctgatcctg ctgagtgccc tggcagatcc caatcagtat cacttttcag
      361 gctctgaact aggaggggag tttgagttca tggatgatgc caacatgtgc attgctatcg
      421 caatctctct cctcatgatc ctgatatgtg ccatggctac ttacggtgca tacaagcaac
      481 atgctgcctg gatcatcccg ttcttctgtt accagatctt tgattttgcc ctgaatactt
      541 tggttgcaat cactgtgctt gtctatccga actccattca ggaatacata cgacagctgc
      601 ctcctagctt tccctacaga gatgatataa tgtccgtgaa tcctacctgt ttggtcctta
      661 ttattcttct gtttatcggc attcttttga cacttaaggg ctacttgatt agctgcgttt
      721 ggagctgcta caggtacatc aacggcagga actcctccga tgtcctggtg tatgttacca
      781 gcaatgatac cacagtgctg ctgcctccgt acgatgatgc tactgctgtg cctagcactg
      841 ccaaggaacc accaccacct tacgtgtccg cctgaacctg gtgcggaaga gctgagagca
      901 gcagtttgag cccttagctg catgaattat cctgtggttt cacttccatg atgaactctc
      961 tgagccacat tttacaattt agatgttaag ctgaagcctc tgttgacaca tgccctgtag
     1021 ctaagcactg actagcgagg ctgtaggagt ggagtgtggt gagttcccag agtctttctc
     1081 aaaactacag acgttggtcc ccgggctggc ttatacctgc ctggccccag agctgggtgg
     1141 gcagtcatac ttttcttctc cattccctct gattgttttg aaagtataaa attaaaatta
     1201 gatgatactt aaatctttcc agtatacgta atacaaatag tattaattgc tctaattaga
     1261 tagttaggag cccttccata tgtgatataa gaattcccct actatccctg aattcaatga
     1321 tactctgaat ttgctggtca aggattttct ttgggccaaa taaagacccc caaggtaata
     1381 ggcaacagtg agggcaacag ctgccgggct gcctgttgtt ttgggctatg gttgatgtgt
     1441 ctccctgtgt gaaagggggg ccagcttgct ctgcactgag agactcacac tcccttttcc
     1501 ttggttacct gcaccaacag agccaccatg tatgtttggg aaaaggtgtt cacactcttt
     1561 tcttgcaagg tacaacctgc tttgaatttc taagtatgcc taatcattca ttaaaatgtc
     1621 aagcagtctt cagaaagata aggaggtttg ttcccatgta gaatactcta gactgtctgg
     1681 attgtgaaag acgtttatgt tcatgtctct gaatgtgagc aggtctcctg cttggtcctt
     1741 gctcaatgtg ctgtacacaa aggctttgca attaaagttt gtctgcatcc aagaaaa
//
