LOCUS       NM_008640               1365 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus lysosomal-associated protein transmembrane 4A
            (Laptm4a), mRNA.
ACCESSION   NM_008640
VERSION     NM_008640.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Kaji,D.A., Montero,A.M., Patel,R. and Huang,A.H.
  TITLE     Transcriptional profiling of mESC-derived tendon and fibrocartilage
            cell fate switch
  JOURNAL   Nat Commun 12 (1), 4208 (2021)
   PUBMED   34244516
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Milkereit,R. and Rotin,D.
  TITLE     A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4
            proteins
  JOURNAL   PLoS One 6 (11), e27478 (2011)
   PUBMED   22096579
  REMARK    GeneRIF: The results suggest that while some requisites of LAPTM5
            lysosomal sorting are conserved among LAPTM4 proteins, LAPTM4a and
            LAPTM4b have also developed distinct sorting requirements.
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Hogue,D.L., Nash,C., Ling,V. and Hobman,T.C.
  TITLE     Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha)
            requires two tandemly arranged tyrosine-based signals for sorting
            to lysosomes
  JOURNAL   Biochem J 365 (Pt 3), 721-730 (2002)
   PUBMED   11980562
  REMARK    GeneRIF: LAPTM4 alpha is the first example of a membrane protein
            that requires two tandemly arranged tyrosine-based sorting signals
            for efficient localization in lysosomes and endosomes.
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Cabrita,M.A., Hobman,T.C., Hogue,D.L., King,K.M. and Cass,C.E.
  TITLE     Mouse transporter protein, a membrane protein that regulates
            cellular multidrug resistance, is localized to lysosomes
  JOURNAL   Cancer Res 59 (19), 4890-4897 (1999)
   PUBMED   10519401
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Hogue,D.L., Ellison,M.J., Young,J.D. and Cass,C.E.
  TITLE     Identification of a novel membrane transporter associated with
            intracellular membranes by phenotypic complementation in the yeast
            Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 271 (16), 9801-9808 (1996)
   PUBMED   8621662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140354.2.
            
            On Dec 23, 2021 this sequence version replaced NM_008640.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075699.1, BC086667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC140354.2         134242-134464
            224-344             AC140354.2         143798-143918
            345-421             AC140354.2         146866-146942
            422-544             AC140354.2         147036-147158
            545-640             AC140354.2         148157-148252
            641-739             AC140354.2         148867-148965
            740-1365            AC140354.2         150287-150912
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.96 cM"
     gene            1..1365
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /note="lysosomal-associated protein transmembrane 4A"
                     /db_xref="GeneID:17775"
                     /db_xref="MGI:MGI:108017"
     exon            1..223
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..814
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /note="transporter protein; golgi 4-transmembrane-spanning
                     transporter; membrane transporter protein"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 4A"
                     /protein_id="NP_032666.3"
                     /db_xref="CCDS:CCDS36402.1"
                     /db_xref="GeneID:17775"
                     /db_xref="MGI:MGI:108017"
                     /translation="MVSMTFKRSRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMA
                     ILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAI
                     SYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSC
                     LLFIVLVFFVVFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFETPPQYVLPTYEMA
                     VKIPEKEPPPPYLPA"
     exon            224..344
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            345..421
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            422..544
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            545..640
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            641..739
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1365
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /note="hexamer: AATAAA"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /note="hexamer: CATAAA"
     polyA_site      1351
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
                     /note="major polyA site"
     polyA_site      1365
                     /gene="Laptm4a"
                     /gene_synonym="LAPTM4; mKIAA0108; MTP; Mtrp"
ORIGIN      
        1 agaagacgcg tcctttggct gtggacaccg tcgtagagtc gtctgggttg aaccgctggg
       61 ccgaaagctt ttgtcagggg cctgggcgag aacgaggccc gcgaggttcc ggatggtgtc
      121 catgactttc aaacggagcc gcagcgaccg gttctacagc acccggtgct gcggctgttg
      181 ccatgtccgc accgggacga tcatcctggg gacctggtac atggtggtca acctgttgat
      241 ggccattttg ctgaccgtgg aggtgactca tccaaattcc atgccagctg tcaacattca
      301 gtatgaagtc attggtaatt actattcatc tgagagaatg gctgataatg cctgcgttct
      361 ttttgccgtc tctgttctta tgtttataat cagttcaatg ctggtttatg gagccatttc
      421 ttatcaagtg ggctggctga ttcctttctt ctgctaccga ctctttgact tcgttctcag
      481 ttgtctggtg gccatcagtt ctctcactta cttgccaaga atcaaagaat atctggatca
      541 gttgcctgat ttcccataca aagatgacct cctggcattg gactccagct gcctcctgtt
      601 catcgtcctt gtgttctttg tggtattcat catttttaag gcttacctaa tcaattgtgt
      661 ttggaactgc tacaaataca tcaacaacag aaatgtgcca gagattgccg tgtaccctgc
      721 ctttgaaaca cctccacagt atgttttgcc aacctatgaa atggctgtga agattcctga
      781 gaaagagcca ccacctcctt acctgcctgc ctgaggacat tctgccttgt caataaagcc
      841 tataccagct tctcgtcttg tttattttac agaaagctgc agtgcgggcc tctcagactt
      901 gtttgataga aagtacactg tcttgtctga gcatttattt tcaaacacta aggagctttt
      961 ggacatttat taaaaacttt ttgttaagta tcacatttta gagacttttt gaagacaatc
     1021 tagattaagc aagagccaag tgccattgtt agcctttagc tgagggtatg ggggggaggg
     1081 gtctccatgt tttctttttt aactttgcac tttctttgta taataatagt ttatgttttg
     1141 gatgtttggt gccctgagta gtttccgggg cgtgactaca gtgttgagga tgaataggtt
     1201 gggtataaca cctgcagttt ccagctctat gaaacaggag agagagagaa atagcagttt
     1261 gacttgactg tggaagatga tggttgcatg cttctcattt gtacgtttcc atctttgtga
     1321 taaaccgctt taataaagct cataaatttt accattgtcc ttaaa
//
