LOCUS       NM_024434               2267 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine aminopeptidase 3 (Lap3), mRNA.
ACCESSION   NM_024434
VERSION     NM_024434.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Osana,S., Kitajima,Y., Naoki,S., Murayama,K., Takada,H.,
            Tabuchi,A., Kano,Y. and Nagatomi,R.
  TITLE     The aminopeptidase LAP3 suppression accelerates myogenic
            differentiation via the AKT-TFE3 pathway in C2C12 myoblasts
  JOURNAL   J Cell Physiol 238 (9), 2103-2119 (2023)
   PUBMED   37435895
  REMARK    GeneRIF: The aminopeptidase LAP3 suppression accelerates myogenic
            differentiation via the AKT-TFE3 pathway in C2C12 myoblasts.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Kruber,P., Angay,O., Winkler,A., Bosl,M.R., Kneitz,S., Heinze,K.G.
            and Gessler,M.
  TITLE     Loss or oncogenic mutation of DROSHA impairs kidney development and
            function, but is not sufficient for Wilms tumor formation
  JOURNAL   Int J Cancer 144 (6), 1391-1400 (2019)
   PUBMED   30367465
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Rezvani,K., Teng,Y., Pan,Y., Dani,J.A., Lindstrom,J., Garcia
            Gras,E.A., McIntosh,J.M. and De Biasi,M.
  TITLE     UBXD4, a UBX-containing protein, regulates the cell surface number
            and stability of alpha3-containing nicotinic acetylcholine
            receptors
  JOURNAL   J Neurosci 29 (21), 6883-6896 (2009)
   PUBMED   19474315
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Towne,C.F., York,I.A., Watkin,L.B., Lazo,J.S. and Rock,K.L.
  TITLE     Analysis of the role of bleomycin hydrolase in antigen presentation
            and the generation of CD8 T cell responses
  JOURNAL   J Immunol 178 (11), 6923-6930 (2007)
   PUBMED   17513741
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Mashimo,T., Glaser,P., Lucas,M., Simon-Chazottes,D., Ceccaldi,P.E.,
            Montagutelli,X., Despres,P. and Guenet,J.L.
  TITLE     Structural and functional genomics and evolutionary relationships
            in the cluster of genes encoding murine 2',5'-oligoadenylate
            synthetases
  JOURNAL   Genomics 82 (5), 537-552 (2003)
   PUBMED   14559211
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Peters,J., Povey,S., Jeremiah,S. and De Giorgi,L.
  TITLE     Linkage relationships of peptidase-7, Pep-7, in the mouse
  JOURNAL   Biochem Genet 21 (7-8), 801-807 (1983)
   PUBMED   6626149
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Matossian-Rogers,A., DeGiorgi,L. and Povey,S.
  TITLE     Alloimmune interactions of a lymphoproliferative disease-inducer
            gene Arp and linkage to Pep-7
  JOURNAL   Immunogenetics 18 (6), 639-648 (1983)
   PUBMED   6228526
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Comparative gene mapping: the linkage relationships of the
            homologous genes for phosphoglucomutase and peptidase S are
            conserved in man and mouse
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 573-576 (1978)
   PUBMED   752543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092711.14, AK011604.1 and BY416332.1.
            
            On Aug 4, 2009 this sequence version replaced NM_024434.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016536.1, AK010502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC092711.14        142549-142663
            116-2249            AK011604.1         2-2135
            2250-2267           BY416332.1         341-358
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 24.98 cM"
     gene            1..2267
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /note="leucine aminopeptidase 3"
                     /db_xref="GeneID:66988"
                     /db_xref="MGI:MGI:1914238"
     exon            1..188
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1646
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /EC_number="3.4.11.5"
                     /EC_number="3.4.11.1"
                     /EC_number="3.4.13.23"
                     /note="proline aminopeptidase; prolyl aminopeptidase;
                     peptidase 7; leucyl aminopeptidase;
                     cysteinylglycine-S-conjugate dipeptidase; peptidase S"
                     /codon_start=1
                     /product="cytosol aminopeptidase"
                     /protein_id="NP_077754.3"
                     /db_xref="CCDS:CCDS19274.1"
                     /db_xref="GeneID:66988"
                     /db_xref="MGI:MGI:1914238"
                     /translation="MYLLPLPAAARVALRRLGVRGLWDRGLSTADMTKGLVLGIYAKD
                     KDDDLPQFTSAGESFNKLVSGKLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLG
                     KRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAEGAVLGLY
                     EYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARHLMESPANEMTPTRFAEI
                     IEKNLKSASSKTKVHIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYMGSPNATEAP
                     LVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPL
                     CENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATL
                     TGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADV
                     NNLGKYRSAGACTAAAFLREFVTHTKWAHLDIAGVMTNKDEIPYLRKGMSGRPTRTLI
                     EFLLRFSKDSS"
     exon            189..304
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            305..359
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            360..465
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            466..625
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            626..790
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            791..949
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1074
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1163
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1266
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1346
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1456
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..2267
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /note="hexamer: AATGAA"
     polyA_site      1735
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /note="major polyA site"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /note="hexamer: AATAAA"
     polyA_site      2250
                     /gene="Lap3"
                     /gene_synonym="2410015L10Rik; Lap; LAP-3; Lapep; Pep-7;
                     Pep-S; Pep7; Peps"
                     /note="major polyA site"
ORIGIN      
        1 ccggaggtcc cgcctccagg cgcgcgccct gccacgcgcc acgtgctcct tctctggagg
       61 gcggcgccga gggccgagcc gagaagatgt acttgctgcc ccttccggct gccgcgcgag
      121 tcgcgctccg ccgcctggga gtgagaggtc tctgggatcg gggtctgtcc accgcagaca
      181 tgacgaaggg ccttgtttta ggaatttatg ccaaagacaa agatgatgac ctgccacaat
      241 ttacaagtgc gggagagagt tttaataagt tggtgtctgg aaagctgagg gaaatgttga
      301 acatatctgg acctcctctc aaagcaggca aaaccagaac cttctatggt ctgcatcagg
      361 acttccccag cgtggtggtg gtcggccttg gcaagcgatc ggctggagtt gatgaccagg
      421 aaaactggca cgaaggcaaa gaaaacatca gagctgctgt tgcagcggga tgcaggcagg
      481 tccaagacct ggagctgccg tcggtggagg tggatccctg tggagatgcg caagctgctg
      541 cagaaggagc tgtgcttggt ctctatgagt acgatgacct gaagcagaag aagaaggtgg
      601 ctgtgtcggc gaagctccac ggaagcggtg atctcgaggc ctgggagaaa ggggtcctct
      661 ttgcttctgg acagaacttg gcccgtcatc tgatggagtc tccagccaat gagatgacac
      721 caaccagatt cgctgaaatc attgaaaaaa acctcaaaag tgccagtagt aaaaccaagg
      781 tccatatcag acccaagtcc tggatagagg aacaagaaat gggttcgttc ctaagtgtag
      841 ccaaggggtc tgaagaacca ccagtcttct tggaaatcca ctacatgggc agccccaatg
      901 caaccgaggc acccctggtg tttgtgggga agggcattac ctttgacagt ggaggtatct
      961 ccatcaaggc ttctgcaaac atggacctca tgagggctga tatgggagga gcagcaacaa
     1021 tatgctcggc cattgtgtct gcggcaaagc tcaacttgcc cattaacatc attggtttgg
     1081 cccctctttg tgaaaatatg cctagcggca aggccaacaa gccaggggat gtcgtcagag
     1141 ccaggaatgg gaagaccatc caggttgata acactgacgc cgaggggagg ctcatcctgg
     1201 ccgatgcact ctgttatgca cacaccttta atcccaaggt catcatcaat gctgccacct
     1261 taacaggtgc catggatgta gccctggggt caggtgccac tggagtcttt accaattcgt
     1321 cctggctgtg gaacaaacta tttgaggcca gcgtagaaac tggggaccga gtctggagga
     1381 tgcccctctt tgagcattat acaagacaag tcatagattg ccagcttgct gatgtcaaca
     1441 atcttggaaa atacagatct gcaggtgcgt gtacagctgc cgcattcctg cgagagtttg
     1501 tgacacatac gaagtgggca cacttagaca tagcaggagt gatgaccaac aaagatgaga
     1561 ttccctacct gcggaagggg atgagtgggc ggcccacgag gactctgatt gagttcttac
     1621 ttcgattcag taaagacagt tcttagttca ctcacagatt actccatctg tcttgaattg
     1681 gatatttgac cttcaaaata tttttgaatg aatgaaaatc ttttaaagac taaaatgaat
     1741 gttgttcttt tttttaatct taatttttgg aatactttaa tatgcttgaa tcatggaaat
     1801 ctaaatgata tatgacttaa tataggccct ttaaactatt aaaacatctt gtaataatat
     1861 gcattttcaa gccatattta ctatttttac aagatagggg aaatcttaag tccataaaaa
     1921 tggacaaagg ccaggcatgg ggtgcagaac tttgatccca gcatttggga ggcagaggca
     1981 gctcgatttc tgagtttgag accatcgtgg tctacagagt gaattccagg atagccatgg
     2041 ctatacagag aaaccctgtc ttggaaaagc aaaacaaaac aaaaacaaaa aaaacaacgc
     2101 ataccaccac caccaaaatg tagaaaggaa aatataatga atgactttgt tatattttcc
     2161 aagttttgat tcttaaggta gattatttaa gtgttcctat aactttcaaa atctgatcca
     2221 atgcagtaaa taaaatattt ccttctgtta gttgtttgtt cactgtg
//
