LOCUS       NM_133892               1958 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus L-amino acid oxidase 1 (Lao1), mRNA.
ACCESSION   NM_133892
VERSION     NM_133892.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Zhang H, Liu H, Kataoka S, Kinukawa M, Uchiyama K, Kambe J,
            Watanabe G, Jin W and Nagaoka K.
  TITLE     L-amino acid oxidase 1 in sperm is associated with reproductive
            performance in male mice and bulls
  JOURNAL   Biol Reprod 104 (5), 1154-1161 (2021)
   PUBMED   33590844
  REMARK    GeneRIF: L-amino acid oxidase 1 in sperm is associated with
            reproductive performance in male mice and bulls.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Shigeno Y, Zhang H, Banno T, Usuda K, Nochi T, Inoue R, Watanabe G,
            Jin W, Benno Y and Nagaoka K.
  TITLE     Gut microbiota development in mice is affected by hydrogen peroxide
            produced from amino acid metabolism during lactation
  JOURNAL   FASEB J 33 (3), 3343-3352 (2019)
   PUBMED   30433825
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Usuda K, Kawase T, Shigeno Y, Fukuzawa S, Fujii K, Zhang H,
            Tsukahara T, Tomonaga S, Watanabe G, Jin W and Nagaoka K.
  TITLE     Hippocampal metabolism of amino acids by L-amino acid oxidase is
            involved in fear learning and memory
  JOURNAL   Sci Rep 8 (1), 11073 (2018)
   PUBMED   30038322
  REMARK    GeneRIF: LAO1 KO mice exhibited impaired fear learning and memory
            owing to low hippocampal acetylcholine levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Fujii K, Zhang H, Usuda K, Watanabe G and Nagaoka K.
  TITLE     Lactogenic hormone stimulation and epigenetic control of L-amino
            acid oxidase expression in lactating mammary glands
  JOURNAL   J Cell Physiol 230 (11), 2755-2762 (2015)
   PUBMED   25820447
  REMARK    GeneRIF: this is the first demonstration showing that LAO
            expression is induced in cell culture, and stimulation of
            lactogenic hormone and change of histone modification are promising
            signals to show highly expression of LAO in lactating mammary
            glands.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Nagaoka K, Aoki F, Hayashi M, Muroi Y, Sakurai T, Itoh K, Ikawa M,
            Okabe M, Imakawa K and Sakai S.
  TITLE     L-amino acid oxidase plays a crucial role in host defense in the
            mammary glands
  JOURNAL   FASEB J 23 (8), 2514-2520 (2009)
   PUBMED   19276171
  REMARK    GeneRIF: LAO-knockout mice were healthy and had normal mammary
            gland development; however, the antibacterial activity normally
            observed in milk from wild-type mice was absent from the milk of
            knockout mice.
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Sun Y, Nonobe E, Kobayashi Y, Kuraishi T, Aoki F, Yamamoto K and
            Sakai S.
  TITLE     Characterization and expression of L-amino acid oxidase of mouse
            milk
  JOURNAL   J Biol Chem 277 (21), 19080-19086 (2002)
   PUBMED   11907037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606922.5 and AK052781.1.
            
            On Apr 25, 2009 this sequence version replaced NM_133892.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB034801.2, BC017599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL606922.5         177349-177378
            31-866              AK052781.1         2-837
            867-1958            AL606922.5         183201-184292
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.24 cM"
     gene            1..1958
                     /gene="Lao1"
                     /note="L-amino acid oxidase 1"
                     /db_xref="GeneID:100470"
                     /db_xref="MGI:MGI:2140628"
     exon            1..63
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1604
                     /gene="Lao1"
                     /codon_start=1
                     /product="L-amino acid oxidase 1 precursor"
                     /protein_id="NP_598653.3"
                     /db_xref="CCDS:CCDS18568.1"
                     /db_xref="GeneID:100470"
                     /db_xref="MGI:MGI:2140628"
                     /translation="MSFRTMAKKSGILVWGILLCVSSCLALYENLVKCFQDPDYEAFL
                     LIAQNGLHTSPLSKRVVVVGAGMAGLVAAKTLQDAGHEVTILEASNHIGGRVVTLRNK
                     EEGWYLELGPMRIPESHKLIHTYVQKLGLKLNKFHQYDSNTWYLLNGQRYRASEVMAN
                     PGILGYPLRPSEKNKTVTDLFYQAITKIKPHRKTSNCSQLLSLYDSYSTKAYLMKEGT
                     LSKGAIEMIGDIMNENAGYYKSLLESLRIASIFSKSDQFSEITGGFDQLPNGLSASLK
                     PGTIRLGSKVERVVRDGPKVKVMYRTDGPTSALHKLTADYAIITASAKATRLITFQPP
                     LSREKTHALRSVHYTSATKVVLVCNERFWEQDGIRGGYSITDRPSRFIYYPSHSLPGG
                     KGVLLASFTVGDDSSFFAALKPNQVVDVVLDDLAAVHRIPKEELKRMCPKSAIKHWSL
                     DPLTIGAFTEFTPYQFVDYSKQLSQPEGRIYFAGEHTCLPHSWIDTAIKSGIRASCNI
                     QAAVDKEATRGHTAL"
     exon            64..278
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..391
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..593
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..662
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..799
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1958
                     /gene="Lao1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaagagaa gaggagaggc tcagagttcc gcatgagttt caggaccatg gccaagaaga
       61 gtggaatcct tgtttggggg atcctgctct gcgtctccag ctgtcttgcc ctctatgaga
      121 accttgtcaa gtgtttccag gatcccgatt atgaggcctt ccttctcata gcccagaatg
      181 ggctccatac ctccccactg tctaagcgtg tggtggtagt gggagctggc atggcaggcc
      241 tagtggcagc taagacccta caggatgctg gtcacgaggt aaccatcttg gaggccagca
      301 accacatcgg aggtagggtg gtcacactca gaaacaagga agaaggctgg tacttagaac
      361 ttggaccaat gcgaatccca gaaagccaca agctaatcca cacctatgtc cagaagcttg
      421 gcctgaaact gaataagttc caccagtatg atagcaacac ctggtaccta ctcaatggac
      481 aacgctatcg tgcctcagaa gtcatggcta acccaggaat cttgggctac cccctgaggc
      541 cctcagagaa gaacaaaact gtcacagacc tgttctacca agccatcact aagatcaaac
      601 cacataggaa gacatccaac tgcagccagc tgctctccct ttatgactct tactccacca
      661 aggcttacct gatgaaggaa ggaacgctga gcaaaggggc catcgagatg atcggggata
      721 taatgaatga gaatgctgga tactataagt ccctcctgga gtctctgagg attgcaagca
      781 tcttctccaa aagtgaccaa ttttcagaga tcaccggtgg ctttgaccaa ctccccaatg
      841 gcctcagtgc tagcctgaag cctggcacca tccgtctggg gtccaaagta gaaagagtgg
      901 tgagagacgg gcccaaggtt aaggttatgt accgcacaga tgggcccacc tctgcactgc
      961 acaaactcac tgcggattac gccatcatca ctgcctcagc caaggccact cgcctcatca
     1021 ccttccagcc acctctgtcc cgagagaaaa cacatgccct gcgctccgtt cattacacca
     1081 gtgccaccaa ggtggtttta gtgtgcaacg aacgcttctg ggaacaagat ggcatccggg
     1141 gcggctactc catcactgac cgaccctccc gcttcattta ctatcccagc cacagcctgc
     1201 caggcggcaa gggagtcctg ctggcctctt tcactgtggg tgatgattcc tccttctttg
     1261 ctgccctgaa gcccaaccag gtggtcgatg ttgtgctgga tgaccttgcg gcagtgcacc
     1321 gcatacccaa ggaggagcta aagcgcatgt gcccaaagtc agcgatcaag cactggtctc
     1381 tagaccccct caccattggc gcctttacag agttcacacc ctaccaattt gtagactatt
     1441 cgaagcagct ctcccagcca gagggccgca tctactttgc tggggagcat acctgcctgc
     1501 cgcacagctg gatagacacc gccatcaagt cgggcatccg ggcctcctgc aacattcagg
     1561 ctgcagtgga caaggaggcc actcgaggac atacggctct ttagaggccc tttgccaaca
     1621 atcaggatgc cccaccacca ccaccaagaa caatctgtgg gagagtctaa gagaataaat
     1681 aggctagaag atgaaaggaa gccgagaccc aggagagaag tcaccactgg tcccttggtc
     1741 tacaagcaga agcccaactg ggaagctaca agagacacca ccccctattc tgtctcactc
     1801 cctctctcta tgggaaatag cagagccagg gcatacaaag gcagggagta gggggtagct
     1861 gtcaaggctg gagaattcta gaatcagcct ttagcttgaa ggaaattgtc tcctgctaca
     1921 aaacaataac aagcaaaaag aaaaaagtgt caatacct
//
