LOCUS       NM_173414               3920 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LanC lantibiotic synthetase component C-like 3
            (bacterial) (Lancl3), mRNA.
ACCESSION   NM_173414 XM_001006384
VERSION     NM_173414.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Lai,K.Y., Galan,S.R.G., Zeng,Y., Zhou,T.H., He,C., Raj,R.,
            Riedl,J., Liu,S., Chooi,K.P., Garg,N., Zeng,M., Jones,L.H.,
            Hutchings,G.J., Mohammed,S., Nair,S.K., Chen,J., Davis,B.G. and van
            der Donk,W.A.
  TITLE     LanCLs add glutathione to dehydroamino acids generated at
            phosphorylated sites in the proteome
  JOURNAL   Cell 184 (10), 2680-2695 (2021)
   PUBMED   33932340
REFERENCE   3  (bases 1 to 3920)
  AUTHORS   Romanov,R.A., Tretiakov,E.O., Kastriti,M.E., Zupancic,M.,
            Haring,M., Korchynska,S., Popadin,K., Benevento,M., Rebernik,P.,
            Lallemend,F., Nishimori,K., Clotman,F., Andrews,W.D.,
            Parnavelas,J.G., Farlik,M., Bock,C., Adameyko,I., Hokfelt,T.,
            Keimpema,E. and Harkany,T.
  TITLE     Molecular design of hypothalamus development
  JOURNAL   Nature 582 (7811), 246-252 (2020)
   PUBMED   32499648
REFERENCE   4  (bases 1 to 3920)
  AUTHORS   He,C., Zeng,M., Dutta,D., Koh,T.H., Chen,J. and van der Donk,W.A.
  TITLE     LanCL proteins are not Involved in Lanthionine Synthesis in Mammals
  JOURNAL   Sci Rep 7, 40980 (2017)
   PUBMED   28106097
  REMARK    GeneRIF: Very similar concentrations of lanthionine ketimine
            (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out,
            LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse
            brains, suggesting that LanCL proteins are not involved in
            lanthionine biosynthesis.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031623.1 and AK043841.1.
            
            On May 30, 2009 this sequence version replaced NM_173414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031623.1, AK043841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1037              AK031623.1         2-1038
            1038-2821           AK043841.1         239-2022
            2822-3269           AK031623.1         2823-3270
            3270-3920           AK031623.1         3272-3922
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.18 cM"
     gene            1..3920
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /note="LanC lantibiotic synthetase component C-like 3
                     (bacterial)"
                     /db_xref="GeneID:236285"
                     /db_xref="MGI:MGI:2443335"
     exon            1..830
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1520
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /codon_start=1
                     /product="lanC-like protein 3"
                     /protein_id="NP_775590.2"
                     /db_xref="CCDS:CCDS30007.1"
                     /db_xref="GeneID:236285"
                     /db_xref="MGI:MGI:2443335"
                     /translation="MDTKRCFANRFDDYQGSLLAGQCEEAVAPLVTSTIERILQELPP
                     LGGGAEARGATGAGSSCQGGLYSGVAGVAYMLYHVSQSPLFAAARERYLRFAKRLIDA
                     CLRAEEWGETDADTRAAFLLGGAGVYAVATLVYHALGRPDYVQPLGKFRALCAVCAPV
                     SFLDCGSDELFVGRAGYLCAALVLKQKLAQEVLTPTQIKAICQAILDSGKQYALKKRK
                     PFPLMYSYYGTEYLGAAHGLSSILQMLLSYQEHLKPSDRELVWQSVDFLMEQEQNCNW
                     PPELGETIERENELVHWCHGAPGIAYLFAKAYLISKKPQYLDTCIRCGELTWQKGLLK
                     KGPGICHGVAGSAYVFLLLYRLTGNSKYIYRAQRFAQFLFTEEFKSGSRVLESIYSLY
                     EGFSGTVCFLIDLLQPNQAEFPLFSVFV"
     exon            831..954
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1152
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1360
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..3920
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1949
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /note="major polyA site"
     regulatory      3389..3394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3410
                     /gene="Lancl3"
                     /gene_synonym="6030463G20Rik"
ORIGIN      
        1 attcctagct ctgcctcggg ccaccccgga gcctcgcggc agctcgttgt cccacttggc
       61 cactggctcc gtgatccctc cttgcgcctg cctcgtcttg tcacctcccg tctcaccctc
      121 ctcgctccat cctccaccac ctcatccaca gccatctgag cgagcgcgcc tctgagagca
      181 ggaggtactg ctccgggctt cagggcgcgc cctccaaagg tgcccagctc gacattcggg
      241 accccgcggg cgacagcatg gacaccaagc gctgcttcgc caaccgcttc gatgactacc
      301 agggcagcct gctggcgggc cagtgcgagg aggcagtggc gcccttggtc acctccacca
      361 tcgaacgcat tcttcaggag ctgcccccgc tggggggcgg cgctgaggct cggggggcga
      421 caggcgcggg cagcagctgc caggggggtc tgtacagcgg cgtggccggg gtggcctaca
      481 tgctctacca cgtctcccag agcccgctct tcgccgccgc ccgggagcgc tacctgcgct
      541 tcgccaagcg cctcatcgac gcgtgcctcc gcgccgagga gtggggcgag acggacgcgg
      601 acacccgtgc tgcctttctg ctcgggggcg cgggcgtgta tgcggtggcc acgctggtct
      661 accacgccct gggccgcccc gactacgtgc agcccctcgg caagttccgg gctctgtgcg
      721 ccgtctgcgc gccggtctcc ttcctggact gtggctccga cgagctgttc gtgggtcgcg
      781 ccggctacct gtgcgccgcg ctcgtgctca agcagaagct cgcccaggag gtattgaccc
      841 caacacaaat taaagcaata tgccaggcga ttctggactc tgggaagcag tatgctctga
      901 agaagagaaa accattcccc ctgatgtatt cttactacgg aacagaatac ctgggggcag
      961 ctcacggcct gtcgtccatt ctccagatgc tcctttccta ccaggagcat ctcaaacctt
     1021 cagatcggga gctggtgtgg cagagcgtgg atttcctcat ggaacaggag cagaattgca
     1081 actggccacc agagcttggc gagaccatcg agagagagaa tgaacttgtc cactggtgcc
     1141 acggcgctcc aggaattgct tatctgtttg ccaaagctta tctcatttcc aagaaaccgc
     1201 agtacctgga cacatgtatc cggtgtgggg agctgacatg gcagaaaggc ctgttgaaga
     1261 aggggccagg gatttgccat ggtgtagctg gcagtgccta tgtcttcctt cttctgtacc
     1321 gtcttacagg aaactcgaaa tatatctacc gtgcccaaag gtttgctcag ttcttattca
     1381 ctgaagaatt caaatccggt tcccgggtcc ttgaaagcat ctacagcttg tacgaaggct
     1441 tctctggaac tgtttgcttt ctcattgatc tactgcagcc caatcaggca gaatttcctc
     1501 tcttcagcgt ctttgtttaa aaggttccat ctccccttgc agtcagtgga agtcccctga
     1561 gatttcctga acctcctcta ggcagttttc cttgtaatcc acatccaatg gtctcacgac
     1621 catgagcctt cccattgctg ccagatggat gagatgagtc tgatgaagac agcgtgatgc
     1681 cagactgcag agagagcctg tcaaaccaag atgccacaac tcatctaaaa agcaccgatt
     1741 taatgtttca ggggagagat ggccaactca agatcagaga gaaaaggggg aaaacattta
     1801 atgtttttca gtttgtgaca caaaaggcaa aagtgaacta gaaatgacag ggataaaatg
     1861 ccaacacttc caaaactgag caacaaatgt gaccatctat gtatgcccaa tacccctaaa
     1921 ttcagaagta aagacagcca gaatcgaaac gaattttgcc ctgttaaaaa ctgttagcag
     1981 ggatcaagtg tcaagacgaa ggacatgaaa agaaaccatt ggctgtccta ggactttact
     2041 tactgaaatt cataattctt ttctgagtgg agatatgtga atatgtaggc aggattttta
     2101 ttttatctta ttttttgacc actattctgg gcactttaaa aaacatcata ttataactta
     2161 ttttgaacac tgaaatttga agctgcctta ggccttagga tgtctctttt ccagttgctt
     2221 ttttctttgc tagagctcag aatagtaagc ttcagggcag gaaggagtgt agcttagaga
     2281 cagggttgga gcttactatc tcagggcgta gcttgtttag catgcataag gcccctggtc
     2341 catgcctagt accacaagca ggcaaaagac aaaacaacaa caaaagaaga cagaaaaatt
     2401 tgtatctagc aaacaaatgt cactatcgtg tttttctcaa ttgaacgtgt gacctggatg
     2461 ttgtgaatgt tagtaatttt tcaaatgtct ttatctttgt aatgtctatg aagctattag
     2521 attgtaaact atgctctcgg tgaaaatcga tcatctcaaa catcagggta acttaccaca
     2581 aaggtaagtc atttctggat ttcatagaag tctgggaaag acatggggtg agaaaacttg
     2641 aaatggttct cgaaagaatg ttgctccatt tcatcctatt atagtaagag tggaatgaac
     2701 tccctggctc ttcacctcac cttgcaaaaa acacaggaca cactagagat tgtctattat
     2761 gccagttgat tctagtcacc atatctagtt tacttctgct acaaacacaa gttataaaaa
     2821 tgtttcaagt ccatagtgga ttgctgaaca ccaataggag caactgtcaa tatgcagacc
     2881 atgagattgc cacagtccta atatttaacc actgaagttc agacatcaca tttagaagac
     2941 agttgtgccg tatacagtgt cattatttgt agtcattaga tatttggata tgtttctata
     3001 cataagtaca tgtgtgtata tgctacatct attcccatat aaactgaagc actatttgaa
     3061 ctgtagatag actttttgag gaattaggta atagtctgct gcctggaaac atttgtgtgt
     3121 gtgctggctt gtggaactat atgaaccaat ggatttgtgt gggtttccat gcatgttgta
     3181 tgtgtgatcc tattttggaa aagaggacct cttgtattta taagattctc aatgaatctt
     3241 aaccaaagaa aagaactgtt ttttttttta atattttgtg gctctttgta tgtttacaat
     3301 cgtcaacacg agctgggaca aactaatttt tgtaaaatat gtaccttgtt ggcttattgt
     3361 cccattttca taccctcgga tttcaacata taaaattgtc tttaattgct tatctgtgag
     3421 aagagtgttt ggggtaaagc ttaattagac ttcagaagtt ctttcttgag gagaaaaagc
     3481 accttttgga aagccttaag gaagatgcta tccacagaat ggtcttcttt ttggacggac
     3541 aatggcatgc ccctcaccat ctcattttca atacattttg cataggccct acaggctaca
     3601 gataataact atccaaaatt aggatgcata gatgtgttgt atctgttata ttgctaggag
     3661 ctttacaaac aactggaact accttttgaa gttgtggtag agtgattata gctttgtgct
     3721 gatcactgtg aaaaggtcac tctttgtata tcatatctaa aaaatggtca tgtttgggtg
     3781 tggtctttct gtaagtacca cctggagatt tataactagt caaagaaagt atacacaggc
     3841 aaaaggtgta actcagcagt aggagactta cctagcatgc gtgctgccct aggccctagg
     3901 cccaccatca gaaacaaaag
//
