LOCUS       NM_133737               3657 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus LanC (bacterial lantibiotic synthetase component
            C)-like 2 (Lancl2), mRNA.
ACCESSION   NM_133737 XM_907995
VERSION     NM_133737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3657)
  AUTHORS   Spinelli,S., Cossu,V., Passalacqua,M., Hansen,J.B., Guida,L.,
            Magnone,M., Sambuceti,G., Marini,C., Sturla,L. and Zocchi,E.
  TITLE     The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte
            Browning and Energy Expenditure
  JOURNAL   Int J Mol Sci 24 (4), 3489 (2023)
   PUBMED   36834900
  REMARK    GeneRIF: The ABA/LANCL1/2 Hormone/Receptor System Controls
            Adipocyte Browning and Energy Expenditure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3657)
  AUTHORS   Magnone,M., Spinelli,S., Begani,G., Guida,L., Sturla,L.,
            Emionite,L. and Zocchi,E.
  TITLE     Abscisic Acid Improves Insulin Action on Glycemia in
            Insulin-Deficient Mouse Models of Type 1 Diabetes
  JOURNAL   Metabolites 12 (6), 523 (2022)
   PUBMED   35736456
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3657)
  AUTHORS   Spinelli,S., Begani,G., Guida,L., Magnone,M., Galante,D.,
            D'Arrigo,C., Scotti,C., Iamele,L., De Jonge,H., Zocchi,E. and
            Sturla,L.
  TITLE     LANCL1 binds abscisic acid and stimulates glucose transport and
            mitochondrial respiration in muscle cells via the
            AMPK/PGC-1alpha/Sirt1 pathway
  JOURNAL   Mol Metab 53, 101263 (2021)
   PUBMED   34098144
REFERENCE   5  (bases 1 to 3657)
  AUTHORS   Lai,K.Y., Galan,S.R.G., Zeng,Y., Zhou,T.H., He,C., Raj,R.,
            Riedl,J., Liu,S., Chooi,K.P., Garg,N., Zeng,M., Jones,L.H.,
            Hutchings,G.J., Mohammed,S., Nair,S.K., Chen,J., Davis,B.G. and van
            der Donk,W.A.
  TITLE     LanCLs add glutathione to dehydroamino acids generated at
            phosphorylated sites in the proteome
  JOURNAL   Cell 184 (10), 2680-2695 (2021)
   PUBMED   33932340
REFERENCE   6  (bases 1 to 3657)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 3657)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3657)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3657)
  AUTHORS   Magnone,M., Sturla,L., Jacchetti,E., Scarfi,S., Bruzzone,S.,
            Usai,C., Guida,L., Salis,A., Damonte,G., De Flora,A. and Zocchi,E.
  TITLE     Autocrine abscisic acid plays a key role in quartz-induced
            macrophage activation
  JOURNAL   FASEB J 26 (3), 1261-1271 (2012)
   PUBMED   22042223
  REMARK    GeneRIF: Data show that LANCL2 silencing resulted in a 70%
            inhibition of the plasma membrane lipid peroxidation induced by
            abscisic acid (ABA).
REFERENCE   10 (bases 1 to 3657)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127307.3 and BC016072.1.
            
            On Dec 9, 2009 this sequence version replaced NM_133737.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035967.1, SRR7974084.18529.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC127307.3         112391-112536
            147-1962            BC016072.1         1-1816
            1963-3657           AC127307.3         147691-149385
FEATURES             Location/Qualifiers
     source          1..3657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     gene            1..3657
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /note="LanC (bacterial lantibiotic synthetase component
                     C)-like 2"
                     /db_xref="GeneID:71835"
                     /db_xref="MGI:MGI:1919085"
     exon            1..809
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             606..1958
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /note="testis-specific adriamycin sensitivity protein"
                     /codon_start=1
                     /product="lanC-like protein 2"
                     /protein_id="NP_598498.1"
                     /db_xref="CCDS:CCDS20185.1"
                     /db_xref="GeneID:71835"
                     /db_xref="MGI:MGI:1919085"
                     /translation="MGETMSKRLKFHLGEAEMEERSFPNPFPDYEAAASAAGLAAGSA
                     EETGRVCPLPTTEDPGLPFHPNGKIVPNFIKRIQTKIKDLLQQMEEGLKTADPHDCSA
                     YTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAV
                     IYHKLKSECESQECITKLLQMHRTIVCQESELPDELLYGRAGYLYALLYLNTEIGPGT
                     VGETAIKEVVSAIIESGKSLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQP
                     EAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHVLLQA
                     YQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTSGNGYSFLSLYRLTQDKKYLYR
                     ACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDILVPETARFPAFELGFLQKD
                     "
     exon            810..927
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1135
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1283
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1430
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1613
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1790
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1863
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..3657
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3650
                     /gene="Lancl2"
                     /gene_synonym="1700003F10Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcccagtggt gatgaatggg agggactgta tcccccccca cccccttcgg gaggctatct
       61 tttcactgtt ttaggccgtt ttgaatttct tttctttaga agaggtattt ttaatcaaag
      121 tagctactgt tcctgtgatt ggcgcacgac caggggccga ggacactgac gggcggcaag
      181 gctgggctgg tgaaatgcag tccgtttggt gatggagcat ctgaaggtgc gcttttccct
      241 ggtctgcaaa tcgctcacac tttgaatgaa cccatcttta caggctttcc ctactggaac
      301 gtgagctttc taggcgtgcg ttttctctag aatctctcgg aaggacacgg ccacgggaga
      361 ggcgagggta actgggagac tgtgcggctc ggcgggctgg gccgtcaggc tgagagctgc
      421 tgctgggagg gcgtgactgg cgaaggctgg aggttcggct ttttcgcgct agctgcatcc
      481 agatgtgcaa gccactgttc tccaggaagg cttcgccgcg gagccccggc ccaaacgcct
      541 tccaggaggt ttgtccctgc ctgcgcgccg tgccctgagc tctcaggcag ggaaagcgcg
      601 cggacatggg cgagaccatg tcaaagagac tcaagttcca cctaggagag gcggagatgg
      661 aggagcggtc gttccccaat cccttcccag actatgaagc cgccgcctcc gccgcagggc
      721 tcgccgctgg aagtgcggag gaaaccggcc gtgtctgccc tctccccacc acggaagacc
      781 cgggcctccc tttccaccct aacgggaaga ttgttcccaa cttcataaag cgtatccaga
      841 ccaaaatcaa agatcttctg cagcagatgg aggaaggact gaagacagcg gaccctcatg
      901 actgctctgc atatactggt tggacaggca tagcactttt gtacctgcag ctgtaccggg
      961 tcactggtga ccagacctac ctgcttcgat ccctggatta cgtgaagaga acactccgaa
     1021 atttgagtgg tcgcagagtc actttccttt gtggagatgc tgggcccctt gctgtgggag
     1081 ctgtgatata tcataaactc aaaagtgaat gtgagtccca ggaatgcatc acaaaacttc
     1141 tacagatgca tagaactatt gtctgtcaag agtcagagct tcctgatgaa ctgctgtatg
     1201 gacgagcagg atacctgtat gccttactgt acctgaacac agagattggc cctggcactg
     1261 ttggtgagac agctattaaa gaggtagtca gtgctattat tgagtcggga aagagtctat
     1321 caagggaaga aaggaaatct gagcgctgcc ccctgctcta tcagtggcac agaaaacaat
     1381 atgttggagc agcccatggt atggctggca tctactacat gctaatgcag ccagaagcaa
     1441 aagtggacca agaaacctta accgaaatgg tgaaacccag cattgattat gtgcgccata
     1501 aaaaattccg atctggaaat tatccatcat cattaagcaa tgaaacagat cgattggtcc
     1561 actggtgcca tggtgctcca ggagtcatcc acgtgctctt acaggcatac caggttttta
     1621 aggaggaaaa atacttgaaa gaggccatgg agtgtagcga tgtgatttgg cagcgaggtc
     1681 tgctccggaa aggttatgga atctgccatg gaacctctgg caatggctat tcctttttgt
     1741 ccctttatcg cctgacgcag gataagaagt atctctatcg agcttgtaag tttgcagagt
     1801 ggtgtctaga ttacggagca catggatgcc gcattcctga cagaccttat tccctctttg
     1861 aaggtatggc tggtgctgtt cacttccttt ctgacatctt ggtaccagag acagcacggt
     1921 ttccagcatt tgaacttggc tttttgcaga aggattaaaa aggtgcaaaa agacaactaa
     1981 catacccgtt ggaccaaaag ccacctgatt gattagtgcc tgacacagaa cccactgtaa
     2041 accctaaaag aagaagacga caggacagaa accttcacaa gccccctttg ttgcaaagac
     2101 ccccaattag agcatgagcg atagaaatca tgtcatcagc attctgtgac agcgtgtccc
     2161 ttaaaggtgt gaaatctgaa tccttcatct ctaggctcct tctagtgtgc atgtttcttg
     2221 gtgcttgtct ataggtgtaa attgaataac tagaaaagcc acactcatta catgaactct
     2281 tagctgagca catgtgagtg ttaaaggtga caggcacaca tttttgtata tagtatctaa
     2341 actagggtat catctctatc aacacagaaa cagttgtgtg atgtctgtct tgaccatcag
     2401 ctagcagatc tagatatcct gtgagaatac atgttagcat tttccatggg catgcgtgag
     2461 aggcagcctc ccaaacccga atgaagggca ggtcagtgtg cactgcagag ctcaggaagg
     2521 cacaattgac acctcctccc tctgtgtgtc ttgtggtcaa tgtaattaat ggctaagcat
     2581 taggaattct gagacattta ctcagataca tattattaaa acagatacct ccttactgtt
     2641 ttcagaatag cttattacta tataaaacag agtagctgta atgccagaaa gatctatcca
     2701 tagcccttca aaaatttatt tcacattttg gtaaactatt ataaatttga aattaataca
     2761 ttccttattt ttcatccagt ttgaggtgat aaaataaatt ctaagctgaa tttatacatg
     2821 taagaagcaa aatattttaa ataagacaat tattatctgg gtaattttta aaattatttt
     2881 taagggcatt aattttgact cacatgcgtt agaaatcctg tcataaattt cagagtttgg
     2941 ttgtcgtttg tggtacaagt aggctagatt tcctaagcat gttttattgt gtaagggaaa
     3001 ttaatatatg tttcctgaag gaagcacctg gggccgtctt gtaaacctgc atcaatgtgg
     3061 aacttgtacg gccatgattt tggccaaggg ccctcagagt agcagcagta gtagtgactc
     3121 tccccagtat gtttacttat acttgtttgg tagatactat tatctttttg accaacatgc
     3181 tgagggaaaa ataaaatgac catagaataa atggagatga ttttttttac agatttcctt
     3241 ttaagacagg tggattgaca ccttcctgct taccactagg tatcaacaca tgtgcatttc
     3301 agtgacgcca ttgacttcct tcgttatatc cactacatgt gctgctgtgc atcccatgag
     3361 gctgcagccc caatcccatg aggtaaagga gaaatggcac gtgaaccagg atttaggggt
     3421 cacttatggc catttcagag ttataaatgt ttaaaattaa atttaagaac atctcacttt
     3481 tgtttcttag gcttgtacta tgtcaacaac tgtactctaa atgtgttgga aagcttaaaa
     3541 tatgtacaca caaaataaca ttttgaaatc ttaagggaaa acgtcagtgt tcacaaaaag
     3601 tgtttggggt tctttggttt tgttaataaa agacagtttt gtggtgatga cttatgg
//
