LOCUS       NM_001190985            4461 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LanC (bacterial lantibiotic synthetase component
            C)-like 1 (Lancl1), transcript variant 1, mRNA.
ACCESSION   NM_001190985
VERSION     NM_001190985.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Spinelli,S., Cossu,V., Passalacqua,M., Hansen,J.B., Guida,L.,
            Magnone,M., Sambuceti,G., Marini,C., Sturla,L. and Zocchi,E.
  TITLE     The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte
            Browning and Energy Expenditure
  JOURNAL   Int J Mol Sci 24 (4), 3489 (2023)
   PUBMED   36834900
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4461)
  AUTHORS   Huang,C., Yang,C., Pang,D., Li,C., Gong,H., Cao,X., He,X., Chen,X.,
            Mu,B., Cui,Y., Liu,W., Luo,Q., Cheng,A., Jia,L., Chen,M., Xiao,B.
            and Chen,Z.
  TITLE     Animal models of male subfertility targeted on LanCL1-regulated
            spermatogenic redox homeostasis
  JOURNAL   Lab Anim (NY) 51 (5), 133-145 (2022)
   PUBMED   35469022
REFERENCE   4  (bases 1 to 4461)
  AUTHORS   Spinelli,S., Begani,G., Guida,L., Magnone,M., Galante,D.,
            D'Arrigo,C., Scotti,C., Iamele,L., De Jonge,H., Zocchi,E. and
            Sturla,L.
  TITLE     LANCL1 binds abscisic acid and stimulates glucose transport and
            mitochondrial respiration in muscle cells via the
            AMPK/PGC-1alpha/Sirt1 pathway
  JOURNAL   Mol Metab 53, 101263 (2021)
   PUBMED   34098144
REFERENCE   5  (bases 1 to 4461)
  AUTHORS   Lai,K.Y., Galan,S.R.G., Zeng,Y., Zhou,T.H., He,C., Raj,R.,
            Riedl,J., Liu,S., Chooi,K.P., Garg,N., Zeng,M., Jones,L.H.,
            Hutchings,G.J., Mohammed,S., Nair,S.K., Chen,J., Davis,B.G. and van
            der Donk,W.A.
  TITLE     LanCLs add glutathione to dehydroamino acids generated at
            phosphorylated sites in the proteome
  JOURNAL   Cell 184 (10), 2680-2695 (2021)
   PUBMED   33932340
REFERENCE   6  (bases 1 to 4461)
  AUTHORS   Nielsen,J.E., Hansen,M.A., Jorgensen,M., Tanaka,M., Almstrup,K.,
            Skakkebaek,N.E. and Leffers,H.
  TITLE     Germ cell differentiation-dependent and stage-specific expression
            of LANCL1 in rodent testis
  JOURNAL   Eur J Histochem 47 (3), 215-222 (2003)
   PUBMED   14514412
  REMARK    GeneRIF: LanC-like protein 1 expression in rat testes was initiated
            already in pachytene spermatocytes in stage IX, but otherwise
            similar to mouse.
REFERENCE   7  (bases 1 to 4461)
  AUTHORS   Mayer,H., Bauer,H., Breuss,J., Ziegler,S. and Prohaska,R.
  TITLE     Characterization of rat LANCL1, a novel member of the lanthionine
            synthetase C-like protein family, highly expressed in testis and
            brain
  JOURNAL   Gene 269 (1-2), 73-80 (2001)
   PUBMED   11376939
REFERENCE   8  (bases 1 to 4461)
  AUTHORS   Mayer,H., Bauer,H. and Prohaska,R.
  TITLE     Organization and chromosomal localization of the human and mouse
            genes coding for LanC-like protein 1 (LANCL1)
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 100-104 (2001)
   PUBMED   11474189
REFERENCE   9  (bases 1 to 4461)
  AUTHORS   Bauer,H., Mayer,H., Marchler-Bauer,A., Salzer,U. and Prohaska,R.
  TITLE     Characterization of p40/GPR69A as a peripheral membrane protein
            related to the lantibiotic synthetase component C
  JOURNAL   Biochem Biophys Res Commun 275 (1), 69-74 (2000)
   PUBMED   10944443
REFERENCE   10 (bases 1 to 4461)
  AUTHORS   Mayer,H., Breuss,J., Ziegler,S. and Prohaska,R.
  TITLE     Molecular characterization and tissue-specific expression of a
            murine putative G-protein-coupled receptor
  JOURNAL   Biochim Biophys Acta 1399 (1), 51-56 (1998)
   PUBMED   9714732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133187.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.153751.1,
                                           SRR9219380.1823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC133187.3         114644-115021
            379-496             AC133187.3         119275-119392
            497-704             AC133187.3         132451-132658
            705-840             AC133187.3         143470-143605
            841-987             AC133187.3         144142-144288
            988-1170            AC133187.3         146466-146648
            1171-1347           AC133187.3         148550-148726
            1348-1420           AC133187.3         149105-149177
            1421-4461           AC133187.3         149959-152999
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.75 cM"
     gene            1..4461
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /note="LanC (bacterial lantibiotic synthetase component
                     C)-like 1"
                     /db_xref="GeneID:14768"
                     /db_xref="MGI:MGI:1336997"
     exon            1..378
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            497..704
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            705..840
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            841..987
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1170
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1347
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1420
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..4461
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /note="hexamer: AATGAA"
     polyA_site      1603
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /note="major polyA site"
     regulatory      4440..4445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
                     /note="hexamer: AATAAA"
     polyA_site      4461
                     /gene="Lancl1"
                     /gene_synonym="Gpr69; Gpr69a; p40"
ORIGIN      
        1 gcatctgtta ttgtcgccgc tgcgcggttt gcggagccgc tggagaggcg tgcgggttcc
       61 atcatctccg tgtgctcccc actcgtgggc gtgggacgtg ggtgaacaac gggctccctt
      121 cctcccgcgg ggctccgagc agcggccgct gtcccgcgcg cttgcggagc ggctgccagc
      181 cggggaccgc tcggagggaa ggggctgtca aagggccttc agtcgcgtcc caaccccagg
      241 tcccagcccc ccttgagatc tctctttccc ctgttctgca ggttcgcttg cggcgtcatg
      301 gctcagaggg cctttccgaa tccttatgcc gattataaca agtcgctggc cgaaaactac
      361 tttgattcta ctgggaggct gactcctgag ttctcacatc gcttgaccaa taagatccga
      421 gagctccttc agcaaatgga gagaggccta aagtctgcag accctcggga tggcactggg
      481 tacactggct gggcaggcat cgctgtgctt tacctccacc tccacaatgt gtttggggac
      541 ccagcctatc tacagatggc gcacagctat gtaaagcaaa gcctcaactg tctgagcagg
      601 cgttccatca ccttcctgtg tggcgatgcg ggccccctgg ctgtggctgc tgtgctgtac
      661 cacaagatga acagtgagaa gcaggccgag gagtgcatca cacggctcat tcacctaaat
      721 aagattgatc cccacgtacc aaatgaaatg ctctatggcc gcataggcta catctttgct
      781 ctgctttttg tcaataagaa ctttggagag gagaagattc ctcagagcca tattcagcag
      841 atttgtgaaa acatcttaac ctctggggaa aacctatcta gaaagagaaa cttggcggca
      901 aagtctccac tgatgtatga gtggtaccag gaatattacg tgggggctgc tcatggcttg
      961 gcaggcattt attactacct gatgcagccc agccttcagg tgaaccaagg aaagttgcat
     1021 agtttggtga agcccagtgt agactttgtc tgccggctga agtttccttc cggcaattac
     1081 cctccatgtt tggatgatac cagagacctg cttgtccatt ggtgccacgg tgctcctggg
     1141 gtcatctata tgctcatcca agcatacaag gtgttcaaag aagagcgtta cctgtgtgat
     1201 gcccagcagt gtgctgacgt gatctggcag tacgggctac tgaagaaggg ctacgggctg
     1261 tgccatggtg ctgcagggaa tgcctacgct ttcctggcac tctacaacct cacacaggat
     1321 ctgaagtatc tgtacagggc ctgcaagttt gctgagtggt gcttagacta cggggagcac
     1381 ggatgcagga cagcggacac ccccttctcc ctctttgaag ggatggctgg aacaatatat
     1441 ttcttggctg acctgttagt ccccacaaag gccaagttcc ctgcatttga actctgaaaa
     1501 gaaagcatgt ctcctgccgc ttacagcatg actctgtgta ttactctggg ctacatattg
     1561 cccttgcttt tgaaggaagc agaatgaaac tgtgtacttt gaagtggtcg agtttttatt
     1621 tccataattt gtctttagca gttcagcacc ttttattatt tactttttat ttataagtgt
     1681 acttgaagcc atcttaattc ccttccagag ggaaggatgg atgacagtac agtatcttct
     1741 gatcattcgc atggttccca gacatgcagg aaatgttcct cttactactt atccatcaat
     1801 gtgatccatg cctgggagca tgttatccca tctcctgggg agagaggcag gaggatcaca
     1861 agttcaaggc caacctaggc aacttagtga gacccgtttt caaggtaaag agcaggagag
     1921 atctggcacg tagctgagtg gtagaacact cctagcatgg agaagagccc tgggccctgc
     1981 cccaacacag atacacacag tgcacacagt gcacacacga gctcagtgca ggtggacaca
     2041 ttacatgtga tggctgttgc tgggtactgc cttccagctc ttctgttgag cattctgcct
     2101 ccacagagag tagtagttct gggactgggt tctctcaagt ggtgagcaaa ggggaccaaa
     2161 aaatgtagcc cgtgcttctg gaagaaaaac tgcaagagtt atagactaga tttttgggcc
     2221 taaatgtcat ttttttaaat tcctagtttc tgtctgaact agaaatccca cttcatgagc
     2281 cacacaggcc ctatctagca gcaacaggat caaaacttaa atggttggga tgcacattct
     2341 gatctgaaag tttactcaca aataacagtt ccttggcttg tgttagattt cagaaatgtt
     2401 tgttttaaaa gttgtctgtc ctttagtact cagatgagat ctagaagtag attgtctgtg
     2461 tgaatttgct gagacagggt cccacctgac ctttggctga ccttgagacg tttggctcag
     2521 ctttgccttg cttttcgctg actgtgcctg agtgagtgcc acatgtcatc accttctgtc
     2581 aattgacttg aacattgatc tcgtcactaa ctagtacaaa ctctaactct gcttacaaag
     2641 agtgtggaaa gggagctgct ctgaccagta gcttctaaga aaacacggct cttggctgga
     2701 atgggatgtg actgccttca tgcgtgtaac aaatggcggt ttgcatatcc caagagcaag
     2761 tgtccttcac attccgagac cacctcggag tcaggtttgt ttgtacacga agactccccc
     2821 gtgtttcgac ctctgaacaa acgcctattg actctttagc tcctcccttc tttcctcgat
     2881 atcaaaggcc taaccagact ctaacctacg tggtaacatt ttccagcttt aaaacaacag
     2941 ggtctaagaa tatttaatgt gctatttgtg gctcttttgg tcattcagtt tttattggag
     3001 atcaaatccc catggagtgt atcctggttg ctatgaggag taatctcctg ttattttcta
     3061 tttggtacca agatagctaa tattacgtga aattttctgg cccttttaag ggtgcctaca
     3121 gtaggatcca aagagcagcc cagcactcga tttctaggat tgaattggtc cttctgtgac
     3181 ccctgtgcat cctcagaagt tgtgtgtaga ctgtgccagg tgaaggcttt gtatcaatat
     3241 ttataagtca ctcttagaca gtaaagtgca gctgtttggc tgggtgtcca gctttagaaa
     3301 agaaagccca ctttgtttag ttaaatggct tattatattc tgtctgcact ttactataga
     3361 tacttattaa agaaaaagag gaagtgtttt gatcagccag tagacttggt cacagtgctt
     3421 ccccaggcat cctgatgagt gttgcctcct gcatattgtc acccatgaac agactcatga
     3481 acaccattca gctctcttca ctgtagcatt ttagaaactc actacactga cagtgtttat
     3541 gccgctgttg actaatgttt aagagctagg agagttttct aaggatctta aactcacata
     3601 gagtaaaggc tgacaccaac gcccctcctc gggtagaggc tgcaagaacc atttccattc
     3661 aggtgtcgtg cagacatggt tggttttatt cttatgcatt tttccttcag aggttttaat
     3721 tcctagtttc aaaaccttcc agtggctgct ttggaaaact cagtggcatt gttcatctcc
     3781 atccagagac tgggcagtaa ggggttctga gcctgccagg cagtctattt atccccttgt
     3841 gcttttcagc cctaaacttg aatcgtgtaa catgtcagca ttgacatggc cgtctccata
     3901 gatcccacca gggagttcat ttcatcccag ctgtcggtct cccatcctca gggtcatctg
     3961 gttcccttat cctcatcatg ccctgcctgt atcaacgcag aaagccccca tgtagataga
     4021 cttagattga agaggatcta cgagtatttt tttctccttc cctgtttctc taagtaacag
     4081 aattgcagca ctctattcct gtgtcctcag gtcaatttgt atctagatta ctgggcctaa
     4141 tcttgaagta agtagtgtaa gtgggatctt tcacttctct cctccttagg ctccaagaac
     4201 tcaggtgtag tccccggctt acttgacatt aattccagtt cctcttgctt cctcaaaacc
     4261 ggtcagacca ggtttctggg ggctccatac tgctgggcca tagaaaactg tttacatctg
     4321 gtgaacagga gtcagtgtgg ggggcattga gcaatcaccc caaggttcat tgccactaaa
     4381 ctgggaaagg ctggtttcat atgtgtatgt tatgggaggg attgaaccca ctggtcttca
     4441 ataaaatgtt attaggcctg a
//
