LOCUS       NM_026774                905 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 5 (Lamtor5), mRNA.
ACCESSION   NM_026774 XM_001478151 XM_001478161 XM_001480844 XM_001480846
VERSION     NM_026774.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Zhang,W., Sha,Z., Tang,Y., Jin,C., Gao,W., Chen,C., Yu,L., Lv,N.,
            Liu,S., Xu,F., Wang,D. and Shi,L.
  TITLE     Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase
            and Lysosomal Acidification
  JOURNAL   Adv Sci (Weinh) 11 (22), e2400446 (2024)
   PUBMED   38639386
  REMARK    GeneRIF: Defective Lamtor5 Leads to Autoimmunity by Deregulating
            v-ATPase and Lysosomal Acidification.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Qin,Y., Ni,P., Zhang,Q., Wang,X., Du,X., Yin,Z., Wang,L., Ye,L. and
            Chen,L.
  TITLE     Hbxip is essential for murine embryogenesis and regulates embryonic
            stem cell differentiation through activating mTORC1
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35608036
  REMARK    GeneRIF: Hbxip is essential for murine embryogenesis and regulates
            embryonic stem cell differentiation through activating mTORC1.
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Zhang,W., Zhuang,N., Liu,X., He,L., He,Y., Mahinthichaichan,P.,
            Zhang,H., Kang,Y., Lu,Y., Wu,Q., Xu,D. and Shi,L.
  TITLE     The metabolic regulator Lamtor5 suppresses inflammatory signaling
            via regulating mTOR-mediated TLR4 degradation
  JOURNAL   Cell Mol Immunol 17 (10), 1063-1076 (2020)
   PUBMED   31467416
  REMARK    GeneRIF: The metabolic regulator Lamtor5 suppresses inflammatory
            signaling via regulating mTOR-mediated TLR4 degradation.
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Yang,Q.C., Wu,C.C., Cao,L.Y., Xiao,Y., Li,H., Liu,B. and Sun,Z.J.
  TITLE     Increased Expression of LAMTOR5 Predicts Poor Prognosis and Is
            Associated with Lymph Node Metastasis of Head and Neck Squamous
            Cell Carcinoma
  JOURNAL   Int J Med Sci 16 (6), 783-792 (2019)
   PUBMED   31337951
  REMARK    GeneRIF: Study found LAMTOR5 was overexpressed in human and Pten
            cKO mice head and neck squamous cell carcinoma (HNSCC), and its
            expression was significantly associated with patients' overall
            survival, lymph node metastasis and lymph node grade. Furthermore,
            LAMTOR5 expression was significantly correlated with the expression
            of immune checkpoints and macrophage markers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Li,H., Wang,Z., Li,Y., Fang,R., Wang,H., Shi,H., Zhang,X., Zhang,W.
            and Ye,L.
  TITLE     Hepatitis B X-interacting protein promotes the formation of the
            insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal
            pancreatic beta-cells
  JOURNAL   J Biol Chem 293 (6), 2053-2065 (2018)
   PUBMED   29259128
  REMARK    GeneRIF: Hbxip stimulated insulin enhancer activity by interacting
            with Pdx-1 and recruiting Neurod1 to Pdx-1.
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI552736.1 and BC028547.1.
            
            On May 20, 2009 this sequence version replaced NM_026774.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV044391.1, AK146289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AI552736.1         1-314
            315-905             BC028547.1         145-735
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.79 cM"
     gene            1..905
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 5"
                     /db_xref="GeneID:68576"
                     /db_xref="MGI:MGI:1915826"
     exon            1..256
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..497
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /note="hepatitis B virus X-interacting protein homolog;
                     HBX-interacting protein homolog; HBV X-interacting protein
                     homolog; hepatitis B virus x interacting protein; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 5"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR5"
                     /protein_id="NP_081050.2"
                     /db_xref="CCDS:CCDS51042.1"
                     /db_xref="GeneID:68576"
                     /db_xref="MGI:MGI:1915826"
                     /translation="MPFRKERGRGAALNFVPLETPSRRPPRSSHVIEVCGEGGSVLLR
                     GPGLGRTACGMEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVL
                     AQQAARLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS"
     exon            257..318
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /inference="alignment:Splign:2.1.0"
     exon            319..436
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /inference="alignment:Splign:2.1.0"
     exon            437..884
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      864..869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /note="hexamer: AATAAA"
     polyA_site      884
                     /gene="Lamtor5"
                     /gene_synonym="1110003H18Rik; Hbxip; XIP"
                     /note="major polyA site"
ORIGIN      
        1 tttgaaggcc cagcaccccc aatcgaaagc cagccatcac tggtcctgtg gtagtagcta
       61 tgccttttcg taaagagcgc ggacgcggcg ccgcgctgaa tttcgtccct ctggagacgc
      121 cgtccaggcg cccgcctcgg tcaagtcacg tgatcgaggt ttgcggtgaa ggaggaagtg
      181 ttttgctgcg gggtcctggc ctggggcgga cagcctgcgg gatggaggcg actttggagc
      241 agcatttgga ggacacaatg aagaatccat ccattgttgg agtcctatgc acagattcac
      301 aaggacttaa tctgggctgc cgtggtaccc tgtcggatga gcacgctgga gtcatatctg
      361 ttctagccca gcaggcagct aggctaacct ctgaccccac cgacatccct gtggtatgtt
      421 tagaatcaga taatgggaac attatgatcc agaaacacga tggcatcaca gtggctgtgc
      481 acaaaatggc ctcttgacat ctgatgtcag ctctccagtg gcctctcacc gggattcagt
      541 catgcctgtc tcagctcatt tgtaaaacta ttaaagttcc agaaataggc cattcagtta
      601 atgtccaatg tggactccct tatttatatg acagccagtt accaagacat cagttagaga
      661 ggagcaattg tttgggcttt tgtcactctg ctctttggtg acagtcactg tagtccagga
      721 tcacagccca tcatggccta gaactatgta gcccaggctg acttcaaatg tatggtcttc
      781 ctgctttaaa cacatacatc ctggaattaa agcatttgtc actaaggttt aggtcacttt
      841 gtatatagaa cttcattatg gccaataaac ctgttctgag gaaaaaaaaa aaaaaaaaaa
      901 aaaaa
//
