LOCUS       NM_001081108             900 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 4 (Lamtor4), mRNA.
ACCESSION   NM_001081108 XM_132434
VERSION     NM_001081108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 900)
  AUTHORS   De Pace,R., Britt,D.J., Mercurio,J., Foster,A.M., Djavaherian,L.,
            Hoffmann,V., Abebe,D. and Bonifacino,J.S.
  TITLE     Synaptic Vesicle Precursors and Lysosomes Are Transported by
            Different Mechanisms in the Axon of Mammalian Neurons
  JOURNAL   Cell Rep 31 (11), 107775 (2020)
   PUBMED   32553155
REFERENCE   3  (bases 1 to 900)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   4  (bases 1 to 900)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   5  (bases 1 to 900)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC144958.1 and BC056178.1.
            
            On May 19, 2009 this sequence version replaced NM_001081108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144958.1, AK003086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               BC144958.1         1-642
            643-900             BC056178.1         340-597
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.0 cM"
     gene            1..900
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 4"
                     /db_xref="GeneID:66096"
                     /db_xref="MGI:MGI:1913346"
     exon            1..322
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..619
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /note="UPF0539 protein C7orf59 homolog; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 4"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR4"
                     /protein_id="NP_001074577.1"
                     /db_xref="CCDS:CCDS39342.1"
                     /db_xref="GeneID:66096"
                     /db_xref="MGI:MGI:1913346"
                     /translation="MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAIS
                     ELVSTACGFQLHHGTNIPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV"
     exon            323..403
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            404..521
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..877
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /note="major polyA site"
ORIGIN      
        1 tttcttcttg gaagccaccg gcagatgcat attcctattg caaaggatag aagcagtgca
       61 cgttcgtgtg gcgacactgc cccgcgactc tccggacaac tctcgcaggc aaatcctgag
      121 gggcggggaa atgcaaccaa tccacgaatg tgttcggaaa gcggggctcc gcagtggttg
      181 ataaagtata atgacatacc cgccatccaa tcctcaagcg aagggctggg ctacagtcag
      241 ctggtgaaac cacctgaccc gagcctggag ccggaaacta cctatccggc agactgctta
      301 cactgcacct acggctgcga tgacttccgc actgacccaa gggctggagc gaatcccaga
      361 ccagcttggc tacctggtgc tgagcgaagg tgcagtgctg gcgtcatctg gggaccttga
      421 gaacgatgag caagcagcca gtgccatctc ggagttggtc agcacagcct gtggcttcca
      481 gttgcaccat ggcacgaaca tccctttcaa acgcctgtct gtggtctttg gtgaacacac
      541 gctgctggtg actgtgtcag gacagagggt gtttgtagtg aagaggcaga accgaggtcg
      601 tgaacctatt gatgtctgag ctataaaagg cacgggctgg agaagaagcc tgcctctggg
      661 gcctgtcccc ggggtgtggg ggtggggaag cataccacct tctgctgtcc ttgctggagt
      721 tgggcttgtg ctcactacct ccttcctgac cccccacctg agcgaggcac caggcttaag
      781 agacttctac gctaagggac taggggaact atgactaggg ggaccccttt tcttcccttc
      841 tgcctaataa acactagtcc aacctgtcta gggctcaaaa aaaaaaaaaa aaaaaaaaaa
//
