LOCUS       NP_001074577              99 aa            linear   ROD 30-APR-2024
DEFINITION  ragulator complex protein LAMTOR4 [Mus musculus].
ACCESSION   NP_001074577 XP_132434
VERSION     NP_001074577.1
DBSOURCE    REFSEQ: accession NM_001081108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 99)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 99)
  AUTHORS   De Pace,R., Britt,D.J., Mercurio,J., Foster,A.M., Djavaherian,L.,
            Hoffmann,V., Abebe,D. and Bonifacino,J.S.
  TITLE     Synaptic Vesicle Precursors and Lysosomes Are Transported by
            Different Mechanisms in the Axon of Mammalian Neurons
  JOURNAL   Cell Rep 31 (11), 107775 (2020)
   PUBMED   32553155
REFERENCE   3  (residues 1 to 99)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   4  (residues 1 to 99)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   5  (residues 1 to 99)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC144958.1 and BC056178.1.
            
            On Feb 6, 2007 this sequence version replaced XP_132434.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144958.1, AK003086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..99
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.0 cM"
     Protein         1..99
                     /product="ragulator complex protein LAMTOR4"
                     /note="UPF0539 protein C7orf59 homolog; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 4"
                     /calculated_mol_wt=10547
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q0VGL1; propagated from
                     UniProtKB/Swiss-Prot (Q8CF66.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine, in Ragulator complex protein
                     LAMTOR4, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:Q0VGL1; propagated from
                     UniProtKB/Swiss-Prot (Q8CF66.2)"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q0VGL1; propagated from
                     UniProtKB/Swiss-Prot (Q8CF66.2)"
     CDS             1..99
                     /gene="Lamtor4"
                     /gene_synonym="0910001L09Rik"
                     /coded_by="NM_001081108.2:320..619"
                     /db_xref="CCDS:CCDS39342.1"
                     /db_xref="GeneID:66096"
                     /db_xref="MGI:MGI:1913346"
ORIGIN      
        1 mtsaltqgle ripdqlgylv lsegavlass gdlendeqaa saiselvsta cgfqlhhgtn
       61 ipfkrlsvvf gehtllvtvs gqrvfvvkrq nrgrepidv
//
