LOCUS       NM_019920               1263 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 3 (Lamtor3), mRNA.
ACCESSION   NM_019920
VERSION     NM_019920.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Schiefermeier,N., Scheffler,J.M., de Araujo,M.E., Stasyk,T.,
            Yordanov,T., Ebner,H.L., Offterdinger,M., Munck,S., Hess,M.W.,
            Wickstrom,S.A., Lange,A., Wunderlich,W., Fassler,R., Teis,D. and
            Huber,L.A.
  TITLE     The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal
            adhesion dynamics during cell migration
  JOURNAL   J Cell Biol 205 (4), 525-540 (2014)
   PUBMED   24841562
  REMARK    GeneRIF: We show an essential function for late endosomes carrying
            the p14-MP1 (LAMTOR2/3) complex in focal adhesion dynamics.
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Boggiatto,P.M., Martinez,P.A., Pullikuth,A., Jones,D.E.,
            Bellaire,B., Catling,A. and Petersen,C.
  TITLE     Targeted extracellular signal-regulated kinase activation mediated
            by Leishmania amazonensis requires MP1 scaffold
  JOURNAL   Microbes Infect 16 (4), 328-336 (2014)
   PUBMED   24463270
  REMARK    GeneRIF: This novel mechanism for localization of intracellular
            Leishmania amazonensis-mediated ERK1/2 phosphorylation required the
            endosomal scaffold protein MP1 and localized to Leishmania
            amazonensis parasitophorous vacuoles.
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   de Araujo,M.E., Stasyk,T., Taub,N., Ebner,H.L., Furst,B.,
            Filipek,P., Weys,S.R., Hess,M.W., Lindner,H., Kremser,L. and
            Huber,L.A.
  TITLE     Stability of the endosomal scaffold protein LAMTOR3 depends on
            heterodimer assembly and proteasomal degradation
  JOURNAL   J Biol Chem 288 (25), 18228-18242 (2013)
   PUBMED   23653355
  REMARK    GeneRIF: Data indicate that LAMTOR3 protein is stabilized by
            associating with LAMTOR2.
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Kurzbauer,R., Teis,D., de Araujo,M.E., Maurer-Stroh,S.,
            Eisenhaber,F., Bourenkov,G.P., Bartunik,H.D., Hekman,M., Rapp,U.R.,
            Huber,L.A. and Clausen,T.
  TITLE     Crystal structure of the p14/MP1 scaffolding complex: how a twin
            couple attaches mitogen-activated protein kinase signaling to late
            endosomes
  JOURNAL   Proc Natl Acad Sci U S A 101 (30), 10984-10989 (2004)
   PUBMED   15263099
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Lunin,V.V., Munger,C., Wagner,J., Ye,Z., Cygler,M. and Sacher,M.
  TITLE     The structure of the MAPK scaffold, MP1, bound to its partner, p14.
            A complex with a critical role in endosomal map kinase signaling
  JOURNAL   J Biol Chem 279 (22), 23422-23430 (2004)
   PUBMED   15016825
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Vomastek,T., Schaeffer,H.J., Tarcsafalvi,A., Smolkin,M.E.,
            Bissonette,E.A. and Weber,M.J.
  TITLE     Modular construction of a signaling scaffold: MORG1 interacts with
            components of the ERK cascade and links ERK signaling to specific
            agonists
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 6981-6986 (2004)
   PUBMED   15118098
REFERENCE   10 (bases 1 to 1263)
  AUTHORS   Schaeffer,H.J., Catling,A.D., Eblen,S.T., Collier,L.S., Krauss,A.
            and Weber,M.J.
  TITLE     MP1: a MEK binding partner that enhances enzymatic activation of
            the MAP kinase cascade
  JOURNAL   Science 281 (5383), 1668-1671 (1998)
   PUBMED   9733512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC146607.2.
            
            On Nov 17, 2006 this sequence version replaced NM_019920.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF082526.1, BC083155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC146607.2         97764-97872         c
            110-155             AC146607.2         97509-97554         c
            156-190             AC146607.2         96472-96506         c
            191-249             AC146607.2         91257-91315         c
            250-383             AC146607.2         89485-89618         c
            384-447             AC146607.2         89017-89080         c
            448-1263            AC146607.2         87665-88480         c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.97 cM"
     gene            1..1263
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 3"
                     /db_xref="GeneID:56692"
                     /db_xref="MGI:MGI:1929467"
     exon            1..109
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..155
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..521
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /note="mitogen activated protein, binding protein; MEK
                     binding partner 1; mitogen-activated protein kinase
                     scaffold protein 1; mitogen-activated protein kinase
                     kinase 1-interacting protein 1; late endosomal/lysosomal
                     adaptor and MAPK and MTOR activator 3; MAPK scaffold
                     protein 1"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR3"
                     /protein_id="NP_064304.1"
                     /db_xref="CCDS:CCDS51078.1"
                     /db_xref="GeneID:56692"
                     /db_xref="MGI:MGI:1929467"
                     /translation="MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHA
                     LRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGL
                     IVSLEKELAPLFEELIKVVEVS"
     exon            156..190
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..249
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..383
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..447
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1263
                     /gene="Lamtor3"
                     /gene_synonym="Map2k1ip1; Mapbp; Mapksp1; Mp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacgagta atgtgacagc gacttgacag gcggcttcag agaggcgact gaactgcggg
       61 aacaccgggg caggtcttcc caggctggag cgcgcgtgcg tctgcagagg agtggagatc
      121 gattctgcga ggaaaagggg ttcatcatgg cggatgatct aaagcgattc ctgtacaaaa
      181 agttgccaag tgttgaaggg ctccatgcaa ttgttgtgtc agatagagac ggggtgccgg
      241 ttattaaagt ggctaacgac agtgccccag agcacgccct gagacctggc ttcctatcca
      301 cgtttgccct cgcaacagac caaggcagca aactcggact ttcaaaaaac aaaagcatca
      361 tctgctacta taacacctac caggtggttc agttcaatcg tttgcctctg gtggtgagtt
      421 tcatagccag cagcagtgcc aacacaggac taattgtcag cctagaaaag gagctagctc
      481 cgttatttga agaactgata aaagttgtgg aagtgtctta atccagcagt ggttctgatg
      541 cacacctggg cctcactgca gcaaccctgg accaggccag caaccttccg accacaatag
      601 tacttgtagc tatgtattca gaaggccgct tttccacatt acactaaaga agagcctatt
      661 gctataattt atagacagat caattgttat atttatgtgt ataaaatctt ttcttactta
      721 gtgaggtctg agaacaccac agaaatggtc attcgattgc agctcccatg gagttagtgc
      781 aggcacctga aagtgagtgg tatctgtcca gagcagaggg tcagaccggg accgtgaggc
      841 ccttgagcca gcaggcacac ctgctgaact ctgctccact ccataagccg cagacccttt
      901 tactgagaat aataatgagg tcatattttt cttcagatta tattttattt ctttgcattg
      961 tgaggaagat gaaatggctt agtaaaaata attaagtaca atcactaacg cccctctctc
     1021 tgtgttctcg gtgaggatga gttactaatg gatttgattc ttcagggtgc tgctgttcac
     1081 tgagagcaca atcactgctt atgatgtctc tccgctttgc tgtaaccgtg cttccaccat
     1141 tgtgttcttt gtacaattga aatgcatgtt actgagttct gtttccttat caggatgtat
     1201 ataaaatgac aggatggcca ttttttatac atgtgtataa ataaaatagt atttttaaag
     1261 gta
//
