LOCUS       NM_031248                611 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 2 (Lamtor2), transcript variant 1, mRNA.
ACCESSION   NM_031248
VERSION     NM_031248.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Zhu,L., Zhang,C., Ge,X., Meng,B., Wu,T. and Li,J.
  TITLE     [LAMTOR2 deficiency exacerbates Klebsiella pneumoniae-induced liver
            sepsis in mice]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (6), 481-486 (2022)
   PUBMED   35732604
  REMARK    GeneRIF: [LAMTOR2 deficiency exacerbates Klebsiella
            pneumoniae-induced liver sepsis in mice].
REFERENCE   2  (bases 1 to 611)
  AUTHORS   Lamberti,G., De Smet,C.H., Angelova,M., Kremser,L., Taub,N.,
            Herrmann,C., Hess,M.W., Rainer,J., Tancevski,I., Schweigreiter,R.,
            Kofler,R., Schmiedinger,T., Vietor,I., Trajanoski,Z., Ejsing,C.S.,
            Lindner,H.H., Huber,L.A. and Stasyk,T.
  TITLE     LAMTOR/Ragulator regulates lipid metabolism in macrophages and foam
            cell differentiation
  JOURNAL   FEBS Lett 594 (1), 31-42 (2020)
   PUBMED   31423582
  REMARK    GeneRIF: LAMTOR2 regulates lipid metabolism in macrophages and foam
            cell differentiation.
REFERENCE   3  (bases 1 to 611)
  AUTHORS   Lyszkiewicz,M., Kotlarz,D., Zietara,N., Brandes,G.,
            Diestelhorst,J., Glage,S., Hobeika,E., Reth,M., Huber,L.A.,
            Krueger,A. and Klein,C.
  TITLE     LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating
            Endosomal BCR Trafficking
  JOURNAL   Front Immunol 10, 497 (2019)
   PUBMED   30936881
  REMARK    GeneRIF: LAMTOR2 (p14) Controls B Cell Differentiation by
            Orchestrating Endosomal BCR Trafficking.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 611)
  AUTHORS   Fu,W.M., Zhu,X., Wang,W.M., Lu,Y.F., Hu,B.G., Wang,H., Liang,W.C.,
            Wang,S.S., Ko,C.H., Waye,M.M., Kung,H.F., Li,G. and Zhang,J.F.
  TITLE     Hotair mediates hepatocarcinogenesis through suppressing miRNA-218
            expression and activating P14 and P16 signaling
  JOURNAL   J Hepatol 63 (4), 886-895 (2015)
   PUBMED   26024833
  REMARK    GeneRIF: Hotair silence activates P16(Ink4a) and P14(ARF) signaling
            by enhancing miR-218 expression and suppressing Bmi-1 expression,
            resulting in the suppression of tumorigenesis in HCC.
REFERENCE   5  (bases 1 to 611)
  AUTHORS   Scheffler,J.M., Sparber,F., Tripp,C.H., Herrmann,C.,
            Humenberger,A., Blitz,J., Romani,N., Stoitzner,P. and Huber,L.A.
  TITLE     LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent
            mTOR signalling
  JOURNAL   Nat Commun 5, 5138 (2014)
   PUBMED   25336251
  REMARK    GeneRIF: LAMTOR2 has a role in regulating dendritic cell
            homeostasis through FLT3-dependent mTOR signalling
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 611)
  AUTHORS   Qian,C., Zhang,Q., Wang,X., Zeng,L., Farooq,A. and Zhou,M.M.
  TITLE     Structure of the adaptor protein p14 reveals a profilin-like fold
            with distinct function
  JOURNAL   J Mol Biol 347 (2), 309-321 (2005)
   PUBMED   15740743
  REMARK    GeneRIF: Data report the three-dimensional solution structure of
            the adaptor protein p14, which includes a profilin-like fold with a
            central five-stranded beta-sheet sandwiched between alpha-helices.
REFERENCE   7  (bases 1 to 611)
  AUTHORS   Kurzbauer,R., Teis,D., de Araujo,M.E., Maurer-Stroh,S.,
            Eisenhaber,F., Bourenkov,G.P., Bartunik,H.D., Hekman,M., Rapp,U.R.,
            Huber,L.A. and Clausen,T.
  TITLE     Crystal structure of the p14/MP1 scaffolding complex: how a twin
            couple attaches mitogen-activated protein kinase signaling to late
            endosomes
  JOURNAL   Proc Natl Acad Sci U S A 101 (30), 10984-10989 (2004)
   PUBMED   15263099
  REMARK    GeneRIF: spatial regulation of MAPK signaling, illustrating how p14
            and MP1 collaborate as an endosomal adaptor/scaffold complex
REFERENCE   8  (bases 1 to 611)
  AUTHORS   Lunin,V.V., Munger,C., Wagner,J., Ye,Z., Cygler,M. and Sacher,M.
  TITLE     The structure of the MAPK scaffold, MP1, bound to its partner, p14.
            A complex with a critical role in endosomal map kinase signaling
  JOURNAL   J Biol Chem 279 (22), 23422-23430 (2004)
   PUBMED   15016825
REFERENCE   9  (bases 1 to 611)
  AUTHORS   Wunderlich,W., Fialka,I., Teis,D., Alpi,A., Pfeifer,A.,
            Parton,R.G., Lottspeich,F. and Huber,L.A.
  TITLE     A novel 14-kilodalton protein interacts with the mitogen-activated
            protein kinase scaffold mp1 on a late endosomal/lysosomal
            compartment
  JOURNAL   J Cell Biol 152 (4), 765-776 (2001)
   PUBMED   11266467
REFERENCE   10 (bases 1 to 611)
  AUTHORS   Bhartur,S.G., Calhoun,B.C., Woodrum,J., Kurkjian,J., Iyer,S.,
            Lai,F. and Goldenring,J.R.
  TITLE     Genomic structure of murine Rab11 family members
  JOURNAL   Biochem Biophys Res Commun 269 (2), 611-617 (2000)
   PUBMED   10708602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY062676.1, AA250375.1 and BE947263.1.
            
            On Apr 12, 2018 this sequence version replaced NM_031248.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031816.1, CD769274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BY062676.1         1-97
            98-480              AA250375.1         18-400
            481-611             BE947263.1         1-131               c
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.87 cM"
     gene            1..611
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 2"
                     /db_xref="GeneID:83409"
                     /db_xref="MGI:MGI:1932697"
     exon            1..156
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..466
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ragulator complex protein LAMTOR2; endosomal adaptor
                     protein p14; roadblock domain-containing protein 3; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 2;
                     late endosomal/lysosomal MP1 interacting protein;
                     mitogen-activated protein-binding protein-interacting
                     protein"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR2 isoform 1"
                     /protein_id="NP_112538.1"
                     /db_xref="CCDS:CCDS17478.1"
                     /db_xref="GeneID:83409"
                     /db_xref="MGI:MGI:1932697"
                     /translation="MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARV
                     TAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFG
                     MLKAKAQALVQYLEEPLTQVAAS"
     exon            157..319
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..409
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /inference="alignment:Splign:2.1.0"
     exon            410..595
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      577..582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /note="hexamer: AATAAA"
     polyA_site      595
                     /gene="Lamtor2"
                     /gene_synonym="2010111E04Rik; Mapbpip; P14; Rab25; Robld3"
                     /note="major polyA site"
ORIGIN      
        1 tcctgggcca ccggaagcga ctgagggaga gcaagaggct gcgactgtag gggtgtgttg
       61 gtgcaggtca gggttaagag acgcaggcat gctgcgtccc aaggctttga cgcaggtgct
      121 aagccaagcc aacactggag gagtccagag caccctgctg ctgaataatg agggatcgct
      181 gctggcctac tccggttatg gggacacaga tgcccgggtc actgcggcca tcgccagtaa
      241 catctgggcc gcgtatgata ggaacgggaa ccaagcgttt aatgaagaca gtctcaaatt
      301 tatcctgatg gactgcatgg agggccgtgt agccattacg agggtggcca accttctgct
      361 atgtatgtat gccaaggaga ccgtaggctt cggaatgctc aaggctaagg cccaggccct
      421 ggtgcagtac ctggaggaac ccctcaccca agtagcagca tcataacagc gtgatggagg
      481 ctggagtaga aaagggatga tgatctggag ggaggggcgg ggccctagaa acgccatatc
      541 gggcgaggta caggaagggg gggttgcttt tttctgaata aattttcaac tcttaaaaaa
      601 aaaaaaaaaa a
//
