LOCUS       NM_029530               2134 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus lysosomal-associated membrane protein family, member 5
            (Lamp5), transcript variant 1, mRNA.
ACCESSION   NM_029530 XM_894935 XM_902161 XM_902164 XM_902167 XM_918310
            XM_925634 XM_925635 XM_925636
VERSION     NM_029530.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Lowenstein,E.D., Ruffault,P.L., Misios,A., Osman,K.L., Li,H.,
            Greenberg,R.S., Thompson,R., Song,K., Dietrich,S., Li,X.,
            Vladimirov,N., Woehler,A., Brunet,J.F., Zampieri,N., Kuhn,R.,
            Liberles,S.D., Jia,S., Lewin,G.R., Rajewsky,N., Lever,T.E. and
            Birchmeier,C.
  TITLE     Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
  JOURNAL   Neuron 111 (14), 2184-2200 (2023)
   PUBMED   37192624
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   David,A., Tiveron,M.C., Defays,A., Beclin,C., Camosseto,V.,
            Gatti,E., Cremer,H. and Pierre,P.
  TITLE     BAD-LAMP defines a subset of early endocytic organelles in
            subpopulations of cortical projection neurons
  JOURNAL   J Cell Sci 120 (Pt 2), 353-365 (2007)
   PUBMED   17215451
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928798.20 and AL845354.13.
            
            On Oct 7, 2017 this sequence version replaced NM_029530.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.88610.1, AK018222.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AL928798.20        187837-188465
            630-802             AL928798.20        189035-189207
            803-934             AL928798.20        189584-189715
            935-1040            AL928798.20        189839-189944
            1041-1229           AL928798.20        190927-191115
            1230-2134           AL845354.13        8368-9272
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.26 cM"
     gene            1..2134
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /note="lysosomal-associated membrane protein family,
                     member 5"
                     /db_xref="GeneID:76161"
                     /db_xref="MGI:MGI:1923411"
     exon            1..629
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..1408
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /note="LAMP family protein C20orf103 homolog; Protein
                     C20orf103; brain-associated LAMP-like protein;
                     lysosome-associated membrane protein 5; brain and
                     dendritic cell-associated LAMP; lysosome-associated
                     membrane glycoprotein 5"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 5
                     precursor"
                     /protein_id="NP_083806.2"
                     /db_xref="CCDS:CCDS16789.1"
                     /db_xref="GeneID:76161"
                     /db_xref="MGI:MGI:1923411"
                     /translation="MDLRVRTLLGGDRLRILLMFFHVMVQTVAEQEVENLSGLSTNPE
                     KDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQAEISLTRGAEVKGHCGHN
                     ESELEVFWVDHAYTLRMLFVKESHNTSKGPEATWNLNKVHFVYDSSEKTHFKAPVKVN
                     KYIASSHHLSALVTPAGMSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFV
                     FSEEHKCPVDEQEQLEETLPLILGLILGLVIVITLVIYHIHHKMTANQVQIPRDRSQY
                     KHMG"
     exon            630..802
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            803..934
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1040
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1229
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2134
                     /gene="Lamp5"
                     /gene_synonym="3110035N03Rik; 6330527O06Rik; BAD-LAMP;
                     LAMP-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctctgaaa gccggaaact gttgccatag cattttcctt ctctgttcct gcctaccttc
       61 cttctccaaa gaatgaacaa tctgaaacaa atctattggt ttgtttcaag agcagaattc
      121 ggagctccgg tggtgttata tctacagtac atactggctg tacctggtgg gagggtttag
      181 caagtccgag ggtggcatta agtttcctag gacagagtca tctttgcaga taccattgca
      241 gagcagtata cagacccagg gagaaatttc ctcccccaca ccaccccaat cccattggcc
      301 ttctagacaa gccaaattac aagtcctgaa acacaacctc gttatttcca gaactctcag
      361 cgtggacagc tcctgcatcc tgggtgcttc ctctgcagtg tgcggcggga gagccatagc
      421 acccagtgca gcacgcgact atcccgcgcg ctccctcctc ccagtccgcc ccctccctta
      481 gctcactcta ccggccactt tgagggattt cctcccgggg cggcctttgc agcagaaaca
      541 catctgcctg gttcgcggca acagcatgga tctccgagta agaacccttc ttggtggaga
      601 cagacttcgg attctcctaa tgttcttcca tgtaatggtc caaaccgtgg cagaacaaga
      661 agtggaaaat ctttcgggcc tttccacgaa ccccgagaaa gacatatttg tggtgcggga
      721 aaatgggacg acgtgtctca tggcagagtt tgcagccaaa tttattgtac cttatgatgt
      781 gtgggccagc aattatgtgg atctgatcac agaacaggct gagatctcct tgacccgggg
      841 agctgaggtg aagggccact gtggccacaa cgagtcggag ctggaggtgt tctgggtaga
      901 tcacgcctac acactcagaa tgctctttgt aaaggaaagt cacaacactt ccaaaggacc
      961 agaggcgact tggaatctga acaaggtgca ttttgtctat gattcctcgg agaagactca
     1021 ctttaaagcc cctgtgaagg ttaataagta catcgccagc tctcatcacc tctctgcctt
     1081 ggtcacccca gctgggatgt cctatgagtg tcaggctcag cagaccattt ctctggcctc
     1141 cagtgaccct cagaagactg tcaccatgat cctgtccgca gtgcacatcc agccctttga
     1201 tatcatctct gactttgtct tcagtgaaga acataaatgt ccagtggatg agcaagagca
     1261 gttggaagag accctgcccc tgatcctggg cctcatcttg ggccttgtca ttgtcataac
     1321 acttgtgatc taccacatcc accataaaat gactgccaat caagtgcaga tccccaggga
     1381 ccgttcccag tacaagcaca tgggctaggg accatcaggc agacatcctc ctcatcctgc
     1441 ccccaaacca gatgatgtag aacgacaatg gcactttttc acctgtatac aggatccacc
     1501 aacatagcta cactccaaca ggcccaggca cctgaggtgt gcctggcctg tgtccatgct
     1561 taaacccagg gatggaaggc atgtcttggg gttcgggggg attaatggtg gatgttgtgt
     1621 ccatactgcg gagtaagtag gggctggtga gtagggtaat agctttctta ttcctgatgg
     1681 tttaattttg attctctgac tttgtaagtc tacagcacgt agaaagaaag aaagatgtgg
     1741 cccttgcatt tagaaagtgg aaacgcttcc tttgggagac ctctctaggc cagaagaacc
     1801 caggtgcttc actccctcgg cctcagctgg catacttaca cggtttttca gtgtacacaa
     1861 aacacaacct cacgctccct gcaagcagca agacccctga aagtgaccca tgcttccggc
     1921 tggcattctg catgtctagt gattgttttg ggaatgtctc actgctacct gcacccagtg
     1981 actctgcagc acaagaaccc gtctaatgac actacgcacg gttgtttgga attcataatg
     2041 tgtcggttcc aagtgagggg acctccagaa tcaatccatg tgagttcgct tttgaaaatg
     2101 aattaaaaag aaaaaaaaaa gcactatact ctgg
//
