LOCUS       NM_177356               3343 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus lysosomal-associated membrane protein 3 (Lamp3), mRNA.
ACCESSION   NM_177356
VERSION     NM_177356.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Hassan,D. and Chen,J.
  TITLE     CEBPA restricts alveolar type 2 cell plasticity during development
            and injury-repair
  JOURNAL   Nat Commun 15 (1), 4148 (2024)
   PUBMED   38755149
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Nakamura,H., Tanaka,T., Zheng,C., Afione,S.A., Warner,B.M.,
            Noguchi,M., Atsumi,T. and Chiorini,J.A.
  TITLE     Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent
            Cell Death by Impairing Autophagic Caspase 8 Degradation in the
            Salivary Glands of Individuals With Sjogren's Disease
  JOURNAL   Arthritis Rheumatol 75 (9), 1586-1598 (2023)
   PUBMED   37096570
  REMARK    GeneRIF: Lysosome-Associated Membrane Protein 3 Induces
            Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8
            Degradation in the Salivary Glands of Individuals With Sjogren's
            Disease.
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Zhu,J., Long,T., Gao,L., Zhong,Y., Wang,P., Wang,X., Li,Z. and
            Hu,Z.
  TITLE     RPL21 interacts with LAMP3 to promote colorectal cancer invasion
            and metastasis by regulating focal adhesion formation
  JOURNAL   Cell Mol Biol Lett 28 (1), 31 (2023)
   PUBMED   37062845
  REMARK    GeneRIF: RPL21 interacts with LAMP3 to promote colorectal cancer
            invasion and metastasis by regulating focal adhesion formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Chang,D.R., Martinez Alanis,D., Miller,R.K., Ji,H., Akiyama,H.,
            McCrea,P.D. and Chen,J.
  TITLE     Lung epithelial branching program antagonizes alveolar
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 110 (45), 18042-18051 (2013)
   PUBMED   24058167
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   White,C., Yuan,X., Schmidt,P.J., Bresciani,E., Samuel,T.K.,
            Campagna,D., Hall,C., Bishop,K., Calicchio,M.L., Lapierre,A.,
            Ward,D.M., Liu,P., Fleming,M.D. and Hamza,I.
  TITLE     HRG1 is essential for heme transport from the phagolysosome of
            macrophages during erythrophagocytosis
  JOURNAL   Cell Metab 17 (2), 261-270 (2013)
   PUBMED   23395172
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Lovgren,A.K., Kovarova,M. and Koller,B.H.
  TITLE     cPGES/p23 is required for glucocorticoid receptor function and
            embryonic growth but not prostaglandin E2 synthesis
  JOURNAL   Mol Cell Biol 27 (12), 4416-4430 (2007)
   PUBMED   17438133
REFERENCE   9  (bases 1 to 3343)
  AUTHORS   Salaun,B., de Saint-Vis,B., Pacheco,N., Pacheco,Y., Riesler,A.,
            Isaac,S., Leroux,C., Clair-Moninot,V., Pin,J.J., Griffith,J.,
            Treilleux,I., Goddard,S., Davoust,J., Kleijmeer,M. and Lebecque,S.
  TITLE     CD208/dendritic cell-lysosomal associated membrane protein is a
            marker of normal and transformed type II pneumocytes
  JOURNAL   Am J Pathol 164 (3), 861-871 (2004)
   PUBMED   14982840
REFERENCE   10 (bases 1 to 3343)
  AUTHORS   Salaun,B., de Saint-Vis,B., Clair-Moninot,V., Pin,J.J.,
            Barthelemy-Dubois,C., Kissenpfennig,A., Peronne,C., Bates,E.,
            Mattei,M.G. and Lebecque,S.
  TITLE     Cloning and characterization of the mouse homologue of the human
            dendritic cell maturation marker CD208/DC-LAMP
  JOURNAL   Eur J Immunol 33 (9), 2619-2629 (2003)
   PUBMED   12938238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY067461.1, AK028039.1, AK033379.1 and BY388271.1.
            
            On Dec 2, 2006 this sequence version replaced NM_177356.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028039.1, AK033379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY067461.1         11-59
            50-324              AK028039.1         2-276
            325-387             AK033379.1         277-339
            388-426             AK028039.1         340-378
            427-815             AK033379.1         379-767
            816-843             AK028039.1         768-795
            844-1310            AK033379.1         797-1263
            1311-2257           AK028039.1         1263-2209
            2258-3338           AK033379.1         2211-3291
            3339-3343           BY388271.1         444-448
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.17 cM"
     gene            1..3343
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /note="lysosomal-associated membrane protein 3"
                     /db_xref="GeneID:239739"
                     /db_xref="MGI:MGI:2441659"
     exon            1..150
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1337
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /note="lysosome-associated membrane glycoprotein 3;
                     dendritic cells-lysosome associated membrane glycoprotein;
                     LAMP-3; DC LAMP; DC-lysosome-associated membrane
                     glycoprotein"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 3
                     precursor"
                     /protein_id="NP_796330.2"
                     /db_xref="CCDS:CCDS37285.1"
                     /db_xref="GeneID:239739"
                     /db_xref="MGI:MGI:2441659"
                     /translation="MPGQISAVAVLFLSLTVILHGYQIREKEFPKARGYLQYTATSAE
                     QITTKPLLQLINQRSHITLASRFKDDYIQMAAETSAIENTAHITMKTVTPVTTKSLPP
                     ISSASYTFVRSNNAHMTASSTDDTIGSGSIAHLPVPTTRASLAIVNYITGRATQLGGQ
                     TTLPKTFFTASHKSTTNQRPTLSTNVLGTSTPTHKDRSTTSPVPLVPRPTLVTWSSPA
                     KIGTYEVLNGSRLCIKAEMGLALIVQEKDLDSATQRYFNIDPSLTHASGKCDSQKSNL
                     FLNFQGGSVNITFTKEENLYYISEVGAYLTISNTEKTYQGKKNTLMMFETVVGHSFKC
                     VSEQSIQLSAQLQMKTMNIHLQAFDFEGDSFGNVNECLSDYTVVLPMVAIIVVVICVV
                     GLSVYKIRQRHQSSAYQRI"
     exon            151..845
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            846..974
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1032
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1203
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..3343
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /note="hexamer: AATAAA"
     polyA_site      3341
                     /gene="Lamp3"
                     /gene_synonym="1200002D17Rik; Cd208; DC-LAMP; DCLAMP;
                     LAMP; TSC403"
                     /note="major polyA site"
ORIGIN      
        1 gagcttggtg ttccttggtg ttctgtggat ctgctctgaa actgagtcca ttcctacaga
       61 agactcaagc acacaacagt ggtagaataa tcttacctgc catgcctggg cagatctctg
      121 cagtagctgt actcttcctg tccctgactg taattttaca tggctatcaa ataagagaaa
      181 aagaatttcc aaaagccaga ggctatcttc aatatactgc aacatcagca gaacagatca
      241 caacaaaacc tctactacaa ctgattaacc aaagatctca tataacttta gcatcaagat
      301 tcaaggatga ttacattcaa atggctgctg aaacttcagc cattgaaaac acagcccata
      361 taacaatgaa aacagtaacc ccagtaacta caaagagcct tccacccatc agctcagcta
      421 gttatacctt tgtcagatct aataacgcac acatgactgc ttcatctact gacgatacca
      481 ttggctctgg ctcaattgca catttaccag ttcctacaac cagagctagt ctagccattg
      541 tcaactatat aactgggaga gctacacaac ttggtggtca gactaccctt cccaaaacat
      601 ttttcacagc atcacacaaa agcacaacca atcagaggcc aactctgtcc actaatgtct
      661 taggaacatc aacacctaca cacaaggaca gatcaacgac ctcacctgtt cccctagttc
      721 ctaggcctac tcttgtaact tggtcatcac cagccaagat cggaacttat gaagtcctaa
      781 atggaagcag gctctgtatt aaagcagaga tgggactagc actgattgtt caagaaaagg
      841 atttggattc tgcaacccaa agatatttca acattgaccc cagcctaacc catgcatctg
      901 ggaaatgtga ctcccaaaaa tccaacctct tcttgaattt ccagggtgga tctgtgaata
      961 tcacatttac caaggaagaa aacttatatt atattagtga agttggagca tatttgacca
     1021 tctcaaatac agagaagact taccagggaa agaagaatac tttgatgatg tttgagacag
     1081 tagttgggca ttccttcaag tgtgtcagtg agcagagcat ccagctgtca gctcagcttc
     1141 aaatgaaaac aatgaatatc caccttcagg cctttgattt cgaaggagac tcctttggaa
     1201 atgtgaacga gtgtttgtct gactacacag ttgtgcttcc tatggttgca atcatcgtgg
     1261 tcgtcatctg tgttgtgggt ctgagtgttt acaaaatccg ccaaaggcat cagtcatctg
     1321 cataccagag aatctaattt gtaaccaaag gaaatggcaa tagagtttag aaaaaaatct
     1381 cattatttcc agaacgttgg cggcatctac taaaaccaat aagtgattag tgattcaaat
     1441 tgaagcagta tatcaattct gaacattttt gcttatttca tgaaagacta aggaagatat
     1501 tgagtatttt ctagcttttg ttggaaaaat ttaactactc aaatgaatat ttgagataca
     1561 cagaattagc ataatgttca aaagtggtag ataattacaa attataagcc aaaataattg
     1621 attttaaata cacaaaatta acatattgtt caaaagtggt agatatttat aaattataaa
     1681 ccataataat tgattttaat taatcctacc ggtgtttgcc tagagaaatg tattttgaca
     1741 ttaacatttt tattttaaga atattttgat ggattttctt actatctatg tttagtttat
     1801 gtatgtacat ctgacatggt actcacctac tttttcattt aaatattttt agttatcaaa
     1861 ataacacatc tcatattgtt tagactttac atggaaaaac attttttttc tttatgaatc
     1921 ttgcttcaga attaacaaag attaagaaat aggtgcctga tagagtttga tccggtctca
     1981 tgcacaaggt gcccatgtcc cgcttcccag cgcctgcagt gaagatgtcc cacgcatccc
     2041 gggcagccaa gccctccaac tccaagaacc catgagtctt ctttgacgtg gacatcggcg
     2101 gggagcgagt tggacgaatt gttttagaat tgtttgcaga tattgttccc aaaactgcag
     2161 aaaattttcg tgcattgtat acaggaaaaa aaggaactgg gtccacgacc gggaagcctc
     2221 tccattttaa aggatgccct ttccaccaaa ttattaagaa atttatgatt cagggtggag
     2281 acttctcaaa tcagaatggg acaggtggca aaagtattta tggtgaaaaa tttgaagatg
     2341 agaattttca ttataagcat gatcgggagg gtttgctgag catggcaaat gcaggcccca
     2401 atagttccaa ctcctcattt ggatgggaaa catgtggtat ttggtcaagt cataaaaggg
     2461 ctaggtgtgg caaggatgct tgaaaatgta aatggtgaaa aacctgccaa actctgtgtt
     2521 attgcagtat gtggagaatt gaaagaaggg gatgactggg gaatattccc caaagatggc
     2581 tctggtgaca gtcatccaga cttccccgag gatgcagata tagatttaaa agatgtagat
     2641 aaaattttat taatatctga agactaaaaa acattgggaa tacttttttc aagtctcaga
     2701 actgggactg ggggcagatc tggggtcctc agatctggaa gtgtggcttt gggagccgaa
     2761 ttaaaacaaa tcattagaac taattcccaa caaatggcta ttaaaacata tgggaaggtt
     2821 ttaaggtatg tggatagttc aaaggctgtt actgagaaag caggtagacc cagactgcaa
     2881 cctatagcct taagttgtgt gctgaatatt ggtgcctgta agctgaagat gtcaaattgg
     2941 cagggggcaa ctgacagttg cttagaggct cttgaaatgg acccttcaaa tactaaagca
     3001 ctgtaccgaa aagccaagga tggcaaggat tgaaggaata tgatcaagca ttggctgatc
     3061 ttaagaaggc acaggagata gctccaggag ataaagctat ccaggcagaa ttgcttaaag
     3121 tcaaacaaat gataaaggca cagaaagata aagagaaggc tgtgtatgca aaaatgtttg
     3181 cttaataatg attaaactct ttttaactgt tatacattga ttatataaag gacaatgtat
     3241 attactgtct acgatccctg atgtgtttcc cttgatcttt gtcattgttt acatagcagt
     3301 gctgacatag gtttcttctt aataaagagt taaaaaatac agt
//
