LOCUS       NM_001017959            1788 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus lysosomal-associated membrane protein 2 (Lamp2),
            transcript variant 1, mRNA.
ACCESSION   NM_001017959
VERSION     NM_001017959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Reynolds,C.A., Pelka,S., Gjergjova,F., Tasset,I., Khawaja,R.R.,
            Lindenau,K., Krause,G.J., Gavathiotis,E., Cuervo,A.M. and Macian,F.
  TITLE     Restoration of LAMP2A expression in old mice leads to changes in
            the T cell compartment that support improved immune function
  JOURNAL   Proc Natl Acad Sci U S A 121 (38), e2322929121 (2024)
   PUBMED   39259591
  REMARK    GeneRIF: Restoration of LAMP2A expression in old mice leads to
            changes in the T cell compartment that support improved immune
            function.
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Sohn,E.J. and Park,K.T.
  TITLE     Transcriptional genes of lysosome-associated membrane protein 2A in
            sciatic nerve injuries by bioinformatics
  JOURNAL   Neuroreport 35 (12), 771-779 (2024)
   PUBMED   38935077
  REMARK    GeneRIF: Transcriptional genes of lysosome-associated membrane
            protein 2A in sciatic nerve injuries by bioinformatics.
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1788)
  AUTHORS   Zou,W., Lv,Y., Zhang,S., Li,L., Sun,L. and Jiao,J.
  TITLE     Lysosomal dynamics regulate mammalian cortical neurogenesis
  JOURNAL   Dev Cell 59 (1), 64-78 (2024)
   PUBMED   38103552
REFERENCE   5  (bases 1 to 1788)
  AUTHORS   Sutton,K.A. and Wilkinson,M.F.
  TITLE     The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2
            are closely linked in the proximal region of the mouse X chromosome
  JOURNAL   Genomics 45 (2), 447-450 (1997)
   PUBMED   9344676
REFERENCE   6  (bases 1 to 1788)
  AUTHORS   Cella,N., Cornejo-Uribe,R.R., Montes,G.S., Hynes,N.E. and
            Chammas,R.
  TITLE     The lysosomal-associated membrane protein LAMP-1 is a novel
            differentiation marker for HC11 mouse mammary epithelial cells
  JOURNAL   Differentiation 61 (2), 113-120 (1996)
   PUBMED   8983177
REFERENCE   7  (bases 1 to 1788)
  AUTHORS   Gough,N.R., Hatem,C.L. and Fambrough,D.M.
  TITLE     The family of LAMP-2 proteins arises by alternative splicing from a
            single gene: characterization of the avian LAMP-2 gene and
            identification of mammalian homologs of LAMP-2b and LAMP-2c
  JOURNAL   DNA Cell Biol 14 (10), 863-867 (1995)
   PUBMED   7546292
REFERENCE   8  (bases 1 to 1788)
  AUTHORS   Dardik,A., Smith,R.M. and Schultz,R.M.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   9  (bases 1 to 1788)
  AUTHORS   Granger,B.L., Green,S.A., Gabel,C.A., Howe,C.L., Mellman,I. and
            Helenius,A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   10 (bases 1 to 1788)
  AUTHORS   Cha,Y., Holland,S.M. and August,J.T.
  TITLE     The cDNA sequence of mouse LAMP-2. Evidence for two classes of
            lysosomal membrane glycoproteins
  JOURNAL   J Biol Chem 265 (9), 5008-5013 (1990)
   PUBMED   2318880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163933.1, AK159272.1 and AL513356.8.
            
            On Mar 13, 2014 this sequence version replaced NM_001017959.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159272.1, AK159731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AK163933.1         2-47
            47-971              AK159272.1         2-926
            972-972             AL513356.8         44246-44246         c
            973-1773            AK159272.1         928-1728
            1774-1788           AL513356.8         18313-18327         c
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.67 cM"
     gene            1..1788
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /note="lysosomal-associated membrane protein 2"
                     /db_xref="GeneID:16784"
                     /db_xref="MGI:MGI:96748"
     exon            1..212
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            213..328
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..542
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..701
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..913
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1036
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1100
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1265
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1788
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /note="hexamer: AATAAA"
     polyA_site      1773
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /note="major polyA site"
ORIGIN      
        1 gcccctggtc ttatgactcc agctgaagcg gcgagtccag gcttttgcgg tgcctgggtg
       61 cctcggtcgg tggtctctcg tgctttcgct tccgcagggc tgcgagggga ttcgttggaa
      121 ttgtcggtcc ggtggtcgcc tggcctgagg gatcacgatg tgcctctctc cggttaaagg
      181 cgcaaagctc atcctgatct ttctgttcct aggagccgtt cagtccaatg cattgatagt
      241 taatttgaca gattcaaagg gtacttgcct ttatgcagaa tgggagatga atttcacaat
      301 aacatatgaa actacaaacc aaaccaataa aactataacc attgcagtac ctgacaaggc
      361 gacacacgat ggaagcagtt gtggggatga ccggaatagt gccaaaataa tgatacaatt
      421 tggattcgct gtctcttggg ctgtgaattt taccaaggaa gcatctcatt attcaattca
      481 tgacatcgtg ctttcctaca acactagtga tagcacagta tttcctggtg ctgtagctaa
      541 aggagttcat actgttaaaa atcctgagaa tttcaaagtt ccattggatg tcatctttaa
      601 gtgcaatagt gttttaactt acaacctgac tcctgtcgtt cagaaatatt ggggtattca
      661 cctgcaagct tttgtccaaa atggtacagt gagtaaaaat gaacaagtgt gtgaagaaga
      721 ccaaactccc accactgtgg cacccatcat tcacaccact gccccgtcga ctacaactac
      781 actcactcca acttcaacac ccactccaac tccaactcca actccaaccg ttggaaacta
      841 cagcattaga aatggcaata ctacctgtct gctggctacc atggggctgc agctgaacat
      901 cactgaggag aaggtgcctt tcatttttaa catcaaccct gccacaacca acttcaccgg
      961 cagctgtcaa cctcaaagtg ctcaacttag gctgaacaac agccaaatta agtatcttga
     1021 ctttatcttt gctgtgaaaa atgaaaaacg gttctatctg aaggaagtga atgtctacat
     1081 gtatttggct aatggctcag ctttcaacat ttccaacaag aaccttagct tctgggatgc
     1141 ccctctggga agttcttata tgtgcaacaa agagcaggtg ctttctgtgt ctagagcgtt
     1201 tcagatcaac acctttaacc taaaggtgca accttttaat gtgacaaaag gacagtattc
     1261 tacagctcaa gactgcagtg cagatgaaga caacttcctt gtgcccatag cggtgggagc
     1321 agctctggga ggagtactta ttctagtgtt gctggcttat tttattggtc tcaagcgcca
     1381 tcatactgga tatgagcaat tttagtaact gcaatctgat tgattatatt acagaataca
     1441 tacaaaaaaa caaagttgtc ttacctgtca gtgtatgaag cactttgctc cttaagacag
     1501 acaccttgga actttcattc ggaaattagt ccccgaagtt tgagataagt ctttttttga
     1561 attttttttt ctctgatctg cttaaaatgc agattggctt taaaaagaaa agaaaacaaa
     1621 cacacatatg caatgtttta aggtctgtct taagaagctt tggccaaatt gggatcctaa
     1681 cctaagatgc cttaaactta ttaacatgac cattataaga aaagatatat ggagttgtat
     1741 cttactggaa ttaataaaca ctgcttgacc accggtgttc tgtttcaa
//
