LOCUS       NM_010684               2239 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus lysosomal-associated membrane protein 1 (Lamp1),
            transcript variant 2, mRNA.
ACCESSION   NM_010684
VERSION     NM_010684.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Kim,J., Yu,Y.S., Choi,Y., Lee,D.H., Han,S., Kwon,J., Noda,T.,
            Ikawa,M., Kim,D., Kim,H., Ballabio,A., Kim,K.I. and Baek,S.H.
  TITLE     USF2 and TFEB compete in regulating lysosomal and autophagy genes
  JOURNAL   Nat Commun 15 (1), 8334 (2024)
   PUBMED   39333072
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Liu,W., Wang,Y., Liu,S., Zhang,X., Cao,X. and Jiang,M.
  TITLE     E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by
            Promoting LAMP-1 Proteasomal Degradation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2309560 (2024)
   PUBMED   39031743
  REMARK    GeneRIF: E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal
            Degradation by Promoting LAMP-1 Proteasomal Degradation.
REFERENCE   4  (bases 1 to 2239)
  AUTHORS   Ha,H.T., Liu,S., Nguyen,X.T., Vo,L.K., Leong,N.C., Nguyen,D.T.,
            Balamurugan,S., Lim,P.Y., Wu,Y., Seong,E., Nguyen,T.Q., Oh,J.,
            Wenk,M.R., Cazenave-Gassiot,A., Yapici,Z., Ong,W.Y., Burmeister,M.
            and Nguyen,L.N.
  TITLE     Lack of SPNS1 results in accumulation of lysolipids and lysosomal
            storage disease in mouse models
  JOURNAL   JCI Insight 9 (8), e175462 (2024)
   PUBMED   38451736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2239)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2239)
  AUTHORS   Dardik,A., Smith,R.M. and Schultz,R.M.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   7  (bases 1 to 2239)
  AUTHORS   Granger,B.L., Green,S.A., Gabel,C.A., Howe,C.L., Mellman,I. and
            Helenius,A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   8  (bases 1 to 2239)
  AUTHORS   Arterburn,L.M., Earles,B.J. and August,J.T.
  TITLE     The disulfide structure of mouse lysosome-associated membrane
            protein 1
  JOURNAL   J Biol Chem 265 (13), 7419-7423 (1990)
   PUBMED   2332434
REFERENCE   9  (bases 1 to 2239)
  AUTHORS   Cha,Y., Holland,S.M. and August,J.T.
  TITLE     The cDNA sequence of mouse LAMP-2. Evidence for two classes of
            lysosomal membrane glycoproteins
  JOURNAL   J Biol Chem 265 (9), 5008-5013 (1990)
   PUBMED   2318880
REFERENCE   10 (bases 1 to 2239)
  AUTHORS   Heffernan,M., Yousefi,S. and Dennis,J.W.
  TITLE     Molecular characterization of P2B/LAMP-1, a major protein target of
            a metastasis-associated oligosaccharide structure
  JOURNAL   Cancer Res 49 (21), 6077-6084 (1989)
   PUBMED   2676155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049097.1, AK159376.1 and AI835725.1.
            
            On Dec 1, 2015 this sequence version replaced NM_010684.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049097.1, AK172007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1887              BC049097.1         1-1887
            1888-2220           AK159376.1         1753-2085
            2221-2239           AI835725.1         8-26                c
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..2239
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /note="lysosomal-associated membrane protein 1"
                     /db_xref="GeneID:16783"
                     /db_xref="MGI:MGI:96745"
     exon            1..274
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1449
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lysosomal membrane glycoprotein A; CD107
                     antigen-like family member A; lysosome-associated membrane
                     protein 1; 120 kDa lysosomal membrane glycoprotein; Lamp
                     I; lysosomal membrane glycoprotein 1; LYSOSOME-ASSOCIATED
                     MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A)
                     (LGP-120) (CD107A) (P2B)"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 1
                     isoform 2 precursor"
                     /protein_id="NP_034814.2"
                     /db_xref="CCDS:CCDS22106.1"
                     /db_xref="GeneID:16783"
                     /db_xref="MGI:MGI:96745"
                     /translation="MAAPGARRPLLLLLLAGLAHGASALFEVKNNGTTCIMASFSASF
                     LTTYETANGSQIVNISLPASAEVLKNGSSCGKENVSDPSLTITFGRGYLLTLNFTKNT
                     TRYSVQHMYFTYNLSDTEHFPNAISKEIYTMDSTTDIKADINKAYRCVSDIRVYMKNV
                     TVVLRDATIQAYLSSGNFSKEETHCTQDGPSPTTGPPSPSPPLVPTNPTVSKYNVTGN
                     NGTCLLASMALQLNITYLKKDNKTVTRAFNISPNDTSSGSCGINLVTLKVENKNRALE
                     LQFGMNASSSLFFLQGVRLNMTLPDALVPTFSISNHSLKALQATVGNSYKCNTEEHIF
                     VSKMLSLNVFSVQVQAFKVDSDRFGSVEECVQDGNNMLIPIAVGGALAGLVLIVLIAY
                     LIGRKRSHAGYQTI"
     exon            275..393
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            394..613
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            614..772
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            773..951
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1071
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1138
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1309
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..2229
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /note="hexamer: AATAAA"
     polyA_site      2229
                     /gene="Lamp1"
                     /gene_synonym="CD107a; Lamp-1; LGP-120; LGP-A; P2B; Perk"
                     /note="major polyA site"
ORIGIN      
        1 gcctcccgaa gaagtgagga gtaagctggc ggtccacggg ctctcgcgag accctcggct
       61 cacgtgaccg gcgggcgcgg cactgctcac gtgacaggcg ctgccggccg cagggtcctc
      121 tccgtgccgg cgccgcagct gcggggcctc tcgagtcggt ggacgcgccc tcccgccggc
      181 ctcgccgccc gcgcaaccgc cgtcctccgg cctcggctgc gtcgcgccat ggcggccccc
      241 ggcgcccggc ggccgctgct cctgctgctg ctggcaggcc ttgcacatgg cgcctcagca
      301 ctctttgagg tgaaaaacaa tggcacaacg tgtataatgg ccagcttctc tgcctccttt
      361 ctgaccacct acgagactgc gaatggttct cagatcgtga acatttccct gccagcctct
      421 gcagaagtac tgaaaaatgg cagttcttgt ggtaaagaaa atgtttctga ccccagcctc
      481 acaattactt ttggaagagg atatttactg acactcaact tcacaaaaaa tacaacacgt
      541 tacagtgtcc agcatatgta ttttacatat aacttgtcag atacagaaca ttttcccaat
      601 gccatcagca aagagatcta caccatggat tccacaactg acatcaaggc agacatcaac
      661 aaagcatacc ggtgtgtcag tgatatccgg gtctacatga agaatgtgac cgttgtgctc
      721 cgggatgcca ctatccaggc ctacctgtcg agtggcaact tcagcaagga agagacacac
      781 tgcacacagg atggaccttc cccaaccact gggccaccca gcccctcacc accacttgtg
      841 cccacaaacc ccactgtatc caagtacaat gttactggta acaacggaac ctgcctgctg
      901 gcctctatgg cactgcaact gaatatcacc tacctgaaaa aggacaacaa gacggtgacc
      961 agagcgttca acatcagccc aaatgacaca tctagtggga gttgcggtat caacttggtg
     1021 accctgaaag tggagaacaa gaacagagcc ctggaattgc agtttgggat gaatgccagc
     1081 tctagcctgt ttttcctgca aggagtgcgc ttgaatatga ctcttcctga tgccctagtg
     1141 cccacattca gcatctccaa ccattcactg aaagctcttc aggccactgt gggaaactca
     1201 tacaagtgca acactgagga acacatcttt gtcagcaaga tgctctccct caatgtcttc
     1261 agtgtgcagg tccaggcttt caaggtggac agtgacaggt ttgggtctgt ggaagagtgt
     1321 gttcaggatg gtaacaacat gttgatcccc attgctgtgg gcggtgccct ggcagggctg
     1381 gtcctcatcg tcctcattgc ctacctcatt ggcaggaaga ggagtcacgc cggctatcag
     1441 accatctagc ctggtgggca ggtgcaccag agatgcacag gggcctgttc tcacatcccc
     1501 aagcttagat aggtgtggaa gggaggcaca ctttctggca aactgtttta aaatctgctt
     1561 tatcaaatgt gaagttcatc ttgcaacatt tactatgcac aaaggaataa ctattgaaat
     1621 gacggtgtta attttgctaa ctgggttaaa tattttgcta actggttaaa tgttaatatg
     1681 ttaccaaagt agagctctaa agaggatgag aaggctccac tgatttgact tttaagactt
     1741 ggtgtttggt tcttcattct tttactcaga tttaagcctt acaaagggaa tctctggtcc
     1801 agacccttgg gcctggcaag ggtggctgat ggttaggctg cacacttaag aagcaaacgg
     1861 gagcagggaa ggcttgccac acaggcacgc acagggtcaa cctctggaca cttggcttgg
     1921 gctacctggc ctgggggggc tgaactctgg catctggctg ggtacacacc cccccatatt
     1981 tctgtgctct gccacccgtg agctgccact ttcctaaata gaaaatggca ttatttttat
     2041 ttactttttt gtaaagtgat ttccagtctt gtgttggcgt tcagggtggc cctgtctctg
     2101 cactgtgtac aataatagat tcacactgct gacgtgtctt gcagcgtagg tgggttgtac
     2161 actgggcatc agctcacgta atgcattgcc tgtaacgatg ctaataaaaa gtctccttct
     2221 ttgtctgtca aaaaaaaaa
//
