LOCUS       NM_011836               8478 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus laminin gamma 3 (Lamc3), mRNA.
ACCESSION   NM_011836 XM_130071
VERSION     NM_011836.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8478)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8478)
  AUTHORS   Song,W., Li,Q., Wang,T., Li,Y., Fan,T., Zhang,J., Wang,Q., Pan,J.,
            Dong,Q., Sun,Z.S. and Wang,Y.
  TITLE     Putative complement control protein CSMD3 dysfunction impairs
            synaptogenesis and induces neurodevelopmental disorders
  JOURNAL   Brain Behav Immun 102, 237-250 (2022)
   PUBMED   35245678
REFERENCE   3  (bases 1 to 8478)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8478)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8478)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   6  (bases 1 to 8478)
  AUTHORS   Gersdorff,N., Muller,M., Otto,S., Poschadel,R., Hubner,S. and
            Miosge,N.
  TITLE     Basement membrane composition in the early mouse embryo day 7
  JOURNAL   Dev Dyn 233 (3), 1140-1148 (2005)
   PUBMED   15895400
REFERENCE   7  (bases 1 to 8478)
  AUTHORS   Gersdorff,N., Kohfeldt,E., Sasaki,T., Timpl,R. and Miosge,N.
  TITLE     Laminin gamma3 chain binds to nidogen and is located in murine
            basement membranes
  JOURNAL   J Biol Chem 280 (23), 22146-22153 (2005)
   PUBMED   15824114
  REMARK    GeneRIF: Laminin gamma3 chain, located in murine basement
            membranes, binds to nidogen
REFERENCE   8  (bases 1 to 8478)
  AUTHORS   Klaffky,E., Williams,R., Yao,C.C., Ziober,B., Kramer,R. and
            Sutherland,A.
  TITLE     Trophoblast-specific expression and function of the integrin alpha
            7 subunit in the peri-implantation mouse embryo
  JOURNAL   Dev Biol 239 (1), 161-175 (2001)
   PUBMED   11784026
REFERENCE   9  (bases 1 to 8478)
  AUTHORS   Iivanainen,A., Morita,T. and Tryggvason,K.
  TITLE     Molecular cloning and tissue-specific expression of a novel murine
            laminin gamma3 chain
  JOURNAL   J Biol Chem 274 (20), 14107-14111 (1999)
   PUBMED   10318827
REFERENCE   10 (bases 1 to 8478)
  AUTHORS   Koch,M., Olson,P.F., Albus,A., Jin,W., Hunter,D.D., Brunken,W.J.,
            Burgeson,R.E. and Champliaud,M.F.
  TITLE     Characterization and expression of the laminin gamma3 chain: a
            novel, non-basement membrane-associated, laminin chain
  JOURNAL   J Cell Biol 145 (3), 605-618 (1999)
   PUBMED   10225960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX511243.3 and AL928893.10.
            
            On Apr 24, 2018 this sequence version replaced NM_011836.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096366.1, AF083372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               BX511243.3         30852-31314
            464-768             BX511243.3         41801-42105
            769-899             BX511243.3         44046-44176
            900-1066            BX511243.3         47001-47167
            1067-1255           BX511243.3         49179-49367
            1256-1373           BX511243.3         49480-49597
            1374-1472           BX511243.3         52165-52263
            1473-1609           BX511243.3         55562-55698
            1610-1720           BX511243.3         56607-56717
            1721-1913           BX511243.3         58185-58377
            1914-2032           BX511243.3         58531-58649
            2033-2257           AL928893.10        2450-2674
            2258-2446           AL928893.10        5020-5208
            2447-2692           AL928893.10        7095-7340
            2693-2843           AL928893.10        8224-8374
            2844-2986           AL928893.10        8925-9067
            2987-3165           AL928893.10        9519-9697
            3166-3307           AL928893.10        11160-11301
            3308-3513           AL928893.10        12130-12335
            3514-3590           AL928893.10        12573-12649
            3591-3722           AL928893.10        15384-15515
            3723-3870           AL928893.10        17226-17373
            3871-4014           AL928893.10        18474-18617
            4015-4117           AL928893.10        22321-22423
            4118-4317           AL928893.10        24482-24681
            4318-4464           AL928893.10        26103-26249
            4465-4564           AL928893.10        27279-27378
            4565-8478           AL928893.10        31762-35675
FEATURES             Location/Qualifiers
     source          1..8478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..8478
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /note="laminin gamma 3"
                     /db_xref="GeneID:23928"
                     /db_xref="MGI:MGI:1344394"
     exon            1..463
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4809
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /note="laminin subunit gamma-3; laminin-12 subunit gamma;
                     laminin-14 subunit gamma; laminin-15 subunit gamma"
                     /codon_start=1
                     /product="laminin subunit gamma-3 precursor"
                     /protein_id="NP_035966.2"
                     /db_xref="CCDS:CCDS15903.1"
                     /db_xref="GeneID:23928"
                     /db_xref="MGI:MGI:1344394"
                     /translation="MAVSRVLSLLATVASMALVIQETHFAAGADMGSCYDGVGRAQRC
                     LPEFENAAFGRRAEASHTCGRPPEDFCPHVGAPGAGLQCQRCDDADPGRRHDASYLTD
                     FHSPDDSTWWQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTSRPESFAIYKRT
                     YASGPWEPYQYYSASCQKTYGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFST
                     LEGRPSAYNFEESPVLQEWVTSTDILISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSV
                     GGRCKCNGHASECEPNAAGQLACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECL
                     PCNCSGHSEECTFDRELYRSTGHGGHCQRCRDHTTGPHCERCEKNYYRWSPKTPCQPC
                     DCHPAGSLSLQCDNSGVCPCKPTVTGWKCDRCLPGFHSLSEGGCRPCACNVAGSLGTC
                     DPRSGNCPCKENVEGSLCDRCRPGTFNLQPHNPVGCSSCFCYGHSKVCSPAAGFQEHH
                     IRSDFRHGAGGWQIRSMGVSKRPLQWSQSGLLLGLRGGEELSAPKKFLGDQRLSYGQP
                     VILTLQVPPGGSPPPIQLRLEGAGLALSLRPSSLPSPQDTRQPRRVQLQFLLQETSEE
                     AESPLPTFHFQRLLSNLTALSIWTSGQGPGHSGQVLLCEVQLTSAWPQRELAPPASWV
                     ETCLCPQGYTGQFCEFCALGYKREIPHGGPYANCIPCTCNQHGTCDPNTGICLCGHHT
                     EGPSCERCMPGFYGNAFSGRADDCQPCPCPGQSACATIPESGDVVCTHCPPGQRGRRC
                     ESCEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPHSGHCLRCLYNTTGAHCE
                     HCREGFYGSAVATRPVDKCAPCSCDLRGSVSEKTCNPVTGQCVCLPYVSGRDCSRCSP
                     GFYDLQSGRGCQSCKCHPLGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKG
                     CRDCRCSPLGAASSQCHENSTCVCRPGFVGYKCDRCQDNFFLADGDTGCQECPTCYAL
                     VKEEAAKLKARLMLMEGWLQRSDCGSPWGPLDILQGEAPLGDVYQGHHLLQETRGTFL
                     QQMVGLEDSVKATWEQLQVLRGHVHCAQAGAQKTCIQLAELEETLQSSEEEVLRAASA
                     LSFLASLQKGSSTPTNWSHLASEAQILARSHRDTATKIEATSERALLASNASYELLKL
                     MEGRVASEAQQELEDRYQEVQAAQTALGIAVAEALPKAEKALATVKQVIGDAAPHLGL
                     LVTPEAMNFQARGLSWKVKALEQKLEQKEPEVGQSVGALQVEAGRALEKMEPFMQLRN
                     KTTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPKEQAALKKKAGSIRTRLL
                     EDTKRKTKQAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALLREGKQGYRHASR
                     LASQTQATLRRASRLLLTSEAHKQELEEAKQVTSGLSTVERQIRESRISLEKDTKVLS
                     ELLVKLGSLGVHQAPAQTLNETQRALESLRLQLDSHGALHHKLRQLEEESARQELQIQ
                     SFEDDLAEIRADKHNLETILSSLPENCAS"
     exon            464..768
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..899
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1066
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1255
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1373
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1472
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1609
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1720
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1913
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2032
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2257
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2446
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2692
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2843
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2986
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3165
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3307
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3513
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3590
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3722
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3870
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4014
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4117
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4317
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4464
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4564
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..8478
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8456..8461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8478
                     /gene="Lamc3"
                     /gene_synonym="1110064A23Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggctaagc gcagaccgca gcgtagagtg gatcccggag cagtgcagag cggggcgagg
       61 accatggctg tatccagggt cctgtccctc ctggcaacgg tggcatcgat ggcgctggtg
      121 attcaggaga cacacttcgc ggcaggcgcg gacatgggct cttgctacga cggtgtggga
      181 cgcgcacagc gctgtctgcc tgagttcgag aacgcggcgt tcggccgacg cgccgaggcc
      241 tcccacacgt gcggacggcc cccggaggac ttctgtccac acgtgggggc accaggggct
      301 gggctacagt gccagcgctg cgacgatgct gaccccggac gacgccacga cgcctcctac
      361 ctcacagact tccacagccc cgatgacagc acctggtggc agagcccatc catggccttc
      421 ggggtgcagt accccacctc tgttaacctg accttgagct tagggaaggc ctatgagatt
      481 acctatgtga ggctgaagtt ccacaccagt cgccctgaga gttttgccat ctacaagcgc
      541 acgtacgcca gtggcccctg ggagccctac caatactaca gtgcctcctg ccagaaaacc
      601 tatggccgtc ctgagggcca ctacctgcga ccgggcgagg atgagagggt ggccttctgc
      661 acctctgagt tcagtgacat ctcccccttg aacgggggca acgtggcctt ctccaccctg
      721 gaaggccgtc ccagtgccta caactttgag gagagccctg tgctgcagga gtgggtcacc
      781 agcactgaca tcctgatctc tctagatcgg ctcaacacgt ttggggatga catcttcaag
      841 gaccccagag tgctccagtc ttactactac gctgtgtctg acttctctgt gggtggcagg
      901 tgcaaatgca atggtcacgc cagtgaatgc gaacccaatg cggctggtca gctggcttgc
      961 cgctgtcagc acaacaccac aggagtggac tgcgagcgtt gtctgccctt cttccaggac
     1021 cgtccgtggg cccgaggcac cgccgaggat gccaacgagt gtctgccctg caactgcagt
     1081 gggcactctg aggagtgcac gtttgacagg gagctctatc ggagcacagg ccatggtggg
     1141 cactgtcagc ggtgccgtga ccacacaact gggccacact gtgagcgctg tgagaagaac
     1201 tactacagat ggtccccgaa gacaccatgc caaccctgtg actgccaccc agcaggctct
     1261 ctgagtctcc agtgtgacaa ctcaggcgtc tgtccctgca agcccacagt gacaggctgg
     1321 aagtgtgatc gctgcctgcc tggattccac tcactcagtg agggcggctg cagaccctgt
     1381 gcctgcaatg tcgccggcag cttgggcacc tgtgaccccc gcagtgggaa ctgtccctgc
     1441 aaagagaatg tagaaggcag cctgtgtgac agatgccgcc ctgggacatt taacctgcag
     1501 ccccacaatc cagtgggctg cagcagctgc ttctgttatg gccactccaa ggtgtgttct
     1561 cctgctgccg ggttccagga acaccacatc cgctcagact tccgccatgg agctggtggc
     1621 tggcagatca gaagcatggg agtgtccaag cgtcctctgc aatggagcca gagtgggctc
     1681 ctcctgggcc tgcgaggagg ggaggaactc tcagccccaa agaagttcct gggagaccag
     1741 agactcagct atggacagcc agtcatactg accctccaag taccccctgg aggctcccca
     1801 cctcctattc agctgagact ggagggagca ggcttggctc tgtctctgag gccctccagt
     1861 ctacccagcc ctcaggacac caggcagcca agacgagttc agctccagtt cctcttgcag
     1921 gagacttctg aggaggcaga gtccccactg cccaccttcc acttccagcg cctgctttcc
     1981 aatctgactg ctctgagcat ctggaccagt ggccaaggac cgggccattc tggccaagtg
     2041 ctcttgtgtg aagttcagct cacatcggcc tggccccagc gtgagcttgc ccctccagcc
     2101 tcttgggtgg agacctgctt atgtccccag ggatacacag gccagttctg tgaattctgt
     2161 gctctgggat acaagagaga aatacctcat gggggtccct atgccaactg cattccctgc
     2221 acctgcaacc agcatggcac ctgtgacccc aacacaggga tctgcctgtg tggccaccac
     2281 accgagggtc catcctgtga gcggtgcatg ccaggtttct acggtaacgc cttctcaggc
     2341 cgtgctgatg attgccagcc ctgtccgtgc cctggccaat cagcctgtgc aaccatccca
     2401 gagagtggag atgtggtgtg cacacactgc cctcctggtc agagaggacg acgatgcgag
     2461 agctgcgaag atggcttttt tggggatcct ctagggctct ctggagctcc ccagccctgc
     2521 cgccgatgcc agtgcagcgg gaacgtggat ctcaatgctg tgggcaactg tgatcctcat
     2581 tctggccact gcttgcgctg tctgtacaac acgacagggg cccactgcga gcactgtcgg
     2641 gagggtttct acgggagtgc cgtggccaca aggcccgtgg acaaatgtgc tccctgcagc
     2701 tgtgacctga ggggctcagt cagtgagaag acctgcaacc ctgtgactgg ccagtgtgtc
     2761 tgcctgcctt atgtctccgg gagggactgc agccgctgca gccctggctt ctatgacctc
     2821 cagtctggga ggggctgcca gagctgcaaa tgtcacccac ttggatcctt ggagaataag
     2881 tgccacccca agactggcca gtgtccctgc cgacctggtg tcactggcca agcctgtgac
     2941 agatgccagc taggtttctt tggcttctcc atcaagggct gccgagactg taggtgctcc
     3001 ccattgggtg ctgcctcatc tcagtgccat gagaacagca cctgtgtgtg ccggcccggc
     3061 tttgtgggct ataaatgcga ccgctgccag gacaatttct tcctcgcgga tggcgacaca
     3121 ggctgccaag agtgtcccac ttgctatgcc ctagtgaagg aagaggcagc caagctgaag
     3181 gccaggttga tgctgatgga ggggtggctt caaaggtctg actgtggtag cccctgggga
     3241 ccactagaca ttctgcaggg agaagcccct ctgggggatg tctaccaagg tcaccaccta
     3301 cttcaagaga cccgggggac cttcctgcag cagatggtgg gcctggagga ttctgtgaag
     3361 gccacttggg agcagttgca ggtgctgaga gggcatgtac actgtgccca ggctggagct
     3421 cagaagacct gcatccagct ggcagagctg gaggagacat tgcagtcctc agaggaggag
     3481 gtccttcgtg cagcctcagc tctctcattt ctggcaagtc ttcagaaagg atccagcaca
     3541 cccaccaatt ggagtcacct ggcatcagag gcccagatcc ttgccagaag ccacagggac
     3601 acggccacca agatcgaagc tacctcggaa agggccctgc tcgcctccaa cgccagctat
     3661 gagctcctga agctgatgga aggcagagtg gcctcggaag cccagcagga actggaggac
     3721 aggtaccagg aggtgcaggc agctcagact gccctgggca tagctgtggc agaggcgctg
     3781 cccaaagctg aaaaggcact ggccacggtg aagcaagtca ttggtgacgc agccccacat
     3841 ctaggcttgc tggtcacccc tgaagcaatg aacttccaag ccaggggcct gagctggaaa
     3901 gtgaaggccc tggagcagaa gctggagcag aaggagcccg aggtgggcca gtctgtggga
     3961 gccctgcagg tggaggctgg aagagccttg gagaagatgg agccctttat gcagctacgc
     4021 aataagacca cagctgcctt cacacgggct tcctcagctg tgcaagctgc caaggtgacc
     4081 gtcataggag cagagaccct gctagctgac ctagagggaa tgaagctgag gtctcctcta
     4141 cccaaggagc aggcagcgct gaagaagaaa gcaggcagca tcaggaccag gctcctggag
     4201 gacacaaaga ggaagaccaa gcaggcagag aggatgctgg gaaatgctgc ctctctctcc
     4261 tccagcacca agaagaaaag caaagaagca gaactgatgt ctaaggacaa tgccaagctc
     4321 tccagagctt tgctgaggga aggcaagcag ggctaccgtc atgccagccg actcgccagc
     4381 cagacccagg ccacactccg tcgggcctct cgcctgctgc tgacctcaga agcacacaag
     4441 caggagctgg aggaagctaa acaggtgacc tctgggctga gcactgtgga gcgccagatc
     4501 cgagagtctc ggatctcctt ggagaaggac accaaggtcc tgtcagagct gcttgtgaag
     4561 ctggggtccc tgggtgtcca ccaagcccct gctcagaccc tgaacgagac ccagcgggca
     4621 ctagaaagct tgaggctgca gctggattcc cacggagccc tgcatcacaa actgaggcag
     4681 ctggaggaag agtctgctcg acaggagctg cagattcaga gctttgagga cgaccttgct
     4741 gagatccgcg ctgacaagca caacttggag accattctga gcagtctgcc agagaactgt
     4801 gccagctaga ccctggtaca ccctccccac cctgccgttt cctgtccact ccctgtaggt
     4861 gtcccaggtc tgcctgtcgt atgttcacgt gaatgcttgt ttgctggtgc atcttcggtc
     4921 tgagcaggag tgaatacatg ctcacacctc cacagatgac cctgtatgta gtcctcagtg
     4981 tgtactctct aaacgtgcat cagcatacac accccagtat ttgcacatat gtgtatgtga
     5041 tgcactgatg tgttaagacc acctgtgtgc atgcacacat atgagagtct agagctgtgg
     5101 agaggcagtc ctgagcttgg gcacattcca cattctgggt gggtcctgtt atgaaatatt
     5161 ccctgcaggg atgacacatc tacaaccctc cctccagaaa tcaggggcca acaggggtgg
     5221 tacctccgag gctgagagac tatctatcct cagagatttt gagaagcctc agaaagtccc
     5281 atgtgcatgg tcacagagct ggccctggac ccactatgct cctctgtccc ctaactggtc
     5341 acccagcagc tctgagaact gaggtaccag acagatcaag cagtgcccag attctaacag
     5401 ggttcctgga agtgtcacct gaggccacgt gggcctgcaa agccacaggg caaggtaaga
     5461 tggaggtatc ttttgtggac gattccccag agggatctgg accagctgtt tcattgaggg
     5521 aagtgcctga tccatccacc ttcaatgtcc tgacctacct gaagaaccag cttcttcagg
     5581 gtctggctca taagccctca ggcaggcaat ggggacagcc ctttgtgcct tgctgacccg
     5641 gttagccttt gattgacact tctcagactg gtcttgtggc cccacctgtc atgaagtatg
     5701 tcacagggat gtgggagcct ggctgtcatt ctaagcctgc tacccatgac tgcctccccc
     5761 agaaatccct ggcatttctt cctgataccc cctctttttc tcagagctct ttagaacaca
     5821 gcagagccta ggcactggga taacagccac ctttgcaagc ccaatccctt ccccaggtcc
     5881 cagaggaact gattgtgatt ctgaggaaat aaaggaccct tttcctgtgc tgtgcctttg
     5941 gtcctccagt gctagtgtgg cgaccagggc ctgctgtggg tatgcacaga gcacttcctg
     6001 tggctggccc ggaaagcagg tagtgatttc ctgcatttgt gatcccatgt gtgggaagga
     6061 ggttggcaga actgggcttg tgccatcctg gggtctgtcg tgttggcctt agcaggggca
     6121 ctgtgactac cacctttctt ctcagatcca gggggctttc agacaaaggt gaggggcctg
     6181 gatagaggtg gtacacaaag agttcgtctg ccactccctg gttcagggtg gagacactga
     6241 ggcagagaac tgaacttaat tctgtccagt aggacggtaa gaggaaagga gggccaccat
     6301 cgagaggagg gggccttgag cctgggtctg gaagggtgga gagacgggga cagagggggg
     6361 agaatgaccc atataagagg gcaggtagca gccaaggtta cagcctggct tggatcggtc
     6421 attgcaaact tagattagag cagattgtaa agcatcctct attttattaa ggcgttaggc
     6481 cacaaggcca aaatgattac cagattagct tcaatgggac agtggaagtc gctgggaggg
     6541 tgatttggac ttctgggcta ggagaggctg ccaggcttta gagaaaccta agcctggggc
     6601 tgctgagatg ggtagctttt ccctcctgcc ttcttccttg gcctcagctt ggctcttttc
     6661 cgtttgctta ggccttgcct ctacaaatta gctttccttg tctttcttgt acataatggt
     6721 tgatgatatt gcacccttcc tccatcctct acaaagccct gggcatgcat atcatcagct
     6781 cattattttt atttttttat tcattttttt ttcaagacag ggtttctctg tgtagccctg
     6841 gctgtcctgg aactctctct gtggaccagg ctggcctcga acttggagat ctgcctgcct
     6901 ctgcctccca agtgctggga ttaaaggtgt gaactaccat tgctcagcta ttatttttat
     6961 tttgagattc tgttcatttt tgttttatat gtatgtgtgc tttgcctgcg tgcatatctg
     7021 ggaaccacat gcatgcttca ggtcctctgg aactggagtt acagatagct gatagctgcc
     7081 atgtgagtga tggaagccaa acccaggtga acaaacagac acttctcttc ttcttcttct
     7141 tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct
     7201 tcttcttctt cttcttcttc ttcttcttct tcttttttgt tcttccgaga cagggtttct
     7261 ctgtgtagcc ctggctgtct tggaactcac tctgtagacc aggctggcct tgaactcaga
     7321 aatccgcctg cctctgcctc ccaagtgccg ggattaaagg catgcgccac cactgttcag
     7381 caagcagaca cttcttttaa ctgctgatcc accactccag ccccacatca aatgttgagt
     7441 ggtcaagtcc cctgcttggc caaaatacca gggactttgt gtccaaggct ttgtggtgag
     7501 acatgccata tatgtacagg caaagtgttc tgaggagagg agcatccctc cagagagaac
     7561 cttgaggtca aggtgaggct gaggatggtg tggctgccat tttatgttga gtgggactga
     7621 tatggtaggt tgccagggtt ggggtagaaa gacggaagac gggattgggt aattaggatc
     7681 tggtgtgtga tataaaggac atgggagctc taaagtcaaa atctggggca ggatccggca
     7741 cttctctggc cttaacccag tttctccact gatggatggc caacctctac ccacttgagc
     7801 catgatgtac agcaaagcgt ggtcccagca tctctagtgg gcggagacca ggcttcctag
     7861 gaaacaagtc tcaggcctgc caagtgactc atgcggtatg gtcatgcctg gtgtatgcag
     7921 agccactcag aaggtccaga ggtggggctg cacatgacgg aggggaatgc tagcagcagc
     7981 tgaacatctg tctaactcag cagccagctg agcagtagaa cttgggatgg cccctgtcct
     8041 atcccactga acagccagga acagctgtgg agcagtcttc tctgaggaga aaacattcct
     8101 tccggtaggg gggctcctca ggcagagagg taaacagccc aaaacaagag cttcaagagc
     8161 tccctgaaac tgagcggatt ccccaggccc cttcctgccg gcctcagcag aacccagctg
     8221 caagaagact cttagacaag tagagttgcc tgctggttag actaactgat gccccgggaa
     8281 aggagactct ccatccaacc tgtcacactg tctgtagacc atgcggcggg ctccaggttc
     8341 ccagttttgt gagctgtcat ccatgctagg gggtggactt tggcaacaca gctgtctgtg
     8401 agtcatttct gtttctgtaa gttaactctt cacccatatt cttgtaaata accctaataa
     8461 agcttactgg gtcaccaa
//
