LOCUS       NM_008485               5182 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus laminin, gamma 2 (Lamc2), mRNA.
ACCESSION   NM_008485
VERSION     NM_008485.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Zhang,J., Ji,F., Tan,Y., Zhao,L., Zhao,Y., Liu,J., Shao,L., Shi,J.,
            Ye,M., He,X., Jin,J., Zhao,B., Huang,J., Roessler,S., Zheng,X. and
            Ji,J.
  TITLE     Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic
            Cholangiocarcinoma via Promoting EGFR Translation
  JOURNAL   Adv Sci (Weinh) 11 (21), e2309010 (2024)
   PUBMED   38526177
  REMARK    GeneRIF: Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic
            Cholangiocarcinoma via Promoting EGFR Translation.
REFERENCE   4  (bases 1 to 5182)
  AUTHORS   Sproule,T.J., Wilpan,R.Y., Wilson,J.J., Low,B.E., Kabata,Y.,
            Ushiki,T., Abe,R., Wiles,M.V., Roopenian,D.C. and Sundberg,J.P.
  TITLE     Dystonin modifiers of junctional epidermolysis bullosa and models
            of epidermolysis bullosa simplex without dystonia musculorum
  JOURNAL   PLoS One 18 (10), e0293218 (2023)
   PUBMED   37883475
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5182)
  AUTHORS   Sproule,T.J., Wilpan,R.Y., Low,B.E., Silva,K.A., Reyon,D.,
            Joung,J.K., Wiles,M.V., Roopenian,D.C. and Sundberg,J.P.
  TITLE     Functional analysis of Collagen 17a1: A genetic modifier of
            junctional epidermolysis bullosa in mice
  JOURNAL   PLoS One 18 (10), e0292456 (2023)
   PUBMED   37796769
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5182)
  AUTHORS   Kozak,C.A., Adamson,M.C., Buckler,C.E., Segovia,L., Paralkar,V. and
            Wistow,G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   7  (bases 1 to 5182)
  AUTHORS   Utani,A., Kopp,J.B., Kozak,C.A., Matsuki,Y., Amizuka,N.,
            Sugiyama,S. and Yamada,Y.
  TITLE     Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue
            distribution
  JOURNAL   Lab Invest 72 (3), 300-310 (1995)
   PUBMED   7898049
REFERENCE   8  (bases 1 to 5182)
  AUTHORS   Sugiyama,S., Utani,A., Yamada,S., Kozak,C.A. and Yamada,Y.
  TITLE     Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a
            subunit of epithelial cell laminin
  JOURNAL   Eur J Biochem 228 (1), 120-128 (1995)
   PUBMED   7882992
REFERENCE   9  (bases 1 to 5182)
  AUTHORS   Aberdam,D., Aguzzi,A., Baudoin,C., Galliano,M.F., Ortonne,J.P. and
            Meneguzzi,G.
  TITLE     Developmental expression of nicein adhesion protein (laminin-5)
            subunits suggests multiple morphogenic roles
  JOURNAL   Cell Adhes Commun 2 (2), 115-129 (1994)
   PUBMED   8081888
REFERENCE   10 (bases 1 to 5182)
  AUTHORS   Aberdam,D., Galliano,M.F., Mattei,M.G., Pisani-Spadafora,A.,
            Ortonne,J.P. and Meneguzzi,G.
  TITLE     Assignment of mouse nicein genes to chromosomes 1 and 18
  JOURNAL   Mamm Genome 5 (4), 229-233 (1994)
   PUBMED   8012114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ094114.1, BB617855.1, AC099735.47, CF733033.1, DV654715.1,
            DV658346.1 and BU758039.1.
            
            On Jul 22, 2006 this sequence version replaced NM_008485.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               CJ094114.1         2-524
            524-821             BB617855.1         288-585
            822-948             AC099735.47        187112-187238       c
            949-1071            AC099735.47        185819-185941       c
            1072-1261           AC099735.47        184003-184192       c
            1262-1374           AC099735.47        180714-180826       c
            1375-1593           AC099735.47        179589-179807       c
            1594-1776           AC099735.47        178801-178983       c
            1777-2360           CF733033.1         120-703
            2361-2537           AC099735.47        171773-171949       c
            2538-2617           AC099735.47        169852-169931       c
            2618-2767           AC099735.47        168674-168823       c
            2768-2887           AC099735.47        166923-167042       c
            2888-3581           DV654715.1         1-694
            3582-3844           DV658346.1         209-471
            3845-5126           AC099735.47        157869-159150       c
            5127-5182           BU758039.1         1-56                c
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.26 cM"
     gene            1..5182
                     /gene="Lamc2"
                     /note="laminin, gamma 2"
                     /db_xref="GeneID:16782"
                     /db_xref="MGI:MGI:99913"
     exon            1..194
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..387
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..576
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..712
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..811
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..948
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1071
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1261
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1374
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1593
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1776
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2022
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2168
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2331
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2537
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2617
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2767
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2912
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3062
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3177
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3377
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3536
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3636
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..5164
                     /gene="Lamc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5141..5146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamc2"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="Lamc2"
                     /note="major polyA site"
ORIGIN      
        1 gtgcccttga gactccctcg ccccctccgg ttttgaggaa ggggtggctg atatctacaa
       61 cctgagttct gcccaggacc accccgggag agaacggctg tgtgtagcgg ggtgcgggtg
      121 gagggagggg atatggcaca ttccagaagg atctctggac cgcagcctca gtaccacgcc
      181 ctcggcgggg ccaggactga gtcagggaga agagtcgata aaacacctga tcgagggaaa
      241 aggaaggcac agcagagcga agactcggcg cccggcaggc acccgcagcg gcggagcgcg
      301 gcccggccat gcctgcgctc tggctcagct gctgccttgg tgtcgcgctc ctgctgcccg
      361 cagcccaggc cacctccagg agggaagtct gtgattgcaa tgggaagtcc aggcaatgtg
      421 tctttgatca ggagctccat cgacagacag gcagcgggtt ccgttgcctc aactgcaatg
      481 acaatacagc gggggttcac tgcgagcggt gcagggaggg gttttaccga catcgagaca
      541 gagaccgctg cctaccctgc aactgccact caaagggttc cctcagtgct ggatgtgaca
      601 actctggaca atgcaggtgt aagccaggtg tgacaggaca aagatgtgac cgatgtcagc
      661 caggcttcca tatgctcacc gatgctggat gcacccgaga ccaggggcaa ctagattcca
      721 agtgtgactg tgacccagct ggcatctctg gaccctgtga ttctggccga tgtgtctgca
      781 aaccagccgt cactggagag cgctgtgata ggtgccgacc aggctactat catctggacc
      841 gggcaaaccc tgagggctgt acccagtgtt tctgctatgg gcattcagcc agctgccacg
      901 cctctgccga cttcagtgtc cacaaaatca cttcaacttt cagtcaggat gtggatggtt
      961 ggaaggcggt tcagagaaac ggggcacctg caaaactcca ctggtcacag cgccatcggg
     1021 acgtgtttag ttctgcccga agatcagacc ccgtctattt cgtggcccct gccaaattcc
     1081 tcggtaacca gcaagtgagt tacgggcaga gcctgtcttt tgactaccgc gtggacagag
     1141 gaggtagaca gccgtctgcc tacgatgtga tcctggaagg tgctggtcta cagatcagag
     1201 ctcctctgat ggctccaggc aagacacttc cctgtgggat cacaaagact tacacattca
     1261 gactgaatga acatccaagc agtcactgga gtccccagct gagttatttc gaatatcgaa
     1321 ggttactgcg gaacctcaca gccctcctga tccgagctac gtacggagaa tatagtacag
     1381 ggtacattga taacgtgacc ctggtttcag cccgccctgt ctctggagcc ccagcccctt
     1441 gggttgaacg ttgtgtatgc cctgctgggt acaagggaca attctgccag gaatgtgctt
     1501 ctggttacaa aagagattcg gcaagattgg ggccttttgg cgcctgtgtt ccctgtaact
     1561 gccaaggggg aggggcctgt gatccagaca cgggagattg ctactcgggg gacgagaatc
     1621 ctgacattga gtgtgctgac tgtcccatcg gtttctacaa tgacccacat gacccccgca
     1681 gctgcaagcc atgtccctgt cacaatgggt tcagctgttc agtgatgcct gagacagagg
     1741 aggtggtgtg taacaactgt ccccctgggg tcacaggtgc ccgctgtgag ctctgtgctg
     1801 atggcttctt tggggatccc tttggggaac gtggcccagt gaggccttgt caacgctgcc
     1861 aatgcaacaa caacgtggac cccaatgcct ctgggaactg tgaccagttg acaggcagat
     1921 gcttgaaatg tatctacaac acggccggtg tctactgtga ccagtgcaaa gcaggttact
     1981 ttggagaccc attggctccc aacccagcag acaagtgtcg agcttgcaac tgcagcccca
     2041 tgggctcgga gcctggagag tgtcgaggtg atggcagctg tgtttgcaag ccaggctttg
     2101 gcggcctcaa ctgtgatcac gcagccctaa ccagttgtcc tgcttgctac aatcaagtga
     2161 agattcagat ggaccagttt acccagcagc tccagagcct ggaggccctg gtttcaaagg
     2221 ctcagggtgg tggtggtggt ggtacagtcc ccagtgggga gctggaaggc aggatgcagc
     2281 aggctgagca ggcccttcga gacattctaa gagaagctca gatttcagaa ggggcaatga
     2341 gagcccttgg cttccggctg gccaaggcaa ggagccaaga gaacgactac aagacccgcc
     2401 tggatgacct caagatgact gcagaaagga tccgggccct gggcagtcag catcagaaca
     2461 gagttcagga tacgagcaga ctcatctctc agatgcgcct gagtctggca ggaagcgaag
     2521 cttccctgca aaacactaat atccattctt ctgagcacta cgtggggccg aatggattta
     2581 aaagtctggc tcaggaggct acaagattgg cagacagcca cgctgagtca gctaacgcaa
     2641 tgaagcaact agcaagggaa actgaggact actccaaaca agcactttca ttggcccgca
     2701 aggctctgag tggaggaggc ggaagtggcg tcttggacag ctccgtggta caaggtctta
     2761 tgggaaaatt agagaaaacc aagtccctga gccagcagct gtcaagggag ggcacccaag
     2821 ccgacattga agctgatagg tcgtatcagc acagtctccg cctcctggat tctgcctctc
     2881 agcttcaggg agtcagtgat ctgtcctttc aggtggaagc aaagaggatc agacaaaagg
     2941 ctgattctct ctcaaacctg gtgaccagac aaacggatgc attcacgcgt gtgcgaaaca
     3001 atctggggaa ctgggaaaaa gaaacacggc agcttttaca gactggaaag gataggagac
     3061 agacttcaga tcagctgctt tcccgtgcca accttgctaa aaacagagcc caagaagcgc
     3121 taagtatggg caatgccact ttttatgaag ttgagaacat cctgaagaac ctccgagagt
     3181 ttgatctgca ggttgaagac agaaaagcag aggctgaaga ggccatgaag agactctcct
     3241 ctattagcca gaaggttgca gatgccagtg acaagaccca gcaagcagaa acggccctgg
     3301 ggagcgccac tgccgacacc caacgggcaa agaacgcagc tagggaggcc ctggagatca
     3361 gcagcgagat agagcaggag atagggagtc tgaacttgga agctaatgtg acagcagatg
     3421 gggccttggc catggagaag ggactggcca ctctgaagag cgagatgaga gagatggagg
     3481 gggagctggc cagaaaggag ctggagtttg acacggataa ggacacggtg cagctggtga
     3541 ttactgaagc ccagcaagct gatgccagag ccacgagtgc cggagttacc atccaagaca
     3601 cactcaacac attggacggc atcctacacc tcatagacca gcctggcagt gtggatgaag
     3661 aagggatgat gctattagaa caagggcttt tccaagccaa gacccagatc aacagtcgac
     3721 ttcggccctt gatgtctgac ctggaggaga gggtgcgtcg gcagaggaac cacctccatc
     3781 tgctggagac cagcatagat ggaattctag ctgatgtgaa gaacctggag aacattcgag
     3841 acaacctgcc cccaggctgc tacaataccc aagctcttga gcaacagtga agttgtcata
     3901 gagatttgtc cactgtggtg aaaggacaca gacctcaggg gtcaggagcc atctcgtgtg
     3961 gatgggctgg gctcaggcta tctgaacaca tttaatgggt ttgttcaggt ccaattccat
     4021 ccctgagacc atgggcgggt ggatgtcttc ctgtaccaat ataatactgt ttgcttcctg
     4081 atgctggcag tgaggcagat agcgttgagt atgagattga tcaaggacca acaaatgctg
     4141 cgctcagaac agtgacaaac tgaattctgg gatatagaaa gtcctgctgc tatgtcagga
     4201 caagagatct aatcccgctg tggccagtaa agtactcttg cttcacccac tagacgtttt
     4261 ttgtccacca catttcctcc agtgcccacc caatacatga gtatgtcctc cacttcatgc
     4321 tgagtgcaga gagcagtgat gggtatagat ctggaaatct ggcccatgtg gagcagtggt
     4381 gcccgctgcc acccctcacc ttcatgctct cggcctgagt gtaacagcct ttctcctaat
     4441 ggtgcgaaca acttagaggc tgtatttttt atgaaagcat cttttaccag ccaagcaatc
     4501 attgggaaag tatttccttt gagtttcaaa gtgatataag aaaatgtgtc ctgggcacta
     4561 aaggaagtgg agttatctaa aagatatatt catcataatc caatcttcct ttggaaacac
     4621 taaaactcat atacatctgt gtattgtatc ttattttctc tttctcccta aatcagggat
     4681 aatccagcct tctaacatat atttattgcg tcactactgt gtgccagggg tgagtggaac
     4741 agtatggaca gtctctactc tcatggagtt gagtgtctag tgagaagaac aaacattaga
     4801 ataagtaaat ggaaactccc atgccttgtt catctcatgt gatatttatt gcagtcaccc
     4861 accctttggt ttgaaacctc ttttcttaat aatgtgttgc aagacattcc catgagggta
     4921 cttgagttag agcaaagttg agatcgctct gagttgtaca catttctcta tgttccagcc
     4981 gtctctccac cccttcccac aacagactgt tgccacagac ggttgcatca gggcaatacc
     5041 agtgggaatt gctgaaggaa ccgaggcatt gggacctcag tttggaagac ctgtactgtc
     5101 tcacctctgt atctccttgt cttttcatgg atgtgtatta aataaaggag tgttagatgc
     5161 tgggaaaaaa aaaaaaaaaa aa
//
