LOCUS       NM_008484               4055 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus laminin, beta 3 (Lamb3), transcript variant 1, mRNA.
ACCESSION   NM_008484
VERSION     NM_008484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4055)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4055)
  AUTHORS   Han,S., Zhang,M., Qu,X., Wu,Z., Huang,Z., Hu,Y., Li,Y., Cui,L.,
            Si,L., Liu,J. and Shao,Y.
  TITLE     SOX10 deficiency-mediated LAMB3 upregulation determines the
            invasiveness of MAPKi-resistant melanoma
  JOURNAL   Oncogene 43 (6), 434-446 (2024)
   PUBMED   38102338
  REMARK    GeneRIF: SOX10 deficiency-mediated LAMB3 upregulation determines
            the invasiveness of MAPKi-resistant melanoma.
REFERENCE   4  (bases 1 to 4055)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   5  (bases 1 to 4055)
  AUTHORS   Hazra,R., Brine,L., Garcia,L., Benz,B., Chirathivat,N., Shen,M.M.,
            Wilkinson,J.E., Lyons,S.K. and Spector,D.L.
  TITLE     Platr4 is an early embryonic lncRNA that exerts its function
            downstream on cardiogenic mesodermal lineage commitment
  JOURNAL   Dev Cell 57 (21), 2450-2468 (2022)
   PUBMED   36347239
REFERENCE   6  (bases 1 to 4055)
  AUTHORS   Dowling,J., Yu,Q.C. and Fuchs,E.
  TITLE     Beta4 integrin is required for hemidesmosome formation, cell
            adhesion and cell survival
  JOURNAL   J Cell Biol 134 (2), 559-572 (1996)
   PUBMED   8707838
REFERENCE   7  (bases 1 to 4055)
  AUTHORS   Utani,A., Kopp,J.B., Kozak,C.A., Matsuki,Y., Amizuka,N.,
            Sugiyama,S. and Yamada,Y.
  TITLE     Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue
            distribution
  JOURNAL   Lab Invest 72 (3), 300-310 (1995)
   PUBMED   7898049
REFERENCE   8  (bases 1 to 4055)
  AUTHORS   Aberdam,D., Aguzzi,A., Baudoin,C., Galliano,M.F., Ortonne,J.P. and
            Meneguzzi,G.
  TITLE     Developmental expression of nicein adhesion protein (laminin-5)
            subunits suggests multiple morphogenic roles
  JOURNAL   Cell Adhes Commun 2 (2), 115-129 (1994)
   PUBMED   8081888
REFERENCE   9  (bases 1 to 4055)
  AUTHORS   Aberdam,D., Galliano,M.F., Mattei,M.G., Pisani-Spadafora,A.,
            Ortonne,J.P. and Meneguzzi,G.
  TITLE     Assignment of mouse nicein genes to chromosomes 1 and 18
  JOURNAL   Mamm Genome 5 (4), 229-233 (1994)
   PUBMED   8012114
REFERENCE   10 (bases 1 to 4055)
  AUTHORS   Baudoin,C., Miquel,C., Blanchet-Bardon,C., Gambini,C., Meneguzzi,G.
            and Ortonne,J.P.
  TITLE     Herlitz junctional epidermolysis bullosa keratinocytes display
            heterogeneous defects of nicein/kalinin gene expression
  JOURNAL   J Clin Invest 93 (2), 862-869 (1994)
   PUBMED   8113417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101470.1, BY098011.1, AC022675.7, BY248755.1, CK023039.1,
            CX237661.1 and AK078970.1.
            
            On Sep 1, 2006 this sequence version replaced NM_008484.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               BY101470.1         2-247
            247-306             BY098011.1         243-302
            307-360             BY101470.1         308-361
            361-416             BY098011.1         357-412
            417-478             AC022675.7         100740-100801
            479-672             BY248755.1         29-222
            673-673             AC022675.7         104112-104112
            674-898             BY248755.1         224-448
            899-993             AC022675.7         106234-106328
            994-1114            AC022675.7         108149-108269
            1115-1303           AC022675.7         108890-109078
            1304-1318           AC022675.7         110295-110309
            1319-1975           CK023039.1         1-657
            1976-2147           AC022675.7         112585-112756
            2148-2759           CX237661.1         11-622
            2760-2922           AK078970.1         276-438
            2923-2965           AC022675.7         119114-119156
            2966-3546           AK078970.1         482-1062
            3547-3547           AC022675.7         121153-121153
            3548-4026           AK078970.1         1064-1542
            4027-4055           AC022675.7         124105-124133
FEATURES             Location/Qualifiers
     source          1..4055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.71 cM"
     gene            1..4055
                     /gene="Lamb3"
                     /note="laminin, beta 3"
                     /db_xref="GeneID:16780"
                     /db_xref="MGI:MGI:99915"
     exon            1..148
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            149..208
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3687
                     /gene="Lamb3"
                     /note="laminin subunit beta-3; kalinin B1 chain; nicein
                     subunit beta; kalinin subunit beta; epiligrin subunit
                     bata; laminin-5 subunit beta; nicein, 125kDa"
                     /codon_start=1
                     /product="laminin subunit beta-3 precursor"
                     /protein_id="NP_032510.2"
                     /db_xref="CCDS:CCDS15637.1"
                     /db_xref="GeneID:16780"
                     /db_xref="MGI:MGI:99915"
                     /translation="MTAFFLLWLALPGFLCAQQACSRGACYPPVGDLLIGRTQLLRAS
                     STCGLTKPETYCTQYGQWQMKCCKCDSRLPRNYNSHRVENVASSSGPMRWWQSQNDVS
                     PVSLQLDLDKRMQLQDIMMDFKGLTPAGMLIERSSDFGKTWRVYQYLATDCASTFPQV
                     HQGQPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMDLASAIPASQSKKIQELGDITNLR
                     VNFTKLAPVPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGSTTAVQVNNVC
                     VCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHSETCHFDPAVFAASQG
                     TNGGVCDNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAVQGAPCDRL
                     TGQCVCKEYVQGERCDLCKPGFTGLTFANPKGCHACDCSILGARKDMPCEEETGRCLC
                     LPNVVGPKCDQCAPSHWKLASGLGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTC
                     SSAAIRQCPDQTYGHVATGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQR
                     GHCDRYPVCVACHSCFQAYDTDLQEQARRLHSLRNATEGLWTGTGLEDHGLASRLLDA
                     KSKIEQIRQILEGTSVTEQDVAQVANGILSIRRTLQGLPLDLPLEEEMESFSGDLGNL
                     DRSFSRLLLMYRSKKEQFEKLSSEDPSGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLR
                     DSRREAEGLERQAGGGGTGGAQLMALRLEMASLPDLTPTINKLCGRSRQTACTPGDCP
                     GELCPQDNGTACGSHCRGALPRAKGAFHMAGRVAEQLRNFNTQLQQTRQMIRAAEEAA
                     SRVQADAQRLETQVSTSRLLMEEDVQRTRLLIQQVRGFLTDPDTDAATIQQVSEAVLA
                     LWLPTDSATVLRKMKEIQAIAARLPNVDSVLSQTKQDIARARRLQAEAEQARSRAHAV
                     EGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVGEVQQVLVPAERLVKGMKE
                     QMSGFWARMKELRRQAQEEQAQAMQARQLAEGASQQAMNAQEGFKRLKQKYTELKDRL
                     GQSPVLGEQGNRILSIKMEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSADLSGL
                     EKRVEQIRSYINGRVLYYATCK"
     exon            209..363
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..478
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..552
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..744
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..808
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..993
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1114
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1303
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1459
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1656
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1768
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2147
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2308
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2526
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2724
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2869
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3077
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3219
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3396
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3550
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..4055
                     /gene="Lamb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4010..4015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lamb3"
                     /note="hexamer: AATAAA"
     polyA_site      4052
                     /gene="Lamb3"
                     /note="major polyA site"
ORIGIN      
        1 agcagtgggg ctacacccag ccagggagtc tccagaggtg aggctgttgt ttaaaactgt
       61 ggagccaaga gaggggaccc cacattccca gggagctctc cgagagggat ctggagaaag
      121 gcaggggagc ataggagctc agggtgaggc gacccctctg aggacctgca ctggctcagg
      181 atgacagcat ttttcctcct gtggcttgcc ttgcctggct tcctgtgtgc ccagcaagcc
      241 tgctcccgag gggcctgtta tccacctgtg ggggacttgc tcattggaag gactcagctt
      301 cttcgagcct catctacctg tggattgacc aaacctgaga cctattgcac ccaatatgga
      361 cagtggcaga tgaaatgctg caagtgtgac tccaggctgc ctcgaaatta caacagtcac
      421 cgagtggaga atgtcgcatc gtcttcaggc cccatgcgct ggtggcagtc acagaatgat
      481 gtgagccctg tctctctgca gctggaccta gacaagagga tgcagcttca ggacatcatg
      541 atggatttta agggtctcac accagctggc atgttgattg agcgctcttc tgactttggc
      601 aagacatgga gggtgtacca gtacctggcg acagactgtg ccagcacctt tccccaggtc
      661 caccagggcc agcccaagaa ctggcaggac gtccggtgcc ggcccttgtc ccagaggcct
      721 aatgggcatc tgactggggg aaaggtccaa cttaacctta tggatttagc atcagctatc
      781 cctgcatctc aaagtaaaaa gattcaagaa cttggggaca tcacaaactt gagagtcaac
      841 ttcaccaagc tggcccctgt gccccagagg ggctcctatc cacccagcgc ctactttgca
      901 gtgtcacagc tacgtctaca ggggagttgc ttctgtcacg gacatgccga ccgctgtgcc
      961 cctaatcctg gaggttctac cactgctgtg caggtcaaca atgtctgtgt ctgccagcat
     1021 aacacagctg gccccaattg tgaccgctgt gcccctttct acaacaaccg tccatggaga
     1081 cctgcagagg gccaggacac ccacgagtgc caaaggtgtg actgcaatgg gcactcagag
     1141 acctgccact tcgacccagc tgtgtttgct gccagccagg ggacaaatgg aggtgtgtgt
     1201 gacaactgcc gggaccacac cgagggcaag aactgcgagc gctgtcagct acactatttc
     1261 cggaatagac gacccagcgc tcccattcat gagacttgta ttccctgtga gtgtgatcca
     1321 gatggagcag tccagggagc tccctgtgac cgactgacgg gccagtgtgt gtgcaaagag
     1381 tacgtgcaag gagagcgctg cgacctttgc aagcctggct tcaccgggct caccttcgcc
     1441 aacccgaagg gctgccatgc ctgtgactgc agtatcttag gtgcccggaa agatatgcct
     1501 tgtgaggagg aaaccggacg ctgcttgtgt ctgcccaatg tagtgggccc caaatgtgac
     1561 cagtgtgccc cttcccactg gaagctggcc agcggcctgg gctgcgagcc ctgtgcctgt
     1621 gaccctcgca actccctaag ctcccagtgc aaccagttta caggacagtg tccttgtcgg
     1681 gaagggtttg gcggcctcac gtgtagttct gcagccatcc gccagtgtcc tgaccagacc
     1741 tatggacacg tggccacagg gtgccgagct tgtgactgtg acttcagagg aacagagggt
     1801 cctggctgtg acaaagcctc aggccgttgc ctctgccgcc ctggctttac cgggccccgc
     1861 tgtgaccaat gccaacgagg tcactgtgac cgctacccag tatgtgtggc ctgccactcc
     1921 tgcttccagg cctatgacac agacctccag gagcaagctc gacgccttca cagtctccgt
     1981 aatgccaccg aaggcctgtg gacagggaca ggtctggaag accatggcct ggcttctcgg
     2041 ttgctagatg ccaagagcaa gattgagcag atcagacaga ttctggaagg cacttctgtc
     2101 acagagcagg atgtggctca ggtggccaat ggcatcttgt ctatcaggag aactcttcag
     2161 ggcctgccgc tggacctgcc cttagaggag gagatggaat ccttctctgg agacctgggg
     2221 aatctagaca gaagcttcag tcggctcctc cttatgtacc gaagcaagaa ggagcaattt
     2281 gagaagctaa gcagtgaaga cccttcagga gccttccgca tgctgaccat ggcttatgag
     2341 cagtcctccc gggctgcaca gcaagtgtct gacagttcta gcctgctgag ccagttgagg
     2401 gacagtcgca gggaagcaga gggcctggag agacaggctg gaggaggagg caccggagga
     2461 gctcagctca tggccctgcg cctagaaatg gcttcgctgc ctgacttgac acccaccatc
     2521 aacaagcttt gtggcaggtc taggcagaca gcctgtactc caggagattg ccctggagag
     2581 ctgtgtcctc aggacaatgg tacagcttgt ggctctcact gcaggggagc cctgcccaga
     2641 gccaaagggg ccttccacat ggcagggcgg gtagctgagc agctacgaaa cttcaacacc
     2701 cagctccagc agaccaggca aatgatcagg gcagccgagg aagcagcatc aagggtccaa
     2761 gccgatgccc agcgccttga gacccaggtg agtaccagcc gcttgctgat ggaggaagat
     2821 gtccagcgca cacggcttct catccaacag gtccggggct ttctcacaga tcctgacaca
     2881 gatgcagcca ccatccaaca ggtcagcgag gcagtgctgg ctctctggct gcccacagac
     2941 tcagccacag tgctgcgcaa gatgaaagag atccaggcca ttgcggccag gctccctaat
     3001 gtggactcag tgctatccca gaccaaacaa gacatcgcac gggcccgcag gctccaggct
     3061 gaggctgagc aggccagaag ccgagcccac gctgtggaag ggcaggtaga tgatgtggtc
     3121 gggaaccttc ggcagggcac cgtggctctg caggaagctc aggacacaat gcagggtact
     3181 ggccgctctc ttcggctcat ccaggaaagg gttggtgagg ttcagcaggt ccttgtacca
     3241 gctgaaaggc tggtgaaagg catgaaggaa cagatgagtg gattctgggc acggatgaag
     3301 gagcttcgcc gtcaggccca ggaggagcag gcccaggcaa tgcaggcccg gcagcttgca
     3361 gagggtgcca gccagcaggc aatgaatgcc caggagggct ttaagagact taagcaaaag
     3421 tatacagagt tgaaggaccg gctgggtcag agtcctgtgc tgggcgagca aggcaatcga
     3481 atcctgagca tcaagatgga ggcagaggag ctctttgggg agaccatgga aatgatggac
     3541 aaaatgaaag acatggagtc agagctgctt cgagggagtc aggctatcat gctgcgctct
     3601 gcagacctgt cggggctgga gaagcgtgtg gagcagatcc gcagttacat caatgggcga
     3661 gtgctctact atgccacctg caagtgacct taagtcccaa cctcagaccc tccccctgac
     3721 cccaccccgc cttggaaggg cacactgggg aggggaatgt ctccaccatt gatagcatag
     3781 actggtcacc ctggacgtgc ttcaaggtac tgttcccact gagcctgtgc ttgcatgact
     3841 acattgagga gagagatggt accgggggtg gggctgtcac aactgaaaac cctccagctg
     3901 gaatggacaa tgtgccccca acaccaactc ctcctgccct ccactgtggt agagtctggg
     3961 accaactcaa aaacggaaca aggagtgatg atgtatgaac acaaaaccca ataaaaatct
     4021 ttgaatagga gcctggaagc tcaagaagaa aatga
//
