LOCUS       NM_008480               9518 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus laminin, alpha 1 (Lama1), mRNA.
ACCESSION   NM_008480
VERSION     NM_008480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9518)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 9518)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9518)
  AUTHORS   Liu,Y., Tan,D., Ma,K., Luo,H., Mao,J., Luo,J., Shen,Q., Xu,L.,
            Yang,S., Ge,L., Guo,Y., Zhang,H. and Xiong,H.
  TITLE     Lama1 upregulation prolongs the lifespan of the dyH/dyH mouse model
            of LAMA2-related congenital muscular dystrophy
  JOURNAL   J Genet Genomics 51 (10), 1066-1078 (2024)
   PUBMED   38777118
  REMARK    GeneRIF: Lama1 upregulation prolongs the lifespan of the
            dy[H]/dy[H] mouse model of LAMA2-related congenital muscular
            dystrophy.
REFERENCE   4  (bases 1 to 9518)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9518)
  AUTHORS   Schevenels,G., Cabochette,P., America,M., Vandenborne,A., De
            Grande,L., Guenther,S., He,L., Dieu,M., Christou,B., Vermeersch,M.,
            Germano,R.F.V., Perez-Morga,D., Renard,P., Martin,M.,
            Vanlandewijck,M., Betsholtz,C. and Vanhollebeke,B.
  TITLE     A brain-specific angiogenic mechanism enabled by tip cell
            specialization
  JOURNAL   Nature 628 (8009), 863-871 (2024)
   PUBMED   38570687
REFERENCE   6  (bases 1 to 9518)
  AUTHORS   Schuger,L., Varani,J., Killen,P.D., Skubitz,A.P. and Gilbride,K.
  TITLE     Laminin expression in the mouse lung increases with development and
            stimulates spontaneous organotypic rearrangement of mixed lung
            cells
  JOURNAL   Dev Dyn 195 (1), 43-54 (1992)
   PUBMED   1292752
REFERENCE   7  (bases 1 to 9518)
  AUTHORS   Dong,L.J. and Chung,A.E.
  TITLE     The expression of the genes for entactin, laminin A, laminin B1 and
            laminin B2 in murine lens morphogenesis and eye development
  JOURNAL   Differentiation 48 (3), 157-172 (1991)
   PUBMED   1725162
REFERENCE   8  (bases 1 to 9518)
  AUTHORS   Aeschlimann,D. and Paulsson,M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   9  (bases 1 to 9518)
  AUTHORS   Schuger,L., Skubitz,A.P., O'Shea,K.S., Chang,J.F. and Varani,J.
  TITLE     Identification of laminin domains involved in branching
            morphogenesis: effects of anti-laminin monoclonal antibodies on
            mouse embryonic lung development
  JOURNAL   Dev Biol 146 (2), 531-541 (1991)
   PUBMED   1907584
REFERENCE   10 (bases 1 to 9518)
  AUTHORS   Klein,G., Ekblom,M., Fecker,L., Timpl,R. and Ekblom,P.
  TITLE     Differential expression of laminin A and B chains during
            development of embryonic mouse organs
  JOURNAL   Development 110 (3), 823-837 (1990)
   PUBMED   2088723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051116.1, CA535780.1, CN535171.1, AC154823.2, J04064.1 and
            CN461817.1.
            
            On Nov 1, 2006 this sequence version replaced NM_008480.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2035              AK051116.1         2-2036
            2036-2336           CA535780.1         283-583
            2337-2655           CN535171.1         147-465
            2656-2792           AC154823.2         98120-98256
            2793-2924           CN535171.1         601-732
            2925-3080           AC154823.2         100825-100980
            3081-3325           J04064.1           3059-3303
            3326-3454           AC154823.2         102903-103031
            3455-3598           AC154823.2         104371-104514
            3599-3778           AC154823.2         106077-106256
            3779-3964           AC154823.2         107102-107287
            3965-4092           AC154823.2         107879-108006
            4093-5463           J04064.1           4071-5441
            5464-5959           J04064.1           5445-5940
            5960-6610           CN461817.1         90-740
            6611-9518           J04064.1           6592-9499
FEATURES             Location/Qualifiers
     source          1..9518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 38.8 cM"
     gene            1..9518
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /note="laminin, alpha 1"
                     /db_xref="GeneID:16772"
                     /db_xref="MGI:MGI:99892"
     exon            1..152
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..9322
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /note="laminin subunit alpha-1; S-LAM alpha; laminin A
                     chain; S-laminin subunit alpha; laminin-1 subunit alpha;
                     laminin-3 subunit alpha"
                     /codon_start=1
                     /product="laminin subunit alpha-1 precursor"
                     /protein_id="NP_032506.2"
                     /db_xref="CCDS:CCDS37681.1"
                     /db_xref="GeneID:16772"
                     /db_xref="MGI:MGI:99892"
                     /translation="MRGSGTGAALLVLLASVLWVTVRSQQRGLFPAILNLATNAHISA
                     NATCGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPISHAIDGTNNWWQS
                     PSIQNGREYHWVTVTLDLRQVFQVAYIIIKAANAPRPGNWILERSVDGVKFKPWQYYA
                     VSDTECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSADDP
                     SPQLLEFTSARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGM
                     CICYGHASSCPWDEEAKQLQCQCEHNTCGESCDRCCPGYHQQPWRPGTISSGNECEEC
                     NCHNKAKDCYYDSSVAKERRSLNTAGQYSGGGVCVNCSQNTTGINCETCIDQYYRPHK
                     VSPYDDHPCRPCNCDPVGSLSSVCIKDDRHADLANGKWPGQCPCRKGYAGDKCDRCQF
                     GYRGFPNCIPCDCRTVGSLNEDPCIEPCLCKKNVEGKNCDRCKPGFYNLKERNPEGCS
                     ECFCFGVSGVCDSLTWSISQVTNMSGWLVTDLMSTNKIRSQQDVLGGHRQISINNTAV
                     MQRLTSTYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSDLMSHADIIIKGNGL
                     TISTRAEGLSLQPYEEYFNVVRLVPENFRDFDTRREIDRDQLMTVLANVTHLLIRANY
                     NSAKMALYRLDSVSLDIASPNAIDLAVAADVEHCECPQGYTGTSCEACLPGYYRVDGI
                     LFGGICQPCECHGHASECDIHGICSVCTHNTTGDHCEQCLPGFYGTPSRGTPGDCQPC
                     ACPLSIDSNNFSPTCHLTDGEEVVCDQCAPGYSGSWCERCADGYYGNPTVPGGTCVPC
                     NCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCRACDCHEN
                     GSLSGICHLETGLCDCKPHVTGQQCDQCLSGYYGLDTGLGCVPCNCSVEGSVSDNCTE
                     EGQCHCGPGVSGKQCDRCSHGFYAFQDGGCTPCDCAHTQNNCDPASGECLCPPHTQGL
                     KCEECEEAYWGLDPEQGCQACNCSAVGSTSAQCDVLSGHCPCKKGFGGQSCHQCSLGY
                     RSFPDCVPCGCDLRGTLPDTCDLEQGLCSCSEDGGTCSCKENAVGPQCSKCQAGTFAL
                     RGDNPQGCSPCFCFGLSQLCSELEGYVRTLITLASDQPLLHVVSQSNLKGTIEGVHFQ
                     PPDTLLDAEAVRQHIYAEPFYWRLPKQFQGDQLLAYGGKLQYSVAFYSTLGTGTSNYE
                     PQVLIKGGRARKHVIYMDAPAPENGVRQDYEVRMKEEFWKYFNSVSEKHVTHSDFMSV
                     LSNIDYILIKASYGQGLQQSRIANISMEVGRKAVELPAEGEAALLLELCVCPPGTAGH
                     SCQDCAPGYYREKLPESGGRGPRPLLAPCVPCNCNNHSDVCDPETGKCLSCRDHTSGD
                     HCELCASGYYGKVTGLPGDCTPCTCPHHPPFSFSPTCVVEGDSDFRCNACLPGYEGQY
                     CERCSAGYHGNPRAAGGSCQTCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEKCLPR
                     HILMESDCVSCDDDCVGPLLNDLDSVGDAVLSLNLTGVSPAPYGILENLENTTKYFQR
                     YLIKENAKKIRAEIQLEGIAEQTENLQKELTRVLARHQKVNAEMERTSNGTQALATFI
                     EQLHANIKEITEKVATLNQTARKDFQPPVSALQSMHQNISSLLGLIKERNFTEMQQNA
                     TLELKAAKDLLSRIQKRFQKPQEKLKALKEANSLLSNHSEKLQAAEELLKEAGSKTQE
                     SNLLLLLVKANLKEFQEKKLRVQEEQNVTSELIAKGREWVDAAGTHTAAAQDTLTQLE
                     HHRDELLLWARKIRSHVDDLVMQMSKRRARDLVHRAEQHASELQSRAGALDRDLENVR
                     NVSLNATSAAHVHSNIQTLTEEAEMLAADAHKTANKTDLISESLASRGKAVLQRSSRF
                     LKESVSTRRKQQGITMKLDELKNLTSQFQESMDNIMKQANDSLAMLRESPGGMREKGR
                     KARELAAAANESAVKTLEDVLALSLRVFNTSEDLSRVNATVQETNDLLHNSTMTTLLA
                     GRKMKDMEMQANLLLDRLKPLKTLEENLSRNLSEIKLLISRARKQVASIKVAVSADRD
                     CIRAYQPQTSSTNYNTLILNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKVAFLWDLG
                     SGSTRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASAAENPPVRTSKSPGPSKVLD
                     INNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFG
                     SSQNEDSSFHFDGSGYAMVEKTLRPTVTQIVILFSTFSPNGLLFYLASNGTKDFLSIE
                     LVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETK
                     QGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRN
                     SYGVRKGCALEPIQSVSFLRGGYVEMPPKSLSPESSLLATFATKNSSGILLVALGKDA
                     EEAGGAQAHVPFFSIMLLEGRIEVHVNSGDGTSLRKALLHAPTGSYSDGQEHSISLVR
                     NRRVITIQVDENSPVEMKLGPLTEGKTIDISNLYIGGLPEDKATPMLKMRTSFHGCIK
                     NVVLDAQLLDFTHATGSEQVELDTCLLAEEPMQSLHREHGELPPEPPTLPQPELCAVD
                     TAPGYVAGAHQFGLSQNSHLVLPLNQSDVRKRLQVQLSIRTFASSGLIYYVAHQNQMD
                     YATLQLQEGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTEYIKRKAFMTVDGQESPS
                     VTVVGNATTLDVERKLYLGGLPSHYRARNIGTITHSIPACIGEIMVNGQQLDKDRPLS
                     ASAVDRCYVVAQEGTFFEGSGYAALVKEGYKVRLDLNITLEFRTTSKNGVLLGISSAK
                     VDAIGLEIVDGKVLFHVNNGAGRITATYQPRAARALCDGKWHTLQAHKSKHRIVLTVD
                     GNSVRAESPHTHSTSADTNDPIYVGGYPAHIKQNCLSSRASFRGCVRNLRLSRGSQVQ
                     SLDLSRAFDLQGVFPHSCPGPEP"
     exon            153..323
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            324..436
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            437..679
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            680..859
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            860..949
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1067
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1246
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1352
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1513
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1654
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1828
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1930
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2142
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2254
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2365
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2493
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2580
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2792
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2899
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3080
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3217
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3454
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3598
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3778
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3964
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4092
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4093..4213
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4351
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4473
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4560
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4754
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4897
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..4987
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            4988..5099
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5100..5262
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5470
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5587
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..5751
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5752..5887
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5888..5981
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            5982..6098
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6099..6281
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6282..6436
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6437..6580
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6581..6714
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..6865
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6866..6990
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            6991..7141
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7142..7286
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7287..7428
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7429..7543
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7544..7714
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7715..7866
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            7867..8052
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8053..8188
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8189..8301
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8302..8491
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8492..8650
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8651..8804
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8805..8938
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            8939..9161
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     exon            9162..9518
                     /gene="Lama1"
                     /gene_synonym="Lama"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9494..9499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lama1"
                     /gene_synonym="Lama"
ORIGIN      
        1 actcgcgcag tgcctgtgag cgagcacggg cgagaccttc cccaggagcg cagggagcgg
       61 cggcgacaac atgcgcggca gcggcacggg agccgcgctc ctggtgctcc tggcctcggt
      121 gctctgggtc accgtgcgga gccagcagag aggcttgttc cctgccattc tcaacctggc
      181 caccaatgcc cacatcagcg ccaatgctac ctgtggagag aaggggcctg agatgttctg
      241 caaactcgtg gagcacgtgc cgggccggcc tgttcgacac gcccaatgcc gggtctgtga
      301 cggtaacagt acgaatccta gagagcgcca tccgatatca cacgcaatcg atggcaccaa
      361 caactggtgg cagagcccca gtattcagaa tgggagagag tatcactggg tcactgtcac
      421 cctggactta cggcaggtct ttcaagttgc atacatcatc attaaagctg ccaatgcccc
      481 tcggcctgga aactggattt tggagcgctc cgtggatggc gtcaagttca aaccctggca
      541 gtactatgcc gtcagcgata cagagtgttt gacccgctac aaaataactc cacggcgggg
      601 acctcccact tacagagcag acaacgaagt catctgcacc tcgtattatt caaagctggt
      661 gccacttgaa catggagaga ttcacacatc actcatcaat ggcagaccca gcgctgacga
      721 cccctcaccc cagttgctgg aattcacctc agcacggtac attcgccttc gtctgcagcg
      781 catcagaaca ctcaacgcag acctcatgac ccttagccat cgggacctca gagaccttga
      841 ccccattgtc acaagacgtt attactattc gataaaagac atttccgttg gaggcatgtg
      901 catttgctac ggccatgcca gcagctgccc gtgggatgaa gaagcaaagc aactacagtg
      961 tcagtgtgaa cacaatacgt gtggcgagag ctgcgacagg tgctgtcctg gctaccatca
     1021 gcagccctgg aggcccggaa ccatttcctc cggcaacgag tgtgaggaat gcaactgtca
     1081 caacaaagcc aaagattgtt actatgacag cagtgttgca aaggagagga gaagcctgaa
     1141 cactgccggg cagtacagtg gaggaggggt ttgtgtcaac tgctcgcaga ataccacagg
     1201 gatcaactgt gaaacctgta tcgaccagta ttacagacct cacaaggtat ctccttatga
     1261 tgaccaccct tgccgtccct gtaactgtga ccctgtgggg tctctgagtt ctgtctgtat
     1321 caaggatgac cgccatgccg atttagccaa tggaaagtgg ccaggtcagt gtccatgtag
     1381 gaaaggttat gctggagata aatgtgaccg ctgccagttt ggctaccggg gtttcccaaa
     1441 ttgcatcccc tgtgactgca ggactgtcgg cagcctgaat gaggatccat gcatagagcc
     1501 gtgtctttgt aagaaaaatg ttgagggtaa gaactgtgat cgctgcaagc caggattcta
     1561 caacttgaag gaacgaaacc ccgagggctg ctccgagtgc ttctgcttcg gtgtctctgg
     1621 tgtctgtgac agcctcacgt ggtccattag tcaggtgacc aatatgtcag ggtggctggt
     1681 cactgacttg atgagcacaa ataagatccg gtcccagcaa gatgtcctgg gtgggcaccg
     1741 tcagatcagc atcaacaaca cggcggtcat gcagaggctg acttccactt actactgggc
     1801 agctcctgag gcctacctcg gaaacaagct gacagcattt ggcggtttcc tgaaatacac
     1861 tgtgtcttac gacattccag tggagacggt ggacagtgac ctcatgtctc atgctgacat
     1921 catcatcaag gggaatgggc tcaccataag cacaagagct gagggcctgt ccttgcaacc
     1981 ctatgaggaa tacttcaacg tggttagact tgtgcctgag aacttccggg actttgatac
     2041 cagaagggag attgaccgtg accagctgat gactgtcctg gccaatgtga cacatctctt
     2101 gatcagagcc aattataatt ctgctaaaat ggcgctctat aggctggatt ctgtctctct
     2161 ggacatagca agccctaatg ctatagactt ggcagtggct gctgatgtgg aacactgtga
     2221 atgtccccaa ggctacacgg ggacctcctg tgaggcctgc ctccctggct attatcgagt
     2281 agacgggata ctctttggag gaatctgtca gccctgcgag tgccacgggc atgcatccga
     2341 gtgtgacatt catggaattt gctctgtgtg tacacacaac accacggggg atcactgtga
     2401 gcagtgcctg cctggcttct atgggacacc ttcacgtggg accccaggag actgccagcc
     2461 ttgtgcctgc cctctctcca ttgactctaa caatttcagc cctacctgcc acctcactga
     2521 tggagaggaa gtggtttgtg accagtgtgc cccgggttac tcaggatcct ggtgtgagag
     2581 atgtgcagat ggttactatg gaaacccaac cgtgccaggg ggaacctgtg taccatgcaa
     2641 ctgcagtggc aatgttgatc ccttggaggc tggccactgt gactctgtca caggggaatg
     2701 cctgaagtgc ttatggaaca cagacggtgc ccattgtgag aggtgtgcag atggcttcta
     2761 tggagatgcc gtgactgcca aaaactgccg agcctgtgac tgccacgaga atggctccct
     2821 ttctggcatc tgccatctgg agactggact gtgtgactgc aaacctcacg tgacaggaca
     2881 gcagtgtgac cagtgcctgt ctggctacta cgggttggac acggggcttg gctgtgtgcc
     2941 ctgtaactgc agtgtggaag gctctgtatc tgacaactgc acggaggaag gacagtgtca
     3001 ctgtggacca ggtgtctctg ggaaacagtg tgacaggtgt tcacacggtt tctatgcatt
     3061 ccaggatggc ggctgcacac cctgtgactg tgctcatacc cagaataact gtgaccccgc
     3121 ctctggagag tgtctctgcc cgcctcacac gcaggggctg aagtgtgagg agtgtgaaga
     3181 ggcatactgg ggtctggacc cggagcaggg gtgccaggct tgcaattgca gtgctgtggg
     3241 ctccacgagt gcccagtgtg atgttctctc tggccactgc ccctgcaaaa aagggtttgg
     3301 tgggcagagc tgccatcagt gttccctagg ctacagaagt tttcctgact gtgtcccctg
     3361 tggctgtgac ctgaggggga cactgcctga cacctgcgac ctggaacagg gtctctgcag
     3421 ctgctcagag gacggtggta cctgctcctg caaggagaat gccgtgggcc cccagtgcag
     3481 taagtgccaa gccggcacct ttgccttgcg aggggacaac cctcaaggct gcagcccctg
     3541 cttctgcttc ggtctgtcgc agctctgctc agagttggag ggttacgtga ggactctgat
     3601 aactctagcc tccgatcagc ccctcctgca tgtggtttca cagagcaacc tcaagggcac
     3661 aatcgaaggc gtgcatttcc agcctcctga caccttgctg gacgcagagg ctgtccgcca
     3721 gcatatctat gcagagccat tttactggcg gctaccaaag cagttccagg gagaccagct
     3781 cttggcttat ggtgggaaac tccagtacag tgtggctttc tactctacac ttggcaccgg
     3841 aacatccaat tatgagcctc aagtcctcat caaaggaggt cgggccagga agcacgtcat
     3901 ttatatggat gccccagcgc ctgagaatgg agtgagacag gattacgaag tgcggatgaa
     3961 agaggaattc tggaaatatt ttaactccgt gtctgagaaa catgtcacac actctgattt
     4021 tatgtctgtt ctcagcaata ttgactacat cctcatcaaa gcatcatacg gccagggact
     4081 gcagcagagc agaattgcca acatttccat ggaggttggc cggaaagctg tcgagctgcc
     4141 cgctgagggc gaggcggcat tgctgttgga gctctgtgtc tgtcctcctg gcaccgcagg
     4201 acactcctgt caggactgtg ctcctgggta ctacagagaa aagctcccag aaagtggtgg
     4261 caggggaccc cgccctctgc tggctccttg tgtgccctgc aattgcaaca accacagtga
     4321 tgtctgtgac cccgaaactg gaaagtgcct gagctgcagg gaccacacat ccggggacca
     4381 ctgtgagctg tgtgcttctg gctactatgg gaaggtgact ggactgcctg gagactgtac
     4441 cccgtgcacc tgtcctcatc accctccttt cagtttcagc cccacttgtg tcgtggaagg
     4501 tgacagtgat ttccggtgca atgcctgcct ccccggctat gaaggacagt actgtgaaag
     4561 gtgctctgca ggctatcacg gcaaccctcg agcagcaggt ggtagctgcc aaacgtgtga
     4621 ttgcaacccc caaggctctg tccacagtga ctgtgaccgt gcatccgggc agtgtgtctg
     4681 caagccagga gctacagggc tccactgtga gaaatgcctg ccgagacaca tcctgatgga
     4741 gagcgactgt gtttcctgtg atgatgactg tgtgggtcct ttgctgaacg acctggattc
     4801 tgttggtgat gccgttctgt ctctgaacct cacgggcgtt tcccctgctc cctatggaat
     4861 cctggaaaat ctggaaaata caactaaata tttccagagg tatttaataa aggaaaatgc
     4921 caagaagatt cgagcagaga tccagctcga agggattgca gagcaaacag aaaatctgca
     4981 aaaggagctc accagagtgt tagcacgcca tcagaaggtg aacgctgaaa tggaaagaac
     5041 ttccaatggg actcaagccc tggccacgtt cattgagcag ctacatgcaa acatcaaaga
     5101 aatcacagaa aaggtggcaa cgttgaacca gacggcgcgt aaagatttcc agccacccgt
     5161 gtctgccctt cagagcatgc accagaacat ttcgtctctg ctgggactca tcaaggaaag
     5221 gaatttcaca gagatgcagc agaatgctac ccttgagctc aaggctgcta aagacttatt
     5281 gtcacggatt cagaaaaggt ttcagaagcc tcaggaaaag ttgaaggcat tgaaggaggc
     5341 caacagcctc ctttccaacc acagtgaaaa actgcaggct gctgaggagc tccttaagga
     5401 agctggaagc aagacccagg agagcaacct cctgctgctc cttgtcaagg ccaacctgaa
     5461 agaattccag gagaaaaagc tgcgtgttca agaagaacaa aatgtgacct cagagctcat
     5521 tgccaagggt agagaatggg tggatgctgc cgggactcac acagctgctg cacaagacac
     5581 cctaacacag ctggagcatc accgagatga actccttctg tgggccagaa aaatcaggag
     5641 ccacgtagat gacctcgtca tgcagatgtc caaacgaaga gcccgtgacc tggtccacag
     5701 ggcagagcag catgcctctg agctgcagag cagggcagga gctttggaca gagaccttga
     5761 aaatgttaga aacgtgtctt tgaatgccac cagtgcggca cacgtccaca gcaacatcca
     5821 gacactgaca gaggaagctg agatgctggc tgctgatgct cacaagacgg cgaataagac
     5881 agacttgatc tccgaatccc tggcttctcg ggggaaagca gtccttcagc gctcgtcccg
     5941 gtttctaaag gaaagtgtca gtaccaggag gaagcagcaa ggcattacga tgaagctgga
     6001 tgagttgaaa aacttaacaa gtcaatttca ggagagcatg gataacatta tgaagcaggc
     6061 caacgactcc cttgcgatgc ttagagaaag ccctggaggt atgagagaga agggcaggaa
     6121 agccagagag ctggcggcag cagccaacga gagtgcggtg aagacactgg aggatgtgct
     6181 ggctttgagc ctgagggtct tcaatacatc agaggacctg tccagagtga atgccacagt
     6241 ccaggagaca aacgaccttc tgcataactc cacgatgacc actctgttgg ctggaagaaa
     6301 aatgaaagac atggaaatgc aagccaacct tttattggat cgattgaaac ctttgaaaac
     6361 cctggaggag aacctgagca gaaacctgtc ggagatcaag ctgctgatca gccgggcccg
     6421 gaaacaagtg gcgtcgatca aagtcgccgt gtctgcagac agagactgca tccgcgccta
     6481 tcagcctcag acttcatcta ccaattacaa caccttgatc ctgaacgtga agacgcagga
     6541 gcccgacaac ctcctcttct acctcggcag cagcagcagt tctgactttc tcgcagtgga
     6601 gatgcggcgg gggaaggtcg cctttctctg ggacctgggc tccgggtcca caaggttgga
     6661 attcccagag gtctccatca ataacaacag atggcacagc atctacataa ccaggtttgg
     6721 aaacatgggg tccctgagtg taaaggaagc aagcgctgcc gagaacccac cggtcaggac
     6781 aagcaaatct cctggaccgt cgaaggttct ggacataaac aattcaacgc tgatgtttgt
     6841 tggagggctc ggaggtcaga tcaagaaatc cccggctgtg aaggttactc attttaaggg
     6901 ctgcatggga gaggccttct tgaatggcaa atcgattggc ctgtggaatt acatcgagag
     6961 agaggggaag tgcaatggct gctttggaag ctcccagaac gaagattcct ccttccattt
     7021 cgatggaagc gggtacgcca tggtggagaa gacgctccgg cccaccgtga cgcagatagt
     7081 aattctcttc agcaccttct ccccgaatgg ccttcttttc tacctggctt caaacggcac
     7141 caaggacttc ctatccatcg agctggtccg tggcagggtc aaagtgatgg tggacctagg
     7201 gtcaggaccc ctcactctta tgacagacag gcggtataac aacggaacct ggtataaaat
     7261 cgccttccag cggaaccgga agcaaggact gctagctgtc ttcgatgcat atgacaccag
     7321 tgacaaggag acaaagcaag gagagactcc aggagccgct tccgacctca atcggctgga
     7381 gaaagacctg atttacgtgg gtggattgcc tcattctaag gctgtgagga aaggggtcag
     7441 cagcagaagc tatgtgggct gtatcaagaa cctagagata tccaggtcca cctttgattt
     7501 gctgagaaat tcctacggag tgagaaaagg ctgcgcactg gagcctatcc agagtgtgag
     7561 tttcctgaga ggcggctatg tggagatgcc acccaagtct ctctcacctg agtcatccct
     7621 gctggccaca ttcgccacca agaacagcag cggaatcctc ctggttgccc tgggcaagga
     7681 tgcggaggag gctggtgggg ctcaggcaca tgtgcccttc ttttccatca tgctgcttga
     7741 gggacgaatt gaagtgcatg tcaactctgg ggacgggacc agtctgagga aggccctcct
     7801 gcatgccccc accggctcct acagtgatgg acaggaacac tccatctccc tggttaggaa
     7861 tcggagagtt atcaccatac aagtggatga gaacagtccc gtagaaatga agttgggtcc
     7921 attaacagaa ggaaagacga tcgacatatc caacctgtac atagggggac ttccggagga
     7981 caaggcgacc ccgatgctca agatgcggac ttcgttccat gggtgtatta aaaacgtggt
     8041 ccttgacgct caacttttgg acttcaccca tgcgactggc tctgagcaag tagagctgga
     8101 cacatgcttg ctggcagaag agcccatgca gagtctgcac agagaacacg gggaactccc
     8161 tccggagccc ccaactctac cacagcctga actgtgcgca gtagacacgg ctccggggta
     8221 tgtggcaggt gctcaccagt ttggcctctc gcagaacagc cacttggtgc tccctctgaa
     8281 tcagtctgat gtccggaaga ggctccaggt gcagctgagc attcggacat ttgcctccag
     8341 tggcctcatt tactatgtgg ctcatcagaa ccaaatggac tacgccacgc tccagctcca
     8401 agagggccgc ctgcacttca tgtttgatct cggcaagggc cggaccaagg tctcccaccc
     8461 tgccctgctc agtgatggca agtggcacac agtcaagaca gaatacatta aaaggaaggc
     8521 gttcatgact gttgacggcc aagagtcccc cagtgtgact gtggtgggca atgcaaccac
     8581 gctggatgtg gaaaggaaac tgtacctcgg aggccttccc agccactaca gggccaggaa
     8641 catcgggact atcacccaca gcatccctgc ctgcattggg gaaatcatgg ttaatggcca
     8701 acagctggat aaagacaggc ccttgtctgc ctctgctgtg gacaggtgct atgtcgtggc
     8761 tcaggaagga actttctttg aaggaagcgg atatgcagct cttgtcaagg aaggttacaa
     8821 agttcgattg gatttaaata tcacactgga gttccgtact acctctaaga atggcgtcct
     8881 cctgggaatc agcagtgcca aagtggatgc cattggccta gagattgtag atggcaaggt
     8941 cttatttcac gtcaacaacg gtgccggaag gataacagcc acctaccagc ccagagccgc
     9001 cagagctctc tgtgatggca agtggcacac actccaagcc cacaaaagca agcaccgcat
     9061 cgtcctgact gtggacggga attccgttag ggctgaaagc ccccacaccc attccacctc
     9121 ggcagacacc aacgatccca tttatgtggg tggctatcct gcccacatca aacagaactg
     9181 cctgagcagc cgggcctcat tccggggctg tgtgaggaac ctcaggctga gcaggggctc
     9241 acaagtgcag tccttggacc tgagccgagc ctttgaccta caaggagtct tccctcattc
     9301 ctgccccggg cctgagccct aaactgtcgc cagcctctgc ccttggaatc atcgccaacg
     9361 catggaagag agcagtttgt gaactcaagc agctcagctc ccattcccat cccattgcca
     9421 tctcaggtta tgtttccaga ggaaaatgct gtatttatgt tgaactaaag ccacacggac
     9481 aacagatacc tctattaaat ggtttaaaac gtcagtgg
//
