LOCUS       NM_010679                733 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lactalbumin, alpha (Lalba), mRNA.
ACCESSION   NM_010679 XM_911937
VERSION     NM_010679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 733)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   2  (bases 1 to 733)
  AUTHORS   Ramakrishnan,B., Boeggeman,E. and Qasba,P.K.
  TITLE     Mutation of arginine 228 to lysine enhances the glucosyltransferase
            activity of bovine beta-1,4-galactosyltransferase I
  JOURNAL   Biochemistry 44 (9), 3202-3210 (2005)
   PUBMED   15736931
REFERENCE   3  (bases 1 to 733)
  AUTHORS   Baltzer,A., Svanborg,C. and Jaggi,R.
  TITLE     Apoptotic cell death in the lactating mammary gland is enhanced by
            a folding variant of alpha-lactalbumin
  JOURNAL   Cell Mol Life Sci 61 (10), 1221-1228 (2004)
   PUBMED   15141307
  REMARK    GeneRIF: a folding variant of alpha-lactalbumin has a role in
            lactating mammary gland apoptosis
REFERENCE   4  (bases 1 to 733)
  AUTHORS   Yamagishi,N., Ishihara,K., Saito,Y. and Hatayama,T.
  TITLE     Hsp105 but not Hsp70 family proteins suppress the aggregation of
            heat-denatured protein in the presence of ADP
  JOURNAL   FEBS Lett 555 (2), 390-396 (2003)
   PUBMED   14644449
REFERENCE   5  (bases 1 to 733)
  AUTHORS   Ramasamy,V., Ramakrishnan,B., Boeggeman,E. and Qasba,P.K.
  TITLE     The role of tryptophan 314 in the conformational changes of
            beta1,4-galactosyltransferase-I
  JOURNAL   J Mol Biol 331 (5), 1065-1076 (2003)
   PUBMED   12927542
REFERENCE   6  (bases 1 to 733)
  AUTHORS   Stacey,A., Schnieke,A., Kerr,M., Scott,A., McKee,C., Cottingham,I.,
            Binas,B., Wilde,C. and Colman,A.
  TITLE     Lactation is disrupted by alpha-lactalbumin deficiency and can be
            restored by human alpha-lactalbumin gene replacement in mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2835-2839 (1995)
   PUBMED   7708733
REFERENCE   7  (bases 1 to 733)
  AUTHORS   Stinnakre,M.G., Vilotte,J.L., Soulier,S. and Mercier,J.C.
  TITLE     Creation and phenotypic analysis of alpha-lactalbumin-deficient
            mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6544-6548 (1994)
   PUBMED   8022817
REFERENCE   8  (bases 1 to 733)
  AUTHORS   Stacey,A., Schnieke,A., McWhir,J., Cooper,J., Colman,A. and
            Melton,D.W.
  TITLE     Use of double-replacement gene targeting to replace the murine
            alpha-lactalbumin gene with its human counterpart in embryonic stem
            cells and mice
  JOURNAL   Mol Cell Biol 14 (2), 1009-1016 (1994)
   PUBMED   8289781
REFERENCE   9  (bases 1 to 733)
  AUTHORS   Vilotte,J.L. and Soulier,S.
  TITLE     Isolation and characterization of the mouse
            alpha-lactalbumin-encoding gene: interspecies comparison, tissue-
            and stage-specific expression
  JOURNAL   Gene 119 (2), 287-292 (1992)
   PUBMED   1398111
REFERENCE   10 (bases 1 to 733)
  AUTHORS   Vilotte,J.L., Soulier,S. and Mercier,J.C.
  TITLE     Sequence of the murine alpha-lactalbumin-encoding cDNA:
            interspecies comparison of the coding frame and deduced pre-protein
  JOURNAL   Gene 112 (2), 251-255 (1992)
   PUBMED   1555774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M80909.1.
            
            On Dec 7, 2005 this sequence version replaced XM_911937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069916.1, BC006922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.48 cM"
     gene            1..733
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /note="lactalbumin, alpha"
                     /db_xref="GeneID:16770"
                     /db_xref="MGI:MGI:96742"
     exon            1..148
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..444
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /EC_number="2.4.1.22"
                     /note="alpha-lactalbumin; lactose synthase B protein;
                     lysozyme g"
                     /codon_start=1
                     /product="alpha-lactalbumin precursor"
                     /protein_id="NP_034809.1"
                     /db_xref="CCDS:CCDS27795.1"
                     /db_xref="GeneID:16770"
                     /db_xref="MGI:MGI:96742"
                     /translation="MMHFVPLFLVCILSLPAFQATELTKCKVSHAIKDIDGYQGISLL
                     EWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCDKLLD
                     DELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQWRCEKP"
     exon            149..307
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /inference="alignment:Splign:2.1.0"
     exon            308..383
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /inference="alignment:Splign:2.1.0"
     exon            384..733
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      715..720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /note="hexamer: AATAAA"
     polyA_site      733
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagtca aaatgatgca tttcgttcct ttgttcctgg tgtgtatttt gtcgttgcct
       61 gcctttcaag ccacagagct tacaaaatgc aaggtgtccc atgccattaa agacatagat
      121 ggctatcaag gcatctcttt gcttgaatgg gcctgtgttt tatttcatac cagtggctac
      181 gacacacaag ctgttgtcaa cgacaacggc agcacagagt acggactctt ccagatcagt
      241 gacagatttt ggtgtaaaag tagtgagttc cccgagtcgg agaacatctg tggcatctcc
      301 tgtgacaagt tattggatga cgagttggat gatgacatag cgtgtgccaa gaagatcctg
      361 gctatcaaag gaatcgacta ctggaaagcc tacaagccca tgtgctctga gaagcttgaa
      421 cagtggcgtt gtgagaagcc ctgagccccc cccccccccc cccccgtcct tgctgctcct
      481 gccccgtggt caggaatgcc tcttccctaa ggctacctca gcttggctct tgctattcct
      541 gtgaagatga tctgcctctg agccttgtac cctgtagtga caccaccgga ctctagagga
      601 cttttttttc cctatgggag tgtgactggc gcactggact gcaaaccctt gcttagtgac
      661 ggcgagggtc tcgatggggg ttttacaaaa tcgagagagc cctctcctgt cccaaataaa
      721 gggccagact tga
//
