LOCUS       NP_034809                143 aa            linear   ROD 28-APR-2025
DEFINITION  alpha-lactalbumin precursor [Mus musculus].
ACCESSION   NP_034809 XP_917030
VERSION     NP_034809.1
DBSOURCE    REFSEQ: accession NM_010679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 143)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   2  (residues 1 to 143)
  AUTHORS   Ramakrishnan,B., Boeggeman,E. and Qasba,P.K.
  TITLE     Mutation of arginine 228 to lysine enhances the glucosyltransferase
            activity of bovine beta-1,4-galactosyltransferase I
  JOURNAL   Biochemistry 44 (9), 3202-3210 (2005)
   PUBMED   15736931
REFERENCE   3  (residues 1 to 143)
  AUTHORS   Baltzer,A., Svanborg,C. and Jaggi,R.
  TITLE     Apoptotic cell death in the lactating mammary gland is enhanced by
            a folding variant of alpha-lactalbumin
  JOURNAL   Cell Mol Life Sci 61 (10), 1221-1228 (2004)
   PUBMED   15141307
  REMARK    GeneRIF: a folding variant of alpha-lactalbumin has a role in
            lactating mammary gland apoptosis
REFERENCE   4  (residues 1 to 143)
  AUTHORS   Yamagishi,N., Ishihara,K., Saito,Y. and Hatayama,T.
  TITLE     Hsp105 but not Hsp70 family proteins suppress the aggregation of
            heat-denatured protein in the presence of ADP
  JOURNAL   FEBS Lett 555 (2), 390-396 (2003)
   PUBMED   14644449
REFERENCE   5  (residues 1 to 143)
  AUTHORS   Ramasamy,V., Ramakrishnan,B., Boeggeman,E. and Qasba,P.K.
  TITLE     The role of tryptophan 314 in the conformational changes of
            beta1,4-galactosyltransferase-I
  JOURNAL   J Mol Biol 331 (5), 1065-1076 (2003)
   PUBMED   12927542
REFERENCE   6  (residues 1 to 143)
  AUTHORS   Stacey,A., Schnieke,A., Kerr,M., Scott,A., McKee,C., Cottingham,I.,
            Binas,B., Wilde,C. and Colman,A.
  TITLE     Lactation is disrupted by alpha-lactalbumin deficiency and can be
            restored by human alpha-lactalbumin gene replacement in mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2835-2839 (1995)
   PUBMED   7708733
REFERENCE   7  (residues 1 to 143)
  AUTHORS   Stinnakre,M.G., Vilotte,J.L., Soulier,S. and Mercier,J.C.
  TITLE     Creation and phenotypic analysis of alpha-lactalbumin-deficient
            mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6544-6548 (1994)
   PUBMED   8022817
REFERENCE   8  (residues 1 to 143)
  AUTHORS   Stacey,A., Schnieke,A., McWhir,J., Cooper,J., Colman,A. and
            Melton,D.W.
  TITLE     Use of double-replacement gene targeting to replace the murine
            alpha-lactalbumin gene with its human counterpart in embryonic stem
            cells and mice
  JOURNAL   Mol Cell Biol 14 (2), 1009-1016 (1994)
   PUBMED   8289781
REFERENCE   9  (residues 1 to 143)
  AUTHORS   Vilotte,J.L. and Soulier,S.
  TITLE     Isolation and characterization of the mouse
            alpha-lactalbumin-encoding gene: interspecies comparison, tissue-
            and stage-specific expression
  JOURNAL   Gene 119 (2), 287-292 (1992)
   PUBMED   1398111
REFERENCE   10 (residues 1 to 143)
  AUTHORS   Vilotte,J.L., Soulier,S. and Mercier,J.C.
  TITLE     Sequence of the murine alpha-lactalbumin-encoding cDNA:
            interspecies comparison of the coding frame and deduced pre-protein
  JOURNAL   Gene 112 (2), 251-255 (1992)
   PUBMED   1555774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M80909.1.
            
            On Dec 7, 2005 this sequence version replaced XP_917030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069916.1, BC006922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Mus musculus"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.48 cM"
     Protein         1..143
                     /product="alpha-lactalbumin precursor"
                     /EC_number="2.4.1.22"
                     /note="alpha-lactalbumin; lactose synthase B protein;
                     lysozyme g"
                     /calculated_mol_wt=14000
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2278
     mat_peptide     21..143
                     /product="alpha-lactalbumin"
                     /calculated_mol_wt=14000
     Region          21..138
                     /region_name="Lys"
                     /note="C-type lysozyme/alpha-lactalbumin family;
                     pfam00062"
                     /db_xref="CDD:395016"
     Site            order(51..52,63..64,125..126,129..130,134,137..138)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:340384"
     Site            order(51..52,63..64,125..126,129..130,134,137..138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:340384"
     Site            65
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29752.1)"
     CDS             1..143
                     /gene="Lalba"
                     /gene_synonym="Lyzg"
                     /coded_by="NM_010679.1:13..444"
                     /db_xref="CCDS:CCDS27795.1"
                     /db_xref="GeneID:16770"
                     /db_xref="MGI:MGI:96742"
ORIGIN      
        1 mmhfvplflv cilslpafqa teltkckvsh aikdidgyqg isllewacvl fhtsgydtqa
       61 vvndngstey glfqisdrfw ckssefpese nicgiscdkl lddeldddia cakkilaikg
      121 idywkaykpm csekleqwrc ekp
//
