LOCUS       NM_001113474            3512 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus leukocyte-associated Ig-like receptor 1 (Lair1),
            transcript variant a, mRNA.
ACCESSION   NM_001113474
VERSION     NM_001113474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3512)
  AUTHORS   Carvalheiro,T., Marut,W., Pascoal Ramos,M.I., Garcia,S., Fleury,D.,
            Affandi,A.J., Meijers,A.S., Giovannone,B., Tieland,R.G., Elshof,E.,
            Ottria,A., Cossu,M., Meizlish,M.L., Veenendaal,T., Ramanujam,M.,
            Moreno-Garcia,M.E., Klumperman,J., Liv,N., Radstake,T.R.D.J. and
            Meyaard,L.
  TITLE     Impaired LAIR-1-mediated immune control due to collagen degradation
            in fibrosis
  JOURNAL   J Autoimmun 146, 103219 (2024)
   PUBMED   38696927
  REMARK    GeneRIF: Impaired LAIR-1-mediated immune control due to collagen
            degradation in fibrosis.
REFERENCE   2  (bases 1 to 3512)
  AUTHORS   Carroll,K.R., Mizrachi,M., Simmons,S., Toz,B., Kowal,C.,
            Wingard,J., Tehrani,N., Zarfeshani,A., Kello,N., El Khoury,L.,
            Weissman-Tsukamoto,R., Levin,J.Z., Volpe,B.T. and Diamond,B.
  TITLE     Lupus autoantibodies initiate neuroinflammation sustained by
            continuous HMGB1:RAGE signaling and reversed by increased LAIR-1
            expression
  JOURNAL   Nat Immunol 25 (4), 671-681 (2024)
   PUBMED   38448779
  REMARK    GeneRIF: Lupus autoantibodies initiate neuroinflammation sustained
            by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1
            expression.
REFERENCE   3  (bases 1 to 3512)
  AUTHORS   Bunting,M.D., Vyas,M., Requesens,M., Langenbucher,A.,
            Schiferle,E.B., Manguso,R.T., Lawrence,M.S. and Demehri,S.
  TITLE     Extracellular matrix proteins regulate NK cell function in
            peripheral tissues
  JOURNAL   Sci Adv 8 (11), eabk3327 (2022)
   PUBMED   35294229
REFERENCE   4  (bases 1 to 3512)
  AUTHORS   Myers,L.K., Winstead,M., Kee,J.D., Park,J.J., Zhang,S., Li,W.,
            Yi,A.K., Stuart,J.M., Rosloniec,E.F., Brand,D.D., Tuckey,R.C.,
            Slominski,A.T., Postlethwaite,A.E. and Kang,A.H.
  TITLE     1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1
            and Attenuate Collagen Induced Arthritis
  JOURNAL   Int J Mol Sci 22 (24), 13342 (2021)
   PUBMED   34948139
  REMARK    GeneRIF: 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3
            Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3512)
  AUTHORS   Keerthivasan,S., Senbabaoglu,Y., Martinez-Martin,N., Husain,B.,
            Verschueren,E., Wong,A., Yang,Y.A., Sun,Y., Pham,V., Hinkle,T.,
            Oei,Y., Madireddi,S., Corpuz,R., Tam,L., Carlisle,S.,
            Roose-Girma,M., Modrusan,Z., Ye,Z., Koerber,J.T. and Turley,S.J.
  TITLE     Homeostatic functions of monocytes and interstitial lung
            macrophages are regulated via collagen domain-binding receptor
            LAIR1
  JOURNAL   Immunity 54 (7), 1511-1526 (2021)
   PUBMED   34260887
REFERENCE   6  (bases 1 to 3512)
  AUTHORS   Lebbink,R.J., de Ruiter,T., Adelmeijer,J., Brenkman,A.B., van
            Helvoort,J.M., Koch,M., Farndale,R.W., Lisman,T., Sonnenberg,A.,
            Lenting,P.J. and Meyaard,L.
  TITLE     Collagens are functional, high affinity ligands for the inhibitory
            immune receptor LAIR-1
  JOURNAL   J Exp Med 203 (6), 1419-1425 (2006)
   PUBMED   16754721
REFERENCE   7  (bases 1 to 3512)
  AUTHORS   Verbrugge,A., Rijkers,E.S., de Ruiter,T. and Meyaard,L.
  TITLE     Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing
            phosphatase-independent function and recruits C-terminal Src kinase
  JOURNAL   Eur J Immunol 36 (1), 190-198 (2006)
   PUBMED   16380958
REFERENCE   8  (bases 1 to 3512)
  AUTHORS   Lebbink,R.J., de Ruiter,T., Verbrugge,A., Bril,W.S. and Meyaard,L.
  TITLE     The mouse homologue of the leukocyte-associated Ig-like receptor-1
            is an inhibitory receptor that recruits Src homology region
            2-containing protein tyrosine phosphatase (SHP)-2, but not SHP-1
  JOURNAL   J Immunol 172 (9), 5535-5543 (2004)
   PUBMED   15100296
  REMARK    GeneRIF: Mouse Lair-1 cytoplasmic tail can become phosphorylated,
            thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2).
            Unlike human LAIR-1, SHP-1 is not recruited to the mouse Lair-1
            cytoplasmic tail.
REFERENCE   9  (bases 1 to 3512)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3512)
  AUTHORS   Kubagawa,H., Burrows,P.D. and Cooper,M.D.
  TITLE     A novel pair of immunoglobulin-like receptors expressed by B cells
            and myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 5261-5266 (1997)
   PUBMED   9144225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY284244.1, AK044465.1, AK050281.1, AK033472.1 and BY515495.1.
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044465.1, AK050281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY284244.1         3-32
            31-1873             AK044465.1         2-1844
            1874-2283           AK050281.1         1830-2239
            2284-3493           AK033472.1         1929-3138
            3494-3512           BY515495.1         393-411
FEATURES             Location/Qualifiers
     source          1..3512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.31 cM"
     gene            1..3512
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /note="leukocyte-associated Ig-like receptor 1"
                     /db_xref="GeneID:52855"
                     /db_xref="MGI:MGI:105492"
     exon            1..136
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..894
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /note="isoform a precursor is encoded by transcript
                     variant a; leukocyte-associated immunoglobulin-like
                     receptor 1"
                     /codon_start=1
                     /product="leukocyte-associated immunoglobulin-like
                     receptor 1 isoform a precursor"
                     /protein_id="NP_001106945.1"
                     /db_xref="CCDS:CCDS51969.1"
                     /db_xref="GeneID:52855"
                     /db_xref="MGI:MGI:105492"
                     /translation="MSLHPVILLVLVLCLGWKINTQEGSLPDITIFPNSSLMISQGTF
                     VTVVCSYSDKHDLYNMVRLEKDGSTFMEKSTEPYKTEDEFEIGPVNETITGHYSCIYS
                     KGITWSERSKTLELKVIKENVIQTPAPGPTSDTSWLKTYSIYIFTVVSVIFLLCLSAL
                     LFCFLRHRQKKQGLPNNKRQQQRPEERLNLATNGLEMTPDIVADDRLPEDRWTETWTP
                     VAGDLQEVTYIQLDHHSLTQRAVGAVTSQSTDMAESSTYAAIIRH"
     exon            137..172
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..502
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..619
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..662
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..700
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..750
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..3512
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /note="hexamer: AATATA"
     polyA_site      1488
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /note="major polyA site"
     regulatory      3471..3476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
                     /note="hexamer: AATAAA"
     polyA_site      3488
                     /gene="Lair1"
                     /gene_synonym="5133400O11Rik; D7Bwg0421e; Lair-1"
ORIGIN      
        1 tagaaacctt gtgacaagct ccagtgcaca catcctgcct cttgtgcctg ctgcagggct
       61 tctgctctga ccagacctgg taaggttgct ggagcctgag tcatgtcact tcatccagtt
      121 atcctgctgg tgcttgtgct gtgcctggga tggaaaatta acacacagga gggttctctg
      181 cctgatatta ccatcttccc taattcaagt cttatgatct cccaagggac ttttgtaact
      241 gttgtgtgct catactctga taaacacgac ttgtataaca tggtccgcct ggagaaggac
      301 ggcagcacct ttatggaaaa gagcactgag ccttataaaa cagaggatga atttgagatt
      361 gggccagtga atgaaaccat tactggacat tatagctgta tctattcgaa ggggattacc
      421 tggtccgaac gtagtaagac gctggagcta aaggtgatca aagaaaatgt catccagact
      481 cctgccccag gtccaacctc agatacatct tggctaaaga catacagcat ttacattttt
      541 actgtggtct ctgtgatttt cctcctttgt ctttccgccc ttctgttctg cttcctcagg
      601 caccgtcaga aaaagcaggg actcccaaac aacaaaagac agcagcagag gccagaagag
      661 aggctaaatc tagctactaa tggcctggag atgactccag acatagttgc agatgacagg
      721 cttcctgagg acagatggac agaaacctgg accccagttg caggagacct tcaagaggtg
      781 acgtatatcc agctggacca tcactccctc acacagaggg cagtcggagc tgtgacctca
      841 cagagcacag atatggctga gtccagcaca tatgcagcca tcatcagaca ctgagcctgg
      901 gcacacctgg agacacacat ggaaaagcct gaagaatcca ctagggcctt cttttgggat
      961 cagcctggtg tggaaagcta ggtccctgtt ccccatccag atgatgaatt gtatatgtgt
     1021 tagtatcatc acttaggaag actatattgc aataactttc agagccctag ttacacttac
     1081 ctagctattt ccagagacac agttatagct cttttagctg tttcttcaga cccatccacg
     1141 tcccatatta tttaatgaat agcactgtaa ttgtccagct gcctttacat ccccagttgt
     1201 gtaatgagcc cagtgaaccc taaaggcttc cttggatctc cctgctgact ctgactggga
     1261 tgtactcatg cagctgaagg ctgagtccct tctcagtgcc aggccttatg gagtgcatca
     1321 tgggtatttt tgaagatgga gcatctacag tccatgtggg tcttggaata cagactgtaa
     1381 ggactcaaac tctgttttca ttgttatcca aagatgagtg gagaaatgaa ggctacaaaa
     1441 gggtgcatat aattcccttt tctttaaaat atatgtttaa ttgaccaaga ttgtgcatac
     1501 tcaagtgtga actatcagaa ctcggtttga cattgtgtat gtagccatta tcacaaatac
     1561 tcaacacaac tgccactgga tgacttgaac atattcactg atgattgaac tttgggttgg
     1621 tgtttcttga tggtatgtgt tgatcaggat tggaagaaaa aggagcactg aaagggaaag
     1681 gcaggctgag ggtgggtaga gggaggtgtt ctatctgtgt acacctatac tcagtgatac
     1741 actgggagat acacagatat gaatacgcac acaaacatat gtacacaagt atattagtgc
     1801 acatggagtg gaagaacact gaatcactgt gagattatat ttgtcaatat ctctgctcca
     1861 taccccttac ctggagtcag attcagtgat cccataccca tgcacatata gtcagcacta
     1921 gttagactca gagacagatc agcaacaaca acagtggtaa cagtaataac ttcaaacagg
     1981 acataccagg acatggtggc acacaccttt aatcctgcta cttaggagac agaggcagat
     2041 ggtttttgtg agttctagac cagccttgtg tatgtatcat gttccaggcc agccagggct
     2101 gcacagtgag accctgtttc aaaaaatagc tgaaactacc ccaaaagaca tgaagtccag
     2161 catgagacaa atcctacaac ggtaggaccc aaagggagtt tggtagaggt attggagagg
     2221 gtcatttcca aacattgatt tttcactttt gtgaaaattt cagaaataaa tttaaaatat
     2281 tagttaaaaa agaaaaatac tcatatgaac ttacaaaaat tgaagcagca agcacaggct
     2341 ctgcacaggt ttgcaccagg ttctgtatat atattgtgac ttccagttta gttacttatg
     2401 gaactcttga gtgtgtgaac aaatggatct ctgattctct gtcttcttgt gggctccttt
     2461 tccttctgct ggtttgcctt atctgacttt gatgtggtgt tttttgttgt aacttattat
     2521 aagaagataa aagaaaagaa aaatacccag aggaccacta gggggaatga gagtgtctca
     2581 ttttgatggt caaaataaac atggctgcag aaaaaacaaa aacagaaaca aaaaacaaca
     2641 acaaaaaaac ccaaccaacc atcaccaaaa acaaagatcc cccaactccc aaacctgatt
     2701 gttaaaacaa tgctttccta aaaaatgccc agtaagaaat cctctcacaa ggagaaaatt
     2761 ggatggtgtc actctggtag gatacagaga ggcagactta ctgacatata cacatgaaga
     2821 cataaccagc atgggagaga tagcttgatg attaagagca ctggctactc ttgtagaagc
     2881 cctaggatca attatcagca cccaccttgt ggtgcacaat cacctctaac tccagctcta
     2941 gaggatttga cacatttttt tttaagaaac cattttattt ctatgtcctt tagtagtatt
     3001 taggtttccc atatatctct tgcatatcta gtctcaggtt catggtcctg tgtacagtgt
     3061 caggcatggg taccagttct ttgagtgcca attacatatt ggttggttag ttctagaagc
     3121 tttgtatcac tattgtacta gtccttcttg taggcaggta cattgtagat tcaaaggttt
     3181 gtaatcaggt tggtttttac ctttcttctt ttgtagtgtg cactgtacct catagtactc
     3241 tgaacacttg tccgtatggg tgaaggctac aggtcatctc ttgctcaact tctccatgtt
     3301 caatgaattt tgaaggtgtg gtgttctgaa ctaatacact gtagtcaatt tgtaaagagc
     3361 aactaatagc tttggaaaga gacttggtgg tttgggggtt cccatggcca acacatcaaa
     3421 tagatgtaac ccatttccag aatgggaggc agaaaactat atatgtaata aataaataaa
     3481 tctttaaaga aggaggagga gaaggaaagg tg
//
