LOCUS       NM_008479               2020 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus lymphocyte-activation gene 3 (Lag3), mRNA.
ACCESSION   NM_008479 XM_981508
VERSION     NM_008479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Mao,X., Gu,H., Kim,D., Kimura,Y., Wang,N., Xu,E., Kumbhar,R.,
            Ming,X., Wang,H., Chen,C., Zhang,S., Jia,C., Liu,Y., Bian,H.,
            Karuppagounder,S.S., Akkentli,F., Chen,Q., Jia,L., Hwang,H.,
            Lee,S.H., Ke,X., Chang,M., Li,A., Yang,J., Rastegar,C.,
            Sriparna,M., Ge,P., Brahmachari,S., Kim,S., Zhang,S., Shimoda,Y.,
            Saar,M., Liu,H., Kweon,S.H., Ying,M., Workman,C.J., Vignali,D.A.A.,
            Muller,U.C., Liu,C., Ko,H.S., Dawson,V.L. and Dawson,T.M.
  TITLE     Aplp1 interacts with Lag3 to facilitate transmission of pathologic
            alpha-synuclein
  JOURNAL   Nat Commun 15 (1), 4663 (2024)
   PUBMED   38821932
  REMARK    Erratum:[Nat Commun. 2024 Jul 30;15(1):6413. doi:
            10.1038/s41467-024-50640-2.. PMID: 39080298]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Zibigu,R., Abidan,A., Adilai,D., Li,Y., Kang,X., Yu,Q., Deng,B.,
            Zheng,X., Wang,M., Li,J., Wang,H. and Zhang,C.
  TITLE     [Effect of LAG3 deficiency on natural killer cell function and
            hepatic fibrosis in mice infected with Echinococcus multilocularis]
  JOURNAL   Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 36 (1), 59-66 (2024)
   PUBMED   38604686
  REMARK    GeneRIF: [Effect of LAG3 deficiency on natural killer cell function
            and hepatic fibrosis in mice infected with Echinococcus
            multilocularis].
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Chen,C., Kumbhar,R., Wang,H., Yang,X., Gadhave,K., Rastegar,C.,
            Kimura,Y., Behensky,A., Kotha,S., Kuo,G., Katakam,S., Jeong,D.,
            Wang,L., Wang,A., Chen,R., Zhang,S., Jin,L., Workman,C.J.,
            Vignali,D.A.A., Pletinkova,O., Jia,H., Peng,W., Nauen,D.W.,
            Wong,P.C., Redding-Ochoa,J., Troncoso,J.C., Ying,M., Dawson,V.L.,
            Dawson,T.M. and Mao,X.
  TITLE     Lymphocyte-Activation Gene 3 Facilitates Pathological Tau
            Neuron-to-Neuron Transmission
  JOURNAL   Adv Sci (Weinh) 11 (16), e2303775 (2024)
   PUBMED   38327094
  REMARK    GeneRIF: Lymphocyte-Activation Gene 3 Facilitates Pathological Tau
            Neuron-to-Neuron Transmission.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Silberstein,J.L., Du,J., Chan,K.W., Frank,J.A., Mathews,I.I.,
            Kim,Y.B., You,J., Lu,Q., Liu,J., Philips,E.A., Liu,P., Rao,E.,
            Fernandez,D., Rodriguez,G.E., Kong,X.P., Wang,J. and Cochran,J.R.
  TITLE     Structural insights reveal interplay between LAG-3
            homodimerization, ligand binding, and function
  JOURNAL   Proc Natl Acad Sci U S A 121 (12), e2310866121 (2024)
   PUBMED   38483996
  REMARK    GeneRIF: Structural insights reveal interplay between LAG-3
            homodimerization, ligand binding, and function.
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Zhang,Q., Duan,Q., Gao,Y., He,P., Huang,R., Huang,H., Li,Y., Ma,G.,
            Zhang,Y., Nie,K. and Wang,L.
  TITLE     Cerebral Microvascular Injury Induced by Lag3-Dependent
            alpha-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment
            in a Mouse Model of alpha-Synucleinopathies
  JOURNAL   Adv Sci (Weinh) 10 (25), e2301903 (2023)
   PUBMED   37381656
  REMARK    GeneRIF: Cerebral Microvascular Injury Induced by Lag3-Dependent
            alpha-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment
            in a Mouse Model of alpha-Synucleinopathies.
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Workman,C.J., Rice,D.S., Dugger,K.J., Kurschner,C. and Vignali,D.A.
  TITLE     Phenotypic analysis of the murine CD4-related glycoprotein, CD223
            (LAG-3)
  JOURNAL   Eur J Immunol 32 (8), 2255-2263 (2002)
   PUBMED   12209638
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Huard,B., Mastrangeli,R., Prigent,P., Bruniquel,D., Donini,S.,
            El-Tayar,N., Maigret,B., Dreano,M. and Triebel,F.
  TITLE     Characterization of the major histocompatibility complex class II
            binding site on LAG-3 protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (11), 5744-5749 (1997)
   PUBMED   9159144
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Mastrangeli,R., Micangeli,E. and Donini,S.
  TITLE     Cloning of murine LAG-3 by magnetic bead bound homologous probes
            and PCR (gene-capture PCR)
  JOURNAL   Anal Biochem 241 (1), 93-102 (1996)
   PUBMED   8921170
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Miyazaki,T., Dierich,A., Benoist,C. and Mathis,D.
  TITLE     LAG-3 is not responsible for selecting T helper cells in
            CD4-deficient mice
  JOURNAL   Int Immunol 8 (5), 725-729 (1996)
   PUBMED   8671660
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Miyazaki,T., Dierich,A., Benoist,C. and Mathis,D.
  TITLE     Independent modes of natural killing distinguished in mice lacking
            Lag3
  JOURNAL   Science 272 (5260), 405-408 (1996)
   PUBMED   8602528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142254.4, BC120591.1 and CO040235.1.
            
            On May 7, 2009 this sequence version replaced NM_008479.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98113.1, BC120591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC142254.4         22339-22622
            285-1956            BC120591.1         217-1888
            1957-2020           CO040235.1         1-64                c
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..2020
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /note="lymphocyte-activation gene 3"
                     /db_xref="GeneID:16768"
                     /db_xref="MGI:MGI:106588"
     exon            1..412
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1920
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /note="lymphocyte activation gene 3 protein; aida;
                     activation-induced cytidine deaminase-linked autoimmunity
                     protein"
                     /codon_start=1
                     /product="lymphocyte activation gene 3 protein precursor"
                     /protein_id="NP_032505.1"
                     /db_xref="CCDS:CCDS20536.1"
                     /db_xref="GeneID:16768"
                     /db_xref="MGI:MGI:106588"
                     /translation="MREDLLLGFLLLGLLWEAPVVSSGPGKELPVVWAQEGAPVHLPC
                     SLKSPNLDPNFLRRGGVIWQHQPDSGQPTPIPALDLHQGMPSPRQPAPGRYTVLSVAP
                     GGLRSGRQPLHPHVQLEERGLQRGDFSLWLRPALRTDAGEYHATVRLPNRALSCSLRL
                     RVGQASMIASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVPVYNSPRHFLAET
                     FLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVLGLEPVAPLTVYAAEGSRVELPC
                     HLPPGVGTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQ
                     QLNATVTLAVITVTPKSFGLPGSRGKLLCEVTPASGKERFVWRPLNNLSRSCPGPVLE
                     IQEARLLAERWQCQLYEGQRLLGATVYAAESSSGAHSARRISGDLKGGHLVLVLILGA
                     LSLFLLVAGAFGFHWWRKQLLLRRFSALEHGIQPFPAQRKIEELERELETEMGQEPEP
                     EPEPQLEPEPRQL"
     exon            413..560
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            561..853
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1117
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1393
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1630
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1761
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2003
                     /gene="Lag3"
                     /gene_synonym="CD223; LAG-3; Ly66"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcagtggg gaggagaagc agaaggactg ggtctggagg agcagctcaa gttctagcta
       61 gctgcagtgg gtttgcctgc actctgctct gggtcccagc ccgggcctct gatcattatc
      121 catcctgctg tctccagtcc ccactcctgg ggcgtcctct tcaccctaca ttctttccct
      181 ccgcctcacc tcctccttgt agaacttctc tctctctctc tctctctctc tctctctctc
      241 tctctctctc tctgtgtgtg tgtgtgtgtc tgtctgtctg tctgtctctc tctcctccca
      301 ggaccttttt ctaacctccc ttggagggct ggggaggccc gggccataga ggagatgagg
      361 gaggacctgc tccttggctt tttgcttctg ggactgcttt gggaagctcc agttgtgtct
      421 tcagggcctg ggaaagagct ccccgtggtg tgggcccagg agggagctcc cgtccatctt
      481 ccctgcagcc tcaaatcccc caacctggat cctaactttc tacgaagagg aggggttatc
      541 tggcaacatc aaccagacag tggccaaccc actcccatcc cggcccttga ccttcaccag
      601 gggatgccct cgcctagaca acccgcaccc ggtcgctaca cggtgctgag cgtggctcca
      661 ggaggcctgc gcagcgggag gcagcccctg catccccacg tgcagctgga ggagcgcggc
      721 ctccagcgcg gggacttctc tctgtggttg cgcccagctc tgcgcaccga tgcgggcgag
      781 taccacgcca ccgtgcgcct cccgaaccgc gccctctcct gcagtctccg cctgcgcgtc
      841 ggccaggcct cgatgattgc tagtccctca ggagtcctca agctgtctga ttgggtcctt
      901 ttgaactgct ccttcagccg tcctgaccgc ccagtctctg tgcactggtt ccagggccag
      961 aaccgagtgc ctgtctacaa ctcaccgcgt cattttttag ctgaaacttt cctgttactg
     1021 ccccaagtca gccccctgga ctctgggacc tggggctgtg tcctcaccta cagagatggc
     1081 ttcaatgtct ccatcacgta caacctcaag gttctgggtc tggagcccgt agcccctctg
     1141 acagtgtacg ctgctgaagg ttctagggtg gagctgccct gtcatttgcc cccaggagtg
     1201 gggacccctt ctttgctcat tgccaagtgg actcctcctg gaggaggtcc tgagctcccc
     1261 gtggctggaa agagtggcaa ttttaccctt caccttgagg ctgtgggtct ggcacaggct
     1321 gggacctaca cctgtagcat ccatctgcag ggacagcagc tcaatgccac tgtcacgttg
     1381 gcggtcatca cagtgactcc caaatccttc gggttacctg gctcccgggg gaagctgttg
     1441 tgtgaggtaa ccccggcatc tggaaaggaa agatttgtgt ggcgtcccct gaacaatctg
     1501 tccaggagtt gcccgggccc tgtgctggag attcaggagg ccaggctcct tgctgagcga
     1561 tggcagtgtc agctgtacga gggccagagg cttcttggag cgacagtgta cgccgcagag
     1621 tctagctcag gcgcccacag tgctaggaga atctcaggtg accttaaagg aggccatctc
     1681 gttctcgttc tcatccttgg tgccctctcc ctgttccttt tggtggccgg ggcctttggc
     1741 tttcactggt ggagaaaaca gttgctactg agaagatttt ctgccttaga acatgggatt
     1801 cagccatttc cggctcagag gaagatagag gagctggagc gagaactgga gacggagatg
     1861 ggacaggagc cggagcccga gccggagcca cagctggagc cagagcccag gcagctctga
     1921 cctggagccg aggcagccag caggtctcag cagctccgcc cgcccgcccg cccgcccgaa
     1981 taaactccct gtcagcagca tcaaaaaaaa aaaaaaaaaa
//
