LOCUS       NM_145381               2958 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus lactamase, beta 2 (Lactb2), transcript variant 1,
            mRNA.
ACCESSION   NM_145381
VERSION     NM_145381.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Sollars,V.E., McEntee,B.J., Engiles,J.B., Rothstein,J.L. and
            Buchberg,A.M.
  TITLE     A novel transgenic line of mice exhibiting autosomal recessive
            male-specific lethality and non-alcoholic fatty liver disease
  JOURNAL   Hum Mol Genet 11 (22), 2777-2786 (2002)
   PUBMED   12374767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116708.19.
            
            On Mar 7, 2023 this sequence version replaced NM_145381.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.751013.1,
                                           SRR13948564.3965762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC116708.19        48113-48309         c
            198-361             AC116708.19        38505-38668         c
            362-488             AC116708.19        35169-35295         c
            489-667             AC116708.19        26015-26193         c
            668-816             AC116708.19        17849-17997         c
            817-898             AC116708.19        15140-15221         c
            899-2958            AC116708.19        12629-14688         c
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.29 cM"
     gene            1..2958
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="lactamase, beta 2"
                     /db_xref="GeneID:212442"
                     /db_xref="MGI:MGI:2442551"
     exon            1..197
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..942
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-lactamase-like protein 2; endoribonuclease LACTB2"
                     /codon_start=1
                     /product="endoribonuclease LACTB2 isoform 1"
                     /protein_id="NP_663356.1"
                     /db_xref="CCDS:CCDS14823.1"
                     /db_xref="GeneID:212442"
                     /db_xref="MGI:MGI:2442551"
                     /translation="MAAALQRIEQLSSRVVRVLGCNPGPMTLQGTNTYLVGTGSRRIL
                     IDTGEPSVPEYISCLKQALVEFDTAIQEILVTHWHSDHSGGIVDICKNINNDTTYCIK
                     KLRRNPQREEIIGNGEQQFIYIENGDVVKTEGATLRVLYTPGHTDDHMALLLEEENAI
                     FSGDCILGEGTTIFEDLYDYMNSLNNLLKIKANIIYPGHGPVIHNAEAKILEYISHRN
                     NREEQIISLFRDNFEKSFTVTELRTMIYKDVPENLHKMAEHNLLLHLRKLEKDGKIFY
                     TTTPVKKWKAVL"
     exon            198..361
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..488
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..667
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..816
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..898
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..2958
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1027..1032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1051
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="major polyA site"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="hexamer: ATTATA"
     polyA_site      1782
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
                     /note="hexamer: AATATA"
     polyA_site      1874
                     /gene="Lactb2"
                     /gene_synonym="Cgi-83; E430032H21Rik"
ORIGIN      
        1 cctccgagcc tgaggtcgca gcacgctgag tgacttggaa ttcgggtgcc ggcggtcacc
       61 gaggtagata gagagatggc tgccgctctg cagcgcatcg agcagctgtc cagtcgggtg
      121 gtgcgcgtgt tgggctgcaa cccgggtccc atgaccctgc aaggcaccaa cacgtacctg
      181 gtggggaccg gcagcaggag aatcctcatt gacactggtg agccatcagt tccagaatat
      241 atcagctgtt taaagcaagc cttggttgag tttgacacag caatccagga aatcctggtg
      301 acacactggc attctgatca ttctggaggc attgtagaca tttgtaaaaa catcaataat
      361 gacaccacct actgcattaa aaaacttcga cggaatcccc agagagaaga aattatagga
      421 aatggagaac agcaatttat ttatatagaa aacggagacg tggttaagac cgagggagcc
      481 actctcagag ttttgtacac tcctggccac actgatgatc acatggcttt actcctggag
      541 gaggagaatg ccatcttttc tggggactgc atcctaggag aagggacgac aatatttgaa
      601 gacctctatg attatatgaa ctccctaaac aacttactaa aaatcaaagc taacattata
      661 tatccaggac atggcccagt catccataat gctgaagcta aaattctgga atatatttct
      721 catagaaata accgagaaga acagattatt tcattattcc gtgataactt tgagaaatca
      781 tttaccgtaa cggaacttag gacaatgatt tacaaggatg ttccagagaa tttacataag
      841 atggcagagc ataatctctt gcttcatttg agaaaactag agaaagatgg gaagatattc
      901 tacacaacaa ctcctgtcaa gaaatggaaa gccgtccttt agttacagat cagtgaagtt
      961 ctgtcttgtt ttgcttttag aagatggtat tttcttttag ctatagatta tatatttata
     1021 gaaaatatta aatgcacaac tttgaaaata acccttgata cttgtaatcc gtgataattg
     1081 taaaatatgt aaattacatt ttatatctgg aggacaggtt actgatctaa ccttggtctt
     1141 ggaaggtttt accagaaatt cagaatctag cactttttca attttctatg gattaagtaa
     1201 agtggttatt aagaataata gattttgaac aattcaaacc agttaatact ttagagtttg
     1261 attgttaggg tttctattgc tgtaaaaaac aaaaatgact aaggcagctc ttataaagga
     1321 agacatttaa ttagggctgg cttacagttc agagattcag tccagtatca tcatggtggg
     1381 aagtatggca gcctgcagac agacatggtg ctggaaaagg agctgagagt tctacatctt
     1441 gatctgaagg cagccagaac aagactgtct tctgcaggca gcctggagga ggctctccca
     1501 agcccacagc gacacacttc ctccaacaag gccatacctc ctaatagtgc cactccctat
     1561 gggccaagca ttcaaacaca tgagtctatg ggggccgttt ctattcaaac caccacagtt
     1621 atttgttagc atttgccagt aatactgctt tctttagcta cttcaatcaa cagcacacat
     1681 atctgcatac gcattccttt tcttcagccc tgtcaatgcc ttttacatac caagtttatt
     1741 tcacttttct atcaattata tcatttaagt attgtttcta cagttctatg ctatgtttat
     1801 tttcttgtaa cggtatccca taagcaattc ataagttgat cattaacaaa tactaaatat
     1861 actaatttaa aatattatgt gattaataat aagtaattct taaaatttta ttttatgtgt
     1921 atgaatattt tgcctacatg agtatctgtg cactccatgt gtgcagtgtg cacagaggcc
     1981 agaaggggca ctggattccc tggaactgca gttacaggtg ttagtcacca tgtgtgtcca
     2041 cagaatcaaa ctgggtcctc tagaagaaca gccattgctc agaactgctg agccatctca
     2101 tctctccagc ccacgacagc atgctttgca attttagatt ttagtataga aatggccatc
     2161 cgtttatata tgaattatat actagaaagt gttttctttt aattagaaga tggcaagata
     2221 gtcttttaaa tatataaata acattctcaa ataatggtta gaatagtggt actgcatagt
     2281 aatttcctcc aaattaaaac attccgtcct ggagggagac tcctaagact cgggaagtaa
     2341 atgaaactta atggggctca ggaaataaat aactcacaag tcttaaaaag tttctgaaac
     2401 ttaaataatt cagcaggtcc ctccccaagg ttatctcggc aatactgatt gctggagaga
     2461 agagacttta gcctcctgag ctgtctacag gtaatagagg agagctccag gaagatgcct
     2521 ttcctgaggc aacacctccc caccccaccc cacccgctga agtgggcttt tcagtgatgc
     2581 atttttatgc aagctaaaca catttttttc ttgttccatg taaatatgtc atatacccag
     2641 aagtgttcca tactacaaaa taactaaaaa ctcaagaatt aaaagccagt gacccagata
     2701 actcacaaat ggacaacaaa tgtttctcca aagaagatgc ctaagagaaa aactgtttct
     2761 cgggctagag agatggctcc gcggttgaga gcaatgactg ctcttccaga ggtcctgagt
     2821 tcaatttcca gcaaccacat ggtggctcac aaccatctgt aatgggatct gatgccctct
     2881 tctggtgtgt ctgaagagag caacaatgga ttcacataca taaattaaat aaataatctt
     2941 taaaaacaaa aaaaaaaa
//
