LOCUS       NM_030717               1978 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus lactamase, beta (Lactb), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_030717
VERSION     NM_030717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Li,S., Liu,H., Hu,H., Ha,E., Prasad,P., Jenkins,B.C., Das,U.S.,
            Mukherjee,S., Shishikura,K., Hu,R., Rader,D.J., Pei,L., Baur,J.A.,
            Matthews,M.L., FitzGerald,G.A., McReynolds,M.R. and Susztak,K.
  TITLE     Human genetics identify convergent signals in mitochondrial
            LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic
            syndrome
  JOURNAL   Cell Metab (2024) In press
   PUBMED   39561766
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Du,J., Zhang,P., Zhao,X., He,J., Xu,Y., Zou,Q., Luo,J., Shen,L.,
            Gu,H., Tang,Q., Li,M., Jiang,Y., Tang,G., Bai,L., Li,X., Wang,J.,
            Zhang,S. and Zhu,L.
  TITLE     MicroRNA-351-5p mediates skeletal myogenesis by directly targeting
            lactamase-beta and is regulated by lnc-mg
  JOURNAL   FASEB J 33 (2), 1911-1926 (2019)
   PUBMED   30216112
  REMARK    GeneRIF: These findings indicate that miRNA-351-5p functions in
            skeletal myogenesis by targeting LACTB and is regulated by lnc-mg,
            supporting the role of the competing endogenous RNA network in
            skeletal myogenesis.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Noordermeer,D., de Wit,E., Klous,P., van de Werken,H., Simonis,M.,
            Lopez-Jones,M., Eussen,B., de Klein,A., Singer,R.H. and de Laat,W.
  TITLE     Variegated gene expression caused by cell-specific long-range DNA
            interactions
  JOURNAL   Nat Cell Biol 13 (8), 944-951 (2011)
   PUBMED   21706023
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Smith,T.S., Southan,C., Ellington,K., Campbell,D., Tew,D.G. and
            Debouck,C.
  TITLE     Identification, genomic organization, and mRNA expression of LACTB,
            encoding a serine beta-lactamase-like protein with an
            amino-terminal transmembrane domain
  JOURNAL   Genomics 78 (1-2), 12-14 (2001)
   PUBMED   11707067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166370.3 and AC159741.2.
            
            On Aug 24, 2022 this sequence version replaced NM_030717.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF317900.1, BC147809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               AC166370.3         105166-105549       c
            385-451             AC166370.3         104843-104909       c
            452-642             AC166370.3         101301-101491       c
            643-997             AC166370.3         100707-101061       c
            998-1163            AC166370.3         97804-97969         c
            1164-1978           AC159741.2         174281-175095       c
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.23 cM"
     gene            1..1978
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /note="lactamase, beta"
                     /db_xref="GeneID:80907"
                     /db_xref="MGI:MGI:1933395"
     exon            1..384
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     exon            385..451
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     exon            452..642
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     exon            643..997
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1163
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1978
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /note="hexamer: AATAAA"
     polyA_site      1978
                     /gene="Lactb"
                     /gene_synonym="LACT-1; Lact1; Mrpl56"
                     /note="major polyA site"
ORIGIN      
        1 aagctaggag gcagccggct ctgcggaggc aacatgtacc ggctcctgtc aagcgtgaca
       61 gctcgggctg cggccaccgc aggcccagcc tgggacggag ggcggcgcgg ggcgcacagg
      121 cgaccgggcc tgcctgtgct gggccttggt tgggccggcg gcctggggct cgggctgggg
      181 ctggctctcg gcgcgaagct ggtggtcggg ctgcggggcg ccgtccccat tcagtccccc
      241 gcggaccccg aggcgtccgg cactaccgag ttatcgcacg agcaggccct gagcccgggg
      301 agcccgcaca cgcctgcgcc gccagcagcc aggggcttct ccagagccat cgagagcagc
      361 cgcgatctgc tacaccggat caaggatgag gttggtgccc ccggcatcgt ggttggagtt
      421 tctgtagatg gaaaagaagt ctggtcagaa ggtttaggct atgcagacgt ggagaaccgc
      481 gtaccctgta agccagaaac ggtcatgaga atcgcaagca tcagcaaaag cctcaccatg
      541 gtggctctgg ctaaactgtg ggaagcaggg aagctggatc tggaccttcc tgtgcagcac
      601 tatgttcccg agttcccaga aaaagaatac gagggtgaaa aggtttctgt cacaacaaga
      661 ttactaattt cgcatttaag tggaattcgt cattatgaaa aggacataaa gaaagtgaaa
      721 gaagagaaag cttataaagc cctgaagatg gtgaaaggga ccccgccacc atctgaccaa
      781 gaaaaagaac tgaaagaaaa gggaggcaaa aacaacgaaa agagcgacgc accgaaagcc
      841 aaagtcgagc aggacagcga agccagatgc cgcagcgcga agccaggcaa gaaaaagaat
      901 gacttcgaac aaggcgaatt gtatttgaaa gaaaagtttg aaaattcaat tgaatcacta
      961 agattattta aaaatgaccc tttattcttt aaacctggta gtcagttttt gtattcaacg
     1021 tttggctata ctctgctggc agccatagta gaaagagctt caggatataa atatttggat
     1081 tatatgcaga aaattttcca tgatttggac atgctgacaa ctgtccagga ggaaaacgag
     1141 ccagtgattt acaacagagc aagattttac gtgtacaata aaaagaaacg tcttgtcaac
     1201 acaccttacg tggataactc ctataaatgg gctggtggtg gatttctgtc cacagtgggt
     1261 gacctcctga aatttggaaa cgcaatgctg tatggctacc aagttgggca gtttaagaac
     1321 tcaaatgaaa atctcttgcc tggatatctc aagccagaaa caatggtgat gatgtggacc
     1381 ccagtcccta acacagagat gtcctgggat aaagagggga aatatgcaat ggcgtggggt
     1441 gtggtagaga agaagcaaac gtacggatcc tgcaggaagc agcggcacta cgcctcacat
     1501 actggaggtg ctgtgggtgc cagtagtgtc ctgctggtcc ttcctgaaga actggactca
     1561 gaggccgtaa ataacaaggt tcccccacga ggaataatcg tctctatcat atgcaacatg
     1621 cagtctgtgg ggctcaatag cactgctttg aagatcgctc tggaatttga taaagacaga
     1681 gctgactaat cctaatggca gcacaggtcc acagtgagcc ttccattctt tgaaatgttg
     1741 acgttcccaa atacataaac cctttaagga tacatttcgt tcccaaatac ataaaccctt
     1801 taaggataca tttgtaatag agtacagtta aatgtggaga attatgtacc tctaattgct
     1861 taattttgta actgcctttt tattggacaa ttagttcttt acactcaggg aaataacagt
     1921 tgtttctact ttttaaaaaa aatgtttact cttgaaataa aatcttctga taaaagaa
//
