LOCUS       NM_172488               2419 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus laccase domain containing 1 (Lacc1), mRNA.
ACCESSION   NM_172488
VERSION     NM_172488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2419)
  AUTHORS   Xu,Z.Y. and Wang,J.C.
  TITLE     LACC1 regulates changes in the intestinal flora in a mouse model of
            inflammatory bowel disease
  JOURNAL   BMC Gastroenterol 23 (1), 358 (2023)
   PUBMED   37848840
  REMARK    GeneRIF: LACC1 regulates changes in the intestinal flora in a mouse
            model of inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2419)
  AUTHORS   Wei,Z., Oh,J., Flavell,R.A. and Crawford,J.M.
  TITLE     LACC1 bridges NOS2 and polyamine metabolism in inflammatory
            macrophages
  JOURNAL   Nature 609 (7926), 348-353 (2022)
   PUBMED   35978195
  REMARK    GeneRIF: LACC1 bridges NOS2 and polyamine metabolism in
            inflammatory macrophages.
            Erratum:[Nature. 2023 Jun;618(7965):E21. doi:
            10.1038/s41586-023-06244-9.. PMID: 37231312]
REFERENCE   5  (bases 1 to 2419)
  AUTHORS   Saveljeva,S., Sewell,G.W., Ramshorn,K., Cader,M.Z., West,J.A.,
            Clare,S., Haag,L.M., de Almeida Rodrigues,R.P., Unger,L.W.,
            Iglesias-Romero,A.B., Holland,L.M., Bourges,C., Md-Ibrahim,M.N.,
            Jones,J.O., Blumberg,R.S., Lee,J.C., Kaneider,N.C., Lawley,T.D.,
            Bradley,A., Dougan,G. and Kaser,A.
  TITLE     A purine metabolic checkpoint that prevents autoimmunity and
            autoinflammation
  JOURNAL   Cell Metab 34 (1), 106-124 (2022)
   PUBMED   34986329
REFERENCE   6  (bases 1 to 2419)
  AUTHORS   Kang,J.W., Yan,J., Ranjan,K., Zhang,X., Turner,J.R. and Abraham,C.
  TITLE     Myeloid Cell Expression of LACC1 Is Required for Bacterial
            Clearance and Control of Intestinal Inflammation
  JOURNAL   Gastroenterology 159 (3), 1051-1067 (2020)
   PUBMED   32693188
  REMARK    GeneRIF: Myeloid Cell Expression of LACC1 Is Required for Bacterial
            Clearance and Control of Intestinal Inflammation.
REFERENCE   7  (bases 1 to 2419)
  AUTHORS   Cader,M.Z., de Almeida Rodrigues,R.P., West,J.A., Sewell,G.W.,
            Md-Ibrahim,M.N., Reikine,S., Sirago,G., Unger,L.W.,
            Iglesias-Romero,A.B., Ramshorn,K., Haag,L.M., Saveljeva,S.,
            Ebel,J.F., Rosenstiel,P., Kaneider,N.C., Lee,J.C., Lawley,T.D.,
            Bradley,A., Dougan,G., Modis,Y., Griffin,J.L. and Kaser,A.
  TITLE     FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine
            Nucleotide Cycle
  JOURNAL   Cell 180 (2), 278-295 (2020)
   PUBMED   31978345
  REMARK    Erratum:[Cell. 2020 Feb 20;180(4):815. doi:
            10.1016/j.cell.2020.02.005.. PMID: 32084343]
REFERENCE   8  (bases 1 to 2419)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2419)
  AUTHORS   Skon-Hegg,C., Zhang,J., Wu,X., Sagolla,M., Ota,N., Wuster,A.,
            Tom,J., Doran,E., Ramamoorthi,N., Caplazi,P., Monroe,J., Lee,W.P.
            and Behrens,T.W.
  TITLE     LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and
            Inflammation
  JOURNAL   J Immunol 202 (1), 183-193 (2019)
   PUBMED   30510070
  REMARK    GeneRIF: this study shows that LACC1 regulates TNF and IL-17 in
            mouse models of arthritis and inflammation
REFERENCE   10 (bases 1 to 2419)
  AUTHORS   Cader,M.Z., Boroviak,K., Zhang,Q., Assadi,G., Kempster,S.L.,
            Sewell,G.W., Saveljeva,S., Ashcroft,J.W., Clare,S.,
            Mukhopadhyay,S., Brown,K.P., Tschurtschenthaler,M., Raine,T.,
            Doe,B., Chilvers,E.R., Griffin,J.L., Kaneider,N.C., Floto,R.A.,
            D'Amato,M., Bradley,A., Wakelam,M.J., Dougan,G. and Kaser,A.
  TITLE     C13orf31 (FAMIN) is a central regulator of immunometabolic function
  JOURNAL   Nat Immunol 17 (9), 1046-1056 (2016)
   PUBMED   27478939
  REMARK    GeneRIF: this study shows that Lacc1 is a central regulator of the
            metabolic function and bioenergetic state of macrophages that is
            under evolutionary selection and determines the risk of
            inflammatory and infectious disease
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK033565.1.
            
            On Apr 6, 2007 this sequence version replaced NM_172488.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033565.1, AK153349.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2419              AK033565.1         2-2420
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.63 cM"
     gene            1..2419
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /note="laccase domain containing 1"
                     /db_xref="GeneID:210808"
                     /db_xref="MGI:MGI:2445077"
     exon            1..121
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            122..300
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..913
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1644
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /EC_number="2.4.2.1"
                     /EC_number="3.5.4.4"
                     /EC_number="2.4.2.28"
                     /note="laccase domain-containing protein 1; laccase
                     (multicopper oxidoreductase) domain containing 1;
                     adenosine deaminase LACC1; guanosine phosphorylase LACC1;
                     fatty acid metabolism-immunity nexus;
                     S-methyl-5'-thioadenosine phosphorylase LACC1"
                     /codon_start=1
                     /product="purine nucleoside phosphorylase LACC1"
                     /protein_id="NP_766076.1"
                     /db_xref="CCDS:CCDS27287.1"
                     /db_xref="GeneID:210808"
                     /db_xref="MGI:MGI:2445077"
                     /translation="MAEAVLIDLSGLQLNAQKNCHETLLETLDGIHYHHAPKAKFLCI
                     ICCRNASKEKDGEYGLCELEAGNGFSRLAGKFETVSHPCLAASLYTIKQKIDEENLSC
                     IKVIVPEHRKLLMKAYVGQLFTEVYEFEFEDLQGAWRDSLLKPSTGINVTTTQELEDI
                     QHEIETYLRSLPALKGDLTIVTSPLIPDNFLHGFTTRTGGISSVPTLSSLNLFSSSKR
                     RDPKVVVQENVRRLANAAGFNAEKFYRIKTDHASEVWVMGKKEPESYDGIVTNQRGVT
                     ITALGADCIPIVFADPVKKACGVAHSGWKGTLLGVAMATVNAMIAEYGCDVEDIIVVL
                     GPSVGSCCFTLPKESAVSFHSLHPSCVRHFDSPRPYVDIRKATRILLERGGILPQNIQ
                     DQKEDLDLCTSCHPEKFFSHVRDGLNFGTQIGFISLRE"
     exon            914..1092
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1258
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1484
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1645
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2419
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2419
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /note="putative"
ORIGIN      
        1 gcggtgaggc gggcggaccg gccggccggt gactttggga gccactgggg ttcgagcgcc
       61 gagcctgcag ctcacgcccc agctcgcggc cgccgaggag agcgcgggaa gcagccctgc
      121 gcacttggga ggcagaggca gaggcaagca ggtgtctgag gtcgaagcca gcctggtcta
      181 catagctagt tccaggactg ctggggctgt tagacagaga agctctgcct cgaatccctg
      241 tcccaaccgc aaccccaaag aagattggct gctgatactg ctcaacttaa tatcctaaag
      301 ctgctatggc ataaaaagtc tttggggcaa aaaagactgc ctgattgaag aatggcagaa
      361 gcagtcttga ttgatctctc tggtttacaa ttgaatgcac agaaaaactg ccatgagacc
      421 ttactggaga cactggatgg tattcactac caccacgctc ccaaggccaa gttcctttgc
      481 ataatatgtt gcagaaatgc cagcaaggaa aaggatgggg agtatggcct ctgtgaattg
      541 gaagcaggaa atggcttttc acgtctcgcg ggaaaattcg agactgttag ccatccctgc
      601 ctggctgcct ctttgtatac aattaaacaa aaaattgatg aagaaaatct gagctgcatt
      661 aaggtgattg tccccgagca caggaaactg ttaatgaagg cttacgttgg tcaactcttc
      721 accgaggtgt atgagtttga gtttgaagat ctacagggag cttggaggga tagccttttg
      781 aaaccatcca ctggaataaa cgtgaccaca actcaagaac tagaagacat ccagcatgaa
      841 atagaaacat acttgagaag cctgccagcg ctgaaagggg acctaactat tgtcacatct
      901 cctctgatcc cagacaactt cctgcatgga tttaccacac ggacaggggg catatcttcc
      961 gtacccactc tcagctccct caatcttttc agtagttcca aaaggagaga tcccaaagtg
     1021 gttgttcaag aaaatgttcg caggttggca aatgctgccg gatttaacgc agagaaattt
     1081 taccgaataa agactgatca cgccagtgaa gtgtgggtta tggggaagaa ggagcctgaa
     1141 tcttacgatg ggatcgtcac aaatcagaga ggagtcacaa tcactgctct tggcgccgac
     1201 tgtataccca tcgtcttcgc agatcctgtg aaaaaggcat gtggggttgc tcactccggc
     1261 tggaaaggta cattgttggg tgtggctatg gctactgtga atgctatgat agcagaatat
     1321 ggctgtgatg tggaagacat tattgttgtt ctgggaccgt cagtgggttc ttgctgcttc
     1381 actcttccca aagaatcagc agtctccttt cacagtcttc atccttcatg tgtgagacac
     1441 tttgactcac cgagacccta cgttgacatc cgaaaagcca ccaggattct tctagaaaga
     1501 ggaggaattc ttccacagaa cattcaagac cagaaggaag atcttgacct ctgcacgtcc
     1561 tgccatcctg agaagttttt ctcccatgtc cgcgatggcc ttaacttcgg tacacagatt
     1621 ggcttcatat cccttagaga atgaggttct tggctggagt tttgcataaa ggatgtttcc
     1681 tgcatccttc cacactggct gcaaaagaaa atacttagct ttctgattta tataaaacca
     1741 tgaggattac aaaagataat tcatctttag ggtatgctct tactgttacc caaagcccag
     1801 tgatcttggt ctaattctta tgacaactga tcaaaaaacc caatgtgatg tcattcctga
     1861 aggtcgttct ctgtatttgt ctataaatca aggccagggc tgttcagtta agtatttggt
     1921 agatgccaac ttttgtttag gcatggagcc cagcacaggg aattgaaatg aagtcagctt
     1981 tctcatttga agcagatgca gctgggagat acctgttccc ttaggtttcc ttatggcatt
     2041 ctcaagcgcc atgtttttgc tgatccttcc ctccccttcc ctgtcccctg tgtccccttc
     2101 cactcccggt agcccctctt tcctgtctca tgggctttaa tacttctccc ttgctcagtc
     2161 ctctctttat gttccctttc tagtatcaac acctatatcc acacctatga ccacaaattt
     2221 acagatccat atatatgtat gtttacataa acagtaaaag ttagaattta tatttatata
     2281 taagaaaaaa tacatgcagt gtttgttatt cccagtctgg attattttgg tcagcataaa
     2341 ataattccag atctctcaat tttcctacaa gtttgataac ttcattatgg ctaaataaaa
     2401 tattgtgtgt atgaactgc
//
