LOCUS       NP_766076                430 aa            linear   ROD 25-APR-2025
DEFINITION  purine nucleoside phosphorylase LACC1 [Mus musculus].
ACCESSION   NP_766076
VERSION     NP_766076.1
DBSOURCE    REFSEQ: accession NM_172488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Li,Y., Ascui,G., Dicker,M., Riffelmacher,T., Chandra,V.,
            Schmiedel,B., Chou,T.F., Vijayanand,P. and Kronenberg,M.
  TITLE     Crohn's Disease-associated variant in laccase domain containing 1
            (LACC1) modulates T cell gene expression, metabolism and T cell
            function
  JOURNAL   Nat Commun 16 (1), 2577 (2025)
   PUBMED   40089498
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Xu,Z.Y. and Wang,J.C.
  TITLE     LACC1 regulates changes in the intestinal flora in a mouse model of
            inflammatory bowel disease
  JOURNAL   BMC Gastroenterol 23 (1), 358 (2023)
   PUBMED   37848840
  REMARK    GeneRIF: LACC1 regulates changes in the intestinal flora in a mouse
            model of inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Wei,Z., Oh,J., Flavell,R.A. and Crawford,J.M.
  TITLE     LACC1 bridges NOS2 and polyamine metabolism in inflammatory
            macrophages
  JOURNAL   Nature 609 (7926), 348-353 (2022)
   PUBMED   35978195
  REMARK    GeneRIF: LACC1 bridges NOS2 and polyamine metabolism in
            inflammatory macrophages.
            Erratum:[Nature. 2023 Jun;618(7965):E21. doi:
            10.1038/s41586-023-06244-9. PMID: 37231312]
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Kang,J.W., Yan,J., Ranjan,K., Zhang,X., Turner,J.R. and Abraham,C.
  TITLE     Myeloid Cell Expression of LACC1 Is Required for Bacterial
            Clearance and Control of Intestinal Inflammation
  JOURNAL   Gastroenterology 159 (3), 1051-1067 (2020)
   PUBMED   32693188
  REMARK    GeneRIF: Myeloid Cell Expression of LACC1 Is Required for Bacterial
            Clearance and Control of Intestinal Inflammation.
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Cader,M.Z., de Almeida Rodrigues,R.P., West,J.A., Sewell,G.W.,
            Md-Ibrahim,M.N., Reikine,S., Sirago,G., Unger,L.W.,
            Iglesias-Romero,A.B., Ramshorn,K., Haag,L.M., Saveljeva,S.,
            Ebel,J.F., Rosenstiel,P., Kaneider,N.C., Lee,J.C., Lawley,T.D.,
            Bradley,A., Dougan,G., Modis,Y., Griffin,J.L. and Kaser,A.
  TITLE     FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine
            Nucleotide Cycle
  JOURNAL   Cell 180 (2), 278-295 (2020)
   PUBMED   31978345
  REMARK    Erratum:[Cell. 2020 Feb 20;180(4):815. doi:
            10.1016/j.cell.2020.02.005. PMID: 32084343]
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Skon-Hegg,C., Zhang,J., Wu,X., Sagolla,M., Ota,N., Wuster,A.,
            Tom,J., Doran,E., Ramamoorthi,N., Caplazi,P., Monroe,J., Lee,W.P.
            and Behrens,T.W.
  TITLE     LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and
            Inflammation
  JOURNAL   J Immunol 202 (1), 183-193 (2019)
   PUBMED   30510070
  REMARK    GeneRIF: this study shows that LACC1 regulates TNF and IL-17 in
            mouse models of arthritis and inflammation
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Cader,M.Z., Boroviak,K., Zhang,Q., Assadi,G., Kempster,S.L.,
            Sewell,G.W., Saveljeva,S., Ashcroft,J.W., Clare,S.,
            Mukhopadhyay,S., Brown,K.P., Tschurtschenthaler,M., Raine,T.,
            Doe,B., Chilvers,E.R., Griffin,J.L., Kaneider,N.C., Floto,R.A.,
            D'Amato,M., Bradley,A., Wakelam,M.J., Dougan,G. and Kaser,A.
  TITLE     C13orf31 (FAMIN) is a central regulator of immunometabolic function
  JOURNAL   Nat Immunol 17 (9), 1046-1056 (2016)
   PUBMED   27478939
  REMARK    GeneRIF: this study shows that Lacc1 is a central regulator of the
            metabolic function and bioenergetic state of macrophages that is
            under evolutionary selection and determines the risk of
            inflammatory and infectious disease
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK033565.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033565.1, AK153349.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.63 cM"
     Protein         1..430
                     /product="purine nucleoside phosphorylase LACC1"
                     /EC_number="2.4.2.1"
                     /EC_number="3.5.4.4"
                     /EC_number="2.4.2.28"
                     /note="laccase domain-containing protein 1; laccase
                     (multicopper oxidoreductase) domain containing 1;
                     adenosine deaminase LACC1; guanosine phosphorylase LACC1;
                     fatty acid metabolism-immunity nexus;
                     S-methyl-5'-thioadenosine phosphorylase LACC1"
                     /calculated_mol_wt=47384
     Region          195..426
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     Site            247
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV20; propagated from
                     UniProtKB/Swiss-Prot (Q8BZT9.1)"
     CDS             1..430
                     /gene="Lacc1"
                     /gene_synonym="9030625A04Rik"
                     /coded_by="NM_172488.2:352..1644"
                     /db_xref="CCDS:CCDS27287.1"
                     /db_xref="GeneID:210808"
                     /db_xref="MGI:MGI:2445077"
ORIGIN      
        1 maeavlidls glqlnaqknc hetlletldg ihyhhapkak flciiccrna skekdgeygl
       61 celeagngfs rlagkfetvs hpclaaslyt ikqkideenl scikvivpeh rkllmkayvg
      121 qlftevyefe fedlqgawrd sllkpstgin vtttqeledi qheietylrs lpalkgdlti
      181 vtsplipdnf lhgfttrtgg issvptlssl nlfssskrrd pkvvvqenvr rlanaagfna
      241 ekfyriktdh asevwvmgkk epesydgivt nqrgvtital gadcipivfa dpvkkacgva
      301 hsgwkgtllg vamatvnami aeygcdvedi ivvlgpsvgs ccftlpkesa vsfhslhpsc
      361 vrhfdsprpy vdirkatril lerggilpqn iqdqkedldl ctschpekff shvrdglnfg
      421 tqigfislre
//
