LOCUS       NM_001359254            4697 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus L3MBTL3 histone methyl-lysine binding protein
            (L3mbtl3), transcript variant 3, mRNA.
ACCESSION   NM_001359254 XM_006512731
VERSION     NM_001359254.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Guo,P., Hoang,N., Sanchez,J., Zhang,E.H., Rajawasam,K.,
            Trinidad,K., Sun,H. and Zhang,H.
  TITLE     The assembly of mammalian SWI/SNF chromatin remodeling complexes is
            regulated by lysine-methylation dependent proteolysis
  JOURNAL   Nat Commun 13 (1), 6696 (2022)
   PUBMED   36335117
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Zhang,C., Leng,F., Saxena,L., Hoang,N., Yu,J., Alejo,S., Lee,L.,
            Qi,D., Lu,F., Sun,H. and Zhang,H.
  TITLE     Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and
            CRL4DCAF5 ubiquitin ligase
  JOURNAL   J Biol Chem 294 (2), 476-489 (2019)
   PUBMED   30442713
  REMARK    GeneRIF: The direct binding of L3MBTL3 to the methylated SOX2
            protein leads to the recruitment of the CRL4(DCAF5) ubiquitin E3
            ligase to target SOX2 protein for ubiquitin-dependent proteolysis.
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Miesfeld,J.B., Moon,M.S., Riesenberg,A.N., Contreras,A.N.,
            Kovall,R.A. and Brown,N.L.
  TITLE     Rbpj direct regulation of Atoh7 transcription in the embryonic
            mouse retina
  JOURNAL   Sci Rep 8 (1), 10195 (2018)
   PUBMED   29977079
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Leng,F., Yu,J., Zhang,C., Alejo,S., Hoang,N., Sun,H., Lu,F. and
            Zhang,H.
  TITLE     Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3
            and CRL4DCAF5 ubiquitin ligase
  JOURNAL   Nat Commun 9 (1), 1641 (2018)
   PUBMED   29691401
  REMARK    GeneRIF: L3MBTL3 binds the K142-methylated DNMT1 and recruits a
            novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Xu,T., Park,S.S., Giaimo,B.D., Hall,D., Ferrante,F., Ho,D.M.,
            Hori,K., Anhezini,L., Ertl,I., Bartkuhn,M., Zhang,H., Milon,E.,
            Ha,K., Conlon,K.P., Kuick,R., Govindarajoo,B., Zhang,Y., Sun,Y.,
            Dou,Y., Basrur,V., Elenitoba-Johnson,K.S., Nesvizhskii,A.I.,
            Ceron,J., Lee,C.Y., Borggrefe,T., Kovall,R.A. and Rual,J.F.
  TITLE     RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of
            Notch signaling via histone demethylase KDM1A/LSD1
  JOURNAL   EMBO J 36 (21), 3232-3249 (2017)
   PUBMED   29030483
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Arai,S. and Miyazaki,T.
  TITLE     Impaired maturation of myeloid progenitors in mice lacking novel
            Polycomb group protein MBT-1
  JOURNAL   EMBO J 24 (10), 1863-1873 (2005)
   PUBMED   15889154
  REMARK    GeneRIF: The mouse MBT-1 protein influences myelopoiesis by
            transiently enhancing p57(KIP2) expression levels.
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152953.1 and AC091763.25.
            
            On Jun 14, 2022 this sequence version replaced NM_001359254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.216533.1,
                                           SRR1660811.167415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC152953.1         34678-35057         c
            381-497             AC152953.1         13138-13254         c
            498-609             AC152953.1         5491-5602           c
            610-684             AC152953.1         5056-5130           c
            685-844             AC152953.1         3387-3546           c
            845-977             AC152953.1         1787-1919           c
            978-1062            AC152953.1         98-182              c
            1063-1154           AC091763.25        189350-189441       c
            1155-1259           AC091763.25        187815-187919       c
            1260-1395           AC091763.25        183402-183537       c
            1396-1487           AC091763.25        181757-181848       c
            1488-1639           AC091763.25        179269-179420       c
            1640-1716           AC091763.25        169959-170035       c
            1717-1802           AC091763.25        167074-167159       c
            1803-1913           AC091763.25        165429-165539       c
            1914-2028           AC091763.25        155205-155319       c
            2029-2131           AC091763.25        154235-154337       c
            2132-2284           AC091763.25        144223-144375       c
            2285-2364           AC091763.25        134362-134441       c
            2365-2840           AC091763.25        131520-131995       c
            2841-2903           AC091763.25        131199-131261       c
            2904-4697           AC091763.25        126052-127845       c
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 13.67 cM"
     gene            1..4697
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /note="L3MBTL3 histone methyl-lysine binding protein"
                     /db_xref="GeneID:237339"
                     /db_xref="MGI:MGI:2143628"
     exon            1..380
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..497
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..609
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..684
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..844
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..977
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1062
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1154
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1259
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1395
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1487
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1639
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1716
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1802
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1913
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2028
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2131
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2284
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2364
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2840
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2903
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..4697
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4680..4685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="L3mbtl3"
                     /gene_synonym="MBT-1"
                     /note="major polyA site"
ORIGIN      
        1 agccagccag ccgccggccg gaggaggagg caaacttgag agcggcgggg ccaggggcgc
       61 actggcggag ggaaaacttt aatcgccttc ttgggagaat agaaaaaggg aaaaagagaa
      121 aaggaaaaaa aaatccaaaa ggcaaaaaag tgcatgtgtg tgggggtttc taggacccga
      181 acctcacgat cggatctgat ccgatcacgg cccaccgcgg ggccgtgaga gaaagttgac
      241 cagcgtggcg gctttcttcg cgtccggccg tggtgtctgt ctgtccgtcc gcgctccgac
      301 caaacgggtg ggagatccag ccgcactgcc gggtcgcgtg ggtcagggct cttgccccac
      361 ccttccacgg ggacacgaag gttacacaat aaatcatgac tgaatctgca tctagcacaa
      421 gtggtcaaga gtttgatgtg tttagtgtta tggactggaa ggatggcgtt ggtaccctac
      481 cagggagtga tttaaagttt cgagtaaatg agtttggagc tttggaagtt atcacagacg
      541 aaagcgagat ggaaagtgtt aagaaagcta cagccactac cacatggatg gtcccaactg
      601 ctcaagacgc cccgacttct cccccgagct ccaggcccgt atttccacct gcctactgga
      661 catctccacc tggatgtccc acagtctttt cagagaagac tggggtaccc ttcaggctga
      721 aggagcaatc aaaagcagac gggcttcagt tttgtgagaa ctgttgtcag tatggcaacg
      781 gagatgaatg tctttcggga ggaaagtatt gcagccagaa ttgtgctcgg catgccaaag
      841 acaaagatca aaaggatgaa cgggatggag gcgaagacaa cgatgaggaa gatcctaagt
      901 gtagtcgaaa gaaaaagcca aaattgtctc tgaaggcgga ctccaaggac gatggagaag
      961 agagagatga tgaaatggag aacaaacaag atggaaggat cctgaggggt tctcagagag
     1021 ccagaaggaa aagacgcggg gattctgccg tcttaaagca aggcttgcct cctaaaggca
     1081 agaagacctg gtgttgggct tcctacctgg aggaggagaa agcagtggct gtgcctacga
     1141 agctgttcaa agagcaccaa tccttcccat ataacaaaaa tggattcaaa gtgggcatga
     1201 agctagaagg cgtggaccct gaccaccagg caatgtactg cgtccttact gtggctgagg
     1261 tttgtggata taggataaaa cttcactttg acggttattc tgattgctat gacttctggg
     1321 taaatgcaga tgctctggac attcacccag taggctggtg tgagaagact ggccataagc
     1381 tccgccctcc aaaagggtat aaagaagaag aatttaattg gcagtcctac cttaagactt
     1441 gcaaagccca ggctgctccc aagtcattat ttgaaaatca gaacataaca gtgatcccgt
     1501 caggctttcg agttgggatg aagctcgagg ctgcagacaa aaagagccct tctgtcatct
     1561 gtgttgctac ggtaacagat atggtggaca atcgtttcct ggtacatttt gacaactggg
     1621 atgagagcta tgactattgg tgtgaatcaa acagtccaca cattcatcca gtcggctggt
     1681 gtaaagagca cagaagaacc ctgattactc caccaggcta ttctcatgtg aaacactttt
     1741 cctgggataa atatttagaa gaaaccaatt ctttacctgc tcctgcaaga gctttcaaag
     1801 tgaaacctcc acatggattc cagaagaaaa tgaagctgga agctgtggac aaaagaaacc
     1861 cgctgttcat cagagtagca actgtagccg acacggatga ccaccggata aaggttcact
     1921 ttgatggctg gagcagttgc tatgactact ggattgatgc agactctcca gatattcacc
     1981 ccgtgggctg gtgttccaag accgggcacc ctcttcaggc tccgctaagc cctgcagaat
     2041 taatggaacc atcagaaacc ggaggatgtc caactctagg ctgcaggggt gttggtcatt
     2101 ttaaaaaatc gagatacctg ggcactcaga gtggtgccaa ctgtccctat tcagaaatca
     2161 acctgagtaa ggaacgcatc ttcccagacc gcctaagtgg tgacacctct ccacctacta
     2221 ctccctcgtt cccaaggagt aaaaggatgg acaccagaga aagttcctcg tctcctgaaa
     2281 ccagggaaaa gcatgccaat aacttcaaag aagattctga aaagaaaaaa gaaaatgaag
     2341 taaagacatc agccgaagcc aaagttgttc gggaagagcc tacccctagt gtacagcaga
     2401 gtcagccacc tcagcaggtg cagcaagtgc agcatgctca acctcctcag caggcacaga
     2461 aggctccgca ggcccagcag gcccagcaag cccagcaggc ccagcaggct ccacaggccc
     2521 cacagactcc acagccccag caggcgccac aggtccagca ggcccagcag gctccacagg
     2581 ctcagcaggc ccagcagccc cagcaggccc agcagcctca gcaggcccca cccgtccaac
     2641 agcctcagca ggttcaacag gctcagccca cccagcagca agcccagacc cagcagcagg
     2701 cccagcgacg ctcagcagta tttctctcct ttaagcctcc cattccgtgt ctgcccttgc
     2761 gctgggagca gcagagcaag cttcttccga ctgtcgctgg tatcccagct agtagagttt
     2821 ccaaatggag cacagacgag gtgtcagaat tcattcagag cttgcctggg tgtgaagaac
     2881 atggaaaggt gtttaaggat gaacaaattg atggagaagc atttttactc atgacccaaa
     2941 cagacattgt taaaatcatg agcattaagc tgggcccagc tctcaaaatt ttcaactcta
     3001 ttctgatgtt caaagctgcg gagaagaatt cccacaatga actgtgaaga cggtgaattc
     3061 tggcaccatt ggcttctgct ttatagctca ttatgttcct tcaaagcaca aggacagctc
     3121 tagctcccaa gtgagaagtc ttcagaattc accggagcag cactccaggg ctccatctgt
     3181 ccgtccagct gcatatgcat tcttaggaaa tgcctgagct tcttaccagc aactgtccaa
     3241 caacagtcac cttttggttc cgctcactga gctaaactta cctttgtaaa cttacctttt
     3301 ttggatgtgg gaggagggtg ggggaaggag gcttctttat ttatggatgg ggcacaatca
     3361 gaacttttgg cattttgtaa acattgtcgg agtctctttc atgtacacct tctttttttc
     3421 aatactttca gaaacctttt tatataactg aatatcaacc taaaccaaat cctttgaacc
     3481 tggctgggtt aagcctcgga ctggtgtcag tcatgttcgc cctgtgccat atttggaatt
     3541 gcagcattag ccaagtgtaa tgttgtgagt cacgatattg cctaactgtg tgtcatcctc
     3601 tgttgggact gaagaattgt aaatacgacc tttctttgaa tccacatttt tacttttgca
     3661 cgcatcatga attgttaaag tacttttcac cagcatcttt actattatta ttaccaaaaa
     3721 aaaatgtata taaaagagtg gagttgaaga ataaactata taaacctact tagatttgaa
     3781 ggaagtagcg tatcgggaca gaatcaattt tgtacatcgt ggtgcccatg tgtttccagc
     3841 agttggcatt agaggattgt gcagttacac atcccaaggg atgttgacga ggaatttgat
     3901 ctgtgaagtt cttgtgtgca tctctgtaaa tgacgtggaa gttgctggtg ctgtaccgaa
     3961 gaggactcac ttgttgctgg aaacactaat cctccaagag ctcccatccg tgccacaggt
     4021 cctctaggcc cagaggattt cctcagagtg agctgagaag cagagtgagc acctgactgc
     4081 acaggcctgc tgtgaccctc gtaaccagca gccgcagaat ttgccacgct cacagattga
     4141 gaaagtggtt cccaaagcca ttactcggga acctccgatg atgaaagagt ccttttccta
     4201 tgaaatattt tgccttgatt tctaagcatc tgaatgcact ttaaatgaga gcccatggtt
     4261 atttataaac tcatagctgg cagtgttttg tttgtaagcg tgtcctccta aggggaaggt
     4321 aaaatatttt gtcagtcttt ggatgtactt tctaattcca caattagaca tttactcaag
     4381 gactgattta aaaatataaa gtttagtagc atgctgtcag aactctgggg gaaagtccca
     4441 cctctttcca tgaactcttt aatgtttttc tgatgtagga cttcctttga tgtgccatag
     4501 ttggagtcct ttgcatttgt catgattcaa ggtaaacagg gtccgtgaca tctgcaatgt
     4561 cctctttctt catttctctg catgaatctg ctaagtaagc tttttattgt tactccccct
     4621 tctttgttgt ggtcagtatt tgtacattaa cttgcacttg ttacatgtga tatgaatgaa
     4681 ataaaatctt aattgca
//
