LOCUS       NM_145993               3487 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus L3MBTL2 polycomb repressive complex 1 subunit
            (L3mbtl2), transcript variant 2, mRNA.
ACCESSION   NM_145993
VERSION     NM_145993.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Meng,C., Liao,J., Zhao,D., Huang,H., Qin,J., Lee,T.L., Chen,D.,
            Chan,W.Y. and Xia,Y.
  TITLE     L3MBTL2 regulates chromatin remodeling during spermatogenesis
  JOURNAL   Cell Death Differ 26 (11), 2194-2207 (2019)
   PUBMED   30760872
  REMARK    GeneRIF: L3MBTL2 regulates chromatin remodeling during
            spermatogenesis.
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3487)
  AUTHORS   Huang,H., Xu,C., Wang,Y., Meng,C., Liu,W., Zhao,Y., Huang,X.R.,
            You,W., Feng,B., Zheng,Z.H., Huang,Y., Lan,H.Y., Qin,J. and Xia,Y.
  TITLE     Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects
            against kidney injury by inhibiting the DNA damage-p53-apoptosis
            pathway in renal tubular cells
  JOURNAL   Kidney Int 93 (4), 855-870 (2018)
   PUBMED   29276099
  REMARK    GeneRIF: L3MBTL2 plays a protective role in kidney injury, in part
            by inhibiting the DNA damage-p53-apoptosis pathway.
REFERENCE   5  (bases 1 to 3487)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 3487)
  AUTHORS   Qin,J., Whyte,W.A., Anderssen,E., Apostolou,E., Chen,H.H.,
            Akbarian,S., Bronson,R.T., Hochedlinger,K., Ramaswamy,S.,
            Young,R.A. and Hock,H.
  TITLE     The polycomb group protein L3mbtl2 assembles an atypical
            PRC1-family complex that is essential in pluripotent stem cells and
            early development
  JOURNAL   Cell Stem Cell 11 (3), 319-332 (2012)
   PUBMED   22770845
  REMARK    GeneRIF: Disruption of L3mbtl2 results in embryonic lethality with
            failure of gastrulation.
REFERENCE   7  (bases 1 to 3487)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3487)
  AUTHORS   Arai,S. and Miyazaki,T.
  TITLE     Impaired maturation of myeloid progenitors in mice lacking novel
            Polycomb group protein MBT-1
  JOURNAL   EMBO J 24 (10), 1863-1873 (2005)
   PUBMED   15889154
REFERENCE   9  (bases 1 to 3487)
  AUTHORS   Markus,J., Feikova,S., Sramko,M., Wolff,L. and Bies,J.
  TITLE     Proliferation-linked expression of the novel murine gene m4mbt
            encoding a nuclear zinc finger protein with four mbt domains
  JOURNAL   Gene 319, 117-126 (2003)
   PUBMED   14597177
REFERENCE   10 (bases 1 to 3487)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY130665.1, AK036510.1 and AC102262.10.
            
            On Jan 25, 2014 this sequence version replaced NM_145993.4.
            
            Transcript Variant: This variant (2) has an additional segment in
            the 3' UTR and coding region compared to variant 1. The encoded
            isoform (2) is shorter and has a distinct C-terminus compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029115.1, AK036510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY130665.1         2-50
            50-3477             AK036510.1         3-3430
            3478-3487           AC102262.10        150468-150477
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.19 cM"
     gene            1..3487
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="L3MBTL2 polycomb repressive complex 1 subunit"
                     /db_xref="GeneID:214669"
                     /db_xref="MGI:MGI:2443584"
     exon            1..136
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2224
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lethal(3)malignant brain tumor-like protein 2;
                     l(3)mbt-like protein 2; l(3)mbt-like 2"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 2
                     isoform 2"
                     /protein_id="NP_666105.2"
                     /db_xref="CCDS:CCDS27669.1"
                     /db_xref="GeneID:214669"
                     /db_xref="MGI:MGI:2443584"
                     /translation="MEKPRGTEEAPSSEPMEEEEEDDLDLFGGYDSFRSYNSSAGSES
                     SSYLEESSEAENEDREAGELPTSPLHLFSSANNRSLDGSGSEPAVCEMCGIVGTREAF
                     FSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHAQG
                     TGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEV
                     LNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAIN
                     SKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFHIKMVESMKYPFRQGMRLEVVDK
                     TQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSD
                     RRCDMSHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGSICVATI
                     CKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPF
                     AWETYLEKTKSKAAPARLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLL
                     SIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNTPQKGKDTTKKKKK
                     QFGKKRKRIPSAKTRPLRQGSKKPLLEDNLEALGVSEPVPDDIIAVCVKEEHQDISSL
                     DRSPSPQLPLPIESIKQERNN"
     exon            137..374
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            375..508
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            509..632
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            633..712
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            713..830
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            831..965
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1054
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1286
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1363
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1468
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1616
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1699
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1934
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2000
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2111
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..3487
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="hexamer: AATAAA"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="major polyA site"
     polyA_site      3484
                     /gene="L3mbtl2"
                     /gene_synonym="4732493N06Rik; M4mbt"
                     /note="major polyA site"
ORIGIN      
        1 atgattggcc cgcagctcgg gcgcagcagc caatgagcac actctcggag agcggcgagg
       61 gcaatatggc ttcctgcacc tggtgacggt tgagggaatt gaatttggta tcatggagaa
      121 accgcggggc actgaggagg cgccatcttc agagccaatg gaagaggagg aggaagatga
      181 cttggatctc tttgggggct acgacagctt ccggagttac aacagcagtg cgggcagcga
      241 gagcagctcc tacttggagg agtcaagtga agcagagaac gaggaccggg aagcagggga
      301 gctgcccacc tcacctctcc atctgttcag ctctgcgaac aaccgctcct tggatggaag
      361 tggttctgag ccagctgtct gtgagatgtg tggtatcgtg ggcacaagag aagctttctt
      421 ctcaaagacc aagaggttct gcagcgtctc gtgttccagg agctactcct ccaactccaa
      481 gaaagccagt atcctggcta gactacaggg aaagccaccc accaagaaag ccaaagtcct
      541 gcacaaggca gcctggtctg ccaaaattgg agcctttctc catgcccagg gaacaggaca
      601 actagcagat gggacaccca ctggacaaga tgctctggtc ctgggcttcg actggggcaa
      661 gttcctgaag gatcatagtt acaaggctgc tcctgtcagc tgctttaaac atgtacccct
      721 ctatgaccag tgggaagacg tcatgaaggg gatgaaggtg gaagtgctca acagcgatgc
      781 tgtgctcccc agccgggtgt actggatcgc cactgtcatc caggcagctg ggtaccgggt
      841 gctgctccga tatgaaggct ttgaaaatga cgccagtcat gacttctggt gcaacttggg
      901 aactgtggat gtccacccca ttgggtggtg tgccatcaac agcaagatcc tggtacctcc
      961 acggaccatc catgccaagt ttactgactg gaagagctac ctcatgaagc ggttggtggg
     1021 ttccaggaca cttcctgcag acttccatat caagatggtg gaaagcatga agtacccttt
     1081 ccgacagggc atgcgcttag aggttgtaga caagactcag gtgtcacgta cccgcatggc
     1141 cgtggtggac acagtaatcg ggggtcgcct ccggctcctc tatgaggatg gtgacagtga
     1201 tgacgacttc tggtgccata tgtggagtcc cctgatccac ccagtgggtt ggtcccggcg
     1261 tgttggccac ggcatcaaga tgtcagacag acgatgtgac atgtctcatc accccacctt
     1321 ccggaaaatc tactgtgatg ctgtacctta cctcttcaag aaggtccgcg ctgtctacac
     1381 agaaggtggc tggttcgagg aaggaatgaa actagaggcc attgaccctc tgaatctggg
     1441 cagtatctgt gtagcaacca tctgcaaggt gctcttggat ggttacctga tgatctgtgt
     1501 ggatgggggg ccctccacgg atggctccga ttggttctgc taccacgcct cctcccatgc
     1561 catcttccca gccaccttct gccaaaagaa tgacattgag ctcacacccc caaaagggta
     1621 tgagacacag ccttttgcct gggagaccta cttagagaag accaagtcaa aagctgctcc
     1681 agcaagactc tttaacatgg actgccccaa ccatggcttc aaggtgggca tgaagctgga
     1741 ggctgtggac ctgatggagc cccggctcat ctgtgtggcc actgtgaagc gggtggtgca
     1801 tcggctcctc agcatccact tcgacggctg ggacaatgag tatgatcagt gggtggactg
     1861 cgaatccccg gacatctacc ctgtcggctg gtgtgagctc accggctacc agctccagcc
     1921 gcctgtgtcc gcagaaccaa acacacctca gaaaggcaag gacaccacaa agaagaagaa
     1981 gaaacagttt gggaagaaaa ggaaaagaat cccatcagcc aagactcggc ccctcagaca
     2041 gggctccaag aaacccttac tggaggacaa ccttgaggct ttgggggtct cggaaccagt
     2101 tcctgatgac attatcgctg tgtgtgtgaa ggaggagcac caggacattt cctcgcttga
     2161 caggtcgccc agtccacagc tgcctcttcc cattgagagc atcaagcagg agaggaacaa
     2221 ctgagacttc cctggcatca gcctggaccc taactgaagc caagcatgga gcagagagga
     2281 ggcccggctt tactgctgtg cagtgaatgg acagcctggc gttccagggc tgcctctgcc
     2341 ctctggctgg cactcattgc accctcagca cactggaaaa ctagactggt ccccatggtc
     2401 tacccaggca agtggtagaa gtaaggttac ggagcagccg acgctgggtg aggacggagc
     2461 cacctccgcc caaaataaat tgagggtcat gtacctcctg ggggcaccct gcaccgcctg
     2521 atgtcccagg ggccccactg tggcagggaa ttgaccaagt agcgggctcg agagatttgg
     2581 gtttgggcct tgacctcagg gataacaaga acactgactt cctttctgag agggaacagc
     2641 tgggaagatg tacagggacc tgagccccta agggagactc gggccaggct acttgctgtc
     2701 aggtacagga tcagacagta gtttggtcca tgtagtcggg gaactgcctg agagagacca
     2761 tccttctcta gagcggggct tgggctaact aacattccct ctccctgcct ggctagccca
     2821 gccactgctc agccccttca cagcatctgg cctttggttt tctcacttgg acacattttt
     2881 gttttatttt tgagacaggg tctatgtagt acttgctgtt ctggggcttg gtatgcagcc
     2941 catgcagatt ctaaaccggt agggatcccc ctgcctctgc cttccgaggc ctgtgcaccc
     3001 agcccccggc tagacagttt ggcctggccc tccaggatca tcctgaacag ccctggggct
     3061 cctgcagtgc ccctgtgtct gactgggatt tggactgaag cagtgaggcc agtggctccc
     3121 tacggctgtg gctgtgccgt gtggccatct ctgggcctac gccagtcaag tcttgttcat
     3181 ccctgagggg agatgtgagt ggccagtcat catggactgg gcaggttctg agagaagttg
     3241 gtcttgatct atccgctaaa gatagcccac cctgtgcaga atctaggcca tgaaagaggc
     3301 ctttgcctgc ctgctctcct caaagggaag aagatgaaag tccacagtaa aaggcaggtt
     3361 caattcccag cacccactca cagcacctgc atcgtgagcg ccaagggagc ctgggcctct
     3421 ggtttccgtg gatacaaatg tgcacatcct taaatgtaaa taaaaataaa atctttgaag
     3481 aaaacaa
//
