LOCUS       NM_001081338            5338 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus L3MBTL1 histone methyl-lysine binding protein
            (L3mbtl1), mRNA.
ACCESSION   NM_001081338 XM_895109
VERSION     NM_001081338.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5338)
  AUTHORS   Mao W, Salzberg AC, Uchigashima M, Hasegawa Y, Hock H, Watanabe M,
            Akbarian S, Kawasawa YI and Futai K.
  TITLE     Activity-Induced Regulation of Synaptic Strength through the
            Chromatin Reader L3mbtl1
  JOURNAL   Cell Rep 23 (11), 3209-3222 (2018)
   PUBMED   29898393
  REMARK    GeneRIF: L3mbtl1 (lethal 3 malignant brain tumor-like 1), a
            polycomb chromatin reader, is downregulated by neuronal activity
            and is essential for synaptic response and downscaling. L3mbtl1
            knockout neurons enhanced synaptic transmission and restored
            homeostatic downscaling.
REFERENCE   2  (bases 1 to 5338)
  AUTHORS   Mattiske T, Lee K, Gecz J, Friocourt G and Shoubridge C.
  TITLE     Embryonic forebrain transcriptome of mice with polyalanine
            expansion mutations in the ARX homeobox gene
  JOURNAL   Hum Mol Genet 25 (24), 5433-5443 (2016)
   PUBMED   27798109
REFERENCE   3  (bases 1 to 5338)
  AUTHORS   Eid A and Torres-Padilla ME.
  TITLE     Characterization of non-canonical Polycomb Repressive Complex 1
            subunits during early mouse embryogenesis
  JOURNAL   Epigenetics 11 (6), 389-397 (2016)
   PUBMED   27081692
REFERENCE   4  (bases 1 to 5338)
  AUTHORS   Shen EY, Jiang Y, Mao W, Futai K, Hock H and Akbarian S.
  TITLE     Cognition and mood-related behaviors in L3mbtl1 null mutant mice
  JOURNAL   PLoS One 10 (4), e0121252 (2015)
   PUBMED   25849281
  REMARK    GeneRIF: L3mbtl1 loss-of-function was associated with significant
            decreases in depression and and anxiety in some of the behavioral
            paradigms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5338)
  AUTHORS   Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S
            and Hock H.
  TITLE     Chromatin protein L3MBTL1 is dispensable for development and tumor
            suppression in mice
  JOURNAL   J Biol Chem 285 (36), 27767-27775 (2010)
   PUBMED   20592034
  REMARK    GeneRIF: generation and analysis of mice after disruption of
            L3MBTL1
REFERENCE   6  (bases 1 to 5338)
  AUTHORS   Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T and
            Reinberg D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   7  (bases 1 to 5338)
  AUTHORS   Li J, Bench AJ, Piltz S, Vassiliou G, Baxter EJ, Ferguson-Smith AC
            and Green AR.
  TITLE     L3mbtl, the mouse orthologue of the imprinted L3MBTL, displays a
            complex pattern of alternative splicing and escapes genomic
            imprinting
  JOURNAL   Genomics 86 (4), 489-494 (2005)
   PUBMED   16081246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606473.6 and AL591584.14.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_001081338.3.
            
            On Oct 6, 2017 this sequence version replaced NM_001081338.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.13133.1,
                                           SRR9219382.76864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AL606473.6         8661-8736
            77-242              AL606473.6         9624-9789
            243-388             AL606473.6         12375-12520
            389-603             AL606473.6         12876-13090
            604-718             AL606473.6         13354-13468
            719-866             AL606473.6         13677-13824
            867-984             AL606473.6         13966-14083
            985-1066            AL606473.6         14654-14735
            1067-1155           AL606473.6         24712-24800
            1156-1260           AL606473.6         25277-25381
            1261-1396           AL606473.6         26143-26278
            1397-1488           AL606473.6         26599-26690
            1489-1640           AL606473.6         29623-29774
            1641-1717           AL606473.6         30198-30274
            1718-1803           AL606473.6         30965-31050
            1804-1914           AL606473.6         31194-31304
            1915-2029           AL606473.6         31742-31856
            2030-2129           AL606473.6         32182-32281
            2130-2327           AL606473.6         32448-32645
            2328-2377           AL606473.6         32753-32802
            2378-2535           AL591584.14        4000-4157
            2536-2598           AL591584.14        5004-5066
            2599-5338           AL591584.14        8226-10965
FEATURES             Location/Qualifiers
     source          1..5338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5338
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /note="L3MBTL1 histone methyl-lysine binding protein"
                     /db_xref="GeneID:241764"
                     /db_xref="MGI:MGI:2676663"
     exon            1..76
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            77..242
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            243..388
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2733
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /note="H-l(3)mbt protein; L(3)mbt protein homolog"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 1"
                     /protein_id="NP_001074807.1"
                     /db_xref="CCDS:CCDS38314.1"
                     /db_xref="GeneID:241764"
                     /db_xref="MGI:MGI:2676663"
                     /translation="MEGHTDMEILRTVKGSSTGEVNVHLVARDSAGPHPQLPTTAFII
                     PTNAATLGLPSTALDVPYPREPVHVGALERVAGSEPVTATILPQLSTGTGTNSTVRLL
                     DWTGVSAPLPGSGMRFRINEYAPLNMIGVERPRSPEQRHEGGMARRDAGIQHPDVHQD
                     RQDITSLEPPVDASSCKCQACGPQQSSGLDVGSSGDRCSQPFQKRSVIVENSGCTIAS
                     ELLKPMKKRKHKEYQSPSEESEPEAVKQGEGKDAEREPTPSTPENEEWSRSQLVSSEK
                     KDGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTV
                     AEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQLPKGYKEEEFSWSQ
                     YLRSTKAQAAPKHLFVSQSHSTPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL
                     VHFDDWGDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTS
                     AVPNWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDF
                     WIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSVSPGGCPPLSHRSPPHTKTSKYNFH
                     HRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAEKNQSRLKAELSDSETAARKKNPSNLS
                     PRKKPRHQGRIGRPPKYRKIPEEDLQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHC
                     KLLPGVAGISASTVSKWTIEEVFGFVQTLTGSEDQARLFKDEMIDGEAFLLLTQADIV
                     KIMSVKLGPALKIYNAILMFKNTDDAFK"
     exon            389..603
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            604..718
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            719..866
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            867..984
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1066
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1155
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1260
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1396
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1488
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1640
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1717
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1803
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2029
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2129
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2327
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2377
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2535
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2598
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..5338
                     /gene="L3mbtl1"
                     /gene_synonym="C630004G01; L3mbtl; mKIAA0681"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtgcgca ggcgcgcgcc gcaccaggct cccacggtcg gtcgctcggt gcgggcggca
       61 accgctagcc atgcaggtag gactccctgg aatcatagac taggtttatg agagtagcct
      121 tgtgaaacca acaagattgg gcagagatgt tgaaatgctg gcgtagtccc agcagaggcc
      181 tcagcctgag gagcaggaag ccctgaacct gagatggccc ggaagagagc cctcaaatga
      241 agacacatct ggatggaggg gcacactgac atggagatac taaggacagt gaaagggtct
      301 tccacagggg aggtcaacgt gcacctggtg gccagagaca gcgcaggtcc ccaccctcag
      361 ctgcctacaa ccgccttcat tattcctacc aatgcagcta cgcttggtct gcctagcact
      421 gccctggatg tgccctatcc ccgggagcca gtccacgtgg gtgccctgga gcgggtggct
      481 ggcagcgaac ccgtaacagc tactattctg ccacagctaa gcactggaac ggggaccaat
      541 agcacagtca ggcttctgga ttggactggc gtttctgcac ctttacctgg tagcggcatg
      601 cggttccgga taaatgagta cgcgccactg aacatgatag gagtggagcg accacgaagc
      661 ccggagcagc gacatgaggg tggcatggcc aggagagatg cgggcatcca gcaccctgat
      721 gttcaccagg accgtcaaga tataacttct ctggaacccc cggtagatgc gagttcctgc
      781 aagtgccagg cttgtgggcc tcaacaaagt agtggcctag acgttggttc atcgggagac
      841 cgatgctctc agcctttcca gaagcggtca gtcatagtag agaactcagg ctgtaccatc
      901 gcttctgagc tcctgaaacc catgaaaaag aggaaacata aggagtatca gagcccatca
      961 gaggagtcag agccggaggc tgtgaagcaa ggagaaggaa aagacgcaga gcgagagccc
     1021 acccctagca ccccggagaa tgaagagtgg agcagaagcc agctggtgtc cagtgagaag
     1081 aaggacggct ggtcctggga gtcctacctg gaggagcaga aggccgtcac agccccagtt
     1141 agcctcttcc aggactccca ggcagtcacc cataacaaga atggcttcaa actgggcatg
     1201 aagctggaag gcattgaccc ccaacacccg tcaatgtact tcatcctcac tgtggctgag
     1261 gtgtgtggct accgcctgcg cctgcacttt gatggctact ctgagtgcca cgacttctgg
     1321 gtcaatgcca actcccctga tattcatccc gctggctggt ttgagaagac tggacacaag
     1381 ctgcagcttc ccaaaggtta caaggaagag gagttcagct ggagccagta cctgcgcagc
     1441 acgaaagctc aggcagcccc caagcacctg tttgtaagcc agagccacag tactccacct
     1501 gtgggcttcc aggtgggcat gaagctggaa gctgtggacc gcatgaaccc ttccctcgtg
     1561 tgtgtggcca gtgtgaccga tgtggtggac agtcgcttcc tggtgcactt tgatgactgg
     1621 ggcgatactt acgactactg gtgtgatccc agcagcccct acatccaccc agtaggctgg
     1681 tgccagaagc aaggaaagcc gctcacccct ccacaagact acccagaccc tgacagcttc
     1741 tgctgggaga aatatctaga agaaactggg acctcggctg tgcccaattg ggccttcaaa
     1801 gtgcgacccc ctcacagctt cctggtgaac atgaagctgg aggctgtaga ccgccggaac
     1861 ccagcactga tccgggtagc cagtgtggaa gatgtggagg atcatcggat aaagctccac
     1921 tttgatggct ggagtcacaa ttatgatttc tggattgatg ccgatcaccc agacatccac
     1981 cctgcaggct ggtgctccaa gacaggacat cccctggagc ctcctctccg gcccagagag
     2041 tccagctctg tctcccctgg gggatgcccc cctctcagcc acaggagccc accccacaca
     2101 aagacctcca aatataactt tcaccaccga aagtgcccca ctcctggctg tgacggctcc
     2161 ggccatgtca ctggcaagtt cacagctcac cattgcctct ctggctgccc gctggccgag
     2221 aaaaaccaga gccggctgaa agcggaactg tccgactcgg agaccgcagc caggaagaag
     2281 aacccgtcta atttgtcccc aaggaaaaag cctcgccatc aaggccggat tggacgccct
     2341 ccaaagtatc gcaagattcc agaagaagat ctccaagccc tccctcccag tgtggtacac
     2401 cagtccctct tcatgtccac cttgccgacc cacgctgatc gcccactctc tgtgtgctgg
     2461 gagcaacact gcaagctgtt gccaggagtg gcgggcatct cagcctccac agtctctaag
     2521 tggaccattg aagaggtctt tggcttcgtt cagaccttga cgggctctga ggaccaagcg
     2581 cgcctcttca aagacgagat gattgacggc gaggccttcc ttttgctgac acaggcggac
     2641 attgtgaaga tcatgagtgt caagctaggc ccagccttga agatctataa cgccattctc
     2701 atgttcaaaa acactgacga tgcctttaag tgactggttg ggggcgggga agtgggggct
     2761 cctcccatcc tcgcggggct ccctctgcaa atggtgcttc tctcccaact tgagttctgc
     2821 acccctgccc tcactgtctg actagatgtg cgggagcaga ggagcctggg gaagcaggtc
     2881 tcagccctcg gtcctagagt tcagttgccc cggggaaggt gtgactaaac cgagacctga
     2941 ctgatataag ggccgcaggt atcctggctg gggtagccta cagctttagc caccttggtt
     3001 attgtcttag gaattaggag gagctaggta gggtaggcat cctctattca gacctatgtc
     3061 gctttttggc atctctatgt cctttctcct ccttggccca tctcctccta cgaagaactg
     3121 gccatgacct tggtgtgcac attttacaca tgataggcgc ctccctccct gtccgctgtt
     3181 ggctgtatac ccttgctccc cgttcatggt ccagccaggc cccatggctc tcttccccca
     3241 tagatgctta agactcagaa atatgggagc atcttactag gagcctctgg ctgtcttctc
     3301 ccttttgcct ctaggcagag attgagagcc caggcaccac cttcctgaac acgttcagtt
     3361 caagatcact cggcgttgaa gtgggcagta cggagtgagc agatggttag agcccatgtc
     3421 ctaacaagca gggcctaagt tccctgctgc tgtctctatt gggtgtgggg ggagatgaag
     3481 tctgccctgg caagcggtcc tgactaggac gtcagacaca ctggaggctt tgactagctc
     3541 cagaaagcgt gatggctgta tcattttctc tgactgtggc tctcagccaa gatagtgcac
     3601 atgagggaga ggcccctgcc agcccagcct cctgccagga gggtgtagca ctggctagca
     3661 cacaaccact atggcatcac attcactctg tcccttaaac atttctcatt ctgctctcga
     3721 gtctaaggaa agccgcttat ggtggagttg gaaaggtccc ctctcctgtc tctgacctcc
     3781 ctggcccttc ttgccagtct ccaacagtct ctcactgcca gctaggttcc tgctggggct
     3841 ctggaactcg aacctttctg tccaagtgga ggttcggcct ccactcaatt actgccaaac
     3901 ccacctccca gcctaagtgg ggagggaacc caggagggag ccgcccctcc aataggtggg
     3961 agcatgtgcc aggcttcagt tcatctggtg ctgaggtgga cctacaggct gaagagcagg
     4021 gttgtccccc agtccagtat acttataggt tatgtggtat gtgtctttcc gtgtgtgtgt
     4081 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat ctttccatgt gtgtgtgtac
     4141 acacgtgttg gtcactcagc agtatctgtc aggtgccggt gtgaggtgca gaactgggga
     4201 tatgaagggc tactgttaag ctatgaggct ttattatttc ctcagaaatg ggaagccaaa
     4261 aagtcctgtt gatttcctgt ttctgtgctt tggggacctc cccttcctag gccagacagc
     4321 ttctggggga cagccaagtg tcacccagct agcctggcag aggctcaggt tccctttccc
     4381 tttcagccct caggggtaac tttctgggag gacactgggc aaggccagcc aagcagggag
     4441 ggagggctag gttgaccgat atgacatcac tgccccattt gctggaagta aagaggagcc
     4501 gaactctcca attgtgattg tctgggttgc agtggaaaac tgccaccacc tggcctttag
     4561 tccgccctac cacacactga cttgtctgag acggcagcag atgttctgtg ttcttgactg
     4621 gagctgtgaa ccacacagct accaacgaaa gggacctcac agcttttgcc gtgcagcttt
     4681 gccagtgatg gttgcctgtg ggagagacca gacggactaa cagacagcct tggagaagac
     4741 gacttgcagc ctcccaactc taggctacac accccttctg cactaatatc agaaaccaaa
     4801 tcttaaaaag tcaaaagaaa catgcctgcc aagcatcccc cccacctgtc caccccactg
     4861 ggtccccact gcacccgagc ctgggagcac aggccatggg tggctgtctc tggcacttgt
     4921 gccctggttt ctagaaacag ggactactta cattttgtcc ccagcaggct tgtccagccg
     4981 ctgcccagcc ctggcagtga tgaactttgt ttaatttctg agacaaagag aatggttccg
     5041 gagtctgaaa atgaaacctg tttgcacctc cattcacacg cactgtgatg gtgttacttt
     5101 tgtttacttg ctctgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt gtctgtgtgt
     5161 gtgtgtgtgt atgtgtgtgt gtatgctctc aagcataaat tcttaaagaa aatcctctgg
     5221 tttaagctaa attgactctt gagagaggaa acgttacaaa gaaaatatag tatgatttgt
     5281 ctgtgtattg agacaaaata aataaataaa taaataaata aataattgac tagtctgc
//
