LOCUS       NM_001081202            2942 bp    mRNA    linear   ROD 05-FEB-2025
DEFINITION  Mus musculus LINE-1 type transposase domain containing 1 (L1td1),
            transcript variant 2, mRNA.
ACCESSION   NM_001081202 XM_355549
VERSION     NM_001081202.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Navarro,P.A., Wang,F., Pimentel,R., Robinson,L.G. Jr., Berteli,T.S.
            and Keefe,D.L.
  TITLE     Zidovudine inhibits telomere elongation, increases the transposable
            element LINE-1 copy number and compromises mouse embryo development
  JOURNAL   Mol Biol Rep 48 (12), 7767-7773 (2021)
   PUBMED   34669125
  REMARK    GeneRIF: Zidovudine inhibits telomere elongation, increases the
            transposable element LINE-1 copy number and compromises mouse
            embryo development.
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Wang,F., Chamani,I.J., Luo,D., Chan,K., Navarro,P.A. and Keefe,D.L.
  TITLE     Inhibition of LINE-1 retrotransposition represses telomere
            reprogramming during mouse 2-cell embryo development
  JOURNAL   J Assist Reprod Genet 38 (12), 3145-3153 (2021)
   PUBMED   34618297
  REMARK    GeneRIF: Inhibition of LINE-1 retrotransposition represses telomere
            reprogramming during mouse 2-cell embryo development.
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Ormundo,L.F., Machado,C.F., Sakamoto,E.D., Simoes,V. and
            Armelin-Correa,L.
  TITLE     LINE-1 specific nuclear organization in mice olfactory sensory
            neurons
  JOURNAL   Mol Cell Neurosci 105, 103494 (2020)
   PUBMED   32387751
  REMARK    GeneRIF: LINE-1 specific nuclear organization in mice olfactory
            sensory neurons.
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Blaudin de The,F.X., Rekaik,H., Peze-Heidsieck,E.,
            Massiani-Beaudoin,O., Joshi,R.L., Fuchs,J. and Prochiantz,A.
  TITLE     Engrailed homeoprotein blocks degeneration in adult dopaminergic
            neurons through LINE-1 repression
  JOURNAL   EMBO J 37 (15) (2018)
   PUBMED   29941661
  REMARK    GeneRIF: LINE-1 overexpression triggers oxidative stress-induced
            DNA strand breaks and that an Engrailed adult function is to
            protect mesencephalic dopaminergic neurons through the repression
            of LINE-1 expression.
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   MacLennan,M., Garcia-Canadas,M., Reichmann,J., Khazina,E.,
            Wagner,G., Playfoot,C.J., Salvador-Palomeque,C., Mann,A.R.,
            Peressini,P., Sanchez,L., Dobie,K., Read,D., Hung,C.C.,
            Eskeland,R., Meehan,R.R., Weichenrieder,O., Garcia-Perez,J.L. and
            Adams,I.R.
  TITLE     Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in
            mouse embryonic stem cells
  JOURNAL   Elife 6, e26152 (2017)
   PUBMED   28806172
  REMARK    GeneRIF: Here the authors show that TEX19.1, which is induced by
            developmentally programmed DNA hypomethylation, can directly
            interact with the LINE-1 (L1) retrotransposon-encoded protein
            L1-ORF1p, stimulate its polyubiquitylation and degradation, and
            restrict L1 mobilization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Rolland,A.D., Lehmann,K.P., Johnson,K.J., Gaido,K.W. and Koopman,P.
  TITLE     Uncovering gene regulatory networks during mouse fetal germ cell
            development
  JOURNAL   Biol Reprod 84 (4), 790-800 (2011)
   PUBMED   21148109
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Iwabuchi,K.A., Yamakawa,T., Sato,Y., Ichisaka,T., Takahashi,K.,
            Okita,K. and Yamanaka,S.
  TITLE     ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC
            generation, but it is dispensable for the maintenance and induction
            of pluripotency
  JOURNAL   PLoS One 6 (5), e20461 (2011)
   PUBMED   21637830
  REMARK    GeneRIF: These data demonstrate the dispensability of ECAT11/L1td1
            in pluripotency, despite its specific expression.
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670941.11.
            
            On Feb 6, 2007 this sequence version replaced XM_355549.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB211064.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN01164134 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL670941.11        54069-54155
            88-163              AL670941.11        54710-54785
            164-1099            AL670941.11        60458-61393
            1100-1401           AL670941.11        63761-64062
            1402-2942           AL670941.11        64261-65801
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.6 cM"
     gene            1..2942
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /note="LINE-1 type transposase domain containing 1"
                     /db_xref="GeneID:381591"
                     /db_xref="MGI:MGI:3578435"
     exon            1..87
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /inference="alignment:Splign:2.1.0"
     exon            88..163
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /inference="alignment:Splign:2.1.0"
     exon            164..1099
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2572
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /note="isoform 2 is encoded by transcript variant 2;
                     LINE-1 type transposase domain-containing protein 1; ES
                     cell-associated protein 11"
                     /codon_start=1
                     /product="LINE-1 type transposase domain-containing
                     protein 1 isoform 2"
                     /protein_id="NP_001074671.1"
                     /db_xref="CCDS:CCDS51235.1"
                     /db_xref="GeneID:381591"
                     /db_xref="MGI:MGI:3578435"
                     /translation="MSGVQSKAARLQKERKEKLSADRERKTATSLCLKHSEVPASMMK
                     QFNALMEMQEVMFAEMRETYKNDIKEMLLKRTAPWVKHLEERIGQQEGDAISERPKPG
                     EKVEELSSGTDEDTENLTVRSKKGKQDKAKPLNSSHVLKSSLERGGEALRGEHGRCGE
                     SSSLVDWKNANEKPAREASCQSEENRLKAPKESPPEGGAGATLRLAADFSAATLDVGR
                     QWSQVFRLLKEKELEPELQCSVKLAFKCDGEANVFSDLHSLRQFTSRKPFLRELLKDV
                     FPQNEGGRRNELRERLGKTLGDTKHEARRIASDSLSFLFIKEVEVASPEVKTYKEETL
                     DRKNKGTLKKQEGEEEEISETQGEETSEGETSELGEEEGSESEEEEESSESEEEEESS
                     ESAEEIGFISLVVDSESEEEVNRKTASQTKKKETFHGLKELAFSYLVWDSKKKKLVRC
                     QEGGAAAASTQRIGMPCLTLYLTSPSESLGAGSDGPKSHSCTKLSALSQVTPLLTNIE
                     KGRYKVPQTEEPTAKEADLILETEENFKRGVISVIRQMQREVDKIKNIYVSDVLNMKS
                     SLDDLNSLACTIEARVSEQEDAVEGLTKDTMQLAREIVDKERLREREDRFRSSNIRVI
                     GIPEKENRENGAVDIIKEVIEENFAELEDQSLEIVSAHRVPNSVDEHRLTPRHILVKF
                     GSASDKQRVLKASRAKQEITYRGSKIRLTADLSPGTIDARSQWCGIIKILQDEGFQPR
                     ILYPAKLAFDFKGKTKIFFDIEEFKKFISDIPYLKDLLNNIH"
     exon            1100..1401
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2942
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2910..2915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /note="hexamer: ATTAAA"
     polyA_site      2934
                     /gene="L1td1"
                     /gene_synonym="ECAT11"
                     /note="major polyA site"
ORIGIN      
        1 gacccagcga gtctctcctg cggtcagacg cccagccctg cttttgtcag cgtgtgtgac
       61 ctcagggctg cacctcgtgg ctctcaggcg ctgtgaaacg cgtggacaga ccaatcccga
      121 cctgaggaga gctggttcct tcctggggaa ggcgcagatt tgggattttg aacttctgac
      181 gctctcgcca ggaaaaggtg cgctttgtgt cagtgtatcc accatgtcgg gcgtgcagtc
      241 caaagcagcc aggcttcaaa aggagcggaa agaaaagctg tcggcagaca gggagagaaa
      301 aacggccaca tctctgtgct taaagcacag cgaagtacct gcatccatga tgaagcagtt
      361 taatgcttta atggaaatgc aagaggtgat gtttgcagag atgagagaaa cctataaaaa
      421 cgatataaag gaaatgctgt taaaacgaac agcaccttgg gtgaagcatt tggaagagcg
      481 gatagggcag caagaaggag atgcaatctc ggaaaggcca aagccaggag agaaagtgga
      541 agagttaagt tctggaacag acgaggacac tgaaaacctg actgtgagaa gcaagaaggg
      601 taagcaggac aaagctaaac cactcaacag cagccatgtc ctgaaatcat cactagagag
      661 agggggagaa gccctgcgtg gggaacatgg caggtgtgga gagagcagca gccttgtaga
      721 ctggaagaat gcgaatgaga agccagcccg agaagccagc tgtcagagtg aagagaatcg
      781 tctcaaggcc cccaaagaga gcccgcccga aggaggcgcc ggagccaccc taaggctggc
      841 tgctgacttc tcggcagcca cgctggatgt cggcaggcag tggagccaag tcttccgcct
      901 tctgaaagaa aaggagttgg agcctgagct gcagtgctcc gtgaagttgg catttaagtg
      961 tgatggggag gcgaacgttt tctcagacct tcacagcctc cgtcagttta ccagcagaaa
     1021 gccttttctg agagagttgc tgaaagatgt gttcccgcaa aatgaaggag gaagaagaaa
     1081 cgagcttcgg gaaagattgg gtaaaacgct aggagacacg aagcatgaag ctagaagaat
     1141 agcgagtgac agtttgagct tcctgttcat caaagaggta gaagttgcta gtccagaggt
     1201 gaagacttac aaagaagaaa cactggaccg gaagaataaa ggaactctca agaagcagga
     1261 gggggaagaa gaagaaatct cagagacaca gggagaagaa acttcagagg gagagacctc
     1321 agagttgggg gaggaagagg gttcggagtc agaagaggag gaagagagtt cggagtcaga
     1381 agaggaggaa gaaagttcag agagtgctga ggagattggc ttcattagtt tggtagtaga
     1441 ttctgaatca gaggaagaag taaacagaaa gacggcttcc cagactaaga aaaaggagac
     1501 cttccatggg cttaaagaac ttgcctttag ttacctggtc tgggactcta agaaaaaaaa
     1561 gctggtgaga tgccaggagg gaggagcagc tgctgcttct actcaaagga tcgggatgcc
     1621 gtgtctaacc ttatatttga cttctccatc agaatcttta ggggcaggta gcgatggtcc
     1681 taaaagccat tcatgtacaa agttgagtgc tctgtcacaa gtcactccac ttttaacgaa
     1741 catagaaaag gggaggtaca aggtgccgca aacagaagag ccaacagcca aagaagcaga
     1801 cttgatcctt gaaaccgaag aaaacttcaa gagaggcgtg atcagtgtta tcagacagat
     1861 gcaaagggag gtcgacaaaa tcaaaaacat ttacgtttcc gacgtcctga atatgaaaag
     1921 ttcactggat gatctgaatt ccttagcttg cacgattgag gccagggtga gcgaacagga
     1981 agatgccgtg gagggactga ccaaggatac aatgcagtta gccagggaga tcgttgataa
     2041 agaaaggctg agagagaggg aagataggtt tcgaagctcc aacatccgag tgatagggat
     2101 tccagagaaa gaaaaccggg agaacggagc ggtggacata attaaggaag taattgaaga
     2161 aaactttgcc gagctagaag accagagcct cgagattgtc agcgctcatc gtgtccctaa
     2221 ttcagtggat gagcacagac tcacgcctag acacatctta gtgaagtttg ggagtgctag
     2281 tgataagcag agagtcctaa aagcttccag agcaaaacaa gaaataacct acagagggtc
     2341 caagatcaga ctgacagctg acttatcacc tggtactata gatgcacgca gccagtggtg
     2401 tggtatcata aaaattctgc aagacgaagg ctttcagcca agaatccttt atcctgccaa
     2461 actggcattt gattttaaag gtaaaaccaa gatatttttt gatattgagg aattcaagaa
     2521 gtttatctct gatataccct atttgaaaga tctgttgaac aatatacatt agcaacctgg
     2581 agtgctctct gtccaccaaa atacaaaacc aagtagagtt ggacagtgga ccatcacgtc
     2641 tctgtcttga agggtggacg gctgactttt tttcccccag ggaaaggggc tggggaagcg
     2701 gtgtaactcc ctgagtgttg gttgagttag acagcgtatg tagcttttca gtagctatct
     2761 accttggtaa ggaggaatct tgtcagtgtg accacacacg gaaaaatact agaggccaca
     2821 gtgggatggg aaaggacatg ataagttaga agagactgca ggctgactga ctcaacaaga
     2881 ttacattgct ttattattta ctattacata ttaaagcttg aagtttgcat ttgtcattgg
     2941 tt
//
