LOCUS       NM_001293560            2275 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus kynurenine aminotransferase 3 (Kyat3), transcript
            variant 1, mRNA.
ACCESSION   NM_001293560 XM_006501430
VERSION     NM_001293560.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Poku,E.K., Ono,M., Higuchi,Y., Chea,J., Melendez,E., Teo,J.L.,
            Nguyen,C., Chimge,N.O. and Kahn,M.
  TITLE     Differential Kat3 Coactivator Usage Regulates Brain Metabolism and
            Neuronal Differentiation
  JOURNAL   Curr Mol Pharmacol 17 (1), e170823219875 (2024)
   PUBMED   37594155
  REMARK    GeneRIF: Differential Kat3 Coactivator Usage Regulates Brain
            Metabolism and Neuronal Differentiation.
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Lipinski,M., Munoz-Viana,R., Del Blanco,B., Marquez-Galera,A.,
            Medrano-Relinque,J., Carames,J.M., Szczepankiewicz,A.A.,
            Fernandez-Albert,J., Navarron,C.M., Olivares,R., Wilczynski,G.M.,
            Canals,S., Lopez-Atalaya,J.P. and Barco,A.
  TITLE     KAT3-dependent acetylation of cell type-specific genes maintains
            neuronal identity in the adult mouse brain
  JOURNAL   Nat Commun 11 (1), 2588 (2020)
   PUBMED   32444594
  REMARK    GeneRIF: KAT3-dependent acetylation of cell type-specific genes
            maintains neuronal identity in the adult mouse brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Pinto,J.T., Krasnikov,B.F., Alcutt,S., Jones,M.E., Dorai,T.,
            Villar,M.T., Artigues,A., Li,J. and Cooper,A.J.
  TITLE     Kynurenine aminotransferase III and glutamine transaminase L are
            identical enzymes that have cysteine S-conjugate beta-lyase
            activity and can transaminate L-selenomethionine
  JOURNAL   J Biol Chem 289 (45), 30950-30961 (2014)
   PUBMED   25231977
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Thermal stability, pH dependence and inhibition of four murine
            kynurenine aminotransferases
  JOURNAL   BMC Biochem 11, 19 (2010)
   PUBMED   20482848
  REMARK    GeneRIF: KAT III inhibited by equimolar methionine and half-life is
            3.9 minutes at 65 degree C.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Han,Q., Robinson,H., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Biochemical and structural properties of mouse kynurenine
            aminotransferase III
  JOURNAL   Mol Cell Biol 29 (3), 784-793 (2009)
   PUBMED   19029248
  REMARK    GeneRIF: The biochemical and structural properties of mouse KAT III
            (mKAT III) were determined.
            Erratum:[Mol Cell Biol. 2018 Apr 30;38(10):e00099-18. doi:
            10.1128/MCB.00099-18.. PMID: 29712768]
REFERENCE   6  (bases 1 to 2275)
  AUTHORS   Yu,P., Li,Z., Zhang,L., Tagle,D.A. and Cai,T.
  TITLE     Characterization of kynurenine aminotransferase III, a novel member
            of a phylogenetically conserved KAT family
  JOURNAL   Gene 365, 111-118 (2006)
   PUBMED   16376499
REFERENCE   7  (bases 1 to 2275)
  AUTHORS   Yu,P., Mosbrook,D.M. and Tagle,D.A.
  TITLE     Genomic organization and expression analysis of mouse kynurenine
            aminotransferase II, a possible factor in the pathophysiology of
            Huntington's disease
  JOURNAL   Mamm Genome 10 (9), 845-852 (1999)
   PUBMED   10441733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115865.9, AK145623.1 and AK049569.1.
            
            On Jun 10, 2014 this sequence version replaced XM_006501430.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF363737.1, AK145623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC115865.9         95981-95983         c
            4-1704              AK145623.1         2-1702
            1705-2274           AK049569.1         1678-2247
            2275-2275           AC115865.9         52120-52120         c
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..2275
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /note="kynurenine aminotransferase 3"
                     /db_xref="GeneID:229905"
                     /db_xref="MGI:MGI:2677849"
     exon            1..128
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            129..231
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1497
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /EC_number="2.6.1.63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kynurenine--oxoglutarate transaminase 3; kynurenine
                     aminotransferase III; cysteine-S-conjugate beta-lyase 2;
                     kynurenine--oxoglutarate transaminase III;
                     kynurenine--glyoxylate transaminase; cysteine
                     conjugate-beta lyase 2"
                     /codon_start=1
                     /product="kynurenine--oxoglutarate transaminase 3 isoform
                     1"
                     /protein_id="NP_001280489.1"
                     /db_xref="CCDS:CCDS80040.1"
                     /db_xref="GeneID:229905"
                     /db_xref="MGI:MGI:2677849"
                     /translation="MLLAQRRLISLGCRSKPIKTIYSSSKVLGLCTSAKMALKFKNAK
                     RIEGLDSNVWVEFTKLAADPSVVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYTRGF
                     GHPALVKALSCLYGKIYQRQIDPNEEILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFY
                     DCYEPMVRMAGAVPVFIPLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAIILNTPH
                     NPLGKVYTRQELQVIADLCVKHDTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITI
                     GSAGKTFSVTGWKLGWSIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKRMD
                     DPECYFNSLPKELEVKRDRMVRLLNSVGLKPIVPDGGYFIIADVSSLGADLSDMNSDE
                     PYDYKFVKWMTKHKKLTAIPVSAFCDSKSKPHFEKLVRFCFIKKDSTLDAAEEIFRAW
                     NSQKS"
     exon            232..290
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            291..435
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            436..585
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            586..672
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            673..798
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            799..919
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            920..996
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1086
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1273
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1347
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1434
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..2275
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /note="hexamer: AATACA"
     polyA_site      1702
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /note="major polyA site"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
                     /note="hexamer: AATGAA"
     polyA_site      1891
                     /gene="Kyat3"
                     /gene_synonym="Ccbl2; Kat3; KATIII"
ORIGIN      
        1 ctctacaatc aggagggttc ctgctgcact ctgcttctgg atccccgagt gcattccgcc
       61 aggaaccccg gcgacaccta gcgacctccg gactaaggcc agggacgcat tggaaccagg
      121 agaacgatca tgcttttggc ccagaggaga ctcatctccc ttggctgcag atcaaagccc
      181 ataaagacaa tttactcttc ttcgaaagtc ctcggactct gcacttctgc caaaatggct
      241 ttgaaattca aaaacgccaa acgaatcgaa ggcctggaca gcaatgtgtg ggttgaattt
      301 actaagttgg ctgcggatcc ttctgtggtg aaccttggac aaggctttcc agatatatcc
      361 cctccttcat acgtaaaaga agagttatca aaggctgcat ttattgataa catgaatcaa
      421 tacacaagag gctttggtca tccagcactt gtgaaagctc tgtcctgctt atatggaaag
      481 atttatcaac gtcaaattga tccaaacgaa gaaatccttg tggccgtggg ggcatatgga
      541 tctctcttta actccatcca aggattggtg gacccaggag atgaagtgat aattatggtg
      601 cctttttacg actgttatga gcccatggtg agaatggccg gagcagtgcc tgtgtttatt
      661 cccctgagat ctaaacctac tgacgggatg aagtggacta gctctgactg gacattcgat
      721 cctcgagaac tggaaagtaa attcagttcc aaaacgaaag ccataatatt aaatactcca
      781 cacaaccccc tcggcaaggt gtataccaga caggagctgc aagtcattgc tgacctttgc
      841 gtcaagcacg acactctgtg catcagcgat gaggtttatg aatggcttgt ctatactgga
      901 catacgcacg taaaaatagc cactcttcca ggtatgtggg agagaacaat aacaatagga
      961 agtgctggca agacattcag tgtgactggc tggaagctcg gctggagcat tggccctgct
     1021 cacctgataa agcatttaca gaccgttcaa cagaacagtt tttacacgtg tgcgactcct
     1081 ttacaggcag ccttggccga ggcgttttgg atcgatatca agcgcatgga tgaccctgag
     1141 tgttacttta attctctgcc aaaggaatta gaagtaaaga gagatcggat ggtccgttta
     1201 cttaacagcg ttggcctgaa acccattgtt cctgacgggg gttacttcat cattgctgat
     1261 gtgtcttcat taggtgctga cctctcggac atgaacagcg atgagcctta tgactataag
     1321 tttgtgaagt ggatgacgaa acataagaaa ctgacagcca ttcctgtttc tgccttctgc
     1381 gactccaagt ctaaaccaca ctttgagaag ctggtgcggt tttgctttat taaaaaagac
     1441 agcacactgg atgctgccga agaaatcttc agggcctgga acagccagaa gtcttgactg
     1501 gttccatctt cctgcaagga cttgctgctc agtgctgcca cctcgtgggc actataaaga
     1561 aacacggttc aggacaaaca tttaaataag tacttccatt gtctacaaag ttaaccccgt
     1621 tcctaaccat gttcggtaca ttcaggtttt attcgtttgg aatacattaa ggtgccttcc
     1681 actgtcgtgg tgggagagtc aacttctccg tgttgtactt tctcatgagt ggaaacggaa
     1741 atcgccgtta ctgcaccaag tgcagcatgg cctgcaaacc cagcacttgg gagggggagg
     1801 caggagttca aggtcatcca cagtgacata gtaagctggg ggtcatgcgg ggttacgtga
     1861 gactctcaat aaatgaaaga aacaaaacca acacatacct catctgcagc tcgtctgtga
     1921 ggactgcagg ctcattcagt gtaaagtctg gcaacctaca agccctcaca ggaggttggc
     1981 caggttcacc tctcggtcct gctgggcgcc agccatgagg gtgcctatag ctccctccct
     2041 aggacactag actttgcccc tggctttgtt ttttttctct tccaagggct gctgtgactt
     2101 gggtggcctc acggtccacg tgggcagcct gtgttttcca ccccctgacc ttgttacctc
     2161 tgccaatgtt cacccctgct ccacctgaac cacccactcc cttggccaca ccttgaaact
     2221 atcatcagtc ggggccgttt cacctttgag atagtaaaca catcctctct atata
//
