LOCUS       NM_001356474            1901 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus kynurenine aminotransferase 1 (Kyat1), transcript
            variant 2, mRNA.
ACCESSION   NM_001356474 XM_006498314
VERSION     NM_001356474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Nadvi,N.A., Salam,N.K., Park,J., Akladios,F.N., Kapoor,V.,
            Collyer,C.A., Gorrell,M.D. and Church,W.B.
  TITLE     High resolution crystal structures of human kynurenine
            aminotransferase-I bound to PLP cofactor, and in complex with
            aminooxyacetate
  JOURNAL   Protein Sci 26 (4), 727-736 (2017)
   PUBMED   28097769
  REMARK    GeneRIF: One is the native structure with the cofactor in the PLP
            form bound to Lys247 with the highest resolution yet available for
            KAT-I at 1.28 A resolution, and the other with the general
            PLP-dependent aminotransferase inhibitor, aminooxyacetate (AOAA)
            covalently bound to the cofactor at 1.54 A.
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Thermal stability, pH dependence and inhibition of four murine
            kynurenine aminotransferases
  JOURNAL   BMC Biochem 11, 19 (2010)
   PUBMED   20482848
  REMARK    GeneRIF: KAT I inhibited by equimolar tryptophan and half-life is
            69.7 minutes at 65 degree C.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Yu,P., Li,Z., Zhang,L., Tagle,D.A. and Cai,T.
  TITLE     Characterization of kynurenine aminotransferase III, a novel member
            of a phylogenetically conserved KAT family
  JOURNAL   Gene 365, 111-118 (2006)
   PUBMED   16376499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845258.5, AK088404.1 and AI182306.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001356474.2.
            
            On Oct 5, 2017 this sequence version replaced XM_006498314.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042391.1, AK088404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL845258.5         92155-92196         c
            43-1865             AK088404.1         6-1828
            1866-1901           AI182306.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.31 cM"
     gene            1..1901
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /note="kynurenine aminotransferase 1"
                     /db_xref="GeneID:70266"
                     /db_xref="MGI:MGI:1917516"
     exon            1..215
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            216..274
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1496
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /EC_number="2.6.1.64"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /note="isoform a is encoded by transcript variant 2;
                     kynurenine aminotransferase I; kynurenine--oxoglutarate
                     transaminase 1; glutamine transaminase K;
                     cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate
                     transaminase; kynurenine--oxoglutarate transaminase I;
                     cytoplasmic (glutamine transaminase K, kyneurenine
                     aminotransferase); cysteine conjugate-beta lyase 1"
                     /codon_start=1
                     /product="kynurenine--oxoglutarate transaminase 1 isoform
                     a"
                     /protein_id="NP_001343403.1"
                     /db_xref="CCDS:CCDS15874.1"
                     /db_xref="GeneID:70266"
                     /db_xref="MGI:MGI:1917516"
                     /translation="MSKQLQARRLEGIDHNPWVEFTRLSKEYDVVNLGQGFPDFSPPD
                     FAVQAFQQATTGNFMLNQYTSAFGYPPLTKILASFFGKLLGQEMDPLKNVLVTVGAYG
                     ALFTAFQALVDEGDEVIIIEPAFNCYEPMTMMAGGRPVFVSLRLSPAPKGQLGSSNDW
                     QLDPTELASKFTPRTKILVLNTPNNPLGKVFSKKELELVAALCQQHDVLCFSDEVYQW
                     LVYDGHQHISIASLPGMWERTLTIGSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNS
                     IFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMGLNRDHMIQSLQSVGLKPLIP
                     QGSYFLIADISDFKSSMPDLPGAMDEPYDTRFAKWMIKNKGLSAIPVSTFYSQPHHKD
                     FDHYIRFCFVKDKATLQAMDKRLCSWKGEPQA"
     exon            275..422
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            423..572
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            573..659
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            660..788
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            789..909
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            910..986
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1076
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1263
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1343
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1430
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1876
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatgctt ggggatccta ggctgtcgcc cagtctttaa agggcacaca gagcttcgca
       61 ctgcttctga cagttctctt gagctaagct gcatctgggc ggaagtagcc catctagggc
      121 tcggcctctt taaaggaaca gacttctgca accttgggaa tacgtttggg gtcgcgggtt
      181 attggacaga gcagcgctat tgtttgctga agcagctcac catgtccaaa cagctgcagg
      241 ctcgaaggct ggaagggatc gatcacaacc cctgggtgga gtttaccaga ctgtccaagg
      301 agtatgatgt cgtgaacttg ggccagggct tccctgactt ctcaccgcca gactttgctg
      361 tgcaagcttt tcagcaggct accactggga acttcatgct caaccagtac acctcagcgt
      421 ttggttaccc tccactgaca aagatcctgg caagtttctt tggcaagctg ctgggacagg
      481 agatggaccc actcaagaat gtgctggtga cagtgggagc ctatggggcc ttgttcacag
      541 cctttcaggc cctggtggat gaaggagacg aggtcatcat catcgaacct gcttttaatt
      601 gttacgaacc catgacaatg atggctggag gtcgccctgt gttcgtgtcc ctgaggctga
      661 gtcctgctcc taaggggcag ctgggatcca gcaatgattg gcagctggac cccacagaac
      721 tggccagcaa gttcacacct cgcaccaaga tcctggtcct caacacaccc aacaaccctc
      781 tgggaaaggt attctctaag aaggagctgg agctggtggc tgcactgtgc caacagcatg
      841 atgtcctgtg cttctctgat gaggtctacc agtggctggt ctatgatggg caccagcaca
      901 tcagcattgc cagcctccct ggcatgtggg aacggacact gaccatcggc agcgcaggca
      961 aaagcttcag tgccactggc tggaaggtgg gctgggtcat gggtccagat aacatcatga
     1021 agcacctgcg gactgtgcac cagaactcta tctttcactg ccccacccag gcccaggctg
     1081 cagtagccca gtgctttgag cgggagcagc aacactttgg acaacccagc agttactttt
     1141 tgcagctgcc acaggccatg ggcctgaacc gagaccacat gatccagagc ctgcagtcag
     1201 tgggcctcaa gcccttgatc ccccagggca gctacttcct cattgcagac atctcagact
     1261 tcaagagcag catgcccgac ctgcctggtg ctatggatga gccctatgat acacgctttg
     1321 ccaagtggat gatcaaaaac aaggggctgt cagccatccc tgtctccacc ttctatagcc
     1381 agccccatca taaggacttt gaccactaca tccgattctg ttttgtgaag gacaaggcta
     1441 cactccaggc catggataag aggctgtgca gctggaaagg agagccccaa gcctgaggcg
     1501 ctcaggcccg cctccaaccc cgagacctca gctgtgcctt atcacagaga tggcgctgca
     1561 gggcccagat gtgtgactgg gcatgtttcc aggaaagagg ccatctcttg ggggtttcag
     1621 ccatcttacc cagtgtctgg actgctatat tgggttgggg gctggttctg gaactcagtc
     1681 tgcgcctcta taggttcttg tagagccttg gttgtttctg gcctctgcct gggacagtaa
     1741 aggatggagg atcaggcctg gagccccagc cccaccttag ccctgctgag gctccatggc
     1801 ttctccactt cttctcatgt gacctcacag tgttgctact gttcctaata aagttttaag
     1861 ttattagaac cctcaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
