LOCUS       NP_001343403             424 aa            linear   ROD 26-OCT-2024
DEFINITION  kynurenine--oxoglutarate transaminase 1 isoform a [Mus musculus].
ACCESSION   NP_001343403 XP_006498377
VERSION     NP_001343403.1
DBSOURCE    REFSEQ: accession NM_001356474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 424)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 424)
  AUTHORS   Nadvi,N.A., Salam,N.K., Park,J., Akladios,F.N., Kapoor,V.,
            Collyer,C.A., Gorrell,M.D. and Church,W.B.
  TITLE     High resolution crystal structures of human kynurenine
            aminotransferase-I bound to PLP cofactor, and in complex with
            aminooxyacetate
  JOURNAL   Protein Sci 26 (4), 727-736 (2017)
   PUBMED   28097769
  REMARK    GeneRIF: One is the native structure with the cofactor in the PLP
            form bound to Lys247 with the highest resolution yet available for
            KAT-I at 1.28 A resolution, and the other with the general
            PLP-dependent aminotransferase inhibitor, aminooxyacetate (AOAA)
            covalently bound to the cofactor at 1.54 A.
REFERENCE   4  (residues 1 to 424)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 424)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (residues 1 to 424)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Thermal stability, pH dependence and inhibition of four murine
            kynurenine aminotransferases
  JOURNAL   BMC Biochem 11, 19 (2010)
   PUBMED   20482848
  REMARK    GeneRIF: KAT I inhibited by equimolar tryptophan and half-life is
            69.7 minutes at 65 degree C.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 424)
  AUTHORS   Yu,P., Li,Z., Zhang,L., Tagle,D.A. and Cai,T.
  TITLE     Characterization of kynurenine aminotransferase III, a novel member
            of a phylogenetically conserved KAT family
  JOURNAL   Gene 365, 111-118 (2006)
   PUBMED   16376499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845258.5.
            
            On Oct 5, 2017 this sequence version replaced XP_006498377.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2215059.1, AK088404.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.31 cM"
     Protein         1..424
                     /product="kynurenine--oxoglutarate transaminase 1 isoform
                     a"
                     /EC_number="2.6.1.64"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /note="kynurenine aminotransferase I;
                     kynurenine--oxoglutarate transaminase 1; glutamine
                     transaminase K; cysteine-S-conjugate beta-lyase;
                     glutamine--phenylpyruvate transaminase;
                     kynurenine--oxoglutarate transaminase I; cytoplasmic
                     (glutamine transaminase K, kyneurenine aminotransferase);
                     cysteine conjugate-beta lyase 1"
                     /calculated_mol_wt=47433
     Region          7..418
                     /region_name="AspB"
                     /note="Aspartate/methionine/tyrosine aminotransferase
                     [Amino acid transport and metabolism]; COG0436"
                     /db_xref="CDD:440205"
     CDS             1..424
                     /gene="Kyat1"
                     /gene_synonym="2010009K05Rik; Ccbl1; Gtk; Kat1; KatI"
                     /coded_by="NM_001356474.2:191..1465"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS15874.1"
                     /db_xref="GeneID:70266"
                     /db_xref="MGI:MGI:1917516"
ORIGIN      
        1 mskqlqarrl egidhnpwve ftrlskeydv vnlgqgfpdf sppdfavqaf qqattgnfml
       61 nqytsafgyp pltkilasff gkllgqemdp lknvlvtvga ygalftafqa lvdegdevii
      121 iepafncyep mtmmaggrpv fvslrlspap kgqlgssndw qldptelask ftprtkilvl
      181 ntpnnplgkv fskkelelva alcqqhdvlc fsdevyqwlv ydghqhisia slpgmwertl
      241 tigsagksfs atgwkvgwvm gpdnimkhlr tvhqnsifhc ptqaqaavaq cfereqqhfg
      301 qpssyflqlp qamglnrdhm iqslqsvglk plipqgsyfl iadisdfkss mpdlpgamde
      361 pydtrfakwm iknkglsaip vstfysqphh kdfdhyirfc fvkdkatlqa mdkrlcswkg
      421 epqa
//
