LOCUS       NM_024291               5514 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kyphoscoliosis peptidase (Ky), mRNA.
ACCESSION   NM_024291
VERSION     NM_024291.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5514)
  AUTHORS   Jokl,E.J., Hughes,G.L., Cracknell,T., Pownall,M.E. and Blanco,G.
  TITLE     Transcriptional upregulation of Bag3, a chaperone-assisted
            selective autophagy factor, in animal models of KY-deficient
            hereditary myopathy
  JOURNAL   Dis Model Mech 11 (7) (2018)
   PUBMED   29914939
  REMARK    GeneRIF: expression of the co-chaperone BAG3 and other
            chaperone-assisted selective autophagy factors was analyzed in the
            cellular, zebrafish and ky/ky mouse models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5514)
  AUTHORS   Miao,Y., Yang,J., Xu,Z., Jing,L., Zhao,S. and Li,X.
  TITLE     RNA sequencing identifies upregulated kyphoscoliosis peptidase and
            phosphatidic acid signaling pathways in muscle hypertrophy
            generated by transgenic expression of myostatin propeptide
  JOURNAL   Int J Mol Sci 16 (4), 7976-7994 (2015)
   PUBMED   25860951
  REMARK    GeneRIF: kyphoscoliosis peptidase (Ky), which plays a vital role in
            muscle growth, was also up-regulated in the transgenic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5514)
  AUTHORS   Jaka,O., Kramerova,I., Azpitarte,M., Lopez de Munain,A., Spencer,M.
            and Saenz,A.
  TITLE     C3KO mouse expression analysis: downregulation of the muscular
            dystrophy Ky protein and alterations in muscle aging
  JOURNAL   Neurogenetics 13 (4), 347-357 (2012)
   PUBMED   22820870
  REMARK    GeneRIF: The Ky gene was downregulated in CAPN3KO muscles
            suggesting that Ky protease may play a complementary role in
            regulating muscle cytoskeleton homeostasis in response to changes
            in muscle activity.
REFERENCE   5  (bases 1 to 5514)
  AUTHORS   Baker,J., Riley,G., Romero,M.R., Haynes,A.R., Hilton,H., Simon,M.,
            Hancock,J., Tateossian,H., Ripoll,V.M. and Blanco,G.
  TITLE     Identification of a Z-band associated protein complex involving KY,
            FLNC and IGFN1
  JOURNAL   Exp Cell Res 316 (11), 1856-1870 (2010)
   PUBMED   20206623
  REMARK    GeneRIF: KY, IGFN1 and FLNC are part of a Z-band associated protein
            complex likely to provide structural support to the skeletal muscle
            sarcomere.
REFERENCE   6  (bases 1 to 5514)
  AUTHORS   Marechal,G., Coulton,G.R. and Beckers-Bleukx,G.
  TITLE     Mechanical power and myosin composition of soleus and extensor
            digitorum longus muscles of ky mice
  JOURNAL   Am J Physiol 268 (2 Pt 1), C513-C519 (1995)
   PUBMED   7864091
REFERENCE   7  (bases 1 to 5514)
  AUTHORS   Skynner,M.J., Gangadharan,U., Coulton,G.R., Mason,R.M.,
            Nikitopoulou,A., Brown,S.D. and Blanco,G.
  TITLE     Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis
  JOURNAL   Genomics 25 (1), 207-213 (1995)
   PUBMED   7774920
REFERENCE   8  (bases 1 to 5514)
  AUTHORS   Bridges,L.R., Coulton,G.R., Howard,G., Moss,J. and Mason,R.M.
  TITLE     The neuromuscular basis of hereditary kyphoscoliosis in the mouse
  JOURNAL   Muscle Nerve 15 (2), 172-179 (1992)
   PUBMED   1372391
REFERENCE   9  (bases 1 to 5514)
  AUTHORS   Mason,R.M. and Palfrey,A.J.
  TITLE     Intervertebral disc degeneration in adult mice with hereditary
            kyphoscoliosis
  JOURNAL   J Orthop Res 2 (4), 333-338 (1984)
   PUBMED   6527158
REFERENCE   10 (bases 1 to 5514)
  AUTHORS   Dickinson,A.G. and Meikle,V.M.
  TITLE     Genetic kyphoscoliosis in mice
  JOURNAL   Lancet 1 (7813), 1186 (1973)
   PUBMED   4123573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450317.13.
            
            On Nov 9, 2022 this sequence version replaced NM_024291.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ293727.2, SRR9219382.197078.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AL450317.13        91376-91576         c
            202-264             AL450317.13        88481-88543         c
            265-327             AL450317.13        84619-84681         c
            328-402             AL450317.13        76291-76365         c
            403-465             AL450317.13        74274-74336         c
            466-548             AL450317.13        72174-72256         c
            549-657             AL450317.13        70850-70958         c
            658-775             AL450317.13        69637-69754         c
            776-964             AL450317.13        59865-60053         c
            965-1155            AL450317.13        58466-58656         c
            1156-5514           AL450317.13        51410-55768         c
FEATURES             Location/Qualifiers
     source          1..5514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.54 cM"
     gene            1..5514
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /note="kyphoscoliosis peptidase"
                     /db_xref="GeneID:16716"
                     /db_xref="MGI:MGI:96709"
     exon            1..201
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2051
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /codon_start=1
                     /product="kyphoscoliosis peptidase"
                     /protein_id="NP_077253.3"
                     /db_xref="CCDS:CCDS23445.1"
                     /db_xref="GeneID:16716"
                     /db_xref="MGI:MGI:96709"
                     /translation="MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNR
                     GGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMP
                     QLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASAS
                     QVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDIL
                     RTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEG
                     RWHLVDSTWGSGLVDTTTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLR
                     QFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGL
                     LSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQ
                     PVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQ
                     RRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWP
                     MFPESFGNWGQDNELLEPLSGVLPANRNIAFKLKLHGIAKALVKGQDTWPLTLNPEGY
                     WEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ"
     exon            202..264
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            265..327
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            328..402
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            403..465
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            466..548
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            549..657
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            658..775
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            776..964
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1155
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..5514
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5487..5492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /note="hexamer: AATAAA"
     polyA_site      5514
                     /gene="Ky"
                     /gene_synonym="CD1; D9Mgc44e"
                     /note="major polyA site"
ORIGIN      
        1 gccatttgca gcctaggcag cctcgcgagc agccgctgcg cgcgggccgg gagggaggcg
       61 gcaccatgga gctgaagaag gacagcaacg ctgtggccat cgacatgctg ctcatcgtgc
      121 actccgagaa gcggcgcgcg gcgcaagcca cgcacttgga cccgcaggcg aacccgggcg
      181 cgctgctgca aaaccgagga ggattccaag gtgtcagaaa cggaatccgg aagtggcaag
      241 agttggaaga aaacagcttt cagggaaact tgccagagaa gcagtgcctt cagcagccgc
      301 aggtcatcac ctcctacgac aaccaaggta ctcagctgac tgtggaaatc cacccccaag
      361 acgccatgcc ccagctgctt aagaagttct ctttggctaa acgtttacaa ggtgataaaa
      421 atggaaacat gagaccccgg cagcctggag ggaaagatgc ccacgcctac ccctgggaca
      481 gatccagttt gaaatccatg cccctggacc tccggctctt tgaaaaactg gatgcctctg
      541 cctcacaggt gacagtcaag agtggcctga atgagctggt gagtgacttg ctccaggaag
      601 cccacagcga tctggaaagg gtcagagcca tctggatctg gatctgccac catatagagt
      661 acgacgttga ggctgcccag gagaaggacc gccaggcctt caaacccact gacatcctga
      721 ggacccagaa gaccaactgt gatggttacg ccggcctctt tgaaaggatg tgcagggttg
      781 ctggtgtgca gtgtgtcacc gtgcctggct actccaaggg ctttggctac cagaccggcc
      841 aaagcttctc cggagagttc gaccacgcct ggaacgctgt gtaccttgag ggtcgttggc
      901 acctggtgga cagcacctgg ggcagcggcc tggtggacac caccacctcc aaattcacct
      961 tcctctacaa tgaattctac ttcctcaccc accccgccct gttcatcgag gatcacttcc
     1021 cagacaacaa aaactggcag ctgctgaagc cgccccagtc tctgaggcag tttgagaaca
     1081 gcatgtacca caagagtgaa ttctacaaca agggcatgct gagcgcccac ccggagacgt
     1141 ccatgatcag aacagtcaat gggaaagcca caatcaccat cgagagccgg gccccaacac
     1201 tgttcatgtt catgctcaat ggcaagcagg agcacgggct cctgagcctc aggaagaacg
     1261 ggatgaagct ggaggtgtac cctccaacca tgggcaccca caagctgcag atcttcgcca
     1321 agggcaactc tgaaatctac agctcggtgc tagaatacac actcaagtgc aactatgtag
     1381 acttctctgt ccagctgccc agtgagctcc accagcccgt gggccccagc tggttctcgg
     1441 agcagatggg catcacgaag ccctctcact ctgaccctat cattcacacc agcgatggcc
     1501 gctgcgccat cagctttagc gtggaagagg gcgtcagtgt cctggcatcc cttcatggcg
     1561 atgacggccc catcactgag gagacacagc ggcgctacat cttccagttg aaccgaggga
     1621 agaggaccga gctcaaagtc cagctgcccc atgccggcaa gtttgccctt aagatctttg
     1681 tgaagaagag gcaggaacaa gggaacttca tctttgtctt caactacctc ttgtgctgcg
     1741 ccaacaccaa ggtgaactgg cccatgttcc ctgagagctt tggcaactgg ggacaggaca
     1801 atgaactgct agagcctctc tccggtgtgc ttcccgccaa ccgcaacata gccttcaaac
     1861 taaagctgca tggtatcgcc aaagctctgg tgaaaggaca ggacacgtgg cccctcactc
     1921 ttaaccccga gggctactgg gagggcagct gcaacacagc tggctgccag gaagtctacg
     1981 tcatggtgct agagaatgct aaccacaact tctacagcta catcctgaaa tacaaagtga
     2041 atgaccagtg aggggctgca tttcttcacg gtcccccagg gttaaggcca gccctgccca
     2101 gggagggccc aagctaagag cagagagccc aggacaccac taatctgcat gaaaccactt
     2161 ctaggcctct gcttcagtcc cctctgcctc aatctccctg ctgtgtcaca ggcactgagg
     2221 aatttgtgcc gccaaaggct cactcaatgt ggctgtggaa gaagagacag aggccagggc
     2281 cctctagaag aaaaaggtgc tatgtaaatc caaggtattg tgaaacgtac acccctgcct
     2341 gtgcctgctc ttgtgttagg actttgttgc tgtagagctg aatgggaaag cggaggtgtt
     2401 gcgggtgctg aaagctttcc ccacgatgcc tgcctggtgc ttgaggctga atctatgaga
     2461 aaggtgtgct ccccctgcaa gtaacatggt gtttctcccc actacttctg gaccccaggg
     2521 aatgtcgggc ctgcccatct tccacattcc tagtgctcct attagctact tcatgctctt
     2581 caagagcttg caaagggggt gggtgtagaa agcaaaccag ctgaccctca gccaactgga
     2641 ggctgctgtc tcctgatgcc tagcatctct gagatgtgct aagggcagga aagcagccgt
     2701 gtgcacattc ggatgtcctg gctggggacc agggatggag tgggtttgca ggtccagcaa
     2761 cccacatgga agggtgaaga ccccgattct atgtgcctac cagagtttag ctgagggcct
     2821 ggagattgcc ccaccccacc ccccaccagc catcctcagg agcctcaaat gcctacatag
     2881 cccactggta gcctggctga tgacctgggc cctgggcaag cagattagcc ccagcagtta
     2941 tcagatacca gggatagtgt ctgataacaa gatgttgctc cttccttaca agccaaacca
     3001 agctgagggg accaccacct gccccctaga gaaagtgttg gtctctgtct ctgaggaaag
     3061 ccctatcata gccattttcc ctcctgtctt tctctgagat gacaacccct gccctgagtt
     3121 caaccttcct tccattggga acagttgagg gcctcttact tgctccggcc tgtcctaaaa
     3181 agcctgagct gcctagctgg ccctcagcag cacctgaggc tggtgtttcc atggcaacag
     3241 ctgagggggg aaaagcaggc tgctgcaaac agggaaggcc tgaggagagc cccccgacaa
     3301 gaggttcctg cagtagcatc ccagtgcaca gatgtgctcc aggagggtcc ctaccaaatt
     3361 tcagggttct aggactctgc tcactgtgcc tgtctcagga ccaccccccc ccccaatccc
     3421 tcactgctct ctaaggaatg tcctcaggct cagctgccgc cagagccagc ctgggatact
     3481 cacagcctct acagtcaagt ctttcctcag taagagccca tcagactcct tcgataagtg
     3541 gctgacccct catgctagat cctgggacta tagaggtgaa cacaaaggac tcagccatag
     3601 gcacccgcat ctctgggtgg gcagtctgcc aagtggaacc tatctgaaga cctaggagcc
     3661 cagaacttca gctcttcatt cccttctgcc cctttcccac aggtccccac tgctacccac
     3721 ctgataccac atagcccccc tccaccagac tgggtagcct cacttgtgat tagcatggct
     3781 gctaggggct gagctgcctt ggctcatgtc cagggtcctc tggcagtctc agcccatcag
     3841 catcttgtca ctcacgcctg gaaaacgcac caaagtgggg tggggtgggg tgggaggtgg
     3901 cgttgtctcc actacaagaa gacggtggag tttgcactgc ctggaaacag cctttcctca
     3961 ccccttttat tttatgagca gtaagaactg tgctatgttt taacgaaata gtaagtgctt
     4021 cggcggtccc tgccactcgc tagacacagc cgcgacagcc actgctagcc ctgcagaaaa
     4081 tgatccccat gtttttttca aaacagcata attaatctat tctggagctt gtggaggatg
     4141 ctaccccaca aaacaggagc tgtcctcagc accagagacc cagaccgagc ctctcccagc
     4201 ggcccgggtc aaccacacgc tccgccctcc tcatataacc aggtagtccc tttgtcaagg
     4261 caactgtagg tgcactcgga aaaacgcctg cgtttctttt tactgaagca aagatacacg
     4321 aaaccgaatc caatcttcat gaatttttac acgcatgctg ctcagcctga aaatttggag
     4381 gctgcgtttt gaaggctttt tattcaaatc cccctctttg tctgctggtc cacgagtctc
     4441 attggccgat caaatggcac gagcgccccc tggtggatca cgtgcgaagt tgccaccgct
     4501 gcaaaccccc aagctggctc tttttatgat gtttgttaaa aatcactagg tgctttctcg
     4561 tcccttgcgg acaagttatg ctgtctacgg catccacatc gtggatagtt atcctcgtgg
     4621 ttgatatgcc aatgtcagcg ttgtcttgca gactgtcaga agagcctggg gagacttccc
     4681 tggcctggcg tggtgagaag ataggatggg attaagaatt gagcatcttg cccagaaagc
     4741 ttttcctgag acagaaaccc tgggcacagg aatgcctgtc tggggtcgct gtgatcacac
     4801 tcattactat ggcaatgaca ggctgaaact gatcaaactc agcgttttgc caggcaggcc
     4861 ccaggatggg cgccagggtg cagaaggatg gggcgtggtg aggcaaaagg gtgcaattaa
     4921 gctctttcag cttgcttcaa aagtgccacc agctcagctg gactgttctc tgtctgattg
     4981 tgaatatttt gagttctcca tatgttacat tgtcccacga ggacggactc ctcccggccc
     5041 acagagatta aagagacgta aatagattaa ctgaagcatg aaggatttga gctagatata
     5101 aagaaccatt tcctgttgtg aagcaggagg gacacgttgc caataaactc tcggcgaaat
     5161 tctcaaagga cttgaaaagg agaaaagttc ccgcagtggt ccggcatttt ctttgccgtg
     5221 cttactgaag cggttgggtt ctccctccgc taactcgtaa ctcttaaaca gtactggttg
     5281 gccggcagta aacaccaggt taatggtgtg accatatagc tcactgttgt gggatttcaa
     5341 aggccgttta tctgaggtct gccatttcct ttcatctgga gtaagtaaag ccgcagaggt
     5401 gactatttct ccccgtgtgt gctgagtagt gtgggccact ggctgttaaa gatgctgtcc
     5461 tcacattgtt gctggggttc tttttcaata aaatttatat tcatttttat ccaa
//
