LOCUS       NM_001347523            4368 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kinectin 1 (Ktn1), transcript variant 8, mRNA.
ACCESSION   NM_001347523 XM_006518646
VERSION     NM_001347523.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4368)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4368)
  AUTHORS   Wei,N., Cheng,Y., Wang,Z., Liu,Y., Luo,C., Liu,L., Chen,L., Xie,Z.,
            Lu,Y. and Feng,Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   3  (bases 1 to 4368)
  AUTHORS   Yates,L.L., Papakrivopoulou,J., Long,D.A., Goggolidou,P.,
            Connolly,J.O., Woolf,A.S. and Dean,C.H.
  TITLE     The planar cell polarity gene Vangl2 is required for mammalian
            kidney-branching morphogenesis and glomerular maturation
  JOURNAL   Hum Mol Genet 19 (23), 4663-4676 (2010)
   PUBMED   20843830
REFERENCE   4  (bases 1 to 4368)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   5  (bases 1 to 4368)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 4368)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4368)
  AUTHORS   Plitz,T. and Pfeffer,K.
  TITLE     Intact lysosome transport and phagosome function despite kinectin
            deficiency
  JOURNAL   Mol Cell Biol 21 (17), 6044-6055 (2001)
   PUBMED   11486041
REFERENCE   8  (bases 1 to 4368)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
REFERENCE   9  (bases 1 to 4368)
  AUTHORS   Morris,C., McDonald,M., Leung,E., Weaver,A. and Krissansen,G.W.
  TITLE     Assignment of the murine kinectin gene (Ktn1) to mouse chromosome
            14C2 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (1), 87-88 (1998)
   PUBMED   9691184
REFERENCE   10 (bases 1 to 4368)
  AUTHORS   Leung,E., Print,C.G., Parry,D.A., Closey,D.N., Lockhart,P.J.,
            Skinner,S.J., Batchelor,D.C. and Krissansen,G.W.
  TITLE     Cloning of novel kinectin splice variants with alternative
            C-termini: structure, distribution and evolution of mouse kinectin
  JOURNAL   Immunol Cell Biol 74 (5), 421-433 (1996)
   PUBMED   8912005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040200.1, BY291140.1, CT009515.16, CK634957.1, CO430909.1,
            BQ571777.1, CK637711.1, CF733377.1, DV661685.1, BE647921.1,
            CN701011.1, DN176640.1, CD363975.1 and CO043537.1.
            
            On Nov 30, 2016 this sequence version replaced XM_006518646.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.173187.1,
                                           SRR1660817.118952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK040200.1         2-11
            11-235              BY291140.1         1-225
            236-297             CT009515.16        167688-167749       c
            298-1022            CK634957.1         1-725
            1023-1584           CO430909.1         93-654
            1585-2158           BQ571777.1         88-661
            2159-2272           CK637711.1         140-253
            2273-2920           CF733377.1         1-648
            2921-2983           DV661685.1         390-452
            2984-3226           BE647921.1         1-243
            3227-3357           CN701011.1         366-496
            3358-3789           DN176640.1         124-555
            3790-4037           CD363975.1         511-758
            4038-4368           CO043537.1         1-331               c
FEATURES             Location/Qualifiers
     source          1..4368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..4368
                     /gene="Ktn1"
                     /note="kinectin 1"
                     /db_xref="GeneID:16709"
                     /db_xref="MGI:MGI:109153"
     exon            1..129
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..689
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3922
                     /gene="Ktn1"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="kinectin isoform 8"
                     /protein_id="NP_001334452.1"
                     /db_xref="CCDS:CCDS84127.1"
                     /db_xref="GeneID:16709"
                     /db_xref="MGI:MGI:109153"
                     /translation="MELYESTYFVVLIPSVVITVIFLFFWLFMKETLYDEVLAKQKRE
                     QKLISTKTDKKKAEKKKNKKKEIQNGTLRESDSEHVPRDFKLSDASPAEDEQFVPAPL
                     NVAETSSSVRERKKKEKKQKPSLEEQVIKESDASKIPGKKVEPVLVTKQPAPPPPLEA
                     AALKKKAGQKKSKNGSEEQDKKVEMLMAPSKEQDVLLSHQDTKQEGGLGKKKGLSKKQ
                     KSENVAVLVDEPLIHATTYIPLDNANSNLMMDKREIIDMIKPDHVEGIQKSGTKKLKI
                     ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIKEALKKSNKGELSGLL
                     HQLQEKERLLSAMKEDAAASKERCKQLTQEMMTEKERSSVVIARMKDRIGTLEKEHNI
                     FQNKMHASYQETQQMQMKFQQVQEQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE
                     LNKLRQDCGRLVSELNEKTGKLQQEGVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR
                     KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRASK
                     EESLQIQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQLKQTED
                     SLANEQDHLASKEEELKDVQNMNFLLKAEVQKLQALANEQAATAHEVEKMQKSIHVKE
                     DKIRLLEEQLQHEVASKMEELKILSEQNKALQSEVQKLQTAVSQQPNKDVVEQMEKCI
                     QEKDEKLRTVEELLETGLIQVATREEELSAIRTENSTLTREVQELKAKQSDQVSFVSL
                     IEDLKRVIHEKDGQIKSVEELLEVELLKVANKEKTVQLSVTSQVQELQNLLRGKEEQV
                     NSMKAALEDRDRDLRGRGTCAQVCSTPQFEELESVLKEKDNEIKRIEVKLKDTESDVS
                     KMSELLKEVQEENKFLKCQLSHQKHQQASFPSQEELQTVISEKEKEITDLCNELESLK
                     NAVEHQRKKNNDLREKNWEAMEALASTEKMLQDRVNKTSKERRQHVEAIELESKDLLK
                     RLFPTVSVPSNLNYSEWLRGFEKKAKACVAGTSDAEAVKVLEHRLKEASEMHTLLQLE
                     CEKYKSVLAETEGILQKLQRSVEQEESKWKIKADESQRMIKQMQSSFTASERELERLR
                     QENKDMENLRREREHLEMELEKAEMERSTYVMEVRELKTQLNETHSKLQNEQTERKKV
                     ADDLHKAQQSLNSIHSKISLKAAGDTVVIENSDISPEMSEVIGKLLVRS"
     exon            690..827
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1001
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1132
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1249
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1390
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1497
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1630
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1718
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1885
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1954
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..1992
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2083
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2152
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2190
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2272
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2341
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2376
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2467
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2536
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2574
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2665
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2703
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2794
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2832
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2923
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..2983
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3018
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3109
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3196
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3286
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3367
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3457
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3550
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3622
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3706
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3790
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3886
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..4351
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ktn1"
                     /note="hexamer: AATAAA"
     polyA_site      4351
                     /gene="Ktn1"
                     /note="major polyA site"
ORIGIN      
        1 gaagccgccc gtttcctgcg gggcggcgcg acggcacctg agctactgcg gcggggcctg
       61 ggagcgcgct gaccaggagg tagagctcgc gccgctgcat cgtcccggcc tggtacccgg
      121 ctgcgcagga ttctgcacag gctctcgtta agagaagact atggagctgt acgagtcaac
      181 gtattttgtt gtcctcatcc cttcagtagt tattaccgtc attttccttt tcttctggct
      241 tttcatgaaa gaaacattat atgatgaagt tcttgcaaaa caaaaaagag agcaaaagtt
      301 gatttctaca aaaacagata aaaagaaggc agaaaagaag aagaataaaa agaaagaaat
      361 ccagaatggg acccttcgtg aatctgattc tgagcacgtg cctcgggact ttaaattatc
      421 cgatgcttct cccgcggagg atgaacagtt tgtacctgct ccactgaatg tggcagaaac
      481 ttccagtagt gttagggaaa gaaagaagaa ggagaagaaa caaaaacctt cccttgaaga
      541 gcaggtcatc aaagaaagtg atgcatcaaa gatcccaggc aaaaaagtgg aacctgtcct
      601 agttaccaaa cagccggccc cacccccacc cctcgaagca gctgccttga agaagaaagc
      661 agggcagaag aagtctaaaa atggaagcga agagcaagat aaaaaggtgg aaatgctgat
      721 ggcaccttca aaagagcagg acgtgttgct ttcccatcaa gacactaagc aagaaggtgg
      781 actaggaaag aagaaaggct tgtcaaagaa gcaaaagtca gaaaatgttg cagtcttggt
      841 agacgagccc cttattcatg caactactta cattcctttg gataatgcta actcaaatct
      901 catgatggat aagagagaaa ttattgatat gattaaacct gatcatgttg aaggaatcca
      961 gaaatctgga acaaaaaagc tgaagattga aactgacaaa gaaaatgctg aagtgaaatt
     1021 taaagatttc cttctgtcct tgaagactat gatgttttct gaagatgaag ctctttgtgt
     1081 tgtagacctg ctgaaggaaa agtctggtgt gataaaagaa gctttaaaga agtcgaataa
     1141 aggagaactg agtggtcttc tgcatcaact tcaggagaag gagaggctgc tctctgccat
     1201 gaaggaagat gctgctgcct caaaggagcg ctgtaagcag ttgactcagg aaatgatgac
     1261 agagaaagaa agaagcagtg ttgttatagc aagaatgaaa gatcggattg gaacactaga
     1321 aaaggaacac aatatatttc aaaacaaaat gcatgccagt taccaagaga ctcagcagat
     1381 gcagatgaag tttcagcaag ttcaggaaca aatggaagca gagatagctc atttgaagca
     1441 ggaaaatggt atcctgagag atgctgtcag taacactaca aaccaactgg aaagcaagca
     1501 atccgcagag ctaaataaac tgcgccaaga ctgtgggagg ctggtgagtg aactgaacga
     1561 gaagacagga aagctgcagc aagagggagt ccagaagaag aatgcggagc aagctgctac
     1621 ccagctcaag gttcaactgc aagaagctga gaggcgctgg gaagaagttc agagctacat
     1681 caggaagagg acggcggagc atgaggctgc ccagcaagat ttacaaagta aatttgtggc
     1741 caaagaaaat gaagtccaga gtctacatag taagctcaca gacaccttgg tatcaaaaca
     1801 gcaattggag caaagactaa tgcagttgat ggaatccgag caaaagaggg cgagcaaaga
     1861 agagtctctg cagatccaag tgcaggatat tttggaacaa aacgaggctt tgaaagctca
     1921 gattcaacaa ttccattccc agatagcagc tcagacctcc gcttcagttc tagcagaaga
     1981 attacataaa gtgattgcag aaaaggacaa gcagctaaag cagactgaag attcattagc
     2041 gaatgaacag gatcacttag caagcaagga ggaggagctt aaggatgtac agaatatgaa
     2101 tttcttatta aaagctgaag tgcagaaatt gcaggccctg gctaatgagc aggctgctac
     2161 cgcacatgag gtggagaaga tgcagaagag tattcacgta aaggaagata aaataagact
     2221 gcttgaggag cagctgcagc acgaagttgc cagcaaaatg gaagaattga agattctgag
     2281 tgagcagaat aaagcattac agtcggaagt tcagaaactg cagaccgctg tttctcagca
     2341 gcctaataaa gatgttgtgg aacaaatgga aaaatgcatt caagaaaaag atgagaagtt
     2401 aaggactgtg gaagaattac tggagactgg actcattcag gtggccacca gagaggagga
     2461 gctgagtgcc ataagaacag agaactccac cctgaccaga gaagttcaag agttgaaggc
     2521 taagcagagc gatcaggttt cttttgtgtc tctaattgaa gatcttaaga gagtgatcca
     2581 tgagaaagat ggacagatca agtctgtgga agagcttcta gaagttgaac ttctcaaagt
     2641 tgcaaataag gagaaaactg tccagctgtc tgtcacttct caagtccagg agctgcagaa
     2701 cttattaaga ggcaaggaag agcaggtgaa cagcatgaag gctgccttag aagacaggga
     2761 cagagacctg agagggagag ggacgtgcgc acaggtgtgt tcgacaccac aatttgaaga
     2821 acttgaaagt gtgttgaaag aaaaggacaa tgaaattaag agaatagaag ttaaattaaa
     2881 ggacacggag agtgatgttt ctaagatgtc agagctatta aaggaggtac aagaggaaaa
     2941 taaattcctt aagtgccagc tcagtcacca gaagcaccaa caggcatctt ttccctctca
     3001 ggaagaatta caaacagtaa tttcagaaaa agagaaagaa ataactgatc tctgcaatga
     3061 gttagagtct ttgaagaatg ctgttgaaca ccagaggaag aaaaacaatg accttcggga
     3121 gaaaaactgg gaagcaatgg aagctttggc atcaactgaa aaaatgctgc aggacagagt
     3181 gaacaagact tccaaggaaa gacggcaaca cgtggaagct attgagttag agtccaaaga
     3241 ccttctgaag aggttatttc caacggtgtc tgtcccttct aatttgaatt acagtgaatg
     3301 gttgcgtggc tttgaaaaga aggcaaaagc gtgcgtagct ggaacttcag acgcagaggc
     3361 ggtcaaggtt ttggagcaca gattgaaaga agctagtgag atgcacactt tgctacagct
     3421 ggaatgtgaa aaatacaagt cggtccttgc agaaacagaa gggattttgc aaaaacttca
     3481 gcgaagtgtg gagcaagaag aaagtaaatg gaaaattaaa gctgacgagt ctcaaaggat
     3541 gattaaacag atgcagtcct ccttcacagc ctcagagcga gagctagagc gactaagaca
     3601 agaaaacaaa gatatggaga atctgagaag agaaagagag catttggaaa tggagctaga
     3661 gaaggccgag atggagcgat cgacttacgt gatggaagtc agagagctca agacacagtt
     3721 aaatgaaaca cactcaaaac ttcaaaatga acaaacggag agaaagaagg tagctgatga
     3781 tttgcataag gctcaacagt ccctgaactc tatccactca aaaatctcac tgaaagctgc
     3841 tggagacact gttgttattg agaacagtga tatttcccca gaaatgagtg aagtaattgg
     3901 gaaattactc gttagaagtt aacagaaggc gttgtattgt attttgccaa attaaagcct
     3961 tatttatgtt ttaccctttc tactttgtca gacactggac agttttgtct tttctaatcc
     4021 ttgttagact actgacttaa agagaaacac tttaaaaagc caactctgta gacaccttca
     4081 gagtttagtt ttataataaa actgtttgaa taattagacc tttacattcc taaagatgaa
     4141 gtaaatgtaa acttttacct tattttgctc aattaaattg ttcagaagat caaagtggta
     4201 tagacaatgt gaaatttaac attttaatac tgatgttgta cactgcttta cttaacattt
     4261 gggaagaagc cgcctctgac atcaactcaa ggaaacactt tttgttgcta ttataatcag
     4321 caaataaagg gacacttatt attcaacatg aaaaaaaaaa aaaaaaaa
//
