LOCUS       NM_001293636            4407 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kinectin 1 (Ktn1), transcript variant 3, mRNA.
ACCESSION   NM_001293636
VERSION     NM_001293636.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4407)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4407)
  AUTHORS   Wei,N., Cheng,Y., Wang,Z., Liu,Y., Luo,C., Liu,L., Chen,L., Xie,Z.,
            Lu,Y. and Feng,Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   3  (bases 1 to 4407)
  AUTHORS   Yates,L.L., Papakrivopoulou,J., Long,D.A., Goggolidou,P.,
            Connolly,J.O., Woolf,A.S. and Dean,C.H.
  TITLE     The planar cell polarity gene Vangl2 is required for mammalian
            kidney-branching morphogenesis and glomerular maturation
  JOURNAL   Hum Mol Genet 19 (23), 4663-4676 (2010)
   PUBMED   20843830
REFERENCE   4  (bases 1 to 4407)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   5  (bases 1 to 4407)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 4407)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4407)
  AUTHORS   Plitz,T. and Pfeffer,K.
  TITLE     Intact lysosome transport and phagosome function despite kinectin
            deficiency
  JOURNAL   Mol Cell Biol 21 (17), 6044-6055 (2001)
   PUBMED   11486041
REFERENCE   8  (bases 1 to 4407)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
REFERENCE   9  (bases 1 to 4407)
  AUTHORS   Morris,C., McDonald,M., Leung,E., Weaver,A. and Krissansen,G.W.
  TITLE     Assignment of the murine kinectin gene (Ktn1) to mouse chromosome
            14C2 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (1), 87-88 (1998)
   PUBMED   9691184
REFERENCE   10 (bases 1 to 4407)
  AUTHORS   Leung,E., Print,C.G., Parry,D.A., Closey,D.N., Lockhart,P.J.,
            Skinner,S.J., Batchelor,D.C. and Krissansen,G.W.
  TITLE     Cloning of novel kinectin splice variants with alternative
            C-termini: structure, distribution and evolution of mouse kinectin
  JOURNAL   Immunol Cell Biol 74 (5), 421-433 (1996)
   PUBMED   8912005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040200.1, BC075697.1, CO431187.1 and CD363975.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075697.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164135 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AK040200.1         2-84
            84-711              BC075697.1         1-628
            712-814             CO431187.1         295-397
            815-3514            BC075697.1         734-3433
            3515-4067           CD363975.1         206-758
            4068-4407           BC075697.1         3987-4326
FEATURES             Location/Qualifiers
     source          1..4407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..4407
                     /gene="Ktn1"
                     /note="kinectin 1"
                     /db_xref="GeneID:16709"
                     /db_xref="MGI:MGI:109153"
     exon            1..129
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..254
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..814
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             806..3952
                     /gene="Ktn1"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="kinectin isoform 3"
                     /protein_id="NP_001280565.1"
                     /db_xref="GeneID:16709"
                     /db_xref="MGI:MGI:109153"
                     /translation="MEAQDKKVEMLMAPSKEQDVLLSHQDTKQEGGLGKKKGLSKKQK
                     SENVAVLVDEPLIHATTYIPLDNANSNLMMDKREIIDMIKPDHVEGIQKSGTKKLKIE
                     TDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIKEALKKSNKGELSGLLH
                     QLQEKERLLSAMKEDAAASKERCKQLTQEMMTEKERSSVVIARMKDRIGTLEKEHNIF
                     QNKMHASYQETQQMQMKFQQVQEQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAEL
                     NKLRQDCGRLVSELNEKTGKLQQEGVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK
                     RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRASKE
                     ESLQIQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQLKQTEDS
                     LANEQDHLASKEEELKDVQNMNFLLKAEVQKLQALANEQAATAHEVEKMQKSIHVKED
                     KIRLLEEQLQHEVASKMEELKILSEQNKALQSEVQKLQTAVSQQPNKDVVEQMEKCIQ
                     EKDEKLRTVEELLETGLIQVATREEELSAIRTENSTLTREVQELKAKQSDQVSFVSLI
                     EDLKRVIHEKDGQIKSVEELLEVELLKVANKEKTVQALKQEIEVLKEEIGNAQLEKAH
                     QLSVTSQVQELQNLLRGKEEQVNSMKAALEDRDRDLRGRGTCAQVCSTPQFEELESVL
                     KEKDNEIKRIEVKLKDTESDVSKMSELLKEVQEENKFLKCQLSHQKHQQASFPSQEEL
                     QTVISEKEKEITDLCNELESLKNAVEHQRKKNNERRQHVEAIELESKDLLKRLFPTVS
                     VPSNLNYSEWLRGFEKKAKACVAGTSDAEAVKVLEHRLKEASEMHTLLQLECEKYKSV
                     LAETEGILQKLQRSVEQEESKWKIKADESQRMIKQLRREREHLEMELEKAEMERSTYV
                     MEVRELKTQLNETHSKLQNEQTERKKVADDLHKAQQSLNSIHSKISLKAAGDTVVIEN
                     SDISPEMSEVIGKLLVRS"
     exon            815..947
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1121
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1252
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1369
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1510
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1617
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1750
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1838
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2005
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2074
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2112
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2203
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2272
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2310
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2392
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2461
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2496
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2587
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2656
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2694
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2785
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2854
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2892
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2983
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3021
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3112
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3172
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3207
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3298
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3388
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3469
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3559
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3652
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3736
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3820
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3916
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4381
                     /gene="Ktn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4353..4358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ktn1"
                     /note="hexamer: AATAAA"
     polyA_site      4381
                     /gene="Ktn1"
                     /note="major polyA site"
ORIGIN      
        1 gaagccgccc gtttcctgcg gggcggcgcg acggcacctg agctactgcg gcggggcctg
       61 ggagcgcgct gaccaggagg tagagctcgc gccgctgcat cgtcccggcc tggtacccgg
      121 ctgcgcaggt ggagtccaaa cagttgtatc tgtgtagacg taaactagtg catatgcagg
      181 cacagccaac atgaagaaaa gagaacaaga aaagctaaat ataaggatga ggaaggactg
      241 cgtgcaggtg ttagattctg cacaggctct cgttaagaga agactatgga gctgtacgag
      301 tcaacgtatt ttgttgtcct catcccttca gtagttatta ccgtcatttt ccttttcttc
      361 tggcttttca tgaaagaaac attatatgat gaagttcttg caaaacaaaa aagagagcaa
      421 aagttgattt ctacaaaaac agataaaaag aaggcagaaa agaagaagaa taaaaagaaa
      481 gaaatccaga atgggaccct tcgtgaatct gattctgagc acgtgcctcg ggactttaaa
      541 ttatccgatg cttctcccgc ggaggatgaa cagtttgtac ctgctccact gaatgtggca
      601 gaaacttcca gtagtgttag ggaaagaaag aagaaggaga agaaacaaaa accttccctt
      661 gaagagcagg tcatcaaaga aagtgatgca tcaaagatcc caggcaaaaa agtggaacct
      721 gtcctagtta ccaaacagcc ggccccaccc ccacccctcg aagcagctgc cttgaagaag
      781 aaagcagggc agaagaagtc taaaaatgga agcgcaagat aaaaaggtgg aaatgctgat
      841 ggcaccttca aaagagcagg acgtgttgct ttcccatcaa gacactaagc aagaaggtgg
      901 actaggaaag aagaaaggct tgtcaaagaa gcaaaagtca gaaaatgttg cagtcttggt
      961 agacgagccc cttattcatg caactactta cattcctttg gataatgcta actcaaatct
     1021 catgatggat aagagagaaa ttattgatat gattaaacct gatcatgttg aaggaatcca
     1081 gaaatctgga acaaaaaagc tgaagattga aactgacaaa gaaaatgctg aagtgaaatt
     1141 taaagatttc cttctgtcct tgaagactat gatgttttct gaagatgaag ctctttgtgt
     1201 tgtagacctg ctgaaggaaa agtctggtgt gataaaagaa gctttaaaga agtcgaataa
     1261 aggagaactg agtggtcttc tgcatcaact tcaggagaag gagaggctgc tctctgccat
     1321 gaaggaagat gctgctgcct caaaggagcg ctgtaagcag ttgactcagg aaatgatgac
     1381 agagaaagaa agaagcagtg ttgttatagc aagaatgaaa gatcggattg gaacactaga
     1441 aaaggaacac aatatatttc aaaacaaaat gcatgccagt taccaagaga ctcagcagat
     1501 gcagatgaag tttcagcaag ttcaggaaca aatggaagca gagatagctc atttgaagca
     1561 ggaaaatggt atcctgagag atgctgtcag taacactaca aaccaactgg aaagcaagca
     1621 atccgcagag ctaaataaac tgcgccaaga ctgtgggagg ctggtgagtg aactgaacga
     1681 gaagacagga aagctgcagc aagagggagt ccagaagaag aatgcggagc aagctgctac
     1741 ccagctcaag gttcaactgc aagaagctga gaggcgctgg gaagaagttc agagctacat
     1801 caggaagagg acggcggagc atgaggctgc ccagcaagat ttacaaagta aatttgtggc
     1861 caaagaaaat gaagtccaga gtctacatag taagctcaca gacaccttgg tatcaaaaca
     1921 gcaattggag caaagactaa tgcagttgat ggaatccgag caaaagaggg cgagcaaaga
     1981 agagtctctg cagatccaag tgcaggatat tttggaacaa aacgaggctt tgaaagctca
     2041 gattcaacaa ttccattccc agatagcagc tcagacctcc gcttcagttc tagcagaaga
     2101 attacataaa gtgattgcag aaaaggacaa gcagctaaag cagactgaag attcattagc
     2161 gaatgaacag gatcacttag caagcaagga ggaggagctt aaggatgtac agaatatgaa
     2221 tttcttatta aaagctgaag tgcagaaatt gcaggccctg gctaatgagc aggctgctac
     2281 cgcacatgag gtggagaaga tgcagaagag tattcacgta aaggaagata aaataagact
     2341 gcttgaggag cagctgcagc acgaagttgc cagcaaaatg gaagaattga agattctgag
     2401 tgagcagaat aaagcattac agtcggaagt tcagaaactg cagaccgctg tttctcagca
     2461 gcctaataaa gatgttgtgg aacaaatgga aaaatgcatt caagaaaaag atgagaagtt
     2521 aaggactgtg gaagaattac tggagactgg actcattcag gtggccacca gagaggagga
     2581 gctgagtgcc ataagaacag agaactccac cctgaccaga gaagttcaag agttgaaggc
     2641 taagcagagc gatcaggttt cttttgtgtc tctaattgaa gatcttaaga gagtgatcca
     2701 tgagaaagat ggacagatca agtctgtgga agagcttcta gaagttgaac ttctcaaagt
     2761 tgcaaataag gagaaaactg tccaggcttt gaaacaggaa atagaggttc taaaagaaga
     2821 aataggaaat gcccagcttg aaaaggctca ccagctgtct gtcacttctc aagtccagga
     2881 gctgcagaac ttattaagag gcaaggaaga gcaggtgaac agcatgaagg ctgccttaga
     2941 agacagggac agagacctga gagggagagg gacgtgcgca caggtgtgtt cgacaccaca
     3001 atttgaagaa cttgaaagtg tgttgaaaga aaaggacaat gaaattaaga gaatagaagt
     3061 taaattaaag gacacggaga gtgatgtttc taagatgtca gagctattaa aggaggtaca
     3121 agaggaaaat aaattcctta agtgccagct cagtcaccag aagcaccaac aggcatcttt
     3181 tccctctcag gaagaattac aaacagtaat ttcagaaaaa gagaaagaaa taactgatct
     3241 ctgcaatgag ttagagtctt tgaagaatgc tgttgaacac cagaggaaga aaaacaatga
     3301 aagacggcaa cacgtggaag ctattgagtt agagtccaaa gaccttctga agaggttatt
     3361 tccaacggtg tctgtccctt ctaatttgaa ttacagtgaa tggttgcgtg gctttgaaaa
     3421 gaaggcaaaa gcgtgcgtag ctggaacttc agacgcagag gcggtcaagg ttttggagca
     3481 cagattgaaa gaagctagtg agatgcacac tttgctacag ctggaatgtg aaaaatacaa
     3541 gtcggtcctt gcagaaacag aagggatttt gcaaaaactt cagcgaagtg tggagcaaga
     3601 agaaagtaaa tggaaaatta aagctgacga gtctcaaagg atgattaaac agctgagaag
     3661 agaaagagag catttggaaa tggagctaga gaaggccgag atggagcgat cgacttacgt
     3721 gatggaagtc agagagctca agacacagtt aaatgaaaca cactcaaaac ttcaaaatga
     3781 acaaacggag agaaagaagg tagctgatga tttgcataag gctcaacagt ccctgaactc
     3841 tatccactca aaaatctcac tgaaagctgc tggagacact gttgttattg agaacagtga
     3901 tatttcccca gaaatgagtg aagtaattgg gaaattactc gttagaagtt aacagaaggc
     3961 gttgtattgt attttgccaa attaaagcct tatttatgtt ttaccctttc tactttgtca
     4021 gacactggac agttttgtct tttctaatcc ttgttagact actgacttaa agagaaacac
     4081 tttaaaaagc caactctgta gacaccttca gagtttagtt ttataataaa actgtttgaa
     4141 taattagacc tttacattcc taaagatgaa gtaaatgtaa acttttacct tattttgctc
     4201 aattaaattg ttcagaagat caaagtggta tagacaatgt gaaatttaac attttaatac
     4261 tgatgttgta cactgcttta cttaacattt gggaagaagc cgcctctgac atcaactcaa
     4321 ggaaacactt tttgttgcta ttataatcag caaataaagg gacacttatt attcaacatg
     4381 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
