LOCUS       NM_001033131             462 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus keratinocyte differentiation associated protein
            (Krtdap), transcript variant 1, mRNA.
ACCESSION   NM_001033131 XM_892255 XM_900014 XM_900023 XM_900032 XM_915781
            XM_923930 XM_923934
VERSION     NM_001033131.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Saito,K., Michon,F., Yamada,A., Inuzuka,H., Yamaguchi,S.,
            Fukumoto,E., Yoshizaki,K., Nakamura,T., Arakaki,M., Chiba,Y.,
            Ishikawa,M., Okano,H., Thesleff,I. and Fukumoto,S.
  TITLE     Sox21 Regulates Anapc10 Expression and Determines the Fate of
            Ectodermal Organ
  JOURNAL   iScience 23 (7), 101329 (2020)
   PUBMED   32674056
REFERENCE   3  (bases 1 to 462)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     Transcriptional profiling of developing mouse epidermis reveals
            novel patterns of coordinated gene expression
  JOURNAL   Dev Dyn 236 (4), 961-970 (2007)
   PUBMED   17330888
  REMARK    GeneRIF: Drmkn and Krtdap are the highest differentially expressed
            genes in epidermis embryonic development in mice.
REFERENCE   4  (bases 1 to 462)
  AUTHORS   Moffatt,P., Salois,P., St-Amant,N., Gaumond,M.H. and Lanctot,C.
  TITLE     Identification of a conserved cluster of skin-specific genes
            encoding secreted proteins
  JOURNAL   Gene 334, 123-131 (2004)
   PUBMED   15256262
REFERENCE   5  (bases 1 to 462)
  AUTHORS   Oomizu,S., Sahuc,F., Asahina,K., Inamatsu,M., Matsuzaki,T.,
            Sasaki,M., Obara,M. and Yoshizato,K.
  TITLE     Kdap, a novel gene associated with the stratification of the
            epithelium
  JOURNAL   Gene 256 (1-2), 19-27 (2000)
   PUBMED   11054531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165340.3.
            
            On Jun 5, 2018 this sequence version replaced NM_001033131.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH100255.1, AK131603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC165340.3         111260-111377
            119-157             AC165340.3         112860-112898
            158-199             AC165340.3         113068-113109
            200-244             AC165340.3         113267-113311
            245-292             AC165340.3         113923-113970
            293-462             AC165340.3         114275-114444
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.24 cM"
     gene            1..462
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /note="keratinocyte differentiation associated protein"
                     /db_xref="GeneID:64661"
                     /db_xref="MGI:MGI:1928282"
     exon            1..118
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..331
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="keratinocyte differentiation-associated protein
                     isoform 1 precursor"
                     /protein_id="NP_001028303.1"
                     /db_xref="CCDS:CCDS21110.1"
                     /db_xref="GeneID:64661"
                     /db_xref="MGI:MGI:1928282"
                     /translation="MKIPILPVVALLSLLALHAVQGAALGHPTIYPEDSSYNNYPTAT
                     EGLNNEFLNFKRLQSAFQSENFLNWHVITDMFKNAFPFINWDFFPKVKGLRSAAPDSQ
                     "
     exon            119..157
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     exon            158..199
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     exon            200..244
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     exon            245..292
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     exon            293..462
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /inference="alignment:Splign:2.1.0"
     regulatory      438..443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /note="hexamer: AATAAA"
     polyA_site      458
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /note="major polyA site"
ORIGIN      
        1 agagcagccc aaaccggaca ccatgaagat cccaattctt cccgtcgtgg ctctcctctc
       61 tcttctggca ttgcatgcgg tccagggagc agccctgggg catcccacga tatacccgga
      121 agatagcagc tacaataatt accctaccgc aacagagggc cttaacaatg agttcctgaa
      181 ctttaagagg ctacagtctg cctttcagtc agaaaacttc ctgaactggc acgtcatcac
      241 tgatatgttc aaaaatgcat ttcctttcat taactgggac ttcttcccta aggtgaaagg
      301 actgagaagt gccgctcctg attcccagtg accattctct ttaagaccta ggacctaggc
      361 tgagcccagt agaagaggag gcaagcatgg aatctgaagt ccatcctacg acaaatcttc
      421 cttgcctcag ttcccccaat aaagtgtttt ccactcaagt gg
//
