LOCUS       NP_001028303             102 aa            linear   ROD 05-DEC-2024
DEFINITION  keratinocyte differentiation-associated protein isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_001028303 XP_897348 XP_905107 XP_905116 XP_905125 XP_920874
            XP_929023 XP_929027
VERSION     NP_001028303.1
DBSOURCE    REFSEQ: accession NM_001033131.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 102)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   2  (residues 1 to 102)
  AUTHORS   Saito,K., Michon,F., Yamada,A., Inuzuka,H., Yamaguchi,S.,
            Fukumoto,E., Yoshizaki,K., Nakamura,T., Arakaki,M., Chiba,Y.,
            Ishikawa,M., Okano,H., Thesleff,I. and Fukumoto,S.
  TITLE     Sox21 Regulates Anapc10 Expression and Determines the Fate of
            Ectodermal Organ
  JOURNAL   iScience 23 (7), 101329 (2020)
   PUBMED   32674056
REFERENCE   3  (residues 1 to 102)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     Transcriptional profiling of developing mouse epidermis reveals
            novel patterns of coordinated gene expression
  JOURNAL   Dev Dyn 236 (4), 961-970 (2007)
   PUBMED   17330888
  REMARK    GeneRIF: Drmkn and Krtdap are the highest differentially expressed
            genes in epidermis embryonic development in mice.
REFERENCE   4  (residues 1 to 102)
  AUTHORS   Moffatt,P., Salois,P., St-Amant,N., Gaumond,M.H. and Lanctot,C.
  TITLE     Identification of a conserved cluster of skin-specific genes
            encoding secreted proteins
  JOURNAL   Gene 334, 123-131 (2004)
   PUBMED   15256262
REFERENCE   5  (residues 1 to 102)
  AUTHORS   Oomizu,S., Sahuc,F., Asahina,K., Inamatsu,M., Matsuzaki,T.,
            Sasaki,M., Obara,M. and Yoshizato,K.
  TITLE     Kdap, a novel gene associated with the stratification of the
            epithelium
  JOURNAL   Gene 256 (1-2), 19-27 (2000)
   PUBMED   11054531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165340.3.
            
            On or before Jan 12, 2006 this sequence version replaced
            XP_929023.1, XP_929027.1, XP_920874.1, XP_905107.1, XP_897348.1,
            XP_905116.1, XP_905125.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH100255.1, AK131603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..102
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.24 cM"
     Protein         1..102
                     /product="keratinocyte differentiation-associated protein
                     isoform 1 precursor"
                     /calculated_mol_wt=9218
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2297
     mat_peptide     23..102
                     /product="Keratinocyte differentiation-associated protein.
                     /evidence=ECO:0000255. /id=PRO_0000317056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V2T4.1)"
                     /calculated_mol_wt=9218
     Region          23..102
                     /region_name="KRTDAP"
                     /note="Keratinocyte differentiation-associated; pfam15200"
                     /db_xref="CDD:464559"
     CDS             1..102
                     /gene="Krtdap"
                     /gene_synonym="Kdap; sk221"
                     /coded_by="NM_001033131.4:23..331"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS21110.1"
                     /db_xref="GeneID:64661"
                     /db_xref="MGI:MGI:1928282"
ORIGIN      
        1 mkipilpvva llsllalhav qgaalghpti ypedssynny ptateglnne flnfkrlqsa
       61 fqsenflnwh vitdmfknaf pfinwdffpk vkglrsaapd sq
//
