LOCUS       NM_201255               2580 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus keratin 9 (Krt9), mRNA.
ACCESSION   NM_201255
VERSION     NM_201255.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Duvall,K., Crist,L., Perl,A.J., Pode Shakked,N., Chaturvedi,P. and
            Kopan,R.
  TITLE     Revisiting the role of Notch in nephron segmentation confirms a
            role for proximal fate selection during mouse and human
            nephrogenesis
  JOURNAL   Development 149 (10) (2022)
   PUBMED   35451473
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Niu,W. and Spradling,A.C.
  TITLE     Two distinct pathways of pregranulosa cell differentiation support
            follicle formation in the mouse ovary
  JOURNAL   Proc Natl Acad Sci U S A 117 (33), 20015-20026 (2020)
   PUBMED   32759216
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Elliott,K.H., Millington,G. and Brugmann,S.A.
  TITLE     A novel role for cilia-dependent sonic hedgehog signaling during
            submandibular gland development
  JOURNAL   Dev Dyn 247 (6), 818-831 (2018)
   PUBMED   29532549
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Rivkin,E., Eddy,E.M., Willis,W.D., Goulding,E.H., Suganuma,R.,
            Yanagimachi,R. and Kierszenbaum,A.L.
  TITLE     Sperm tail abnormalities in mutant mice with neo(r) gene insertion
            into an intron of the keratin 9 gene
  JOURNAL   Mol Reprod Dev 72 (2), 259-271 (2005)
   PUBMED   16015579
  REMARK    GeneRIF: Intron 6 influences the transcriptional efficiency of the
            keratin 9 (K9, Krt1-9) gene by decreasing production of wild-type
            K9 and changing the expression of K9 proteins.
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Foley,J., Dann,P., Hong,J., Cosgrove,J., Dreyer,B., Rimm,D.,
            Dunbar,M., Philbrick,W. and Wysolmerski,J.
  TITLE     Parathyroid hormone-related protein maintains mammary epithelial
            fate and triggers nipple skin differentiation during embryonic
            breast development
  JOURNAL   Development 128 (4), 513-525 (2001)
   PUBMED   11171335
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Powell,B.C. and Rogers,G.E.
  TITLE     The role of keratin proteins and their genes in the growth,
            structure and properties of hair
  JOURNAL   EXS 78, 59-148 (1997)
   PUBMED   8962491
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590873.17.
            
            On Apr 28, 2007 this sequence version replaced NM_201255.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY497550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AL590873.17        89613-90231         c
            620-702             AL590873.17        88424-88506         c
            703-859             AL590873.17        88142-88298         c
            860-1021            AL590873.17        87709-87870         c
            1022-1147           AL590873.17        86906-87031         c
            1148-1371           AL590873.17        86576-86799         c
            1372-2255           AL590873.17        85338-86221         c
            2256-2580           AL590873.17        83766-84090         c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.43 cM"
     gene            1..2580
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /note="keratin 9"
                     /db_xref="GeneID:107656"
                     /db_xref="MGI:MGI:96696"
     exon            1..619
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2275
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /note="CK-9; cytokeratin-9; keratin complex 1, acidic,
                     gene 9"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 9"
                     /protein_id="NP_957707.2"
                     /db_xref="CCDS:CCDS25412.1"
                     /db_xref="GeneID:107656"
                     /db_xref="MGI:MGI:96696"
                     /translation="MSCRQSSSSFWSSSSSCGGGGGRGGSGGSMRSSFSRSSRAGGGG
                     GGRFNSSSGFSGGGFSACGGGGGGSFGSSYGGGYGGGFSTGSYSGMFGGGSGGGFGGG
                     SGGGFGGGSGGGFGGGSGGGEGGILNTNEKIVMQNLNSRLASYMEKVLELEESNTAME
                     KQIQDWYSKRGPKVFQKDNTHYYDTIEDLKDRIVDLTVRNNKTLVDIDNTRMTMDDFR
                     VKLEMEQSLRQGVEGDINGLKKVLDDLVMAKSDLEILLDSLEDEKNALTKNHKEEMSQ
                     LTGQNDGDVNVEINVAPSTDLTRVLNDMREEYEQLISKNRQDIEQHYESKMTQIEQQM
                     TNSGQEMESNMKQVSQLQHTIQELNVELQTQLTTKSALEKALEDTKNRYCGQLQQIQE
                     QISELEAQLAEIRAETECQSQEYSILLSIKTRLEKEIETYRELLEGGQQDFESSGAGQ
                     IGFGSGKGRQRGSGGSYGGGSGGSYGGGSGGSYGGGSGGSYGGGSGGSYGGGSGGSHG
                     GKSGGSHGGGSGGSYGGESGGSHGGGSGGSYGGGSGGSHGGKSGGGYGGGSSSGGGSG
                     GSYGGGSGGSHGGGSGGSYGGGSGGSHGGKSGGGYGGGSSSGGGSGGSYGGGSGGSHG
                     GKSGGSYGGGSGGSYGGGSGGSHGGKSGGGYGGGSSSGGGSGGSYGGGSGGSHGGKSG
                     GSYGGGSSSGGGSGGSYGGGSGSGGGSGGSYGGGNRRPSQSQSSSKSADCDDDSQEHK
                     MRY"
     exon            620..702
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            703..859
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1021
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1147
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1371
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2255
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2580
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /note="hexamer: AGTAAA"
     polyA_site      2567
                     /gene="Krt9"
                     /gene_synonym="EPPK; K9; Krt1-9"
                     /note="major polyA site"
ORIGIN      
        1 ccctgagacc gcttcctggc tacatcctct ggcaggcagc accatgagtt gcagacagag
       61 ctcctcatct ttctggagca gcagcagcag ctgtggagga ggaggaggca gagggggcag
      121 cggaggcagc atgcgatctt ctttcagtcg ctcctccagg gctggtggag gaggaggagg
      181 ccgctttaac tcttccagtg gctttagcgg gggtggcttt tcggcttgtg gcggtggagg
      241 tggtggcagt tttggctcta gctatggtgg agggtatgga gggggtttta gtacagggag
      301 ttacagcggt atgtttggtg gaggttctgg aggtggcttt ggtggtggct ctggcggtgg
      361 ctttggtggt ggctctggag gtggctttgg tggtggctct ggaggtggtg aaggcggtat
      421 tctgaacacc aatgagaaaa tcgttatgca gaacctcaat tcccgtctgg cctcttacat
      481 ggagaaagta ctagaactgg aggagagcaa cactgccatg gagaagcaga tccaggactg
      541 gtattcaaag agggggccca aagtcttcca gaaggacaac actcattact atgacaccat
      601 cgaagacctg aaggacagaa ttgtggatct cacggtgagg aacaacaaaa ctctcgtgga
      661 catcgacaat actcgcatga ctatggatga cttcagagtt aagcttgaga tggagcaaag
      721 cctgcgccaa ggggtggaag gtgacattaa tggcctgaag aaggtgttgg atgatctggt
      781 tatggcgaaa tctgatctgg agatactgct tgatagtttg gaggatgaga agaatgccct
      841 tacgaagaac cacaaggagg agatgagcca gttgacgggc cagaatgatg gagatgttaa
      901 tgtggagata aatgttgctc ctagcacaga tctcacccgg gtcctcaatg acatgcgtga
      961 ggaatacgaa cagctcattt ctaagaaccg ccaggacatt gaacaacact atgagtccaa
     1021 gatgacccag attgagcagc aaatgacaaa tagtggccaa gagatggaga gcaacatgaa
     1081 gcaagtgtcc cagctccagc acactatcca ggaactgaat gtggagctgc agactcagct
     1141 taccacgaaa tcagccctgg agaaggcttt ggaagacaca aagaaccgct actgtggcca
     1201 gctgcagcag atccaggagc agatcagcga gttggaggcc cagcttgctg agatccgggc
     1261 agaaactgaa tgccagagtc aggaatacag cattctgctc agcatcaaga cacggctgga
     1321 gaaagaaatt gagacttacc gggagctcct tgaaggcggc cagcaagact ttgaatcgtc
     1381 tggagctgga caaattggct ttggaagtgg caaaggaaga caaagaggaa gtggtggcag
     1441 ctatggagga ggaagtgggg gcagctatgg aggaggaagt gggggcagct atggaggagg
     1501 aagtgggggc agctatggag gaggaagtgg agggagctat ggaggaggaa gtgggggcag
     1561 tcatggtgga aaaagtggag gcagtcatgg aggaggaagt gggggcagct atggaggaga
     1621 aagtgggggc agccatggag gaggaagtgg gggcagctat ggtggaggaa gtgggggcag
     1681 ccatggtgga aaaagtggag gaggttatgg aggaggaagc agctctgggg gaggaagtgg
     1741 aggcagctat ggaggaggaa gtgggggcag ccatggagga ggaagtgggg gcagctatgg
     1801 tggaggaagt gggggcagcc atggtggaaa aagtggagga ggttatggag gaggaagcag
     1861 ctctggggga ggaagtggag gcagctatgg aggaggaagt gggggcagcc atggtggaaa
     1921 aagtgggggt agctatggag gaggaagtgg tggcagctat ggaggaggaa gtgggggcag
     1981 ccatggtgga aaaagtggag gaggttatgg aggaggaagc agctctgggg gaggaagtgg
     2041 aggcagctat ggaggaggaa gtgggggcag ccatggtgga aaaagtggag gtagctatgg
     2101 aggaggaagc agttctgggg gaggaagtgg aggcagctat ggaggaggaa gtggttctgg
     2161 aggaggaagt gggggtagct atggtggagg aaatagaagg ccatctcagt cccagtcctc
     2221 ctcaaagtct gcagactgcg atgatgattc acaagagcac aagatgcgat actagaaccc
     2281 cgattcactt tctccaccgg accccagctg agactgtccc gggagggcag aagctacatg
     2341 aagcatcctt actgcatcct gacatcaaga caagccggcc acaagctggg gtaaccgttt
     2401 ggaactggat ggagttggca ctgtgcctct ggacatctct tggctctgtt ccttgctggg
     2461 gaggcttcag ggctagggag aatgtgattc ttctttgtgt cctgggggtg gctccactcc
     2521 cttccttgtc ctgacttcct agtaaagctt tcctgttgca aattaaactt ggattctgag
//
