LOCUS       NM_016879               2591 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus keratin 85 (Krt85), mRNA.
ACCESSION   NM_016879
VERSION     NM_016879.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Noto,M., Noguchi,N., Ishimura,A., Kiyonari,H., Abe,T., Suzuki,T.,
            Hasunuma,N., Taira,M., Manabe,M. and Osada,S.I.
  TITLE     Sox13 is a novel early marker for hair follicle development
  JOURNAL   Biochem Biophys Res Commun 509 (4), 862-868 (2019)
   PUBMED   30638933
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Leilei,Y., Bing,L., Yang,L., Shaoxia,W., Yuan,X., Dongping,W.,
            Huahu,Y., Shichen,S., Guangzhou,Z., Ruiyun,P., Lin,Z. and
            Wenlong,L.
  TITLE     iRhom2 mutation leads to aberrant hair follicle differentiation in
            mice
  JOURNAL   PLoS One 9 (12), e115114 (2014)
   PUBMED   25546423
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2591)
  AUTHORS   Kiso,M., Tanaka,S., Saba,R., Matsuda,S., Shimizu,A., Ohyama,M.,
            Okano,H.J., Shiroishi,T., Okano,H. and Saga,Y.
  TITLE     The disruption of Sox21-mediated hair shaft cuticle differentiation
            causes cyclic alopecia in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (23), 9292-9297 (2009)
   PUBMED   19470461
REFERENCE   5  (bases 1 to 2591)
  AUTHORS   Hwang,J., Mehrani,T., Millar,S.E. and Morasso,M.I.
  TITLE     Dlx3 is a crucial regulator of hair follicle differentiation and
            cycling
  JOURNAL   Development 135 (18), 3149-3159 (2008)
   PUBMED   18684741
REFERENCE   6  (bases 1 to 2591)
  AUTHORS   Zhang,Y., Andl,T., Yang,S.H., Teta,M., Liu,F., Seykora,J.T.,
            Tobias,J.W., Piccolo,S., Schmidt-Ullrich,R., Nagy,A., Taketo,M.M.,
            Dlugosz,A.A. and Millar,S.E.
  TITLE     Activation of beta-catenin signaling programs embryonic epidermis
            to hair follicle fate
  JOURNAL   Development 135 (12), 2161-2172 (2008)
   PUBMED   18480165
REFERENCE   7  (bases 1 to 2591)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 2591)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
REFERENCE   9  (bases 1 to 2591)
  AUTHORS   Mikula,M., Schreiber,M., Husak,Z., Kucerova,L., Ruth,J., Wieser,R.,
            Zatloukal,K., Beug,H., Wagner,E.F. and Baccarini,M.
  TITLE     Embryonic lethality and fetal liver apoptosis in mice lacking the
            c-raf-1 gene
  JOURNAL   EMBO J 20 (8), 1952-1962 (2001)
   PUBMED   11296228
REFERENCE   10 (bases 1 to 2591)
  AUTHORS   Montenegro,M.A., Rojas,M., Dominguez,S. and Vergara,A.
  TITLE     Cytokeratin, vimentin and E-cadherin immunodetection in the
            embryonic palate in two strains of mice with different
            susceptibility to glucocorticoid-induced clefting
  JOURNAL   J Craniofac Genet Dev Biol 20 (3), 137-143 (2000)
   PUBMED   11321598
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from MH371176.1.
            
            On Jul 30, 2020 this sequence version replaced NM_016879.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028825.1, AK009099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               MH371176.1         8658-9153           c
            497-705             MH371176.1         5969-6177           c
            706-766             MH371176.1         5398-5458           c
            767-862             MH371176.1         5181-5276           c
            863-1027            MH371176.1         4419-4583           c
            1028-1153           MH371176.1         3994-4119           c
            1154-1374           MH371176.1         3400-3620           c
            1375-1406           MH371176.1         2210-2241           c
            1407-2591           MH371176.1         668-1852            c
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15"
     gene            1..2591
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /note="keratin 85"
                     /db_xref="GeneID:53622"
                     /db_xref="MGI:MGI:1859268"
     exon            1..496
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            497..705
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            706..766
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            767..862
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1027
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1153
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1374
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1406
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2591
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="Krt85"
                     /gene_synonym="Gm49425; Hb5; Krt2-18"
                     /note="major polyA site"
ORIGIN      
        1 aaaggattcc aagtctcaca ctccgcaacc tgcaccaaac ccacagccgc cgcgtagaca
       61 acatccagct cacaccatgt cctgtcgctc ctacaggatc agcccaggat gtggagttac
      121 cagaaacttc agctcctgct cagccgtagc ccccaaaact ggcaaccgct gctgcatcag
      181 cgcagctccc ttccgaggag tgtcttgcta ccggggattg actggcttca gcagccgaag
      241 cctctgtaac ccaagcccct gtgggccccg catggctgtt gggggcttcc gctctggctc
      301 ctgtggacgc agcttcggat accgttctgg aggcgtctgt gggcccagcc cgccctgcat
      361 caccaccgtc tctgtcaatg agagcctgct cacgcccctg aacctggaga tcgaccccaa
      421 tgctcagtgt gtgaagtatg aagagaagga gcagatcaag tgtctcaaca gcaagttcgc
      481 ggccttcatt gacaaggtgc gattcctgga gcaacagaac aagctgctgg agaccaagtg
      541 gcagttctac cagaaccgca agtgctgtga gagcaacctg gagcccctgt ttggaggcta
      601 catcgaggca ctgaggcggg aggctgaatg tgtggaggcg gacagcggga ggctggctgc
      661 tgagctcaac catgtgcagg aggccatgga gggctacaag aaaaagtatg aagaggaggt
      721 ggctctgagg gctacagcag agaatgagtt tgtggtacta aagaaggatg tggactgtgc
      781 ctacttacgt aaatcagacc tggaggccaa cgtggaggcc ttggtggagg agtcaagctt
      841 cctgaagcgt ctttatgaag aggaggtctg tgttctgcaa gcccacatct cagacacctc
      901 tgtcatcgtc aagatggaca acagccgaga cctgaacatg gactgcgtcg tggctgagat
      961 caaggctcag tatgatgacg ttgccagccg cagccgtgct gaggctgagt cctggtaccg
     1021 caccaagtgt gaggagatga aggccaccgt gatccggcat ggggagaccc tgcgccgcac
     1081 gaaggaggag atcaacgagc tgaacagaat gatacagagg ctgaccgccg agatcgagaa
     1141 tgccaagtgc cagcgtgcca agctggaagc tgctgtggct gaggcagagc agcagggaga
     1201 ggccgccctc gctgatgccc gctgcaagct ggctgagctg gagggtgccc tgcagaaggc
     1261 caagcaggac atggcctgcc tgctcaagga gtaccaggag gtaatgaact ccaagctggc
     1321 actggacatc gagatcgcca cctacaggcg cctgctggag ggcgaggagc agaggctctg
     1381 cgagggtgtg ggctctgtga atgtctgtgt cagcagctcc cgtggaggag tcacatgtgg
     1441 gggcctcacc tatggcacaa ccccagggcg ccagattgtc tctggaccct ctgtcactgg
     1501 gggcagcatc acagtgatgg cccctgactc ctgctctcct tgccagcccc gcgcctccag
     1561 ctttacctgt gggagcagcc gctcagtgcg cttcgcttag tgacaggtcc tccaaatgag
     1621 ccacctgtct gccccagagt ggagtggtgt gtgaatggaa aatgtgtgct tgcttccaga
     1681 atcttccaga tgtttctgtg agaggaaaga gttcagggcc actctcctct gccttctcct
     1741 tttagggagt tgtctcccag ttctcctctg gcttcacttt agaaggtcat tcccaaccct
     1801 tcccttaacc ccaacctgtc ttcagatact tgtaaatgat ttgtattatt cgccaagctc
     1861 tccgggacac taccagtcac ccaggctgac tggacaataa agtgtggcct tcctgggtca
     1921 aggcatgatc ctaaccaccc agccatgccc cccaaaacaa gaaccagagg gaacccttcc
     1981 caagcagctc ccacttctgt ccccaggtac aggggcagca agcatatgcc tttagttggt
     2041 tgggtttact aatctcctta gctgtgcctt cctttggggc aaactactct aatcacactt
     2101 cttgggttac ctcccaggaa atagtctgct ctctggggag gcctactacc tacagcccct
     2161 ggctaggggg ctttgaacag gtcttgctgt tcaagaagcc tttgcacatt tcaaagaccc
     2221 ccatactgtt gcaggcctcc cctgcttggg aactgtccaa gggagagctg gtgggatggg
     2281 gactatggcc actttctgtc tgggtgcctc gccttctggg ttgaccccat ctgtgtttca
     2341 ataaatactg ttgtgatgca agggtgtgtg atgttttgtg tcagtggcct ctccccctcc
     2401 ccaatgtctg tttgccggca ccagctaacc agccacacac tggtaacctt ttccactcac
     2461 ccctgtgact ccttccctac ccgttcccaa agcctgatct acttgttttc ctcggtccct
     2521 gctgacttgg acgcagatcc agcttcccct atggtgtcct ccccacaaaa taaatcatcc
     2581 tattgtcctg t
//
