LOCUS       NM_008474               2570 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus keratin 84 (Krt84), mRNA.
ACCESSION   NM_008474
VERSION     NM_008474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Yu,X., Xu,B., Gao,T., Fu,X., Jiang,B., Zhou,N., Gao,W., Wu,T.,
            Shen,C., Huang,X., Wu,Y. and Zheng,B.
  TITLE     E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via
            lysine 48-linked polyubiquitination-mediated degradation of
            KRT36/KRT84
  JOURNAL   FASEB J 37 (10), e23217 (2023)
   PUBMED   37738023
  REMARK    GeneRIF: E3 ubiquitin ligase RNF187 promotes growth of
            spermatogonia via lysine 48-linked polyubiquitination-mediated
            degradation of KRT36/KRT84.
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Xu,M., Horrell,J., Snitow,M., Cui,J., Gochnauer,H., Syrett,C.M.,
            Kallish,S., Seykora,J.T., Liu,F., Gaillard,D., Katz,J.P.,
            Kaestner,K.H., Levin,B., Mansfield,C., Douglas,J.E., Cowart,B.J.,
            Tordoff,M., Liu,F., Zhu,X., Barlow,L.A., Rubin,A.I., McGrath,J.A.,
            Morrisey,E.E., Chu,E.Y. and Millar,S.E.
  TITLE     WNT10A mutation causes ectodermal dysplasia by impairing progenitor
            cell proliferation and KLF4-mediated differentiation
  JOURNAL   Nat Commun 8, 15397 (2017)
   PUBMED   28589954
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Nishiguchi,Y., Ohmoto,M., Koki,J., Enomoto,T., Kominami,R.,
            Matsumoto,I. and Hirota,J.
  TITLE     Bcl11b/Ctip2 is required for development of lingual papillae in
            mice
  JOURNAL   Dev Biol 416 (1), 98-110 (2016)
   PUBMED   27287879
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   5  (bases 1 to 2570)
  AUTHORS   Jonker,L., Kist,R., Aw,A., Wappler,I. and Peters,H.
  TITLE     Pax9 is required for filiform papilla development and suppresses
            skin-specific differentiation of the mammalian tongue epithelium
  JOURNAL   Mech Dev 121 (11), 1313-1322 (2004)
   PUBMED   15454262
REFERENCE   6  (bases 1 to 2570)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 2570)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
REFERENCE   8  (bases 1 to 2570)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2570)
  AUTHORS   McGowan,K. and Coulombe,P.A.
  TITLE     The wound repair-associated keratins 6, 16, and 17. Insights into
            the role of intermediate filaments in specifying keratinocyte
            cytoarchitecture
  JOURNAL   Subcell Biochem 31, 173-204 (1998)
   PUBMED   9932493
  REMARK    Review article
REFERENCE   10 (bases 1 to 2570)
  AUTHORS   Tobiasch,E., Winter,H. and Schweizer,J.
  TITLE     Structural features and sites of expression of a new murine 65 kD
            and 48 kD hair-related keratin pair, associated with a special type
            of parakeratotic epithelial differentiation
  JOURNAL   Differentiation 50 (3), 163-178 (1992)
   PUBMED   1385239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY779643.1, CF173770.1, BC114971.1, CJ052880.1 and AA738772.1.
            
            On Mar 31, 2009 this sequence version replaced NM_008474.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028607.1, BC114971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               BY779643.1         1-339
            340-812             CF173770.1         74-546
            813-980             BC114971.1         766-933
            981-992             CJ052880.1         210-221
            993-2097            BC114971.1         946-2050
            2098-2570           AA738772.1         3-475               c
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.9 cM"
     gene            1..2570
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /note="keratin 84"
                     /db_xref="GeneID:16680"
                     /db_xref="MGI:MGI:96700"
     exon            1..635
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1877
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /note="K84; type-II keratin Kb24; 65 kDa type II keratin;
                     type II hair keratin Hb4; keratin complex 2, gene 16;
                     keratin complex 2, basic, gene 16"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb4"
                     /protein_id="NP_032500.2"
                     /db_xref="CCDS:CCDS27853.1"
                     /db_xref="GeneID:16680"
                     /db_xref="MGI:MGI:96700"
                     /translation="MSCRSYRVSSGRRVGSFSSCSAMAPQHLNRFRSSSVSCRSGPGF
                     RGLGGFGSRSVINFGSSSPRIAVGCSRPVRCGVGFGAGSGMAFGSGDGLGFRASSGVG
                     LGFGAGGCPSYGFGGPGFGGPGFGGPGFGYRIGGIGGPSAPAITAVTVNQSLLTPLNL
                     EIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCARSNL
                     EPLFDNYITNLRRQLDVLSSDQARLQAERNHLQDILEGFKKKYEEEVVFRANAENEFV
                     ALKKDVDAAFLNKSDLEANVDTLIQETEFLKALYHEEIEMLQSHISETSVIVKMDNSR
                     DLNLDGIIAEVKAQYEEVARRSRADVESWYQTKYEEMRVTAGQHCDNLRSTRDEINEL
                     TRLIQRLKAEIEHTKAQCAKLEAAVAEAEQQGEAALNDAKCKLADLEGALQQAKQDMA
                     RQLREYQELMNVKLALDIEIVTYRRLLEGEEIRICEGVGPVNISVSSSRGGVLCGPEL
                     VSGSSLSHNGGVTFSTSSSIRATGGVLASSSLRAGGDLLSSGSRGGSVLVGDACAPSI
                     PCALPTEGGFSSCSGGRGNRSSSVRFSSTTTSRRTRY"
     exon            636..844
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..905
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1001
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1166
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1292
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1513
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1545
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2570
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="Krt84"
                     /gene_synonym="HRb-1; Krt2-16; Krt2-3"
                     /note="major polyA site"
ORIGIN      
        1 agagactccc agctccagct caccccgctc cacattgctc ctcagctacc gtctacaaag
       61 ccaccatgtc ttgccgctcc tacagagtca gctctggccg tcgggtggga agcttcagtt
      121 cttgctcagc aatggcccct cagcatctga accgcttccg gtccagctct gtctcctgca
      181 ggagtgggcc tggcttccgg ggcttgggtg gttttggtag tcggagcgtc atcaactttg
      241 gatcatcctc accccggata gcagttggat gctctcgtcc tgtccgctgt ggagttggct
      301 ttggagctgg cagtgggatg gcctttggat ctggtgatgg cctgggcttt agggccagca
      361 gcggtgttgg cctggggttt ggggctggcg gctgccctag ctatggattc ggaggccctg
      421 gattcggagg ccctggcttt ggtggccctg gctttggcta cagaatcgga ggaattggag
      481 gcccatcagc ccccgctatc acagctgtaa ctgttaacca gagcctgctg acacccctca
      541 acctggagat tgaccccaat gcccagaggg tgaagagaga cgaaaaggag cagatcaaga
      601 ccctcaacaa caaatttgcc tccttcattg ataaggtgag gtttctggag caacagaata
      661 aactcctaga gaccaagtgg agcttcctcc aagaacagaa atgtgcccgg agcaatctgg
      721 agcctctctt cgataactat atcaccaacc tgcggaggca gctggatgtc ctaagcagtg
      781 accaggctcg gctgcaggca gagaggaacc acctgcaaga catccttgag ggcttcaaga
      841 agaagtatga agaggaggtg gtattccggg ccaatgccga gaatgagttt gtagcgctga
      901 agaaggatgt agatgcagct ttcctgaaca aatctgatct ggaagccaat gtggatactc
      961 tgatccagga aactgaattc ctgaaggctc tctaccatga ggaaatcgag atgctgcaat
     1021 cacacatatc agagacatct gtcatcgtga agatggacaa cagccgggat ctgaacctag
     1081 atgggatcat agctgaagtc aaggcacagt atgaggaggt ggcgaggcgg agtcgtgcag
     1141 atgtggagtc gtggtaccag accaagtatg aggagatgcg ggtgaccgct ggccagcact
     1201 gtgacaatct acgtagcaca cgggacgaga tcaatgaact gacccggttg atccagaggc
     1261 tgaaagcaga gatcgagcat accaaggctc agtgtgccaa actggaggct gctgtggctg
     1321 aggcagagca gcagggtgaa gcagccctca atgatgccaa gtgcaagctg gctgatctgg
     1381 agggtgccct gcagcaggcc aagcaggaca tggccaggca gctgcgggag taccaggagc
     1441 tcatgaatgt caagctggcc ctggacatcg agattgtcac ctacaggagg ctgctggagg
     1501 gcgaggaaat tcggatctgc gaaggagttg ggccagtaaa catatctgtg agcagctctc
     1561 gaggaggtgt gctgtgtggg cccgagttag tctctggatc cagcctttcc cacaatggtg
     1621 gagtcacctt ctccaccagc agcagcatcc gtgccaccgg aggggttctg gcttcctcaa
     1681 gcctgagggc tggtggggac ctgctgagct ctgggtccag aggaggctca gtgctggtgg
     1741 gtgatgcctg tgcccccagc atcccctgtg cactgcccac tgagggaggc ttcagtagct
     1801 gcagtggtgg tcgtggtaac aggagctcca gcgtccgctt ctcatctacc accacctccc
     1861 gcaggaccag gtactgagca cctagcccca ggggccactg cccagagaag aaccagctga
     1921 acatcccctg ctcctatccc ctgaggtgca cagactctgg tcctgaggga tctccagcca
     1981 ctcttcctgc cagcacacaa acctagccca tgtcctcctg aaggattctc cctaattcct
     2041 ttccttcgga tcctcctcag gctccagcca cagtaaatgt attttcagca ctactaccga
     2101 aagcagtgcc cctggggaga gaggggtcgt tcagagccag catgagcaca gacccctaag
     2161 atctgcaggc atccttagcc catcttgtcc ctccctcttc ccttccctgg cagaagatgc
     2221 ttcatcatcc ctcccctgac cccaaagggc acacagtcct tggtggcccc agggatacct
     2281 aagttcctgt gacggttctt ctcccagtgg ttcgtccggg ccatttctct tatggttgtt
     2341 ggtttatctg cggtatgtgg gtctgccaag taggtggagt tcatatggag aggtggtctc
     2401 tttagctcca tgtgccttgt tcttgtggtg atgatatgag gcccaactct gtgccctgtg
     2461 gttgcagcag ggttgtgtct gcaaactctg ggagtctggg ggtgggcggg acctgtttgt
     2521 actactcttt gtatttctgg gttttcaata aacttgccaa gctaacttca
//
