LOCUS       NM_001201323            1775 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 83 (Krt83), mRNA.
ACCESSION   NM_001201323 XM_003085066
VERSION     NM_001201323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1775)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1775)
  AUTHORS   Tobiasch,E., Schweizer,J. and Winter,H.
  TITLE     Structure and site of expression of a murine type II hair keratin
  JOURNAL   Mol Biol Rep 16 (1), 39-47 (1992)
   PUBMED   1372089
REFERENCE   4  (bases 1 to 1775)
  AUTHORS   Yu,D.W., Pang,S.Y., Checkla,D.M., Freedberg,I.M., Sun,T.T. and
            Bertolino,A.P.
  TITLE     Transient expression of mouse hair keratins in transfected HeLa
            cells: interactions between 'hard' and 'soft' keratins
  JOURNAL   J Invest Dermatol 97 (2), 354-363 (1991)
   PUBMED   1712823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133718.1 and AI561926.1.
            
            On Jan 14, 2011 this sequence version replaced XM_003085066.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133718.1, M92088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1742              AK133718.1         2-1743
            1743-1775           AI561926.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..1775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.9 cM"
     gene            1..1775
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /note="keratin 83"
                     /db_xref="GeneID:100126226"
                     /db_xref="MGI:MGI:3690448"
     exon            1..426
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1503
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /note="keratin type II"
                     /codon_start=1
                     /product="type II hair keratin"
                     /protein_id="NP_001188252.1"
                     /db_xref="CCDS:CCDS49735.1"
                     /db_xref="GeneID:100126226"
                     /db_xref="MGI:MGI:3690448"
                     /translation="MTCGFRTGNFSCASACGPRPGRCCISAAPYRGISCYRGLSGGFG
                     SQSVCGAFRSGSCGRSFGYRSGGICGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKH
                     EEKEQIKCLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNRKCCESNMEPLFEGYIETL
                     RREAECVEADSGRLAAELNHAQESMEGYKKRYEEEVALRATAENEFVALKKDVDCAYL
                     RKSDLEANAEALTQETDFLRRMYDEETRILHSHISDTSVIVKMDNSRDLNMDCVVAEI
                     KAQYDDIASRSRAEAESWYRTKCEEMKATVIRHGETLRRTREEINELNRMIQRLTAEI
                     ENAKCQNTKLEAAVTQSEQQGEAALADARCKLAELEGALQKAKQDMACLLKEYQEVMN
                     SKLGLDVEIITYRRLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSV
                     CSAPCSGNVAVSTGLCAPCGSGPCHPGRC"
     exon            427..635
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            636..696
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..792
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            793..957
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1083
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1304
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1336
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1757
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1757
                     /gene="Krt83"
                     /gene_synonym="5430421N21Rik"
                     /note="major polyA site"
ORIGIN      
        1 acacggcctc agttccaaac actgtcaact tctctcctct tcgcgcgtgt cttctcctcc
       61 accatgacct gtggctttcg aactggaaac ttcagctgcg cctcagcctg cgggccccgg
      121 cctggccgct gctgcatctc tgcagctccc tacaggggca tctcctgcta ccgaggactc
      181 tcagggggct tcggcagcca gagtgtctgt ggggccttcc gctccggctc ctgtggacgc
      241 agcttcgggt accgatctgg aggcatctgc gggcccagcc caccctgcat caccaccgtc
      301 tctgtcaatg agagcctgct cacacccctg aacctggaga tcgaccccaa tgctcagtgt
      361 gtgaagcatg aggagaaaga gcagatcaag tgtctcaaca gcaggttcgc ggccttcatc
      421 gacaaggtgc gcttcctgga gcagcagaac aagctgctgg agaccaagtg gcagttctac
      481 cagaaccgca agtgctgtga gagcaacatg gagcctctgt tcgagggcta catcgagacg
      541 ctgaggcggg aggctgagtg tgtggaggcc gacagcggga ggctggctgc tgagctcaac
      601 catgcgcagg agtccatgga gggctacaag aagaggtatg aagaagaagt tgcactccgg
      661 gccacagcag agaatgagtt tgtggctcta aagaaggatg tggactgtgc ctacctgcgc
      721 aagtcagatc tggaggccaa cgcagaggct ctgacccaag agaccgactt cctgaggaga
      781 atgtatgatg aggagacccg catcctccat tcccacatct cagacacatc tgtcatcgtc
      841 aagatggaca acagccggga cctgaacatg gactgtgtcg tggctgagat caaggctcag
      901 tatgatgaca ttgccagccg cagccgtgct gaggccgagt cctggtaccg caccaagtgt
      961 gaggagatga aggccacagt gatccggcat ggagagactc tgcgccgcac cagagaggag
     1021 atcaatgagc tgaacagaat gatccagagg ctgactgctg agatcgagaa tgccaagtgc
     1081 cagaacacca agctggaggc tgctgtgacc caatctgagc agcagggaga ggctgccctt
     1141 gctgatgccc gctgcaagct ggctgagttg gagggtgccc tgcagaaggc taagcaggac
     1201 atggcctgcc tgctcaagga gtaccaggag gtgatgaact ccaagctggg gctggacgtg
     1261 gagatcatca cctacaggcg cctgctggag ggcgaggagc agaggctgtg tgaaggcgtg
     1321 ggagctgtga atgtctgtgt cagcagctcc cgtggtggag ttgtgtgcgg ggacctctgt
     1381 gtgtctggct cacggcctgt gacaggcagt gtctgcagtg ccccatgcag cgggaatgtg
     1441 gcagtaagca ctggcctgtg tgcgccctgt ggaagcggcc cttgtcaccc ggggaggtgt
     1501 taggagacaa gagggagcca ggaagtggcc tggactacaa ggctaagcat ggtagcttca
     1561 aggtctgctg cccttgtgtt ctgagaatac attccccatc cccagcagct gccactccat
     1621 tcagctacct gctggcaagg ggcttgctgc tgatagatca gcctcctgcc tcagctgcag
     1681 ccctgggaat acccagtgct gtttcctgtg cctctggcct ctaggccctg ttgtgcaata
     1741 aactgtgctg actctcaaaa aaaaaaaaaa aaaaa
//
