LOCUS       NM_053249               2100 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus keratin 82 (Krt82), mRNA.
ACCESSION   NM_053249
VERSION     NM_053249.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Noto,M., Noguchi,N., Ishimura,A., Kiyonari,H., Abe,T., Suzuki,T.,
            Hasunuma,N., Taira,M., Manabe,M. and Osada,S.I.
  TITLE     Sox13 is a novel early marker for hair follicle development
  JOURNAL   Biochem Biophys Res Commun 509 (4), 862-868 (2019)
   PUBMED   30638933
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Bray,D.J., Walsh,T.R., Noro,M.G. and Notman,R.
  TITLE     Complete Structure of an Epithelial Keratin Dimer: Implications for
            Intermediate Filament Assembly
  JOURNAL   PLoS One 10 (7), e0132706 (2015)
   PUBMED   26181054
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Sotiropoulou,P.A., Karambelas,A.E., Debaugnies,M., Candi,A.,
            Bouwman,P., Moers,V., Revenco,T., Rocha,A.S., Sekiguchi,K.,
            Jonkers,J. and Blanpain,C.
  TITLE     BRCA1 deficiency in skin epidermis leads to selective loss of hair
            follicle stem cells and their progeny
  JOURNAL   Genes Dev 27 (1), 39-51 (2013)
   PUBMED   23271346
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Narhi,K., Tummers,M., Ahtiainen,L., Itoh,N., Thesleff,I. and
            Mikkola,M.L.
  TITLE     Sostdc1 defines the size and number of skin appendage placodes
  JOURNAL   Dev Biol 364 (2), 149-161 (2012)
   PUBMED   22509524
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Zhang,Y., Andl,T., Yang,S.H., Teta,M., Liu,F., Seykora,J.T.,
            Tobias,J.W., Piccolo,S., Schmidt-Ullrich,R., Nagy,A., Taketo,M.M.,
            Dlugosz,A.A. and Millar,S.E.
  TITLE     Activation of beta-catenin signaling programs embryonic epidermis
            to hair follicle fate
  JOURNAL   Development 135 (12), 2161-2172 (2008)
   PUBMED   18480165
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Pin,C.L., Rukstalis,J.M., Johnson,C. and Konieczny,S.F.
  TITLE     The bHLH transcription factor Mist1 is required to maintain
            exocrine pancreas cell organization and acinar cell identity
  JOURNAL   J Cell Biol 155 (4), 519-530 (2001)
   PUBMED   11696558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC108971.2 and AA607752.1.
            
            On Dec 30, 2009 this sequence version replaced NM_053249.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108971.2, AY028606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849383,
                                           SAMN01164138 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1769              BC108971.2         1-1769
            1770-2100           AA607752.1         1-331               c
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.9 cM"
     gene            1..2100
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /note="keratin 82"
                     /db_xref="GeneID:114566"
                     /db_xref="MGI:MGI:2149248"
     exon            1..461
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1607
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /note="K82; type-II keratin Kb22; type II hair keratin
                     Hb2; keratin complex 2, basic, gene 20"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb2"
                     /protein_id="NP_444479.2"
                     /db_xref="CCDS:CCDS27854.1"
                     /db_xref="GeneID:114566"
                     /db_xref="MGI:MGI:2149248"
                     /translation="MSCRNFQLSPRCGNRSFSSCSAIMPRMVTHYEVSKAPCRSGGGG
                     GLRALGCLGSRSLCNVGFGRPRVASRCGMPGFGYRAGATCGSSACITPVTINESLLVP
                     LELEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRSCQ
                     SNMEPLFEGYICALRRQLDCVSGDHGRLEAELCSLQEALEGYKKKYEEELSLRPCAEN
                     EFVTLKKDVDTAFLVKADLETNLEALEHEIEFLKALFEEEIGLLQSQISETSVIVKMD
                     NSRELDVDGIVAEIKAQYDDIASRSKAEAEAWYQCRYEELRLTAGNHCDNLRNRKNEI
                     LEMNKLIQRLQQDIEAVKGQRCKLEGAIAQAEQQGEAALTDAKCKLAGLEEALQKAKQ
                     DMACLLKQYQEVMNCKLGLDIEIATYRRLLEGEEHRLCEGIGPVNISVSSSKGAVLYE
                     PCVMGTPMLRTEYCTGTTGVLRNSGGCNVVGTGELYIPCEPQGLLGCGNGRSSSMKVG
                     VGSNSCSR"
     exon            462..670
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            671..731
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            732..827
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            828..992
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1118
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1339
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1371
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2100
                     /gene="Krt82"
                     /gene_synonym="Krt2-20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcccgtc cccattctcc tttctctcca gggatccacc tctgcctccc aaagtcatgt
       61 catgccgaaa tttccagttg agccccagat gtggcaaccg gagtttcagc tcgtgctcag
      121 ccatcatgcc ccggatggtc acccactatg aagtgagcaa ggcgccctgt cggtccgggg
      181 gtggcggggg cctccgagcc ctgggttgcc ttggctctcg gagcctgtgc aacgtgggtt
      241 tcgggaggcc ccgtgtggcc tccagatgcg gcatgccagg cttcgggtac cgagcgggag
      301 ccacctgtgg atcttctgcc tgcatcaccc ctgtcaccat caatgagagt ctgctggtcc
      361 ccctggagct ggagattgac ccgaccgtgc aaagggtgaa gagagatgaa aaggagcaga
      421 ttaagtgcct gaataaccga ttcgcatcct tcatcaacaa ggtgcggttc ctggagcaga
      481 aaaacaagct tctggagacc aagtggaact tcatgcagca gcagagaagt tgccagagca
      541 acatggagcc gctcttcgag ggctacatct gtgccctgcg gcgacagctg gactgtgtgt
      601 ccggggacca cggcagacta gaggccgagc tctgcagtct ccaggaggcg ctggagggtt
      661 ataagaaaaa gtacgaagag gagctgtctc tgcgtccctg tgctgagaat gagtttgtca
      721 ccctgaagaa ggacgtggac acagccttcc tggtgaaggc tgacctggaa accaacttgg
      781 aggctctaga acatgagatt gagttcctga aagccctgtt tgaggaggag atcggcctgc
      841 tgcagtctca gatctcagag acttcagtca tcgtgaagat ggacaacagc cgggaactgg
      901 atgtggacgg catcgtagcc gagatcaagg cccagtatga cgacatcgcc agccgcagca
      961 aagcagaagc agaggcctgg taccagtgcc ggtatgagga gctgaggtta acggctggga
     1021 accactgtga caacctacgc aaccgcaaaa atgagatcct ggaaatgaac aagctaatcc
     1081 agcggctgca gcaggacatt gaggcagtca aaggccagcg atgcaagctc gagggggcca
     1141 ttgcccaggc agagcagcag ggagaggccg ccctcactga tgccaagtgc aagctggcag
     1201 ggctggagga ggccttgcag aaggccaagc aggacatggc ctgcctgctc aagcagtacc
     1261 aagaggtgat gaactgcaag ctggggctgg acatcgagat cgccacctac aggcgcctgc
     1321 tggagggcga ggagcacagg ttgtgtgaag gcatcgggcc tgtgaatatc tctgtcagca
     1381 gctccaaagg tgccgtactc tacgagccct gtgtgatggg cacgcccatg ctgaggaccg
     1441 aatactgcac cgggaccacg ggtgtcctga ggaacagtgg gggctgcaac gtggtgggca
     1501 ccggtgaact ctacatcccc tgcgagcccc aagggctcct gggctgtgga aatgggcgga
     1561 gctccagcat gaaggtgggg gtgggtagca attcgtgcag ccgctagtgt tagcgctact
     1621 cagattctga aattgctgaa taccacatct ctatggggct gaagaccaga atattccaaa
     1681 actcttccct tcccacacca actacacatt gccctgggat actcctggga gctgagctac
     1741 tcccagcccc gctcatttct tcaaagccac ccttcgcata tctagatgca gaccccaagc
     1801 tggacacaga gtatgtggag acacagagaa gggggtttta ttgtctctgt cacctggggt
     1861 agcaagtcaa ctttaagaca gtcaagagaa tggctatagt cttaccacca cttctctccc
     1921 aggaggggtg gccagctgta cacacaactg ttctgttttg caaaaggctc catttcactt
     1981 tcctcacaaa gccagccctt gtcctttcta ccccatctcc tttccctctg gctctcaaat
     2041 agctaagaaa attgaactca taggacccac ctgaagcatg cagtattata aaaaaaaaaa
//
